STUDIES ON THE SUBACUTE AND CHRONIC ADMINISTRATION OF STILBESTROL IN THE MALE RAT

1954 ◽  
Vol 32 (1) ◽  
pp. 41-49 ◽  
Author(s):  
D. W. Snair ◽  
Sybil E. Jaffray ◽  
H. C. Grice ◽  
L. I. Pugsley
Keyword(s):  
Body Weight ◽  
Chronic Administration ◽  
Seminal Vesicles ◽  
Reproductive Capacity ◽  
Male Rat ◽  
Breeding Experiment ◽  
Percentage Decrease ◽  
The Third ◽  
Accessory Sex Organs ◽  
Daily Dose

The temporary effects of the administration of stilbestrol upon body weight, weight of the accessory sex organs, and the reproductive capacity of the male white rat have been studied. A linear relationship was obtained when the logarithm of the dose of stilbestrol administered (0.0125 to 5.0 mgm.) was plotted against the percentage decrease in testes weight. This same relationship was also found when the log of the dose was plotted against the percentage decrease in body weight although this line had a much more gradual slope.When the administration of stilbestrol was discontinued, the seminal vesicles coagulating glands, and ventral prostrates regained their weight by the third to fourth week but the weights of the testes remained below the control values until the sixth to ninth week. In a breeding experiment it was shown that a daily dose of 7.5 μgm. of stilbestrol causes sterility in the male. This does also slightly affected the weight of the accessory sex organs and their cellular structure.

STUDIES ON THE SUBACUTE AND CHRONIC ADMINISTRATION OF STILBESTROL IN THE MALE RAT

1954 ◽  
Vol 32 (1) ◽  
pp. 41-49 ◽  
Author(s):  
D. W. Snair ◽  
Sybil E. Jaffray ◽  
H. C. Grice ◽  
L. I. Pugsley
Keyword(s):  
Body Weight ◽  
Chronic Administration ◽  
Seminal Vesicles ◽  
Reproductive Capacity ◽  
Male Rat ◽  
Breeding Experiment ◽  
Percentage Decrease ◽  
The Third ◽  
Accessory Sex Organs ◽  
Daily Dose

The temporary effects of the administration of stilbestrol upon body weight, weight of the accessory sex organs, and the reproductive capacity of the male white rat have been studied. A linear relationship was obtained when the logarithm of the dose of stilbestrol administered (0.0125 to 5.0 mgm.) was plotted against the percentage decrease in testes weight. This same relationship was also found when the log of the dose was plotted against the percentage decrease in body weight although this line had a much more gradual slope.When the administration of stilbestrol was discontinued, the seminal vesicles coagulating glands, and ventral prostrates regained their weight by the third to fourth week but the weights of the testes remained below the control values until the sixth to ninth week. In a breeding experiment it was shown that a daily dose of 7.5 μgm. of stilbestrol causes sterility in the male. This does also slightly affected the weight of the accessory sex organs and their cellular structure.

DIETARY RESTRICTION AND THE ENDOCRINE TESTIS; SIMULATION OF THE SYSTEMIC EFFECTS OF SEVERE COLD(−5 °C)

1965 ◽  
Vol 43 (5) ◽  
pp. 809-817 ◽  
Author(s):  
M. J. Perrault ◽  
L. P. Dugal
Keyword(s):  
Body Weight ◽  
Room Temperature ◽  
Seminal Vesicles ◽  
Restricted Diet ◽  
Testosterone Treatment ◽  
Metabolic Alterations ◽  
Weight Percentage ◽  
Loss Of Weight ◽  
Accessory Sex Organs ◽  
Systemic Component

Previous work has suggested that the degeneration of the male reproductive system caused by severe cold (−5 °C; 18–32 days) represents the sum of the following factors: (a) systemic, or metabolic alterations in various structures of the entire organism; (b) endocrine, or neurohumoral events, especially androgenic.Observation of changes in weight of the accessory sex organs, prostate and seminal vesicles, as indicators of androgenic function, permits a demonstration of the two separate effects of cold. A restricted diet given to animals at room temperature results in a loss of body weight (percentage of control) almost identical in rate and in level with the loss caused by cold, and simulates the systemic component of the action of cold; the observed loss of weight of the accessories follows the proportionality (nonlinear) between body weight and organ weight. The further loss observed in the accessories of the cold-exposed rat may then be taken to represent the endocrine component, that is, the true androgenic depression; testosterone treatment in the "starved" castrate at room temperature shows the dissociation between the two components.

Inhibition of prostatic growth in rats by 6-methylene-4-pregnene-3,20-dione

1982 ◽  
Vol 95 (3) ◽  
pp. 311-313 ◽  
Author(s):  
Vladimir Petrow ◽  
G. M. Padilla ◽  
Keith Kendle ◽  
A. Tantawi
Keyword(s):  
Body Weight ◽  
Seminal Vesicles ◽  
Ventral Prostate ◽  
Irreversible Inhibitor ◽  
Immature Rats ◽  
Daily Dose ◽  
Prostatic Growth ◽  
Rat Prostate

6-Methylene-4-pregnene-3,20-dione, a potent irreversible inhibitor of rat prostate 5α-reductase in vitro, markedly inhibited the growth of the ventral prostate and seminal vesicles in immature rats when administered s.c. in a daily dose of 100 mg/kg body weight for 35 days. Kidney and testes weights were reduced, together with some reduction in body weight. In the mature rat treated with this steroid in a dose of 40 mg/kg body weight per day for 11 days, marked regression in ventral prostate and seminal vesicles was observed.

DISTRIBUTION OF MALE AND FEMALE STEROID SEX HORMONES IN SOME ORGANS OF THE MALE RAT

1970 ◽  
Vol 65 (1) ◽  
pp. 103-110 ◽  
Author(s):  
Kjell J. Tveter
Keyword(s):  
Skeletal Muscle ◽  
Pituitary Gland ◽  
Anterior Pituitary ◽  
Liquid Scintillation ◽  
Specific Activity ◽  
Seminal Vesicles ◽  
Anterior Pituitary Gland ◽  
Male Rats ◽  
Male Rat ◽  
Accessory Sex Organs

ABSTRACT [6,7-3H] 17β-Oestradiol with a specific activity of 42.4 Ci/mmole was injected intramuscularly into three to four month old male rats, castrated three days previously. The radioactivity in liver, skeletal muscle, blood, the anterior pituitary gland, the seminal vesicles and in the different prostatic lobes was measured by liquid scintillation counting at different intervals after the administration. A high and prolonged uptake of radioactivity was found in the anterior pituitary gland. The uptake by the accessory sex organs was much lower, but significantly higher than that by skeletal muscle. The uptake by the prostate and the seminal vesicles in castrated animals was similar to that in non-castrated animals. The pattern of radioactivity uptake in the anterior pituitary gland of castrated male rats given [3H] testosterone was distinctly different from that after administration of [3H] 17β-oestradiol. There was a rapid elimination of radioactivity from the adenohypophysis after the administration of [3H] testosterone.

THE ULTRASTRUCTURE OF THE ACCESSORY SEX ORGANS OF THE MALE RAT: THE EFFECT OF CYPROTERONE ACETATE

1974 ◽  
Vol 62 (2) ◽  
pp. 251-255 ◽  
Author(s):  
ERIK DAHL ◽  
K. J. TVETER
Keyword(s):  
Endoplasmic Reticulum ◽  
Cyproterone Acetate ◽  
Marked Reduction ◽  
Seminal Vesicles ◽  
Male Rat ◽  
Secretory Material ◽  
Subcutaneous Injections ◽  
Cell Height ◽  
Secretion Granules ◽  
Accessory Sex Organs

SUMMARY The present paper describes the fine structure of the ventral and lateral prostate and the seminal vesicles of the male rat after administration of an anti-androgen, cyproterone acetate, given as subcutaneous injections for varying periods (5–18 days). The treatment caused a general involution with macroscopic atrophy of the organs and reduced the amount of secretory material. There was a marked reduction of both the cell height and width and loss of cytoplasm. The main cytoplasmic changes consisted of a quantitative reduction of the rough endoplasmic reticulum and free ribosomes; the Golgi apparatus was diminished and the number of secretion granules markedly decreased. All the alterations observed are apparently similar to the changes induced by castration.

scholarly journals PERUBAHAN SEBARAN SEL-SEL ASIDOFIL DAN BASOFIL HIPOFISA PENGARUH PEMBERIAN PASAK BUMI (Eurycoma Longifolia Jack)

2011 ◽  
Vol 12 (2) ◽  
pp. 80-91
Author(s):  
Hurip Pratomo ◽  
Iman Supriatna ◽  
Wasmen Manalu ◽  
Adi Winarto
Keyword(s):  
Body Weight ◽  
Staining Method ◽  
Optimal Dose ◽  
Male Rat ◽  
Research Report ◽  
Dose Treatment ◽  
Eurycoma Longifolia ◽  
The Third ◽  
Treatment Research ◽  
Eurycoma Longifolia Jack

Pasak bumi is popular as an aphrodisiac in the traditional medical herb. Boiled drink water of the root powder of pasak bumi is believed can increase the secondary reproduction characters such as libido and the duration of erection. This article is part of the research report that focus on: the distribution of hypophysis acidophil and basophil cells caused of the pasak bumi optimal dose treatment. Research carried out in an experiment using Hemaktosilin Eosin(HE) staining method to study micromorphological distribution of the acidophil and basophil cells of the male rat hypophysis after pasak bumi treatment (the dose of 18 mg pasak bumi/200 g body weight during three days, and the control of 1 ml aquadest). Result of the research showed that: Basophyl cells increased significantly in the third days of pasak bumi administered. Meanwhile acidophyl cells decreased in the third days of pasak bumi administered.  

scholarly journals Effect of crude alcoholic celery (Apium graveolens) leaves extract on fertility in albino female mice

2011 ◽  
Vol 8 (1) ◽  
pp. 215-221
Author(s):  
Baghdad Science Journal
Keyword(s):  
Body Weight ◽  
Physiological Saline ◽  
Reproductive Organs ◽  
Apium Graveolens ◽  
Alcoholic Extract ◽  
Female Mice ◽  
The Third ◽  
Daily Dose ◽  
Positive Results ◽  
Albino Female

Sixty albino female mice were used in this experiment to study the possible effect of the crude alcoholic extract of the celery leaves on their fertility. These animals were randomly and equally divided into three experimental groups (20 females/group). The first and second groups were orally given a daily dose of 500 and 1000 mg/kg body weight, respectively, of the crude alcoholic extract, while the third group (control) was similarly treated, at the same time, with 0.1 ml/gm body weight of physiological saline for comparison. The treatment, however, lasted for 25 consecutive days. On day 26, after treatment was stopped, the life body weight of all animals was recorded before sacrificing the animals. Thereafter blood samples were collected by heart puncture for hormonal (estrogen, progesterone, luteinizing hormone and follicle stimulating hormone) determination. Reproductive organs (ovaries and uteri) were also isolated and preserved for histological studies. Active ingredients in the extracts were analytically tested. The test gave positive results for flavonoids, steroids, tannins and terbenoids. The effect of the extract on the studied parameters which are related to the fertility is reflected in the following results: 1) significant (p

THE EFFECTS OF ADRENALECTOMY AND CORTISONE ON ZINC METABOLISM IN THE SEX GLANDS AND ADRENAL OF THE MALE RAT

1960 ◽  
Vol 38 (1) ◽  
pp. 845-851 ◽  
Author(s):  
Allan D. Rudzik ◽  
Bernard E. Riedel
Keyword(s):  
Single Dose ◽  
Adrenal Gland ◽  
Whole Blood ◽  
Zinc Concentration ◽  
Chronic Administration ◽  
Daily Treatment ◽  
Male Rat ◽  
Zinc Metabolism ◽  
Daily Dose ◽  
Zinc Concentrations

The effects of adrenalectomy and of cortisone treatment on the uptake of Zn65 and the concentration of zinc were observed in whole blood, adrenals, testis, and dorsolateral and ventral prostates of the rat. Cortisone was administered to both normal and adrenalectomized animals either as a single dose or as a daily dose over a period of 14 days. Zinc concentration was decreased in adrenalectomized animals in the blood and dorsolateral prostate. The incorporation of Zn65 was decreased after adrenalectomy in the testis and dorsolateral prostate. Daily treatment with cortisone resulted in recovery to normal of the zinc concentrations and uptake of Zn65.The adrenal gland was found to contain a relatively large amount of zinc and this concentration was doubled with the chronic administration of cortisone. A single dose of cortisone had no effect on the concentration of zinc but caused an increase in the uptake of Zn65 in the adrenal.

THE EFFECTS OF ADRENALECTOMY AND CORTISONE ON ZINC METABOLISM IN THE SEX GLANDS AND ADRENAL OF THE MALE RAT

1960 ◽  
Vol 38 (8) ◽  
pp. 845-851 ◽  
Author(s):  
Allan D. Rudzik ◽  
Bernard E. Riedel
Keyword(s):  
Single Dose ◽  
Adrenal Gland ◽  
Whole Blood ◽  
Zinc Concentration ◽  
Chronic Administration ◽  
Daily Treatment ◽  
Male Rat ◽  
Zinc Metabolism ◽  
Daily Dose ◽  
Zinc Concentrations

The effects of adrenalectomy and of cortisone treatment on the uptake of Zn65 and the concentration of zinc were observed in whole blood, adrenals, testis, and dorsolateral and ventral prostates of the rat. Cortisone was administered to both normal and adrenalectomized animals either as a single dose or as a daily dose over a period of 14 days. Zinc concentration was decreased in adrenalectomized animals in the blood and dorsolateral prostate. The incorporation of Zn65 was decreased after adrenalectomy in the testis and dorsolateral prostate. Daily treatment with cortisone resulted in recovery to normal of the zinc concentrations and uptake of Zn65.The adrenal gland was found to contain a relatively large amount of zinc and this concentration was doubled with the chronic administration of cortisone. A single dose of cortisone had no effect on the concentration of zinc but caused an increase in the uptake of Zn65 in the adrenal.

THE ULTRASTRUCTURE OF THE ACCESSORY SEX ORGANS OF THE MALE RAT

1975 ◽  
Vol 80 (1) ◽  
pp. 199-208 ◽  
Author(s):  
Erik Dahl ◽  
Renate Hars
Keyword(s):  
Endoplasmic Reticulum ◽  
Fine Structure ◽  
Seminal Vesicles ◽  
Male Rat ◽  
Dorsal Lobe ◽  
Secretory Material ◽  
Cell Height ◽  
Accessory Sex Organs ◽  
Nuclear Changes ◽  
Specific Influence

ABSTRACT The present paper describes the fine structure of the accessory sex organs of the male rat as seen after administration of the anti-androgenic compound chlormadinon acetate for 20 days. There was a general involution of the organs with macroscopic atrophy and reduced amount of secretory material. Ultrastructurally the cells contained less organelles as compared with the controls, loss of cytoplasm and reduction both of cell height and width. The major changes also included reduction of the Golgi areas and the rough endoplasmic reticulum. Within the dorsal lobe prominent nuclear changes were found. The alterations observed in the present study are similar to the changes which were found in rats treated with another anti-androgenic compound, Cyp A. It is concluded that these two anti-androgenic compounds exert their effects through similar mechanisms with a specific influence on the prostate and the seminal vesicles.

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