A novel chemical optical sensor based on molecularly imprinted polymer, optical fibers and inkjet printing technology

Author(s):  
Nunzio Cennamo ◽  
Luigi Zeni ◽  
Bruno Ando ◽  
Salvatore Baglio ◽  
Salvatore Graziani ◽  
...  
2021 ◽  
Vol 6 (43) ◽  
pp. 11865-11875
Author(s):  
Volkan Safran ◽  
Ilgım Göktürk ◽  
Monireh Bakhshpour ◽  
Fatma Yılmaz ◽  
Adil Denizli

2017 ◽  
Vol 27 ◽  
pp. 299-300 ◽  
Author(s):  
Marcos Vinicius Foguel ◽  
Natacha Thaisa Bello Pedro ◽  
Maria Valnice Boldrin Zanoni ◽  
Maria del Pilar Taboada Sotomayor

2019 ◽  
Vol 15 (3) ◽  
pp. 251-257
Author(s):  
Bahareh Sadat Yousefsani ◽  
Seyed Ahmad Mohajeri ◽  
Mohammad Moshiri ◽  
Hossein Hosseinzadeh

Background:Molecularly imprinted polymers (MIPs) are synthetic polymers that have a selective site for a given analyte, or a group of structurally related compounds, that make them ideal polymers to be used in separation processes.Objective:An optimized molecularly imprinted polymer was selected and applied for selective extraction and analysis of clozapine in rat brain tissue.Methods:A molecularly imprinted solid-phase extraction (MISPE) method was developed for preconcentration and cleanup of clozapine in rat brain samples before HPLC-UV analysis. The extraction and analytical process was calibrated in the range of 0.025-100 ppm. Clozapine recovery in this MISPE process was calculated between 99.40 and 102.96%. The limit of detection (LOD) and the limit of quantification (LOQ) of the assay were 0.003 and 0.025 ppm, respectively. Intra-day precision values for clozapine concentrations of 0.125 and 0.025 ppm were 5.30 and 3.55%, whereas inter-day precision values of these concentrations were 9.23 and 6.15%, respectively. In this study, the effect of lipid emulsion infusion in reducing the brain concentration of drug was also evaluated.Results:The data indicated that calibrated method was successfully applied for the analysis of clozapine in the real rat brain samples after administration of a toxic dose to animal. Finally, the efficacy of lipid emulsion therapy in reducing the brain tissue concentration of clozapine after toxic administration of drug was determined.Conclusion:The proposed MISPE method could be applied in the extraction and preconcentration before HPLC-UV analysis of clozapine in rat brain tissue.


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