AGE FACTOR AND INDUCTION OF IMMUNOLOGICAL TOLERANCE TO MALE SKIN ISOGRAFTS IN FEMALE MICE SUBSEQUENT TO THE NEONATAL PERIOD *

2006 ◽  
Vol 87 (1) ◽  
pp. 93-105 ◽  
Author(s):  
T. Mariani ◽  
C. Martinez ◽  
J. M. Smith ◽  
R. A. Good
Keyword(s):  
Neonatal Period ◽  
Immunological Tolerance ◽  
Female Mice ◽  
Age Factor ◽  
Male Skin

Immunological Tolerance to Male Skin Isografts in Female Mice.

1958 ◽  
Vol 99 (2) ◽  
pp. 287-289 ◽  
Author(s):  
T. Mariani ◽  
C. Martinez ◽  
J. M. Smith ◽  
R. A. Good
Keyword(s):  
Immunological Tolerance ◽  
Female Mice ◽  
Male Skin

scholarly journals PRODUCTION OF IMMUNOLOGICAL TOLERANCE IN MICE AFTER REPEATED INJECTIONS OF DISRUPTED SPLEEN CELLS

1963 ◽  
Vol 118 (5) ◽  
pp. 743-758 ◽  
Author(s):  
C. Martinez ◽  
J. M. Smith ◽  
M. Blaese ◽  
R. A. Good
Keyword(s):  
Spleen Cell ◽  
Neonatal Period ◽  
Adult Life ◽  
Immunological Tolerance ◽  
Mammary Adenocarcinoma ◽  
Repeated Injection ◽  
Spleen Cells ◽  
Tolerant Animal ◽  
Male Skin ◽  
Tolerant State

1. Tolerance of male skin isografts has been regularly produced in female mice of the C57B1 strain sublines 1, 4, and 6 during adult life by repeated injection of completely disrupted spleen cells derived from male donors. The tolerant state is long-lasting since such grafts have remained in place more than 9 months. 2. Prolonged survival of homotransplants of skin has regularly been produced in DBA/2 mice during adult life by repeated injections of completely disrupted spleen cells from Balb/C donors. When injections of disrupted spleen cell material are continued over a sufficiently long period, permanent acceptance of the skin homografts may be obtained between these strains. 3. Immunological tolerance across even the strong H-2 histocompatibility barrier was obtained in the neonatal period and during adult life by repeated injection of disrupted spleen cell preparations. The tolerant state has been revealed by both mammary adenocarcinoma and skin homografting across this strong histocompatibility barrier. 4. In contradistinction to the tolerant state produced by injection of intact spleen cells in neonatal animals or during adult life or that produced by parabiotic union, the tolerance produced by repeated injection of disrupted spleen cell preparations cannot be transferred to syngenic neonatal mice with spleen cells of the tolerant animal. 5. The implications of these findings in transplantation biology and in consideration of the basic nature of tolerance are discussed.

Effect of the TP5 analogue of thymopoietin on the rejection of male skin by aged and thymectomized female mice

1981 ◽  
Vol 13 (3) ◽  
pp. 201-204 ◽  
Author(s):  
Ellen H. Goldberg ◽  
Gideon Goldstein ◽  
Edward A. Boyse ◽  
Margrit P. Scheid
Keyword(s):  
Female Mice ◽  
Male Skin

scholarly journals Effects of BCG, levamisole and PS-K on the rejection of male skin grafts by female mice

1979 ◽  
Vol 29 ◽  
pp. 116
Author(s):  
Saiichirou Seo ◽  
Junzo Yasuhara ◽  
Kiyomi Saeki
Keyword(s):  
Skin Grafts ◽  
Female Mice ◽  
Male Skin

DYNAMICS OF CONCENTRATIONS OF NO-SYSTEM COMPONENTS DURING B16/F10 MELANOMA GROWTH IN FEMALE MICE WITH CHRONIC NEUROGENIC PAIN

2019 ◽  
Vol 65 (6) ◽  
pp. 898-903
Author(s):  
Oleg Kit ◽  
Yelena Frantsiyants ◽  
Inga Kotieva ◽  
Yekaterina Surikova ◽  
Irina Kaplieva ◽  
...  
Keyword(s):  
Chronic Pain ◽  
Tumor Growth ◽  
Metabolic Regulation ◽  
Tumor Antigens ◽  
Immunological Tolerance ◽  
Neurogenic Pain ◽  
Female Mice ◽  
Tumor Tissues ◽  
Group 2 ◽  
Skin Conditions

Since chronic neurogenic pain has been reported to affect biological characteristics of B16/F10 melanoma, the purpose of the study was to analyze concentrations of components of the NO-system in mice during the growth of transplantable B16/F10 melanoma combined with chronic neurogenic pain. Methods. The study included 64 female mice. Melanoma was transplanted under the skin of the back to animals of the main group 2 weeks after the bilateral sciatic nerve ligation. Levels of NOS-3, NOS-2, endothelin-1, L-arginine, citrulline, total nitrite and ADMA were determined by ELISA in the intact skin and in tumor tissues. Results. The study showed that the dynamics of the studied parameters differed in tumor growth alone and in combination with chronic pain. Stably increased levels of NO-synthases in the tumor and stably increased ADMA levels with their decrease by week 3 of the growth were registered in the tumor growth with pain. Conclusions. Chronic pain probably contributes to the development of immunological tolerance to tumor antigens in the skin. Conditions are formed that facilitate the survival of tumor cells and contribute to the further development of melanoma. The dynamics of the NO-system activity can stimulate neoangiogenesis and enhance tumor invasion. Changes in the ADMA inhibitor levels in the tumor growth combined with chronic pain may indicate the control of NO levels through the metabolic regulation of NO-synthase activity, thus providing increased melanoma invasiveness.

PROLONGATION OF MALE SKIN GRAFT SURVIVAL BY FEMALE MICE TREATED WITH CIMETIDINE

1979 ◽  
Vol 28 (5) ◽  
pp. 432 ◽  
Author(s):  
ELLEN H. GOLDBERG ◽  
JAMES S. GOODWIN ◽  
SUSAN E. ARRITT ◽  
RALPH C. WILLIAMS
Keyword(s):  
Graft Survival ◽  
Skin Graft ◽  
Female Mice ◽  
Male Skin

Acceptance or Rejection of Male Skin by Isologous Female Mice: Effect of Injection of Sperm

Science ◽  
1964 ◽  
Vol 143 (3601) ◽  
pp. 41-42 ◽  
Author(s):  
G. F. Katsh ◽  
D. W. Talmage ◽  
S. Katsh
Keyword(s):  
Female Mice ◽  
Male Skin
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