scholarly journals Haemophilus influenzae serotype b conjugate vaccine failure in twelve countries with established national childhood immunization programmes

2010 ◽  
Vol 16 (7) ◽  
pp. 948-954 ◽  
Author(s):  
S. Ladhani ◽  
◽  
M.P.E. Slack ◽  
M.E. Ramsay ◽  
P.T. Heath ◽  
...  
Keyword(s):  
Haemophilus Influenzae ◽  
Conjugate Vaccine ◽  
Childhood Immunization ◽  
Vaccine Failure ◽  
Serotype B ◽  
Immunization Programmes

scholarly journals Spontaneous capsule loss in Haemophilus influenzae serotype b associated with Hib conjugate vaccine failure and invasive disease

2019 ◽  
Vol 25 (3) ◽  
pp. 390-391 ◽  
Author(s):  
K. Meyler ◽  
M. Meehan ◽  
D. Bennett ◽  
R. Mulhall ◽  
O. Harrison ◽  
...  
Keyword(s):  
Haemophilus Influenzae ◽  
Conjugate Vaccine ◽  
Invasive Disease ◽  
Vaccine Failure ◽  
Serotype B

scholarly journals Effectiveness of Haemophilus influenzae Type b Conjugate Vaccine Introduction Into Routine Childhood Immunization in Kenya

JAMA ◽  
2006 ◽  
Vol 296 (6) ◽  
pp. 671 ◽  
Author(s):  
Karen D. Cowgill ◽  
Moses Ndiritu ◽  
Joyce Nyiro ◽  
Mary P. E. Slack ◽  
Salome Chiphatsi ◽  
...  
Keyword(s):  
Haemophilus Influenzae ◽  
Conjugate Vaccine ◽  
Haemophilus Influenzae Type ◽  
Haemophilus Influenzae Type B ◽  
Type B ◽  
Childhood Immunization ◽  
Vaccine Introduction ◽  
Routine Childhood

scholarly journals Impact of Introduction of the Haemophilus influenzae Type b Conjugate Vaccine into Childhood Immunization on Meningitis in Bangladeshi Infants

2013 ◽  
Vol 163 (1) ◽  
pp. S73-S78 ◽  
Author(s):  
Nadira K. Sultana ◽  
Samir K. Saha ◽  
Hassan M. Al-Emran ◽  
Joyanta K. Modak ◽  
M. A. Yushuf Sharker ◽  
...  
Keyword(s):  
Haemophilus Influenzae ◽  
Conjugate Vaccine ◽  
Haemophilus Influenzae Type ◽  
Haemophilus Influenzae Type B ◽  
Type B ◽  
Childhood Immunization

WITHDRAWN: Evaluation of Childhood Haemophilus Influenzae Serotype B (HIB) Vaccine Failure in Europe

2006 ◽  
Author(s):  
M. Slack ◽  
M.E. Ramsay ◽  
P.T. Heath ◽  
S. Ladhani ◽  
on behalf of EUIBIS
Keyword(s):  
Haemophilus Influenzae ◽  
Vaccine Failure ◽  
Serotype B

Low serum serotype-specific pneumococcal antibody concentrations in young children with Haemophilus influenzae serotype b (Hib) vaccine failure

Vaccine ◽  
2010 ◽  
Vol 28 (28) ◽  
pp. 4440-4444 ◽  
Author(s):  
Shamez Ladhani ◽  
Ray Borrow ◽  
Paul T. Heath ◽  
Mary E. Ramsay ◽  
Robert Booy
Keyword(s):  
Young Children ◽  
Haemophilus Influenzae ◽  
Vaccine Failure ◽  
Serotype B ◽  
Low Serum

scholarly journals Lagging Immune Response to Haemophilus influenzae Serotype b (Hib) Conjugate Vaccine after the Primary Vaccination with Hib of Infants in The Netherlands

Vaccines ◽  
2020 ◽  
Vol 8 (3) ◽  
pp. 347
Author(s):  
Leo Schouls ◽  
Corrie Schot ◽  
Richarda M. de Voer ◽  
Fiona van der Klis ◽  
Mirjam Knol ◽  
...  
Keyword(s):  
The Netherlands ◽  
Haemophilus Influenzae ◽  
Conjugate Vaccine ◽  
Capsular Polysaccharide ◽  
Sharp Decrease ◽  
Primary Vaccination ◽  
Population Based ◽  
Serum Samples ◽  
National Immunization ◽  
Serotype B

In 1993, a Haemophilus influenzae serotype b (Hib) conjugate vaccine was introduced in the Dutch national immunization program, resulting in a sharp decrease in invasive Hib disease. We used a population-based set of serum samples collected in The Netherlands in 2006–2007 (Pienter-II, 5696 sera) to assess the concentration of antibodies to the capsular polysaccharide of Hib, and compared the results with those obtained from a similar set collected in 1995–1996 (Pienter-I, 7837 sera). Post-primary vaccination serum samples from children aged 6–11 months from the Pienter-II study contained approximately 4-fold lower anti-Hib antibody concentrations than samples from children from the Pienter-I study. No such difference was found in post-booster samples from children older than 11 months of age. In Pienter-II, the proportion of children aged 6–11 months with anti-Hib antibody concentrations below the putative protective concentration of 0.15 µg/mL was 30%, which is significantly higher than in the Pienter-I study (12%). Fewer children in the Pienter-II group developed antibodies able to kill Hib in a serum bactericidal assay compared to the Pienter-I children. The cause of the lagged response in Pienter-II children remain uncertain, but lack of natural boosting, interference by the acellular pertussis vaccine, combining vaccines and acceleration of the schedule may have contributed.

scholarly journals Invasive Haemophilus influenzae Infections in Germany After the Introduction of Routine Childhood Immunization, 2001–2016

2020 ◽  
Vol 7 (10) ◽  
Author(s):  
Anja Takla ◽  
Viktoria Schönfeld ◽  
Heike Claus ◽  
Manuel Krone ◽  
Matthias an der Heiden ◽  
...  
Keyword(s):  
Haemophilus Influenzae ◽  
Disease Surveillance ◽  
Age Groups ◽  
Childhood Immunization ◽  
Comprehensive Overview ◽  
Ampicillin Resistance ◽  
Laboratory Surveillance ◽  
The Mean ◽  
Serotype B ◽  
Increasing Trends

Abstract Background Haemophilus influenzae (Hi) serotype b (Hib) vaccination was introduced in Germany in 1990. This study presents a comprehensive overview on the burden of invasive Hi infections for 2001–2016, including serotype distribution and ampicillin resistance. Methods Nationwide data from statutory disease surveillance (2001–2016) were linked with laboratory surveillance data (2009–2016). Besides descriptive epidemiology, statistical analyses included multiple imputation to estimate secular trends. Results In 2001–2016, 4044 invasive Hi infections were reported. The mean incidence was 3.0 per million inhabitants, higher in males (3.2 vs 2.9 in females) and in the age groups <1 year (15.2) and ≥80 years (15.5). Nontypeable Hi (NTHi) caused 81% (n = 1545) of cases in 2009–2016. Of capsulated cases, 69% were serotype f and 17% serotype b. Of Hib cases eligible for vaccination, 10% (3/29) were fully vaccinated. For 2009–2016, significant increasing trends were observed for NTHi and Hif infections in the age groups <5 years and ≥60 years and for ampicillin resistance in NTHi. Conclusions This is one of the most comprehensive Hi data analyses since the introduction of Hib vaccines. NTHi and Hif cause an increasing disease burden among elderly patients and infants. Ampicillin resistance in NTHi must be considered in the treatment of invasive Hi infections.

scholarly journals Invasive Haemophilus influenzae Infections after 3 Decades of Hib Protein Conjugate Vaccine Use

2021 ◽  
Author(s):  
M. P. E. Slack ◽  
A. W. Cripps ◽  
K. Grimwood ◽  
G. A. Mackenzie ◽  
M. Ulanova
Keyword(s):  
Bacterial Meningitis ◽  
Haemophilus Influenzae ◽  
Conjugate Vaccine ◽  
Virulence Factor ◽  
Etiologic Agent ◽  
Common Cause ◽  
Content Type ◽  
Major Virulence Factor ◽  
Protein Conjugate ◽  
Serotype B

Haemophilus influenzae serotype b (Hib) was previously the most common cause of bacterial meningitis and an important etiologic agent of pneumonia in children aged <5 years. Its major virulence factor is the polyribosyl ribitol phosphate (PRP) polysaccharide capsule.

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