Ascorbic acid: effect on ongoing iron absorption and status in iron-depleted young women

1990 ◽  
Vol 51 (4) ◽  
pp. 649-655 ◽  
Author(s):  
J R Hunt ◽  
L M Mullen ◽  
G I Lykken ◽  
S K Gallagher ◽  
F H Nielsen
Keyword(s):  
Ascorbic Acid ◽  
Young Women ◽  
Iron Absorption ◽  
Acid Effect

scholarly journals Vitamin C—Sources, Physiological Role, Kinetics, Deficiency, Use, Toxicity, and Determination

Nutrients ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 615
Author(s):  
Martin Doseděl ◽  
Eduard Jirkovský ◽  
Kateřina Macáková ◽  
Lenka Krčmová ◽  
Lenka Javorská ◽  
...  
Keyword(s):  
Ascorbic Acid ◽  
Vitamin C ◽  
Iron Absorption ◽  
Plasma Concentrations ◽  
Physiological Role ◽  
Renal Stones ◽  
Anti Oxidant ◽  
High Doses ◽  
Epigenetic Processes

Vitamin C (L-ascorbic acid) has been known as an antioxidant for most people. However, its physiological role is much larger and encompasses very different processes ranging from facilitation of iron absorption through involvement in hormones and carnitine synthesis for important roles in epigenetic processes. Contrarily, high doses act as a pro-oxidant than an anti-oxidant. This may also be the reason why plasma levels are meticulously regulated on the level of absorption and excretion in the kidney. Interestingly, most cells contain vitamin C in millimolar concentrations, which is much higher than its plasma concentrations, and compared to other vitamins. The role of vitamin C is well demonstrated by miscellaneous symptoms of its absence—scurvy. The only clinically well-documented indication for vitamin C is scurvy. The effects of vitamin C administration on cancer, cardiovascular diseases, and infections are rather minor or even debatable in the general population. Vitamin C is relatively safe, but caution should be given to the administration of high doses, which can cause overt side effects in some susceptible patients (e.g., oxalate renal stones). Lastly, analytical methods for its determination with advantages and pitfalls are also discussed in this review.

Maturation, iron deficiency, and ligands in enteric radioiron transport in vitro

1963 ◽  
Vol 204 (1) ◽  
pp. 171-175 ◽  
Author(s):  
W. S. Ruliffson ◽  
J. M. Hopping
Keyword(s):  
Ascorbic Acid ◽  
Iron Deficiency ◽  
Iron Absorption ◽  
Deficiency Anemia ◽  
Anaerobic Incubation ◽  
Reverse Effect ◽  
Factors Affecting ◽  
Everted Gut Sac

The effects in rats, of age, iron-deficiency anemia, and ascorbic acid, citrate, fluoride, and ethylenediaminetetraacetate (EDTA) on enteric radioiron transport were studied in vitro by an everted gut-sac technique. Sacs from young animals transported more than those from older ones. Proximal jejunal sacs from anemic animals transported more than similar sacs from nonanemic rats, but the reverse effect appeared in sacs formed from proximal duodenum. When added to media containing ascorbic acid or citrate, fluoride depressed transport as did anaerobic incubation in the presence of ascorbic acid. Anaerobic incubation in the presence of EDTA appeared to permit elevated transport. Ascorbic acid, citrate, and EDTA all enhanced the level of Fe59 appearing in serosal media. These results appear to agree with previously established in vivo phenomena and tend to validate the in vitro method as one of promise for further studies of factors affecting iron absorption and of the mechanism of iron absorption.

Gastrectomy and Iron Absorption: Effects of Bleeding, Iron Loading and Ascorbic Acid in Rats.

1967 ◽  
Vol 124 (2) ◽  
pp. 577-580 ◽  
Author(s):  
E. E. Rieber ◽  
M. E. Conrad ◽  
W. H. Crosby
Keyword(s):  
Ascorbic Acid ◽  
Iron Absorption ◽  
Iron Loading

Effect of ascorbic acid on apparent iron absorption by women with low iron stores

1994 ◽  
Vol 59 (6) ◽  
pp. 1381-1385 ◽  
Author(s):  
J R Hunt ◽  
S K Gallagher ◽  
L K Johnson
Keyword(s):  
Ascorbic Acid ◽  
Iron Absorption ◽  
Iron Stores

The stability of Fe(III)-As(V) co-precipitate in the presence of ascorbic acid: Effect of pH and Fe/As molar ratio

Chemosphere ◽  
2019 ◽  
Vol 218 ◽  
pp. 670-679 ◽  
Author(s):  
Zidan Yuan ◽  
Guoqing Zhang ◽  
Jinru Lin ◽  
Xiangfeng Zeng ◽  
Xu Ma ◽  
...  
Keyword(s):  
Ascorbic Acid ◽  
Molar Ratio ◽  
Effect Of Ph ◽  
Acid Effect ◽  
The Stability

A stable-isotope study of zinc, copper, and iron absorption and retention by young women fed vitamin B-6-deficient diets

1991 ◽  
Vol 54 (6) ◽  
pp. 1059-1064 ◽  
Author(s):  
J R Turnlund ◽  
W R Keyes ◽  
C A Hudson ◽  
A A Betschart ◽  
M J Kretsch ◽  
...  
Keyword(s):  
Stable Isotope ◽  
Young Women ◽  
Iron Absorption ◽  
Vitamin B ◽  
Isotope Study ◽  
Stable Isotope Study

scholarly journals Ascorbic Acid Influence on the Extraction Intensity of the Anthocyanin Pigment from Black Currant Berries and Its Stability

Food Industry ◽  
2020 ◽  
Vol 5 (4) ◽  
pp. 68-73
Author(s):  
Natalia Chesnokova ◽  
Egor Ashikhmin
Keyword(s):  
Ascorbic Acid ◽  
Optical Density ◽  
Raw Materials ◽  
Solvent System ◽  
Intensity Increase ◽  
Anthocyanin Pigment ◽  
Black Currant ◽  
Plant Raw Materials ◽  
Acid Effect ◽  
Extraction Degree

The article considers the ascorbic acid effect on the extraction rate and stability of anthocyanin pigment exuded from black currant berries. The researchers treated defrosted and crushed black currant berries with 0.2–10.0 % solutions of ascorbic acid at temperatures of 20–90 °C for 5–150 minutes and 100 °C for 2.5 minutes, then filtered the solution out. They determined the color intensity of the solutions by the optical density using spectrophotometer SHIMADZU UV-1800 (Japan). To determine the anthocyanin pigment content, a man diluted samples with solvent system ethanol/water/hydrochloric acid (69/30/1) and measured their optical density at a wavelength of 540 nm. The authors calculate anthocyanins content in solutions using the formula and determine that the use of 0.2–1.0 % solution of ascorbic acid as an extractant leads to the extraction intensity increase of anthocyanin pigment from plant raw materials. Adding a 1.0 % ascorbic acid solution of to the system increases the extraction degree of anthocyanin pigment by 1.4 times. A further increase in the amount of ascorbic acid in the solution to 2.0–10.0 % leads to a slight increase in the extraction intensity of anthocyanin pigment. The most complete anthocyanin pigment is extracted from plant raw materials in the presence of ascorbic acid at exposure temperatures of 20-80 °C for 30 minutes and 100 °C for 2.5 minutes. An increase in the exposure time to 60-150 minutes leads to a drop in the extraction degree of anthocyanin pigment and a change in the solution color. The solution of the pigment color becomes brown.

scholarly journals Oral iron supplements increase hepcidin and decrease iron absorption from daily or twice-daily doses in iron-depleted young women

Blood ◽  
2015 ◽  
Vol 126 (17) ◽  
pp. 1981-1989 ◽  
Author(s):  
Diego Moretti ◽  
Jeroen S. Goede ◽  
Christophe Zeder ◽  
Markus Jiskra ◽  
Vaiya Chatzinakou ◽  
...  
Keyword(s):  
Young Women ◽  
Transferrin Receptor ◽  
Iron Absorption ◽  
Oral Iron ◽  
Soluble Transferrin Receptor ◽  
Iron Supplements ◽  
Key Points

Key Points Iron supplements at doses of 60 mg Fe as FeSO4 or higher increase hepcidin for up to 24 hours and are associated with lower iron absorption on the following day. The soluble transferrin receptor/ferritin ratio and hepcidin are equivalent predictors of iron absorption from supplements.

scholarly journals Iron absorption from rice meals cooked with fortified salt containing ferrous sulphate and ascorbic acid

1974 ◽  
Vol 31 (3) ◽  
pp. 367-375 ◽  
Author(s):  
M. H. Sayers ◽  
S. R. Lynch ◽  
R. W. Charlton ◽  
T. H. Bothwell ◽  
R. B. Walker ◽  
...  
Keyword(s):  
Ascorbic Acid ◽  
Iron Absorption ◽  
Ferrous Sulphate ◽  
Striking Difference ◽  
Red Cell ◽  
Indian Women ◽  
Threefold Increase ◽  
Cooking Process ◽  
Wide Range ◽  
The Mean

1. Iron absorption from rice-containing meals was measured by red cell utilization of radioactive Fe in sixty-six volunteer multiparous Indian women.2. In all the studies salt added during the cooking process was used as the carrier for supplemental inorganic Fe and ascorbic acid.3. Intrinsic Fe in the rice and supplementary inorganic Fe were absorbed to the same extent, with a wide range of absorption values.4. There was a striking difference between the mean absorption of a 3 mg dose of ferrous Fe given to fasting subjects in a solution containing 30 mg ascorbic acid and that of Fe in a rice meal (48.7 and 3.5% respectively).5. When ascorbic acid was added during cooking there was a threefold increase in the absorption of both intrinsic Fe and supplementary Fe when a sufficient quantity (60 mg) was present.6. It is concluded that the Fe nutrition of rice-eating communities could be improved significantly by the addition of ascorbic acid to the diet.

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