Multi-Layer Construction Process for Fabricating Electrospun Fiber Embedded Microfluidic Devices

2015 ◽  
Author(s):  
Karen Chang Yan ◽  
John Sperduto ◽  
Michael Rossini ◽  
Michael Sebok
Keyword(s):  
Biomedical Applications ◽  
Electrospun Fiber ◽  
Microfluidic Devices ◽  
Construction Process ◽  
Preliminary Results ◽  
Device Optimization ◽  
Specialized Equipment ◽  
Microfabrication Techniques

Microfluidic devices are widely used in biomedical applications owing to their inherent advantages. Microfabrication techniques are common methods for fabricating microfluidic devices, which require specialized equipment. This paper presents a multi-layer construction process for producing microfluidic devices via integrating two accessible fabrication techniques — hydrogel molding, a microfabrication-free method, and electrospinning (ES). The formed microchannels were examined via analyzing micrographs. Preliminary results demonstrate the feasibility of the method and potential for incorporating complex channels and device optimization.

scholarly journals Blood Cells Separation and Sorting Techniques of Passive Microfluidic Devices: From Fabrication to Applications

Micromachines ◽  
2019 ◽  
Vol 10 (9) ◽  
pp. 593 ◽  
Author(s):  
Susana O. Catarino ◽  
Raquel O. Rodrigues ◽  
Diana Pinho ◽  
João M. Miranda ◽  
Graça Minas ◽  
...  
Keyword(s):  
Blood Cell ◽  
Physicochemical Properties ◽  
Clinical Diagnosis ◽  
Microfluidic Device ◽  
Blood Cells ◽  
Biomedical Applications ◽  
Microfluidic Devices ◽  
Modern Biology ◽  
Design Considerations ◽  
Microfabrication Techniques

Since the first microfluidic device was developed more than three decades ago, microfluidics is seen as a technology that exhibits unique features to provide a significant change in the way that modern biology is performed. Blood and blood cells are recognized as important biomarkers of many diseases. Taken advantage of microfluidics assets, changes on blood cell physicochemical properties can be used for fast and accurate clinical diagnosis. In this review, an overview of the microfabrication techniques is given, especially for biomedical applications, as well as a synopsis of some design considerations regarding microfluidic devices. The blood cells separation and sorting techniques were also reviewed, highlighting the main achievements and breakthroughs in the last decades.

Versatile acoustic manipulation of micro-object using mode-switchable oscillating bubbles: transportation, trapping, rotation, and revolution

Lab on a Chip ◽  
2021 ◽  
Author(s):  
Wei Zhang ◽  
Bin Song ◽  
Xue Bai ◽  
Lina Jia ◽  
Li Song ◽  
...  
Keyword(s):  
Biomedical Applications ◽  
Microfluidic Devices ◽  
Oscillating Bubbles ◽  
Fixed Design ◽  
On Chip

Controllable on-chip multimodal manipulation of micro-objects in microfluidic devices is urgently required for enhancing the efficiency of potential biomedical applications. However, fixed design and driving models make it difficult to...

scholarly journals 3D Printed Microfluidics

2020 ◽  
Vol 13 (1) ◽  
pp. 45-65 ◽  
Author(s):  
Anna V. Nielsen ◽  
Michael J. Beauchamp ◽  
Gregory P. Nordin ◽  
Adam T. Woolley
Keyword(s):  
3D Printing ◽  
Early Stage ◽  
Three Dimensional ◽  
Microfluidic Devices ◽  
Fabrication Method ◽  
Size Scale ◽  
Additional Work ◽  
Fluidic Devices ◽  
3D Printed ◽  
Microfabrication Techniques

Traditional microfabrication techniques suffer from several disadvantages, including the inability to create truly three-dimensional (3D) architectures, expensive and time-consuming processes when changing device designs, and difficulty in transitioning from prototyping fabrication to bulk manufacturing. 3D printing is an emerging technique that could overcome these disadvantages. While most 3D printed fluidic devices and features to date have been on the millifluidic size scale, some truly microfluidic devices have been shown. Currently, stereolithography is the most promising approach for routine creation of microfluidic structures, but several approaches under development also have potential. Microfluidic 3D printing is still in an early stage, similar to where polydimethylsiloxane was two decades ago. With additional work to advance printer hardware and software control, expand and improve resin and printing material selections, and realize additional applications for 3D printed devices, we foresee 3D printing becoming the dominant microfluidic fabrication method.

scholarly journals Recent advances in nonbiofouling PDMS surface modification strategies applicable to microfluidic technology

TECHNOLOGY ◽  
2017 ◽  
Vol 05 (01) ◽  
pp. 1-12 ◽  
Author(s):  
Aslihan Gokaltun ◽  
Martin L. Yarmush ◽  
Ayse Asatekin ◽  
O. Berk Usta
Keyword(s):  
Rapid Prototyping ◽  
Biomedical Applications ◽  
Gas Permeability ◽  
Low Cost ◽  
Microfluidic Devices ◽  
Mature Stage ◽  
Major Drawback ◽  
Pdms Surface ◽  
Recent Advances ◽  
Hydrophobic Recovery

In the last decade microfabrication processes including rapid prototyping techniques have advanced rapidly and achieved a fairly mature stage. These advances have encouraged and enabled the use of microfluidic devices by a wider range of users with applications in biological separations and cell and organoid cultures. Accordingly, a significant current challenge in the field is controlling biomolecular interactions at interfaces and the development of novel biomaterials to satisfy the unique needs of the biomedical applications. Poly(dimethylsiloxane) (PDMS) is one of the most widely used materials in the fabrication of microfluidic devices. The popularity of this material is the result of its low cost, simple fabrication allowing rapid prototyping, high optical transparency, and gas permeability. However, a major drawback of PDMS is its hydrophobicity and fast hydrophobic recovery after surface hydrophilization. This results in significant nonspecific adsorption of proteins as well as small hydrophobic molecules such as therapeutic drugs limiting the utility of PDMS in biomedical microfluidic circuitry. Accordingly, here, we focus on recent advances in surface molecular treatments to prevent fouling of PDMS surfaces towards improving its utility and expanding its use cases in biomedical applications.

scholarly journals Microfluidic Devices in Fabricating Nano or Micromaterials for Biomedical Applications

2019 ◽  
Vol 4 (12) ◽  
pp. 1900488 ◽  
Author(s):  
Xuan Luo ◽  
Peng Su ◽  
Wei Zhang ◽  
Colin L. Raston
Keyword(s):  
Biomedical Applications ◽  
Microfluidic Devices
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