Effect of high-dose vitamin C supplementation on growth, tissue ascorbic acid concentrations and physiological response to transportation stress in juvenile silver pomfret, Pampus argenteus

2013 ◽  
Vol 29 (6) ◽  
pp. 1337-1341 ◽  
Author(s):  
S. M. Peng ◽  
Z. H. Shi ◽  
Y. Fei ◽  
Q. X. Gao ◽  
P. Sun ◽  
...  
Keyword(s):  
Ascorbic Acid ◽  
Vitamin C ◽  
Physiological Response ◽  
High Dose ◽  
Pampus Argenteus ◽  
Vitamin C Supplementation ◽  
Transportation Stress ◽  
High Dose Vitamin ◽  
Silver Pomfret

scholarly journals Unintended Consequence of High-Dose Vitamin C Therapy for an Oncology Patient: Evaluation of Ascorbic Acid Interference With Three Hospital-Use Glucose Meters

2020 ◽  
pp. 193229682093218
Author(s):  
Brooke M. Katzman ◽  
Brandon R. Kelley ◽  
Gayle R. Deobald ◽  
Nikki K. Myhre ◽  
Sean A. Agger ◽  
...  
Keyword(s):  
Ascorbic Acid ◽  
Vitamin C ◽  
High Dose ◽  
Oncology Patient ◽  
Glucose Meter ◽  
High Doses ◽  
The Impact ◽  
Very High ◽  
High Dose Vitamin ◽  
Hospital Use

The use of high-dose vitamin C in cancer care has offered promising results for some patients. However, the intravenous (IV) doses used for these patients can reach concentrations that interfere with some strip-based glucose meters. We characterized the impact of vitamin C interference, from standard to the very high doses used for some cancer protocols, using three different hospital-use glucose meters. For two of the three devices tested, increasing concentrations of ascorbic acid caused false elevations in the glucose measurements. The third glucose meter did not provide inaccurate results, regardless of the vitamin C concentration present. Rather, above a certain threshold, the device generated error messages and no results could be obtained.

scholarly journals Vitamin C Supplementation in Healthy Individuals Leads to Shifts of Bacterial Populations in the Gut—A Pilot Study

Antioxidants ◽  
2021 ◽  
Vol 10 (8) ◽  
pp. 1278
Author(s):  
Antonius T. Otten ◽  
Arno R. Bourgonje ◽  
Vera Peters ◽  
Behrooz Z. Alizadeh ◽  
Gerard Dijkstra ◽  
...  
Keyword(s):  
Pilot Study ◽  
Vitamin C ◽  
Gut Microbiota ◽  
High Dose ◽  
Healthy Individuals ◽  
Microbial Composition ◽  
Bacterial Populations ◽  
Vitamin C Supplementation ◽  
Anti Inflammatory ◽  
High Dose Vitamin

Gut microbes are crucial to human health, but microbial composition is often disturbed in a number of human diseases. Accumulating evidence points to nutritional modulation of the gut microbiota as a potentially beneficial therapeutic strategy. Vitamin C (ascorbic acid) may be of particular interest as it has known antioxidant and anti-inflammatory properties. In this study, we investigated whether supplementation with high-dose vitamin C may favourably affect the composition of the gut microbiota. In this pilot study, healthy human participants received 1000 mg vitamin C supplementation daily for two weeks. Gut microbiota composition was analysed before and after intervention by performing faecal 16S rRNA gene sequencing. In total, 14 healthy participants were included. Daily supplementation of high-dose vitamin C led to an increase in the relative abundances of Lachnospiraceae (p < 0.05), whereas decreases were observed for Bacteroidetes (p < 0.01), Enterococci (p < 0.01) and Gemmiger formicilis (p < 0.05). In addition, trends for bacterial shifts were observed for Blautia (increase) and Streptococcus thermophilus (decrease). High-dose vitamin C supplementation for two weeks shows microbiota-modulating effects in healthy individuals, with several beneficial shifts of bacterial populations. This may be relevant as these bacteria have anti-inflammatory properties and strongly associate with gut health.

Any Role of High-Dose Vitamin C for Septic Shock in 2021?

2021 ◽  
Vol 42 (05) ◽  
pp. 672-682
Author(s):  
Ankita Agarwal ◽  
David N. Hager ◽  
Jonathan E. Sevransky
Keyword(s):  
Septic Shock ◽  
Vitamin C ◽  
Outcome Measures ◽  
Randomized Clinical Trials ◽  
Secondary Outcome ◽  
High Dose ◽  
Healthy Humans ◽  
Vitamin C Supplementation ◽  
High Dose Vitamin

AbstractWhile the use of vitamin C as a therapeutic agent has been investigated since the 1950s, there has been substantial recent interest in the role of vitamin C supplementation in critical illness and particularly, sepsis and septic shock. Humans cannot synthesize vitamin C and rely on exogenous intake to maintain a plasma concentration of approximately 70 to 80 μmol/L. Vitamin C, in healthy humans, is involved with antioxidant function, wound healing, endothelial function, and catecholamine synthesis. Its function in the human body informs the theoretical basis for why vitamin C supplementation may be beneficial in sepsis/septic shock.Critically ill patients can be vitamin C deficient due to low dietary intake, increased metabolic demands, inefficient recycling of vitamin C metabolites, and loss due to renal replacement therapy. Intravenous supplementation is required to achieve supraphysiologic serum levels of vitamin C. While some clinical studies of intravenous vitamin C supplementation in sepsis have shown improvements in secondary outcome measures, none of the randomized clinical trials have shown differences between vitamin C supplementation and standard of care and/or placebo in the primary outcome measures of the trials. There are some ongoing studies of high-dose vitamin C administration in patients with sepsis and coronavirus disease 2019; the majority of evidence so far does not support the routine supplementation of vitamin C in patients with sepsis or septic shock.

High-dose vitamin C supplementation accelerates the Achilles tendon healing in healthy rats

2008 ◽  
Vol 129 (2) ◽  
pp. 281-286 ◽  
Author(s):  
Suna Ömeroğlu ◽  
Tuncay Peker ◽  
Nurten Türközkan ◽  
Hakan Ömeroğlu
Keyword(s):  
Vitamin C ◽  
Achilles Tendon ◽  
Tendon Healing ◽  
High Dose ◽  
Vitamin C Supplementation ◽  
High Dose Vitamin

scholarly journals Long-term vitamin C supplementation has no markedly favourable effect on serum lipids in middle-aged Japanese subjects

2004 ◽  
Vol 91 (1) ◽  
pp. 81-90 ◽  
Author(s):  
Mi Kyung Kim ◽  
Satoshi Sasaki ◽  
Shizuka Sasazuki ◽  
Shunji Okubo ◽  
Masato Hayashi ◽  
...  
Keyword(s):  
Vitamin C ◽  
Dose Group ◽  
Low Dose ◽  
Favourable Effect ◽  
High Dose ◽  
Vitamin C Supplementation ◽  
The Mean ◽  
High Dose Vitamin ◽  
Β Carotene

Antioxidant vitamins have been reported to be associated with an improvement in blood lipid profiles, but results are not consistent. The present study was designed to determine whether long-term vitamin C supplementation could alter serum lipid concentrations in subjects who completed a 5-year population-based double-blind intervention trial. A total of 439 Japanese subjects with atrophic gastritis initially participated in the trial using vitamin C and β-carotene to prevent gastric cancer. Before and upon early termination of β-carotene supplementation, 134 subjects dropped out of the trial; finally, 161 subjects assigned to the high-dose group (500 mg vitamin C/d) and 144 subjects assigned to the low-dose group (50 mg vitamin C/d) were studied. No favourable effect of vitamin C supplementation on serum concentrations of total cholesterol, HDL- and LDL-cholesterol, and triacylglycerol was observed, although high-dose vitamin C supplementation increased serum vitamin C concentrations substantially. Among women, the mean change in serum triacylglycerol decreased (−0·12 mmol/l, 95 % CI −0·32, 0·09) in the high-dose group, but increased (+0·12 mmol/l, 95 % CI 0·03, 0·22) in the low-dose group. In addition, the mean change in serum triacylglycerol among women with hypertriacylglycerolaemia was statistically significant (−1·21, 95 % CI −2·38, −0·05) after high-dose vitamin C supplementation. The 5-year vitamin C supplementation had no markedly favourable effects on the serum lipid and lipoprotein profile. However, our present results do not preclude the possibility that vitamin C supplementation may decrease triacylglycerol concentrations among women with hypertriacylglycerolaemia.

Failure of High-Dose Vitamin C (Ascorbic Acid) Therapy to Benefit Patients with Advanced Cancer

1979 ◽  
Vol 301 (13) ◽  
pp. 687-690 ◽  
Author(s):  
Edward T. Creagan ◽  
Charles G. Moertel ◽  
Judith R. O'Fallon ◽  
Allan J. Schutt ◽  
Michael J. O'Connell ◽  
...  
Keyword(s):  
Ascorbic Acid ◽  
Vitamin C ◽  
Advanced Cancer ◽  
High Dose ◽  
Acid Therapy ◽  
High Dose Vitamin

High-dose Vitamin C: A Risk for Persons with High Iron Stores?

1999 ◽  
Vol 69 (2) ◽  
pp. 67-82 ◽  
Author(s):  
Gerster
Keyword(s):  
Ascorbic Acid ◽  
Vitamin C ◽  
Iron Overload ◽  
Deficiency Anemia ◽  
High Dose ◽  
Iron Stores ◽  
High Iron ◽  
Increased Risk ◽  
And Storage ◽  
High Dose Vitamin

The contribution of vitamin C (ascorbic acid) to the prevention of iron deficiency anemia by promoting the absorption of dietary non-heme iron – especially in persons with low iron stores – is well established. But the question has been raised whether high-dose intakes of vitamin C might unduly enhance the absorption of dietary iron in persons with high iron stores or in patients with iron overload, possibly increasing the potential risk of iron toxicity. Extensive studies have shown that overall the uptake and storage of iron in humans is efficiently controlled by a network of regulatory mechanisms. Even high vitamin C intakes do not cause iron imbalance in healthy persons and probably in persons who are heterozygous for hemochromatosis. The uptake, renal tubular reabsorption and storage of vitamin C itself are also strictly limited after high-dose intake so that no excessive plasma and tissue concentrations of vitamin C are produced. The effect of high-dose vitamin C on iron absorption in patients with iron overload due to homozygous hemochromatosis has not been studied. Of special importance is the early identification of hemochromatosis patients, which is assisted by the newly developed PCR test for hereditary hemochromatosis. Specific treatment consists of regular phlebotomy and possibly iron-chelating therapy. These patients should moreover avoid any possibility of facilitated absorption of iron and need to limit their intake of iron. Patients with beta-thalassemia major and sickle cell anemia who suffer from iron overload due to regular blood transfusions or excessive destruction of red blood cells need specialized medical treatment with iron chelators and should also control their intake of iron. The serum of patients with pathological iron overload can contain non-transferrin-bound iron inducinglipid peroxidation with subsequent consumption of antioxidants such as vitamin E and vitamin C. The role of iron in coronary heart disease and cancer is controversial. Early suggestions that moderately elevated iron stores are associated with an increased risk of CHD have not been confirmed by later studies. In vitro, ascorbic acid can act as a prooxidant in the presence of transition metals such as iron or copper, but in the living organism its major functions are as an antioxidant. High intakes of vitamin C have thus not been found to increase oxidative damage in humans. Accordingly, the risk of CHD or cancer is not elevated. On the contrary, most studies have shown that diets rich in vitamin C are inversely related to the incidence of these diseases.

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