PTU-257 Correlation of adipokines and intestinal inflammation with mesenteric adipose tissue volumes in symptomatic and asymptomatic diverticulosis: Abstract PTU-257 Table 1

Gut ◽  
2015 ◽  
Vol 64 (Suppl 1) ◽  
pp. A174.2-A175
Author(s):  
K Murray ◽  
C Hoad ◽  
J Garratt ◽  
C Costigan ◽  
A Batra ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Intestinal Inflammation ◽  
Mesenteric Adipose Tissue

scholarly journals Methotrexate is effective in reactivated colitis and reduces inflammatory alterations in mesenteric adipose tissue during intestinal inflammation

2009 ◽  
Vol 60 (4) ◽  
pp. 341-346 ◽  
Author(s):  
Marcia Aparecida Thomaz ◽  
Simone Coghetto Acedo ◽  
Caroline Candida de Oliveira ◽  
José Aires Pereira ◽  
Denise Gonçalves Priolli ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Intestinal Inflammation ◽  
Mesenteric Adipose Tissue

scholarly journals Microbiota in mesenteric adipose tissue from Crohn’s disease promote colitis in mice

Microbiome ◽  
2021 ◽  
Vol 9 (1) ◽  
Author(s):  
Zhen He ◽  
Jinjie Wu ◽  
Junli Gong ◽  
Jia Ke ◽  
Tao Ding ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Ribosomal Rna ◽  
Intestinal Inflammation ◽  
Multidimensional Data ◽  
Mesenteric Adipose Tissue ◽  
Pathologic Characteristic ◽  
Metabolites Production ◽  
Colitis Model

Abstract Background Mesenteric adipose tissue (mAT) hyperplasia, known as creeping fat is a pathologic characteristic of Crohn’s disease (CD). The reserve of creeping fat in surgery is associated with poor prognosis of CD patients, but the mechanism remains unknown. Methods Mesenteric microbiome, metabolome, and host transcriptome were characterized using a cohort of 48 patients with CD and 16 non-CD controls. Multidimensional data including 16S ribosomal RNA gene sequencing (16S rRNA), host RNA sequencing, and metabolome were integrated to reveal network interaction. Mesenteric resident bacteria were isolated from mAT and functionally investigated both in the dextran sulfate sodium (DSS) model and in the Il10 gene-deficient (Il10−/−) mouse colitis model to validate their pro-inflammatory roles. Results Mesenteric microbiota contributed to aberrant metabolites production and transcripts in mATs from patients with CD. The presence of mAT resident microbiota was associated with the development of CD. Achromobacter pulmonis (A. pulmonis) isolated from CD mAT could translocate to mAT and exacerbate both DSS-induced and Il10 gene-deficient (Il10−/−) spontaneous colitis in mice. The levels of A. pulmonis in both mAT and mucous layer from CD patients were higher compared to those from the non-CD group. Conclusions This study suggests that the mesenteric microbiota from patients with CD sculpt a detrimental microenvironment and promote intestinal inflammation.

scholarly journals Microbiota in Mesenteric Adipose Tissue From Crohn’s Disease Promote Colitis in Mice

2021 ◽  
Author(s):  
Zhen He ◽  
Jinjie Wu ◽  
Junli Gong ◽  
Jia Ke ◽  
Tao Ding ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Ribosomal Rna ◽  
Intestinal Inflammation ◽  
Multidimensional Data ◽  
Mesenteric Adipose Tissue ◽  
Pathologic Characteristic ◽  
Metabolites Production ◽  
Colitis Model

Abstract Background: Mesenteric adipose tissue (mAT) hyperplasia, known as creeping fat is a pathologic characteristic of Crohn’s disease (CD). The reserve of creeping fat in surgery is associated with poor prognosis of CD patients, but the mechanism remains unknown.Methods: Mesenteric microbiome, metabolome and host transcriptome were characterized using a cohort of 48 patients with CD and 16 non-CD controls. Multidimensional data including 16S ribosomal RNA gene sequencing (16S rRNA), host RNA sequencing and metabolome were integrated to reveal network interaction. Mesenteric resident bacteria were isolated from mAT and functionally investigated both in dextran sulfate sodium (DSS) model and Il10 gene deficient (Il10-/-) mouse colitis model to validate their pro-inflammatory roles. Results: Mesenteric microbiota contributed to aberrant metabolites production and transcripts in mATs from patients with CD. Presence of mAT resident microbiota was associated with the development of CD. Achromobacter pulmonis (A. pulmonis) isolated from CD mAT could translocate to mAT and exacerbate both DSS-induced and Il10 gene deficient (Il10-/-) spontaneous colitis in mice. The levels of A. pulmonis both in mAT and mucous layer from CD patients were higher compared to those from non-CD group. Conclusions: This study suggests that the mesenteric microbiota from patients with CD sculpt a detrimental microenvironment and promote intestinal inflammation.

Infliximab modifies mesenteric adipose tissue alterations and intestinal inflammation in rats with TNBS-induced colitis

2012 ◽  
Vol 47 (8-9) ◽  
pp. 943-950 ◽  
Author(s):  
Thayane Rodrigues Leite Clemente ◽  
Aline Noronha dos Santos ◽  
José Narciso Sturaro ◽  
Érica Martins Ferreira Gotardo ◽  
Caroline Candida de Oliveira ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Intestinal Inflammation ◽  
Mesenteric Adipose Tissue ◽  
Tissue Alterations

Mesenteric adipose tissue alterations resulting from experimental reactivated colitis

2007 ◽  
Vol 13 (11) ◽  
pp. 1357-1364 ◽  
Author(s):  
Alessandra Gambero ◽  
Marta Maróstica ◽  
Mario José Abdalla Saad ◽  
José Pedrazzoli
Keyword(s):  
Adipose Tissue ◽  
Mesenteric Adipose Tissue ◽  
Tissue Alterations

scholarly journals Global Adiposity and Thickness of Intraperitoneal and Mesenteric Adipose Tissue Depots Are Increased in Women With Polycystic Ovary Syndrome (PCOS)

2013 ◽  
Vol 98 (3) ◽  
pp. 1254-1263 ◽  
Author(s):  
Susana Borruel ◽  
Elena Fernández-Durán ◽  
Macarena Alpañés ◽  
David Martí ◽  
Francisco Álvarez-Blasco ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Ovary Syndrome ◽  
Mesenteric Adipose Tissue ◽  
Adipose Tissue Depots

Obesity and inflammatory bowel disease

2021 ◽  
Vol 75 (1) ◽  
pp. 20-28
Author(s):  
Vladimír Teplan ◽  
Milan Lukáš
Keyword(s):  
Inflammatory Bowel Disease ◽  
Adipose Tissue ◽  
Bowel Disease ◽  
Intestinal Inflammation ◽  
Perioperative Complications ◽  
Overweight And Obesity ◽  
Special Role ◽  
Low Concentrations ◽  
Inflammatory Bowel

The incidence and prevalence of overweight and obesity has dramatically increased in the last decades and is generally considered to be global pandemics. The incidence of inflammatory bowel disease (IBD) is rising parallel with overweight and obesity. Contrary to a conventional believe, about 15–40% patients with IBD are obese, which can contribute to the development and course of IBD, especially in Crohn’s disease. Although the findings of some cohort studies are still conflicting, recent results indicate a special role of visceral adipose tissue and particularly mesenteric adipose tissue known as creeping fat, leading to intestinal inflammation. The involvement of altered adipocyte function and deregulated production of adipokines such as leptin and adiponectin has been suggested in the pathogenesis of IBD. The emerging role of Western diet and microbiota can also open new possibilities in IBD management. The effect of obesity on the IBD-related therapy remains to be studied. The finding that obesity results in suboptimal response to the therapy, potentially promoting rapid clearance of biologic agents and thus leading to their low concentrations, has a great importance. Obesity also makes IBD colorectal surgery technically challenging and might increase a risk of perioperative complications.

scholarly journals Guanylyl cyclase C and guanylin reduce fat droplet accumulation in cattle mesenteric adipose tissue

2017 ◽  
Vol 18 (3) ◽  
pp. 341
Author(s):  
Masahiro Yasuda ◽  
Jyunya Kawabata ◽  
Sayaka Akieda-Asai ◽  
Tetsuo Nasu ◽  
Yukari Date
Keyword(s):  
Adipose Tissue ◽  
Guanylyl Cyclase ◽  
Guanylyl Cyclase C ◽  
Mesenteric Adipose Tissue
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