Superoxide anions and hydrogen peroxide inhibit proliferation of activated rat stellate cells and induce different modes of cell death

2009 ◽  
Vol 29 (6) ◽  
pp. 922-932 ◽  
Author(s):  
Sandra Dunning ◽  
Rebekka A. Hannivoort ◽  
Jan Freark de Boer ◽  
Manon Buist-Homan ◽  
Klaas Nico Faber ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Cell Death ◽  
Stellate Cells ◽  
Superoxide Anions

Signal-regulated oxidation of proteins via MICAL

2020 ◽  
Vol 48 (2) ◽  
pp. 613-620
Author(s):  
Clara Ortegón Salas ◽  
Katharina Schneider ◽  
Christopher Horst Lillig ◽  
Manuela Gellert
Keyword(s):  
Signal Transduction ◽  
Hydrogen Peroxide ◽  
Cell Death ◽  
Redox Regulation ◽  
Signal Transduction Pathways ◽  
Cellular Functions ◽  
Intracellular Signals ◽  
Amino Acid Side Chains ◽  
Specific Receptors ◽  
Sulfur Containing

Processing of and responding to various signals is an essential cellular function that influences survival, homeostasis, development, and cell death. Extra- or intracellular signals are perceived via specific receptors and transduced in a particular signalling pathway that results in a precise response. Reversible post-translational redox modifications of cysteinyl and methionyl residues have been characterised in countless signal transduction pathways. Due to the low reactivity of most sulfur-containing amino acid side chains with hydrogen peroxide, for instance, and also to ensure specificity, redox signalling requires catalysis, just like phosphorylation signalling requires kinases and phosphatases. While reducing enzymes of both cysteinyl- and methionyl-derivates have been characterised in great detail before, the discovery and characterisation of MICAL proteins evinced the first examples of specific oxidases in signal transduction. This article provides an overview of the functions of MICAL proteins in the redox regulation of cellular functions.

scholarly journals Exposure to Hydrogen Peroxide Induces Cell Death via Apoptosis in Primary Cultured Mouse Hepatocytes.

1999 ◽  
Vol 22 (12) ◽  
pp. 1296-1300 ◽  
Author(s):  
Shuuichi KANNO ◽  
Masaaki ISHIKAWA ◽  
Motoaki TAKAYANAGI ◽  
Yoshio TAKAYANAGI ◽  
Ken-ichi SASAKI
Keyword(s):  
Hydrogen Peroxide ◽  
Cell Death ◽  
Mouse Hepatocytes

scholarly journals Iron prochelator BSIH protects retinal pigment epithelial cells against cell death induced by hydrogen peroxide

2008 ◽  
Vol 102 (12) ◽  
pp. 2130-2135 ◽  
Author(s):  
Louise K. Charkoudian ◽  
Tzvete Dentchev ◽  
Nina Lukinova ◽  
Natalie Wolkow ◽  
Joshua L. Dunaief ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Cell Death ◽  
Epithelial Cells ◽  
Retinal Pigment Epithelial ◽  
Retinal Pigment ◽  
Retinal Pigment Epithelial Cells ◽  
Pigment Epithelial ◽  
Pigment Epithelial Cells

Selenium rescues orbital fibroblasts from cell death induced by hydrogen peroxide: another molecular basis for the effects of selenium in graves’ orbitopathy

Endocrine ◽  
2017 ◽  
Vol 58 (2) ◽  
pp. 386-389 ◽  
Author(s):  
Giovanna Rotondo Dottore ◽  
Riccardo Chiarini ◽  
Maria De Gregorio ◽  
Marenza Leo ◽  
Giamberto Casini ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Cell Death ◽  
Molecular Basis ◽  
Graves Orbitopathy ◽  
Orbital Fibroblasts

Erratum to: Selenium rescues orbital fibroblasts from cell death induced by hydrogen peroxide: another molecular basis for the effects of selenium in graves’ orbitopathy

Endocrine ◽  
2017 ◽  
Vol 58 (2) ◽  
pp. 390-390 ◽  
Author(s):  
Giovanna Rotondo Dottore ◽  
Riccardo Chiarini ◽  
Maria De Gregorio ◽  
Marenza Leo ◽  
Giamberto Casini ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Cell Death ◽  
Molecular Basis ◽  
Graves Orbitopathy ◽  
Orbital Fibroblasts
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