Fluorescence-encoded time-domain coherent Raman spectroscopy through single-photon counting

2021 ◽  
Author(s):  
Phillip Charles McCann ◽  
Kotaro Hiramatsu ◽  
Keisuke Goda
Keyword(s):  
Raman Spectroscopy ◽  
Time Domain ◽  
Single Photon ◽  
Photon Counting ◽  
Single Photon Counting ◽  
Coherent Raman

scholarly journals Prospects on Time-Domain Diffuse Optical Tomography Based on Time-Correlated Single Photon Counting for Small Animal Imaging

2016 ◽  
Vol 2016 ◽  
pp. 1-23 ◽  
Author(s):  
Yves Bérubé-Lauzière ◽  
Matteo Crotti ◽  
Simon Boucher ◽  
Seyedrohollah Ettehadi ◽  
Julien Pichette ◽  
...  
Keyword(s):  
Temporal Resolution ◽  
Time Domain ◽  
Single Photon ◽  
Optical Tomography ◽  
Photon Counting ◽  
Diffuse Optical Tomography ◽  
Small Animal ◽  
Acquisition Time ◽  
High Temporal Resolution ◽  
Single Photon Counting

This paper discusses instrumentation based on multiview parallel high temporal resolution (<50 ps) time-domain (TD) measurements for diffuse optical tomography (DOT) and a prospective view on the steps to undertake as regards such instrumentation to make TD-DOT a viable technology for small animal molecular imaging. TD measurements provide information-richest data, and we briefly review the interaction of light with biological tissues to provide an understanding of this. This data richness is yet to be exploited to its full potential to increase the spatial resolution of DOT imaging and to allow probing, via the fluorescence lifetime, tissue biochemical parameters, and processes that are otherwise not accessible in fluorescence DOT. TD data acquisition time is, however, the main factor that currently compromises the viability of TD-DOT. Current high temporal resolution TD-DOT scanners simply do not integrate sufficient detection channels. Based on our past experience in developing TD-DOT instrumentation, we review and discuss promising technologies to overcome this difficulty. These are single photon avalanche diode (SPAD) detectors and fully parallel highly integrated electronics for time-correlated single photon counting (TCSPC). We present experimental results obtained with such technologies demonstrating the feasibility of next-generation multiview TD-DOT therewith.

A Low-Cost Time-Correlated Single Photon Counting System for Multiview Time-Domain Diffuse Optical Tomography

2017 ◽  
Vol 66 (10) ◽  
pp. 2505-2515 ◽  
Author(s):  
Jonathan Bouchard ◽  
Arnaud Samson ◽  
William Lemaire ◽  
Caroline Paulin ◽  
Jean-Francois Pratte ◽  
...  
Keyword(s):  
Time Domain ◽  
Single Photon ◽  
Low Cost ◽  
Optical Tomography ◽  
Photon Counting ◽  
Diffuse Optical Tomography ◽  
Counting System ◽  
Single Photon Counting

Single Point PICA Probing with an Avalanche Photo-Diode

2001 ◽  
Author(s):  
Mike Bruce ◽  
Rama R. Goruganthu ◽  
Shawn McBride ◽  
David Bethke ◽  
J.M. Chin
Keyword(s):  
Single Photon ◽  
Single Point ◽  
Photon Counting ◽  
Ring Oscillator ◽  
Time Resolved ◽  
Single Photon Counting ◽  
Photo Diode ◽  
Avalanche Photo Diode ◽  
Photo Multiplier Tube ◽  
Channel Plate

Abstract For time resolved hot carrier emission from the backside, an alternate approach is demonstrated termed single point PICA. The single point approach records time resolved emission from an individual transistor using time-correlated-single-photon counting and an avalanche photo-diode. The avalanche photo-diode has a much higher quantum efficiency than micro-channel plate photo-multiplier tube based imaging cameras typically used in earlier approaches. The basic system is described and demonstrated from the backside on a ring oscillator circuit.

scholarly journals UVscope and its application aboard the ASTRI-Horn telescope

2021 ◽  
Author(s):  
Maria Concetta Maccarone ◽  
Giovanni La Rosa ◽  
Osvaldo Catalano ◽  
Salvo Giarrusso ◽  
Alberto Segreto ◽  
...  
Keyword(s):  
Gamma Ray ◽  
Single Photon ◽  
Photon Counting ◽  
Light Flux ◽  
Cosmic Ray ◽  
High Energy ◽  
Wide Field ◽  
High Energy Astrophysics ◽  
Single Photon Counting ◽  
Photon Counting Mode

AbstractUVscope is an instrument, based on a multi-pixel photon detector, developed to support experimental activities for high-energy astrophysics and cosmic ray research. The instrument, working in single photon counting mode, is designed to directly measure light flux in the wavelengths range 300-650 nm. The instrument can be used in a wide field of applications where the knowledge of the nocturnal environmental luminosity is required. Currently, one UVscope instrument is allocated onto the external structure of the ASTRI-Horn Cherenkov telescope devoted to the gamma-ray astronomy at very high energies. Being co-aligned with the ASTRI-Horn camera axis, UVscope can measure the diffuse emission of the night sky background simultaneously with the ASTRI-Horn camera, without any interference with the main telescope data taking procedures. UVscope is properly calibrated and it is used as an independent reference instrument for test and diagnostic of the novel ASTRI-Horn telescope.

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