Mycobacterium tuberculosis infection in transplant recipients: early diagnosis and treatment of resistant tuberculosis

2009 ◽  
Vol 14 (6) ◽  
pp. 613-618 ◽  
Author(s):  
Jon-Erik C Holty ◽  
Ramachandra R Sista
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Early Diagnosis ◽  
Tuberculosis Infection ◽  
Diagnosis And Treatment ◽  
Transplant Recipients ◽  
Mycobacterium Tuberculosis Infection ◽  
Resistant Tuberculosis

scholarly journals Activities of Moxifloxacin Alone and in Combination with Other Antimicrobial Agents against Multidrug-Resistant Mycobacterium tuberculosis Infection in BALB/c Mice

2003 ◽  
Vol 47 (1) ◽  
pp. 360-362 ◽  
Author(s):  
Lanfranco Fattorini ◽  
Dejiang Tan ◽  
Elisabetta Iona ◽  
Maurizio Mattei ◽  
Federico Giannoni ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Antimicrobial Agents ◽  
Multidrug Resistant ◽  
Tuberculosis Infection ◽  
Aminosalicylic Acid ◽  
Mycobacterium Tuberculosis Infection ◽  
Resistant Tuberculosis ◽  
Multidrug Resistant Tuberculosis

ABSTRACT The activity of moxifloxacin was enhanced by the addition of ethionamide but not by that of cycloserine, thiacetazone, capreomycin, para-aminosalicylic acid, or linezolid in BALB/c mice infected with a strain of Mycobacterium tuberculosis resistant to isoniazid, rifampin, and six other drugs. These observations are important for the therapy of multidrug-resistant tuberculosis.

scholarly journals Altered Microbial Composition of Drug-Sensitive and Drug-Resistant TB Patients Compared with Healthy Volunteers

2021 ◽  
Vol 9 (8) ◽  
pp. 1762
Author(s):  
Fernanda Valdez-Palomares ◽  
Marcela Muñoz Torrico ◽  
Berenice Palacios-González ◽  
Xavier Soberón ◽  
Eugenia Silva-Herzog
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Healthy Volunteers ◽  
Latent Tuberculosis ◽  
Tuberculosis Infection ◽  
Drug Resistant ◽  
Mycobacterium Tuberculosis Infection ◽  
Microbial Composition ◽  
Tuberculosis Patients ◽  
Resistant Tuberculosis ◽  
And Function

Mycobacterium tuberculosis infection has three discernible outcomes: active tuberculosis, latent tuberculosis, or clearance of the bacterium. The outcome of the infection depends on the interaction of the bacterium, the immune system, and the microbiome of the host. The current study uses 16S rRNA sequencing to determine the diversity and composition of the respiratory microbiome of drug-resistant and drug-sensitive tuberculosis patients as well as healthy volunteers. Tuberculosis patients exhibited increased microbial diversity and differentially abundant bacteria than healthy volunteers. Compositional differences were also observed when comparing drug-sensitive or -resistant tuberculosis patients. Finally, we defined and assessed the differences in the core sputum microbiota between tuberculosis patients and healthy volunteers. Our observations collectively suggest that in sputum, Mycobacterium tuberculosis infection is related to altered bacterial diversity and compositional differences of core members of the microbiome, with potential implications for the bacterial pulmonary ecosystem’s stability and function.

scholarly journals Prevalence of latent Mycobacterium tuberculosis infection in renal transplant recipients

2018 ◽  
Vol 44 (6) ◽  
pp. 461-468
Author(s):  
Mônica Maria Moreira Delgado Maciel ◽  
Maria das Graças Ceccato ◽  
Wânia da Silva Carvalho ◽  
Pedro Daibert de Navarro ◽  
Kátia de Paula Farah ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Renal Transplant ◽  
Graft Function ◽  
Tuberculosis Infection ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Mycobacterium Tuberculosis Infection ◽  
Tuberculosis Case ◽  
Cross Sectional ◽  
Belo Horizonte

ABSTRACT Objective: To estimate the prevalence of latent Mycobacterium tuberculosis infection (LTBI) in renal transplant recipients and to assess sociodemographic, behavioral, and clinical associations with positive tuberculin skin test (TST) results. Methods: This was a cross-sectional study of patients aged ≥ 18 years who underwent renal transplantation at the Renal Transplant Center of the Federal University of Minas Gerais Hospital das Clínicas, located in the city of Belo Horizonte, Brazil. We included renal transplant recipients who underwent the TST between January 2011 and July 2013. If the result of the first TST was negative, a second TST was administered. Bivariate and multivariate analyses using logistic regression were used to determine factors associated with positive TST results. Results: The sample included 216 patients. The prevalence of LTBI was 18.5%. In the multivariate analysis, history of contact with a tuberculosis case and preserved graft function (estimated glomerular filtration rate ≥ 60 mL/min/1.73 m2) were associated with positive TST results. TST induration increased by 5.8% from the first to the second test, which was considered significant (p = 0.012). Conclusions: The prevalence of LTBI was low in this sample of renal transplant recipients. The TST should be administered if renal graft function is preserved. A second TST should be administered if the first TST is negative.

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