scholarly journals Bacterial antibiotic resistance development and mutagenesis following exposure to subminimal inhibitory concentrations of fluoroquinolones in vitro: a systematic literature review protocol

BMJ Open ◽  
2019 ◽  
Vol 9 (10) ◽  
pp. e030747 ◽  
Author(s):  
Carly Ching ◽  
Ebiowei S.F. Orubu ◽  
Veronika J. Wirtz ◽  
Muhammad H. Zaman
Keyword(s):  
Antibiotic Resistance ◽  
Primary Data ◽  
Resistance Development ◽  
Bacterial Antibiotic Resistance ◽  
Ethical Approval ◽  
Medicine Quality ◽  
Review Protocol ◽  
The Impact

IntroductionAntibiotic resistance (AR) is among the most pressing global health challenges. Fluoroquinolones are a clinically important group of antibiotics that have wide applicability in both humans and animals. While many drivers of AR are known, the impact of medicine quality on AR remains largely unknown. The aim of this review is to systematically evaluate the evidence of the impact of in vitro subinhibitory antibiotic exposure, a major tenet of substandard antibiotics, on the development of AR and mutagenesis, using fluoroquinolones as a case study.Methods and analysisEMBASE, Web of Science and PubMed will be systematically searched for primary experimental in vitro studies, from earliest available dates within each database (1947, 1965 and 1966, respectively) through 2018, related to subinhibitory fluoroquinolone exposure and AR. A specifically developed non-weighted tool will be used to critically assess the evidence. Subgroup analyses will be performed for different variables and outcomes.Ethics and disseminationEthical approval is not required as no primary data are to be collected. The completed systematic review will be disseminated through conference meeting presentations and a peer-reviewed publication.

scholarly journals Environmental Movement and the Conservation of Forest: A Case Study on Ratargul Swamp Forest of Sylhet, Bangladesh

2019 ◽  
pp. 1-7
Author(s):  
Kazi Moriom Jahan ◽  
Afm Zakaria
Keyword(s):  
Data Collection ◽  
Group Discussion ◽  
Environmental Movement ◽  
Primary Data ◽  
Environmental Groups ◽  
Forest Department ◽  
Swamp Forest ◽  
Level Of Involvement ◽  
The Impact

Aims: The aim of this paper is to explore and analyze the scope and nature of the environmental movement that may shape the existing management. Study Design: This paper is a qualitative study and based on empirical research. It focuses on the impact of environmental movements around Ratargul Swamp Forest Place and Duration of Study: This research was done around the Ratargul Swamp Forest located in on Sylhet district of Bangladesh. The study period was from January 2016 to November 2017. Methodology: For the primary data collection, 47 respondents were selected by using purposive sampling on the basis of their level of involvement. Data was collected from local people, environmental groups and the forest department. Data collection methods were key informant interview, in-depth interview, case study, focus group discussion and archival research. Results: People of Ratargul village are now more aware of the harmful activities of uncontrolled tourism while the Forest Department brings new management policies and practices in response to the local and civil pressure. It is also found that the Climate Resilient Ecosystem Livelihoods (CREL) project in Bangladesh actually works to negate the strength of the environmental movement rather than as a conservation proponent. The Forest Department is successful to implement their projects due to a lack of coordination between local activists. According to the respondents, 31.1% mark this movement as successful, 23.4% opine as completely failure and while remaining 44.4% thinks that it is partially successful. Conclusion: A strong, integrated, coordinated and organized form of resistance or movement is needed to break up the hegemony of Forest Department that may save the Ratargul Swamp Forest from ongoing damage.

scholarly journals HOW DOES THE INSTITUTIONAL CONTEXT OF AN EMERGING ECONOMY SHAPE THE INNOVATION TRAJECTORY OF DIFFERENT TYPES OF COMPANIES? A CASE STUDY OF INDIA

2020 ◽  
Vol 14 (2) ◽  
pp. 36-51
Author(s):  
Harini Mittal
Keyword(s):  
Multinational Corporations ◽  
Institutional Context ◽  
Emerging Economy ◽  
Qualitative Assessment ◽  
Primary Data ◽  
Institutional Voids ◽  
Innovation Strategies ◽  
Start Ups ◽  
The Impact

Institutional voids faced by emerging economies have received a lot of attention in recent literature. However, the impact of institutional voids in an emerging economy on the level of company innovation strategies and output is a less researched topic. Using India as a case study, this paper presents a qualitative assessment of the impact of the institutional context of this emerging economy on innovation strategies and consequent outputs of private Indian companies of various sizes and ages. Primary data for the study were collected by means of surveys, in-depth interviews, and secondary data sources including government reports, World Bank and United Nations reports, research articles, and in-depth industry surveys. The paper concludes that in India, large companies and start-ups are more innovative. Most innovations are imitative in nature, and/or driven by customer requirements, and/or international quality norms. “New-to-the-world” innovations are scarce and are mostly driven by multinational corporations (MNCs), government institutions, and to some extent large Indian companies. The paper concludes that in a rapidly emerging economy like India, large companies are more innovative because of their resilience, internal systems, and capabilities that can overcome voids, and exploit opportunities. The fast-paced transitions have created more opportunities for start-ups than small and medium-sized enterprises (SMEs), thereby creating unequal innovation opportunities for companies of different sizes and ages, as distinct coping strategies are required for innovation to occur.

scholarly journals Tugas PI

2021 ◽  
Author(s):  
Jean Michael Sitanayah
Keyword(s):  
Qualitative Research ◽  
Secondary Data ◽  
Primary Data ◽  
Fisheries Regulation ◽  
Partnership Agreement ◽  
The Impact ◽  
Opening Up

The new policy to provide broad flexibility to capture lobster seeds is the same as opening up massive exploitation and welcoming the extinction of lobster seeds in Indonesia. The commitment of lobster seed exporters to develop cultivation is very doubtful and is suspected of using partnerships with lobster cultivators as an effort to obtain a lobster seed export license only. After obtaining the license, the exporters are predicted to break the partnership agreement. Therefore, there needs to be an evaluation, given that business actors are not ready with supporting facilities and infrastructure to carry out the cultivation. This qualitative research leads to a case study of the impact of a new policy regarding the export of lobster seeds on the sustainability of lobster in Indonesia. This study uses primary data and secondary data to explore and explain the impact of Minister of Marine Affairs and Fisheries Regulation Number 12 of 2020 in order to draw general conclusions and support the theory.

scholarly journals Protein status of people with phenylketonuria: a scoping review protocol

BMJ Open ◽  
2021 ◽  
Vol 11 (9) ◽  
pp. e049883
Author(s):  
Sarah Firman ◽  
Radha Ramachandran ◽  
Kevin Whelan ◽  
Oliver C Witard ◽  
Majella O’Keeffe
Keyword(s):  
Scoping Review ◽  
Scientific Evidence ◽  
Grey Literature ◽  
The Body ◽  
Future Research ◽  
Advisory Group ◽  
Protein Status ◽  
Ethical Approval ◽  
Review Protocol ◽  
The Impact

IntroductionPhenylketonuria (PKU) is a disorder of protein metabolism resulting in an accumulation of phenylalanine in the body. Dietary management consists of altering the sources of ingested protein to limit phenylalanine intake. Current dietary protein guidelines for PKU are based on limited scientific evidence, thus it remains unclear whether current practice leads to optimal protein status in people with PKU. To date, no attempt has been made to systematically evaluate the protein status of people with PKU, using a combination of validated anthropometric, biochemical and functional measurement tools. Furthermore, factors known to influence protein status in the general population warrant consideration when determining protein status in individuals with PKU, alongside factors unique to PKU such as the type of protein substitute consumed. Understanding the impact of these variables on protein status is crucial to developing a personalised approach to protein recommendations for optimising health and functional outcomes in people with PKU. Therefore, the aim of this scoping review is to examine existing evidence regarding the protein status of people with PKU, and to investigate the nutritional and lifestyle variables that influence protein status.Methods and analysisThis review will be guided by Arksey and O’Malley’s framework, along with guidance from Levac et al, Pawliuk et al and the Joanna Briggs Institute. The following databases will be searched: MEDLINE (Ovid), Embase, CENTRAL, Web of Science and Scopus, alongside grey literature. Identified literature will be assessed by two independent reviewers for inclusion. Descriptive numerical analysis will be performed and a narrative summary will accompany the tabulated results describing how study findings relate to the review questions.Ethics and disseminationThis review protocol does not require ethical approval. Findings will be disseminated through peer-reviewed publication, presented at relevant conferences, and shared with a patient research advisory group to inform discussions on future research.

scholarly journals Enterococcus faecalisCRISPR-Cas is a robust barrier to conjugative antibiotic resistance dissemination in the murine intestine

2018 ◽  
Author(s):  
Valerie J. Price ◽  
Sara W. McBride ◽  
Karthik Hullahalli ◽  
Anushila Chatterjee ◽  
Breck A. Duerkop ◽  
...  
Keyword(s):  
Antibiotic Resistance ◽  
Enterococcus Faecalis ◽  
Resistance Genes ◽  
Antibiotic Resistance Genes ◽  
Conjugative Plasmids ◽  
Resistance Plasmids ◽  
The Impact ◽  
Mammalian Intestine

AbstractCRISPR-Cas systems are barriers to horizontal gene transfer (HGT) in bacteria. Little is known about CRISPR-Cas interactions with conjugative plasmids, and studies investigating CRISPR-Cas/plasmid interactions inin vivomodels relevant to infectious disease are lacking. These are significant gaps in knowledge because conjugative plasmids disseminate antibiotic resistance genes among pathogensin vivo, and it is essential to identify strategies to reduce the spread of these elements. We use enterococci as models to understand the interactions of CRISPR-Cas with conjugative plasmids.Enterococcus faecalisis a native colonizer of the mammalian intestine and harbors pheromone-responsive plasmids (PRPs). PRPs mediate inter- and intraspecies transfer of antibiotic resistance genes. We assessedE. faecalisCRISPR-Cas anti-PRP activity in the mouse intestine and under varyingin vitroconditions. We observed striking differences in CRISPR-Cas efficiencyin vitroversusin vivo. With few exceptions, CRISPR-Cas blocked intestinal PRP dissemination, whilein vitro, the PRP frequently escaped CRISPR-Cas defense. Our results further the understanding of CRISPR-Cas biology by demonstrating that standardin vitroexperiments do not adequately model thein vivoanti-plasmid activity of CRISPR-Cas. Additionally, our work identifies several variables that impact the apparentin vitroanti-plasmid activity of CRISPR-Cas, including planktonic versus biofilm settings, different donor/recipient ratios, production of a plasmid-encoded bacteriocin, and the time point at which matings are sampled. Our results are clinically significant because they demonstrate that barriers to HGT encoded by normal human microbiota can have significant impacts onin vivoantibiotic resistance dissemination.ImportanceCRISPR-Cas is a type of immune system encoded by bacteria that is hypothesized to be a natural impediment to the spread of antibiotic resistance genes. In this study, we directly assessed the impact of CRISPR-Cas on antibiotic resistance dissemination in the mammalian intestine and under varyingin vitroconditions. We observed a robust effect of CRISPR-Cas onin vivobut notin vitrodissemination of antibiotic resistance plasmids in the native mammalian intestinal colonizerEnterococcus faecalis. We conclude that standard laboratory experiments currently do not appropriately model thein vivoconditions where antibiotic resistance dissemination occurs betweenE. faecalisstrains. Moreover, our results demonstrate that CRISPR-Cas encoded by native members of the mammalian intestinal microbiota can block the spread of antibiotic resistance plasmids.

scholarly journals Impact of Foreign Remittances on Quality of Life: A Case Study of District Lower Dir, Pakistan

2019 ◽  
Vol IV (III) ◽  
pp. 132-139
Author(s):  
Haidar Farooq ◽  
Sabahat Subhan ◽  
Yasir Riaz
Keyword(s):  
Quality Of Life ◽  
Family Health ◽  
Primary Data ◽  
Private Hospitals ◽  
Healthcare Needs ◽  
The Impact ◽  
Positive Effect ◽  
Private Doctor

This research study examines the impact of remittances on quality of life. In order to accomplish the objectives, the study uses primary data which are collected from 403 households of District Dir Lower, Pakistan. Results summarized that incoming foreign remittances have a positive effect on education. Foreign remittances improve the household income level, this income is further utilized for different educational expenses. Therefore, remittance recipient families spend more than that of non-receiving families on education. In addition, remittances also increase the probability of children’s enrollment in schools. On the other hand, remittances are positively associated with family health status. The results revealed that 83% of the remittance recipient families have the ability to access basic healthcare needs, whereas 64% of non-receiving households have no access to basic health facilities. Additionally, remittances receiving families mostly prefer a private doctor and private hospitals, whereas non-receiving household usually uses government hospital facilities.

Zakat Disbursement via Capital Assistance: A Case Study of Majlis Agama Islam Johor

2013 ◽  
Vol 1 (2) ◽  
pp. 42
Author(s):  
Ahmad Che Yaacob ◽  
Safiah Mohamed ◽  
Azizah Daut ◽  
Normah Ismail ◽  
Mohd Ali Muhammad Don
Keyword(s):  
Small Business ◽  
Statistical Data ◽  
Secondary Data ◽  
The State ◽  
Primary Data ◽  
Development Programs ◽  
The Poor ◽  
The Impact ◽  
Research Grant

This paper examines management of zakat in the state of Johor and focuses on the distribution of zakat to the recipients of capital assistance who are involved in the socio-development programs. It intends to examine the impact of the program towards their achievements after receiving capital assistance to start their small business ventures. Both primary and secondary data are used in the studies. The primary data were collected from interviews with the officers of Majlis Agama Islam Johor (MAIJ) and the statistical data were obtained from documents such as reports, financial records, and brochures. The findings show commendable improvement in zakat management for the five-year period of study. Nonetheless, recommendations pertaining to supervision, procedures, and cooperation are posed for improving the programs in assisting the poor and needy recipients and to optimize the zakat disbursement. The study was made possible with the research grant from Accounting Research Institute (ARI) of UiTM.

The Impact of Perceptions of Tribalism and Ethnicity on Public Administration in South Africa: A Case Study of the Vuwani in the Vhembe District

Politeia ◽  
2021 ◽  
Vol 39 (2) ◽  
Author(s):  
Mavhungu Elias Musitha ◽  
Mavhungu Abel Mafukata
Keyword(s):  
South Africa ◽  
Public Administration ◽  
Ethnic Disparities ◽  
Primary Data ◽  
National Unity ◽  
Policy Makers ◽  
Local Municipality ◽  
Vhembe District ◽  
The Impact

This study investigated the impact of perceptions of ethnicity and tribalism on public administration in South Africa with reference to the protests of Vuwani communities in 2016 against their area being re-demarcated to fall under the LIM 345 municipality (later named the Collins Chabane Local Municipality) dominated by Xitsonga speakers. The study adopted qualitative and exploration designs and used a literature review and key informant interviews in order to obtain secondary and primary data respectively. This study revealed that Vuwani communities feared domination by the Xitsonga-speaking majority in the proposed new municipality. The council of the proposed new municipality consisted of 72 councillors, 74 per cent of which were Xitsonga-speaking councillors and a mere 26 per cent were Tshivenda-speaking councillors. It also found that perceptions of ethnicity and tribalism in Vuwani had rendered public administration ineffective, thus bringing service delivery to a halt for several months. The study recommended that policy-makers should abolish majority representation based solely on regionalism and should seek to forge national unity. It concluded that the establishment of public institutions based on ethnic homogeneity had the potential of bringing about peace and stability in areas characterised by ethnic disparities.

COVID-19 and food security as catalyst of conflict among rural households in Nigeria: a study of Ilaje community, Ondo state

2021 ◽  
Vol 13 (4) ◽  
pp. 169-185
Author(s):  
Tosin Seun Adebayo ◽  
Logo Oluwamayowa
Keyword(s):  
Food Security ◽  
Mixed Method ◽  
Rural Households ◽  
Primary Data ◽  
Mixed Method Research ◽  
Design Data ◽  
Content Type ◽  
Ondo State ◽  
The Impact

Purpose The compulsory lockdown issued by the Nigeria Government to curb the spread of the virus has undoubtedly negatively affected the livelihoods of households. As a result, many have lost their sources of income and have no other means for survival. It is important to note that it has the potential of triggering violent conflicts and civil unrest as a popular African adage goes as thus: “A hungry man is an angry man”. Unfortunately, little attention has been given, neither has extant literature adequately covered the impact of the coronavirus (COVID-19) outbreak as it directly affects households in a rural community in Nigeria. Design/methodology/approach This study proceeded from on both a qualitative and quantitative method and adopted a mixed-method and case study research design. Data for this study was collected through primary and secondary data. Primary data for this study was collected through a questionnaire and focus group discussions (FGD). The questionnaire used for this study was a validated instrument designed by the US Department of Agriculture (USDA) to measure food security amongst households. The USDA household’s instrument was used and then modified to access the food security status of households during the lockdown. Findings Findings from this study revealed that households, in general, were categorised as having “very low food security” during the lockdown as they testified to all the food insecure conditions. In general, the food intake of household members reported irregular eating patterns as the household lacked the money to purchase food. This study further indicated that a high number of respondents see violence as a means of attaining food. Extreme volatility in their inability to access food as a result of food shortages and the inability to benefit from government palliatives has been found to trigger incidents of conflict and malnutrition on households. Research limitations/implications This method was sampling method was adopted because of the compulsory and constitutional lockdown imposed by the government to curb the spread of the novel COVID-19 which limited the movement of the researcher to other households in the community which proved to be limited during the time this research was carried limiting the scope of the sample size. Originality/value This research adopted mixed-method research and was written by the researchers who did the study. This paper was conducted during the mandatory lockdown issued by the Federal Government in Nigeria with to understand the impact of the mandatory lockdown on rural households using Ilaje local of Ondo state as a case study while establishing a link between food security and conflict.

scholarly journals Towards a deeper understanding of fatty acid bioaccessibility and its dependence on culinary treatment and lipid class: a case study of gilthead seabream (Sparus aurata)

2016 ◽  
Vol 116 (10) ◽  
pp. 1816-1823 ◽  
Author(s):  
Sara Costa ◽  
Cláudia Afonso ◽  
Carlos Cardoso ◽  
Rui Oliveira ◽  
Francisca Alves ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Lipid Class ◽  
Sparus Aurata ◽  
Gilthead Seabream ◽  
Total Lipids ◽  
Class A ◽  
The Impact ◽  
Long Chain

AbstractThe bioaccessibility of total lipids and fatty acids (FA) in raw and grilled gilthead seabream (Sparus aurata) was determined using an in vitro digestion model. The particular impact of grilling on the FA profile of seabream was also studied. In addition, the influence of lipid class on the bioaccessibility of each FA was analysed. Grilling did not change the relative FA profile, and only the absolute values were altered. However, the relative FA profile varied across lipid classes, being more dissimilar between TAG and phospholipids. Long-chain SFA and PUFA seemed to be less bioaccessible. Moreover, grilling reduced bioaccessibility of protein, fat and many FA, with the highest reductions found in PUFA such as the DHA. Strong evidence supporting a predominantly regioselective action of lipase during in vitro digestion was found, and the impact of this phenomenon on FA bioaccessibility was assessed.

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