scholarly journals EFFECT OF FEEDING THE PINEAL BODY UPON THE DEVELOPMENT OF THE ALBINO RAT

1920 ◽  
Vol 31 (3) ◽  
pp. 335-344 ◽  
Author(s):  
Warren R. Sisson ◽  
John M. T. Finney
Keyword(s):  
Microscopic Examination ◽  
Reproductive Organs ◽  
Developmental Changes ◽  
Pineal Body ◽  
Albino Rats ◽  
Endocrine Glands ◽  
Albino Rat ◽  
Microscopic Studies ◽  
And Control ◽  
Effect Of Feeding

The pineal body of young calves was fed to albino rats beginning at the age of 3 weeks and extending over periods of from 3 to 6 weeks. Four litters of rats were used. Of these, fourteen rats were fed the pineal powder and ten were used as control subjects. Observations in regard to developmental changes and microscopic examination of the endocrine glands and reproductive organs were made. The pineal-fed rats of the first two litters remained somewhat smaller than their controls. The pineal-fed and control animals of Litters 3 and 4 showed no differences in development. Microscopic studies showed no differences between pineal-fed and control rats. We may therefore conclude that feeding the desiccated pineal body of young calves to young albino rats fails to produce any effect upon the early development of these animals.

Effects of renovascular hypertension on rat adrenal zona glomerulosa

1978 ◽  
Vol 36 (2) ◽  
pp. 582-583
Author(s):  
G. Mazzocchi ◽  
P. Rebuffat ◽  
C. Robba ◽  
P. Vassanelli ◽  
G. G. Nussdorfer
Keyword(s):  
Renovascular Hypertension ◽  
Left Kidney ◽  
Renin Angiotensin System ◽  
Plasma Renin ◽  
Zona Glomerulosa ◽  
Ultrastructural Changes ◽  
Albino Rats ◽  
Left Renal Artery ◽  
Angiotensin System ◽  
And Control

It is well known that the rat adrenal zona glomerulosa steroidogenic activity is controlled by the renin-angiotensin system. The ultrastructural changes in the rat zona glomerulosa cells induced by renovascular hypertension were described previously, but as far as we are aware no correlated biochemical and morphometric investigations were performed.Twenty adult male albino rats were divided into 2 experimental groups. One group was subjected to restriction of blood flow to the left kidney by the application of a silver clip about the left renal artery. The other group was sham-operated and served as a control. Renovascular hypertension developed in about 10 days: sistolic blood pressure averaged 165 ± 6. 4 mmHg, whereas it was about 110 ± 3. 8 mmHg in the control animals. The hypertensive and control rats were sacrificed 20 days after the operation. The blood was collected and plasma renin activity was determined by radioimmunological methods. The aldosterone concentration was radioimmunologically assayed both in the plasma and in the homogenate of the left capsular adrenal gland.

MONITORING AND CONTROL OF THE “ANIMAL” SUBSYSTEM IN THE COMPLEX BIOTECHNICAL SYSTEM “MAN-MACHINE-ANIMAL” OF A DAIRY FARM

2020 ◽  
pp. 4-10
Author(s):  
VLADIMIR V. KIRSANOV ◽  
◽  
DMITRIY YU. PAVKIN ◽  
FEDOR E. FEDOR E. VLADIMIROV ◽  
EVGENIY А. NIKITIN ◽  
...  
Keyword(s):  
Dairy Farm ◽  
Animal Husbandry ◽  
Reproductive Organs ◽  
Monitoring And Control ◽  
Lactating Cows ◽  
Research Activities ◽  
Mutual Adaptation ◽  
Biotechnical System ◽  
Complex Project ◽  
And Control

A modern dairy farm is a complex biotechnical “man-machine-animal” system, where purposeful human activity concentrates mainly on the control of the “machine” and “animal” subsystems, thus making the whole system ergatic. Increasing the interaction effi ciency of machine subsystems with biological objects (animals) requires an in-depth study of the properties and characteristics of the latter, their behavior, adaptive and refl ex mechanisms that ensure the mutual adaptation of machine and biological subsystems. The paper considers general functionality of the “animal” subsystem, which includes lists of monitored parameters (functions) in pre-weaning, pre-lactation and lactation periods. In a similar way, functionals of the subsystems of the general musculoskeletal development of the animal’s body, respiratory and digestive organs, comfort of the habitat, development and control of the reproductive organs of lactating cows were obtained accompanied with a list of controlled functions and parameters. To carry out a set of research activities in this fi eld, FSAC VIM is planning to carry out a complex project that will increase the levels of automation, digitalization and intellectualization of animal husbandry, provide for comfortable environment, optimal rediced-impact service modes for animals and their extended productive longevity, increased quality of milk and autonomous functioning of individual local biotechnical subsystems.

Effects of Dihydroquercetin on Behavior of Albino Rat Offspring with Transgenerational Chemical Body Burden

2020 ◽  
pp. 38-41
Author(s):  
E.A. Kapustina ◽  
L.G. Lisetskaya
Keyword(s):  
Physical Activity ◽  
Open Field ◽  
Antioxidant Properties ◽  
Body Burden ◽  
Statistical Processing ◽  
Lead Toxicity ◽  
Absorption Spectrometry ◽  
Albino Rats ◽  
Albino Rat ◽  
Rat Offspring

Introduction. Lead pollution is a common environmental problem. Having no physiological functions, this toxicant has a negative polytropic impact on a body, including neurotoxic, reproductive, and transgenerational effects. The mechanism of lead toxicity is oxidative stress. Flavonoids have active antioxidant properties. They are widely represented in plant foods, are able to restore protective capabilities of cells and have chelating properties with respect to lead. One of the representatives of this group of substances is dihydroquercetin. The objective was to study the effect of dihydroquercetin on behavior of rats with hereditary chemical body burden exposed to lead at 60 mg/kg during 25 days. Materials and methods. We studied the behavior of rat offspring in an open field and established their blood lead levels by electrothermal atomization atomic absorption spectrometry. For statistical processing the U-Mann – Whitney test was used. Results. In the present experiment, the effect of lead on the offspring of male albino rats exposed to 60 mg/kg of lead for 25 days caused changes in the activity of animals in the open field. The severity of changes was more pronounced in animals with a hereditary chemical body burden. These animals showed a decrease in orientation and physical activity and increased anxiety. In rats with a hereditary burden, changes in behavior were detected when administering dihydroquercetin. The activity of animals demonstrated a positive dynamics: we observed a statistically significant increase in physical activity and orientation. The number and duration of behavioral acts approached control values. Conclusions. The revealed effects of lead on the offspring of albino rats with a transgenerational chemical body burden require further study to understand the mechanism of the phenomenon.

REPRODUCTIVE TOXICITY OF CHLORPYRIFOS, CYPERMETHRIN AND THEIR INTERACTION IN MALE ALBINO RATS

2018 ◽  
pp. 69-86
Author(s):  
Asmaa ELnamaky ◽  
Amal Halawa ◽  
Mamdouh Abouelmaged
Keyword(s):  
Reproductive Toxicity ◽  
Prostatic Acid Phosphatase ◽  
Serum Levels ◽  
Reproductive Organs ◽  
Male Rats ◽  
Albino Rats ◽  
Glutathione S Transferase ◽  
Significant Drop ◽  
Sperm Abnormalities ◽  
Pituitary Glands

he present work was designed to investigate the reproductive toxicity induced by oral administration of chlorpyrifos (CPF), cypermethrin (CYP) and their combination in adult male albino rats. Forty mature male albino rats were separated into four groups (10 each), the first group was used as control, while second, third and fourth groups received orally 1/20 LD50 of CPF (10 mg/kg b.wt), 1/20 LD50 of CYP (17.22 mg/kg b.wt) and 1/40 LD50 of CPF plus 1/40 LD50 of CYP (5 mg/kg b.wt CPF plus 8.61 mg/kg b.wt CYP) respectively for 26 days. The results revealed that exposure to CPF and/or CYP induced a significant decrease in the reproductive organs weight. Moreover, a significant decrease in spermatic picture (sperm cell concentration and viability) was observed with high percent of sperm abnormalities. Serum levels of testosterone and pituitary gonadotropins (FSH and LH) have been declined significantly in all treated groups. Significant elevations were observed in malondialdehyde and nitric oxide concentrations, while antioxidant enzymes superoxide dismutase and glutathione-S-transferase activities were decreased significantly as a result of induced oxidative stress. A significant drop in prostatic acid phosphatase activity was observed. Additionally, the results showed some histopathological alterations in the reproductive organs as well as neurological lesions in brain and pituitary glands. In conclusion, CPF and CYP induce deleterious effects on reproductive efficiency of male rats which reflect more obvious impacts when both combined

scholarly journals Four Weeks of Aerobic Training Affects Cardiac Tissue Matrix Metalloproteinase, Lactate Dehydrogenase and Malate Dehydrogenase Enzymes Activities, and Hepatorenal Biomarkers in Experimental Hyperhomocysteinemia in Rats

2021 ◽  
Vol 22 (13) ◽  
pp. 6792
Author(s):  
Dusan Todorovic ◽  
Marija Stojanovic ◽  
Ana Medic ◽  
Kristina Gopcevic ◽  
Slavica Mutavdzin ◽  
...  
Keyword(s):  
Physical Activity ◽  
Lactate Dehydrogenase ◽  
Malate Dehydrogenase ◽  
Subcutaneous Injection ◽  
Cardiac Tissue ◽  
Albino Rats ◽  
Wistar Albino Rats ◽  
And Control ◽  
Tissue Matrix ◽  
Increased Activity

The aim of this study was to investigate the effect of the application of homocysteine as well as its effect under the condition of aerobic physical activity on the activities of matrix metalloproteinases (MMP), lactate dehydrogenase (LDH) and malate dehydrogenase (MDH) in cardiac tissue and on hepato-renal biochemical parameters in sera of rats. Male Wistar albino rats were divided into four groups (n = 10, per group): C: 0.9% NaCl 0.2 mL/day subcutaneous injection (s.c.); H: homocysteine 0.45 µmol/g b.w./day s.c.; CPA saline (0.9% NaCl 0.2 mL/day s.c.) and a program of physical activity on a treadmill; and HPA homocysteine (0.45 µmol/g b.w./day s.c.) and a program of physical activity on a treadmill. Subcutaneous injection of substances was applied 2 times a day at intervals of 8 h during the first two weeks of experimental protocol. Hcy level in serum was significantly higher in the HPA group compared to the CPA group (p < 0.05). Levels of glucose, proteins, albumin, and hepatorenal biomarkers were higher in active groups compared with the sedentary group. It was demonstrated that the increased activities of LDH (mainly caused by higher activity of isoform LDH2) and mMDH were found under the condition of homocysteine-treated rats plus aerobic physical activity. Independent application of homocysteine did not lead to these changes. Physical activity leads to activation of MMP-2 isoform and to increased activity of MMP-9 isoform in both homocysteine-treated and control rats.

Effect of Morphine Sulfate on Spontaneous Activity Level of the Albino Rat

1965 ◽  
Vol 16 (3) ◽  
pp. 693-696 ◽  
Author(s):  
L. Glenn Collins
Keyword(s):  
Drug Effect ◽  
Activity Wheel ◽  
Activity Level ◽  
Morphine Sulfate ◽  
Albino Rats ◽  
Systematic Effect ◽  
General Activity ◽  
Albino Rat ◽  
General Activity Level ◽  
Hunger Drive

In two experiments involving 40 albino rats and two dosage levels of morphine sulfate it was found that relatively high analgesic dosages of morphine significantly depressed general activity level in the revolving drum. Also, there was a significant interaction between drug effect and hunger drive. In the case of moderate analgesic doses (7 mg/kg) no systematic effect of morphine on activity-wheel performance was noted.

scholarly journals CHRONIC SODIUM CHLORIDE TOXICITY IN THE ALBINO RAT

1953 ◽  
Vol 98 (1) ◽  
pp. 71-80 ◽  
Author(s):  
George R. Meneely ◽  
Robert G. Tucker ◽  
William J. Darby ◽  
Stewart H. Auerbach
Keyword(s):  
Blood Pressure ◽  
Sodium Chloride ◽  
Relative Volume ◽  
Dietary Sodium ◽  
Albino Rats ◽  
Albino Rat ◽  
Positive Linear Correlation ◽  
Ad Libitum ◽  
Histologic Changes ◽  
Dietary Sodium Chloride

Sustained arterial hypertension developed in male, albino rats chronically fed diets rich in sodium chloride with demineralized drinking water available ad libitum. After 12 months of the experimental regimen a positive, linear correlation (r = 0.91) was found between the systolic blood pressure and the concentration of sodium chloride in the diet. A syndrome of edema and renal failure was observed in 18 per cent of the group fed at the level of 7.0 to 9.8 per cent of sodium chloride. Significant histologic changes occurred in the kidneys and certain other organs in rats consuming rations containing these levels of NaCl. The relative volume of the radiosodium space was increased in the rat by high dietary sodium chloride.

Visual thresholds in albino and pigmented rats

1992 ◽  
Vol 9 (3-4) ◽  
pp. 409-414 ◽  
Author(s):  
Pilar Herreros De Tejada ◽  
Daniel G. Green ◽  
Carmen Muñoz Tedó
Keyword(s):  
Evoked Potentials ◽  
Superior Colliculus ◽  
Absolute Threshold ◽  
Albino Rats ◽  
Response Curves ◽  
Albino Rat ◽  
A Value ◽  
Visual Evoked Cortical Potential ◽  
Single Unit Recordings ◽  
Visual Evoked

AbstractAlbino rats have recently been reported to have increment thresholds against dim backgrounds that are two log units higher than those of pigmented rats. We, on the other hand, have failed to confirm these differences using electroretinogram b waves and pupillary light reflexes. This paper reports on experiments using evoked potentials from cortex and colliculus and single-unit recordings from colliculus.We recorded visual-evoked potentials from cortex and superior colliculus in the strains of albino (CD) and pigmented (Long-Evans) rats used in the earlier studies. Thresholds were determined on eight fully dark-adapted animals by extrapolating intensity-response curves to the point at which there was zero evoked potential. The average dark-adapted threshold for the visual-evoked cortical potential was —5.26 log cd/m2in pigmented and —5.80 log cd/m2 in albino animals. The average dark-adapted threshold for the superior colliculus evoked response was —5.54 log cd/m2 in pigmented and —5.84 log cd/m2 in albinos. The differences were not statistically significant. On the same apparatus, the average absolute threshold for three human observers was —5.3 log cd/m2, a value close to the rat dark-adapted thresholds. Thus, visual-evoked cortical potentials and superior collicular evoked potentials failed to confirm the report of higher dark-adapted thresholds for albinos. In addition, we find that single units in superior colliculus in the albino rat respond to very dim flashes.

Quantitative effects of theelin on body growth and endocrine glands in young albino rats

1937 ◽  
Vol 69 (2) ◽  
pp. 171-177 ◽  
Author(s):  
Clay B. Freudenberger ◽  
Fred W. Clausen
Keyword(s):  
Body Growth ◽  
Albino Rats ◽  
Endocrine Glands
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