Tomoelastography for non-invasive detection of ameloblastoma and metastatic neck lymph nodes

2020 ◽  
Vol 13 (9) ◽  
pp. e235930
Author(s):  
Marie Beier ◽  
Ingolf Sack ◽  
Benedicta Beck-Broichsitter ◽  
Bernd Hamm ◽  
Stephan Rodrigo Marticorena Garcia
Keyword(s):  
Lymph Nodes ◽  
Wave Speed ◽  
Cervical Lymph Nodes ◽  
Shear Wave Speed ◽  
Non Invasive ◽  
Left Mandible ◽  
Complex Shear ◽  
Epithelial Tumour ◽  
Metastatic Involvement ◽  
Neck Lymph Nodes

Ameloblastoma is a benign epithelial tumour and the most common odontogenic tumour, accounting for about 18% of cases. We present a patient to illustrate the first use of tomoelastography for quantitatively mapping tissue stiffness (shear wave speed) and fluidity (loss angle of the complex shear modulus) in a metastasised ameloblastoma of the left mandible. Tomoelastography maps clearly depicted the extent of the tumour by abnormally high values of stiffness and fluidity (1.73±0.23 m/s, 1.18±0.08 rad) compared with normal values in the contralateral mandible (1.04±0.09 m/s, 0.93±0.12 rad). Abnormal stiffness also revealed metastatic involvement of the neck lymph nodes (1.30±0.03 m/s vs 0.86±0.01 m/s). Taken together, stiffness and fluidity measured by tomoelastography can sensitively detect the presence and extent of bone tumours and metastatic spread to cervical lymph nodes.

scholarly journals Shear wave cardiovascular MR elastography using intrinsic cardiac motion for transducer-free non-invasive evaluation of myocardial shear wave velocity

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Marian Amber Troelstra ◽  
Jurgen Henk Runge ◽  
Emma Burnhope ◽  
Alessandro Polcaro ◽  
Christian Guenthner ◽  
...  
Keyword(s):  
Healthy Volunteers ◽  
Shear Wave ◽  
Wave Speed ◽  
Shear Waves ◽  
Valve Closure ◽  
Limits Of Agreement ◽  
Wave Speeds ◽  
Shear Wave Speed ◽  
Non Invasive ◽  
Aortic Valve Closure

AbstractChanges in myocardial stiffness may represent a valuable biomarker for early tissue injury or adverse remodeling. In this study, we developed and validated a novel transducer-free magnetic resonance elastography (MRE) approach for quantifying myocardial biomechanics using aortic valve closure-induced shear waves. Using motion-sensitized two-dimensional pencil beams, septal shear waves were imaged at high temporal resolution. Shear wave speed was measured using time-of-flight of waves travelling between two pencil beams and corrected for geometrical biases. After validation in phantoms, results from twelve healthy volunteers and five cardiac patients (two left ventricular hypertrophy, two myocardial infarcts, and one without confirmed pathology) were obtained. Torsional shear wave speed in the phantom was 3.0 ± 0.1 m/s, corresponding with reference speeds of 2.8 ± 0.1 m/s. Geometrically-biased flexural shear wave speed was 1.9 ± 0.1 m/s, corresponding with simulation values of 2.0 m/s. Corrected septal shear wave speeds were significantly higher in patients than healthy volunteers [14.1 (11.0–15.8) m/s versus 3.6 (2.7–4.3) m/s, p = 0.001]. The interobserver 95%-limits-of-agreement in healthy volunteers were ± 1.3 m/s and interstudy 95%-limits-of-agreement − 0.7 to 1.2 m/s. In conclusion, myocardial shear wave speed can be measured using aortic valve closure-induced shear waves, with cardiac patients showing significantly higher shear wave speeds than healthy volunteers. This non-invasive measure may provide valuable insights into the pathophysiology of heart failure.

scholarly journals Myocardial stiffness assessed by natural shear wave elastography is related to pressure-volume loop derived parameters

2021 ◽  
Vol 42 (Supplement_1) ◽  
Author(s):  
S Bezy ◽  
A Caenen ◽  
J Duchenne ◽  
M Orlowska ◽  
M Amoni ◽  
...  
Keyword(s):  
Shear Wave ◽  
Wave Speed ◽  
Propagation Speed ◽  
Shear Wave Elastography ◽  
Frame Rate ◽  
Myocardial Stiffness ◽  
High Frame Rate ◽  
Shear Wave Speed ◽  
Non Invasive ◽  
Operating Chamber

Abstract Background Several cardiovascular disorders are accompanied by a stiffening of the myocardium and may result in diastolic heart failure. The non-invasive assessment of myocardial stiffness could therefore improve the understanding of the pathophysiology and guide treatment. Shear wave elastography (SWE) is a recent technique with tremendous potential for evaluating myocardial stiffness in a non-invasive way. Using high frame rate echocardiography, the propagation speed of shear waves is evaluated, which is directly related to the stiffness of the myocardium. These waves are induced by for instance mitral valve closure (MVC) and propagate throughout the cardiac muscle. However, validation of SWE against an invasive gold standard method is lacking. Purpose The aim of this study was to compare echocardiographic shear wave elastography against invasive pressure-volume loops, a gold standard reference method for assessing chamber stiffness. Methods In 15 pigs (31.2±4.1 kg) stiffness of the myocardium was acutely changed by inducing ischemia/reperfusion (I/R) injury. For this, the proximal LAD was balloon occluded for 90 minutes with subsequent reperfusion for 40 minutes. Conventional and high frame rate echocardiographic images were acquired simultaneously with pressure-volume loops during baseline conditions and after the induction of the I/R injury. Preload was reduced in order to acquire a set of pressure-volume loops to derive the end-diastolic pressure volume relation (EDPVR). From the EDPVR, the stiffness coefficient β and the operating chamber stiffness dP/dV were obtained. High frame rate echocardiographic datasets of the parasternal long axis view were acquired with an experimental ultrasound scanner (HD-PULSE) at an average frame rate of 1304±115 Hz. Tissue acceleration maps were obtained by drawing an M-mode line along the interventricular septum in order to visualize shear waves after MVC (at end-diastole). The propagation speed was assessed by semi-automatically measuring the slope (Figure A). Results I/R injury led to an elevated chamber stiffness constant β (0.09±0.03 1/ml vs. 0.05±0.01 1/ml; p<0.001) and operating chamber stiffness dP/dV (1.09±0.38 mmHg/ml vs. 0.50±0.18 mmHg/ml; p<0.01). Likewise, shear wave speed after MVC increased after the induction of the I/R injury in comparison to baseline (6.1±1.2 m/s vs. 3.2±0.8 m/s; p<0.001). Shear wave speed had a moderate positive correlation with β (r=0.63; p<0.001) (Figure B) and a strong positive correlation with dP/dV (r=0.81; p<0.001) (Figure C). Conclusion End-diastolic shear wave speed is strongly related to chamber stiffness, assessed invasively by pressure-volume loops. These results indicate that shear wave propagation speed could be used as a novel non-invasive measurement of the mechanical properties of the ventricle. FUNDunding Acknowledgement Type of funding sources: Public grant(s) – National budget only. Main funding source(s): FWO - Research Foundation Flanders

scholarly journals High Resolution Sonography in Diagnosis of Metastatic Cervical Lymph Nodes in Oral Squamous Cell Carcinoma

1970 ◽  
Vol 28 (2) ◽  
pp. 92-99
Author(s):  
SM Anwar Sadat ◽  
Rufia Nasrin Rita ◽  
Asad-Uz Zaman ◽  
Md Abdur Rob ◽  
Md Musharraf Husain ◽  
...  
Keyword(s):  
Lymph Node ◽  
High Resolution ◽  
Lymph Nodes ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Maxillofacial Surgery ◽  
Cost Effective ◽  
Cervical Lymph Nodes ◽  
Non Invasive ◽  
Sensitivity Specificity

Ultrasound is reported superior to clinical palpation fordetecting lymph nodes and metastasis. The advantage ofultrasound over other imaging modalities is price, lowpatient burden, and possibilities for follow up. A crosssectional Study on 29 cases of oral squamous cell carcinomawas done in Department of Oral & Maxillofacial Surgery,Dhaka Dental College & Hospital, Dhaka from January2006 to December 2007. The sensitivity, specificity, positivepredictive value, negative predictive value & Accuracy ofUltrasonographic technique for determining metastaticcervical lymph node were 93.33%, 50%, 66.7%, 87.5% and72.4% respectively. Considering the finding of the study,Sonographic evaluation can improve the diagnosis ofmetastatic cervical lymph node in patients with oralsquamous cell carcinoma. It is cost effective, non-invasive,less burden to patient, does not create problem ofoverlapping with mandible and can be done repeatedly tofollow up. Therefore, high resolution sonography may bean adjunct tool in diagnosing metastatic nodes in patientswith oral squamous cell carcinoma.DOI: 10.3329/jbcps.v28i2.5369J Bangladesh Coll Phys Surg 2010; 28: 92-99

scholarly journals Mengenal gambaran ultrasound lesi jinak, ganas dan metastasis pada nodus limfa leher menggunakan ultrasonografi

2020 ◽  
Vol 3 (3) ◽  
pp. 21
Author(s):  
Lusi Epsilawati ◽  
Hendra Polii ◽  
Erna Herawati
Keyword(s):  
Literature Review ◽  
Lymph Nodes ◽  
Ultrasound Imaging ◽  
Cervical Lymph Nodes ◽  
Imaging Characteristic ◽  
Pathological Conditions ◽  
Different Characteristics ◽  
Neck Lymph Nodes

Objectives: This study is aimed to review the ultrasound imaging (USG) of benign, malignant and metastases lesions in cervical lymph nodes. Literature Review: This article was written based on some scientific literatures in which will explain the interpretation technique and imaging characteristic to distinguish between benign, malignancies and metastases lesions in cervical lymph nodes through ultrasound imaging. There are many pathological conditions may occur in cervical lymph nodes that can be analyzed in ultrasound. The signs of benign, malignant and metastases lesions in cervical lymph nodes, all may have different characteristics. Those characteristics could help the practitioners and radiologists to distinguish the lesions based on several assessment categories. Hopefully, the reader of this article could understand the technique to distinguish benign, malignant and metastases lesions in neck lymph nodes in ultrasound. Conclusion: Ultrasonography is the most commonly used modality for lymph nodes examination, although the accuracy cannot be trusted or guaranteed 100% but this modality always be used and becoming one of all choices. Through the ultrasound, it could be concluded that some of the characteristics of the assessment can be a guide to distinguish benign, malignant and metastases lesions in cervical lymph nodes.

A non-invasive technique for estimating carpal tunnel pressure by measuring shear wave speed in tendon: A feasibility study

2012 ◽  
Vol 45 (16) ◽  
pp. 2927-2930 ◽  
Author(s):  
Yuexiang Wang ◽  
Bo Qiang ◽  
Xiaoming Zhang ◽  
James F. Greenleaf ◽  
Kai-Nan An ◽  
...  
Keyword(s):  
Shear Wave ◽  
Feasibility Study ◽  
Carpal Tunnel ◽  
Wave Speed ◽  
Invasive Technique ◽  
Shear Wave Speed ◽  
Non Invasive

A febrile child with a ‘bunch of grapes’ appearance on neck ultrasonography

2020 ◽  
pp. 004947552097594
Author(s):  
Pratap Kumar Patra ◽  
Aaqib Zaffar Banday ◽  
Naveen Bhagat ◽  
Pandiarajan Vignesh ◽  
Surjit Singh
Keyword(s):  
Kawasaki Disease ◽  
Lymph Nodes ◽  
Clinical Presentation ◽  
Febrile Child ◽  
Imaging Features ◽  
Cervical Lymph Nodes ◽  
Childhood Vasculitis ◽  
Neck Lymph Nodes

Kawasaki disease is a common childhood vasculitis. Fever and lymphadenopathy, at times, are the only clinical presentation of Kawasaki disease, which mimics infectious lymphadenitis, especially, when other features are yet to evolve. In such a scenario, ultrasonography of cervical lymph nodes can help to differentiate Kawasaki disease lymphadenitis from infectious lymphadenitis. We present one such patient who was initially diagnosed as having bacterial lymphadenitis; however, ultrasonography of the neck lymph nodes showed typical imaging features described with Kawasaki disease lymphadenitis.

A combined evaluation strategy of FDG PET/CT and contrast-enhanced diagnostic CT (ceCT) for lymph nodes in the neck.

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. 5578-5578
Author(s):  
Neetha Gandikota ◽  
Su Ann Ng ◽  
Ryan Cotter ◽  
Yildiz Akin ◽  
Peter M. Som ◽  
...  
Keyword(s):  
Lymph Nodes ◽  
Cervical Lymph Nodes ◽  
Incremental Value ◽  
Contrast Enhanced ◽  
Pet Ct ◽  
Metastatic Involvement ◽  
Fdg Pet Ct ◽  
Better Than

5578 Background: Accurate assessment of cervical lymph nodes (LNs) for determination of metastatic involvement is of prime importance for management. Our objective was to determine the incremental value of combining metabolic and morphologic information in the differentiation between benign and malignant LNs. Methods: A total of101 pts with head and neck squamous cell (n=91) or thyroid cancer (n=6) or lymphoma (n=4) were included in the study. PET/CT and neck ceCT were acquired simultaneously or sequentially at staging (n=48) or restaging (n=53). In 131 LNs, variables evaluated includes SUVmax, size, shape (elliptical vs non-elliptical), presence of extracapsular extension (Ecext-irregular margins), necrosis, and fatty hilum. Histopathology (n=96) and 12 mo follow-up (n=35) were used for confirmation of the findings. ROC analyses determined the SUVmax cut-off. Results: Of131 LNs, malignancy wasconfirmed in 49 (37%).Results are shown in table. In the detection of malignancy, SUVmax of 4.5 yielded the best balance between the sensitivity and specificity, performing better than all CT variables alone. Combination analysis improved results only when SUVmax (4.5) was added to Ecext. However, best combination results were obtained at a SUV cut-off of 3.7. Higher SUV cut-off did not significantly improve overall performance of SUVmax alone (Table). Conclusions: In the differentiation of malignant from benign LNs, SUVmax (4.5) yields better results than CT variables alone. However combining a lower SUVmax (3.7) with Ecext produced the best results. Increasing SUVmax cut-off only produced a gain in specificity at a significant cost of sensitivity. [Table: see text]

Benign thyroid inclusions in cervical lymph nodes

JAMA ◽  
1965 ◽  
Vol 194 (1) ◽  
pp. 1-4 ◽  
Author(s):  
A. D. Nicastri
Keyword(s):  
Lymph Nodes ◽  
Cervical Lymph Nodes ◽  
Benign Thyroid
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