scholarly journals Transcriptomic Fingerprint of Bacterial Infection in Lower Extremity Ulcers

2021 ◽  
Author(s):  
Blaine Gabriel Fritz ◽  
Julius Bier Kirkegaard ◽  
Claus Nielsen ◽  
Klaus Kirketerp-Møller ◽  
Matthew Malone ◽  
...  
Keyword(s):  
Lower Extremity ◽  
Cross Validation ◽  
Classification Systems ◽  
Support Vector ◽  
Clinical Classification ◽  
Clinical Infection ◽  
Support Vector Classifier ◽  
Expression Of Genes ◽  
Bacterial Rna ◽  
Objective Classification

Clinicians and researchers utilize subjective classification systems based on clinical parameters to stratify lower extremity ulcer infections for treatment and research. This study compared clinical infection classifications (mild to severe) of lower extremity ulcers (n = 44) with transcriptomic profiles and direct measurement of bacterial RNA signatures by RNA-sequencing. Samples demonstrating similar transcriptomes were clustered and characterized by transcriptomic fingerprint. Clinical infection severity did not explain the major sources of variability among the samples and samples with the same clinical classification demonstrated high inter-sample variability. High proportions of bacterial RNA, however, resulted in a strong effect on transcription and increased expression of genes associated with immune response and inflammation. K-means clustering identified two clusters of samples, one of which contained all of the samples with high levels of bacterial RNA. A support vector classifier identified a fingerprint of 20 genes, including immune-associated genes such as CXCL8, GADD45B, and HILPDA, which accurately identified samples with signs of infection via cross-validation. This suggests that stratification of infection states based on a transcriptomic fingerprint may be a useful tool for studying host-bacterial interactions in these ulcers, as well as an objective classification method to identify the severity of infection.

Combination of Support Vector Machine and K-Fold cross-validation for prediction of long-term degradation of the compressive strength of marine concrete

2018 ◽  
Vol 1 (1) ◽  
pp. 120-130 ◽  
Author(s):  
Chunxiang Qian ◽  
Wence Kang ◽  
Hao Ling ◽  
Hua Dong ◽  
Chengyao Liang ◽  
...  
Keyword(s):  
Support Vector Machine ◽  
Environmental Factors ◽  
Cross Validation ◽  
Concrete Strength ◽  
Simulation Method ◽  
Support Vector ◽  
Svm Model ◽  
Artificial Neural Network Ann ◽  
Influence Degree ◽  
Fold Cross Validation

Support Vector Machine (SVM) model optimized by K-Fold cross-validation was built to predict and evaluate the degradation of concrete strength in a complicated marine environment. Meanwhile, several mathematical models, such as Artificial Neural Network (ANN) and Decision Tree (DT), were also built and compared with SVM to determine which one could make the most accurate predictions. The material factors and environmental factors that influence the results were considered. The materials factors mainly involved the original concrete strength, the amount of cement replaced by fly ash and slag. The environmental factors consisted of the concentration of Mg2+, SO42-, Cl-, temperature and exposing time. It was concluded from the prediction results that the optimized SVM model appeared to perform better than other models in predicting the concrete strength. Based on SVM model, a simulation method of variables limitation was used to determine the sensitivity of various factors and the influence degree of these factors on the degradation of concrete strength.

Research on improving accuracy of MWD based on Support vector Classifier and K-proximity method

2021 ◽  
pp. 1-1
Author(s):  
Hai Yang ◽  
Lizao Zhang ◽  
Tao Luo ◽  
Haibo Liang ◽  
Li Li ◽  
...  
Keyword(s):  
Support Vector ◽  
Support Vector Classifier ◽  
Improving Accuracy

A Novel Sparse Weighted Least Squares Support Vector Classifier

2013 ◽  
Vol 842 ◽  
pp. 746-749
Author(s):  
Bo Yang ◽  
Liang Zhang
Keyword(s):  
Least Squares ◽  
Weighted Least Squares ◽  
Importance Measure ◽  
Support Vector ◽  
Comparative Experiment ◽  
Digit Recognition ◽  
Calculating Method ◽  
Imbalance Problem ◽  
Support Vector Classifier

A novel sparse weighted LSSVM classifier is proposed in this paper, which is based on Suykens weighted LSSVM. Unlike Suykens weighted LSSVM, the proposed weighted method is more suitable for classification. The distance between sample and classification border is used as the sample importance measure in our weighted method. Based on this importance measure, a new weight calculating function, using which can adjust the sparseness of weight, is designed. In order to solve the imbalance problem, a kind of normalization weights calculating method is proposed. Finally, the proposed method is used on digit recognition. Comparative experiment results show that the proposed sparse weighted LSSVM can improve the recognition correct rate effectively.

Bayesian Trigonometric Support Vector Classifier

2003 ◽  
Vol 15 (9) ◽  
pp. 2227-2254 ◽  
Author(s):  
Wei Chu ◽  
S. Sathiya Keerthi ◽  
Chong Jin Ong
Keyword(s):  
Loss Function ◽  
Gaussian Processes ◽  
Likelihood Function ◽  
Support Vector ◽  
Data Sets ◽  
Model Adaptation ◽  
Bayesian Techniques ◽  
Benchmark Data ◽  
Support Vector Classifier ◽  
Set Up

This letter describes Bayesian techniques for support vector classification. In particular, we propose a novel differentiable loss function, called the trigonometric loss function, which has the desirable characteristic of natural normalization in the likelihood function, and then follow standard gaussian processes techniques to set up a Bayesian framework. In this framework, Bayesian inference is used to implement model adaptation, while keeping the merits of support vector classifier, such as sparseness and convex programming. This differs from standard gaussian processes for classification. Moreover, we put forward class probability in making predictions. Experimental results on benchmark data sets indicate the usefulness of this approach.

scholarly journals Intelligent Prediction of Sieving Efficiency in Vibrating Screens

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Bin Zhang ◽  
Jinke Gong ◽  
Wenhua Yuan ◽  
Jun Fu ◽  
Yi Huang
Keyword(s):  
Support Vector Machine ◽  
Cross Validation ◽  
Prediction Performance ◽  
Least Square ◽  
Support Vector ◽  
Adaptive Genetic Algorithm ◽  
Screen Length ◽  
Vibrating Screen ◽  
Working Parameters ◽  
Better Than

In order to effectively predict the sieving efficiency of a vibrating screen, experiments to investigate the sieving efficiency were carried out. Relation between sieving efficiency and other working parameters in a vibrating screen such as mesh aperture size, screen length, inclination angle, vibration amplitude, and vibration frequency was analyzed. Based on the experiments, least square support vector machine (LS-SVM) was established to predict the sieving efficiency, and adaptive genetic algorithm and cross-validation algorithm were used to optimize the parameters in LS-SVM. By the examination of testing points, the prediction performance of least square support vector machine is better than that of the existing formula and neural network, and its average relative error is only 4.2%.

Quaternion support vector classifier

2016 ◽  
Vol 20 (s1) ◽  
pp. S109-S119 ◽  
Author(s):  
G. López-González ◽  
N. Arana-Daniel ◽  
E. Bayro-Corrochano
Keyword(s):  
Support Vector ◽  
Support Vector Classifier
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