The paper evaluates landscape development, land-use changes, and transport infrastructure variations in the city of Martin and the town of Vrútky, Slovakia, over the past 70 years. It focuses on analyses of the landscape structures characterizing the study area in several time periods (1949, 1970, 1993, 2003); the past conditions are then compared with the relevant current structure (2018). Special attention is paid to the evolution of the landscape elements forming the transport infrastructure. The development and progressive changes in traffic intensities are presented in view of the resulting impact on the formation of the landscape structure. The research data confirm the importance of transport as a force determining landscape changes, and they indicate that while railroad accessibility embodied a crucial factor up to the 1970s, the more recent decades were characterized by a gradual shift to road transport.