scholarly journals TGF-βSignaling in Neuronal Stem Cells

2008 ◽  
Vol 24 (4-5) ◽  
pp. 251-255 ◽  
Author(s):  
Chohee Yun ◽  
Jonathan Mendelson ◽  
Tiffany Blake ◽  
Lopa Mishra ◽  
Bibhuti Mishra
Keyword(s):  
Transforming Growth Factor Beta ◽  
Cell Biology ◽  
Neuronal Development ◽  
Transforming Growth Factor ◽  
Es Cells ◽  
Lineage Specification ◽  
Neuronal Stem Cells ◽  
Biological Phenomena ◽  
Growth Factor Beta

Transforming growth factor beta (TGF-β) signaling has diverse and complex roles in various biological phenomena such as cell growth, differentiation, embryogenesis and morphogenesis. ES cells provide an essential model for understanding the role of TGF-βsignaling in lineage specification and differentiation. Recent studies have suggested significant role of TGF-βin stem/progenitor cell biology. Here in this review, we focus on the role of the TGF-βsuperfamily in neuronal development.

scholarly journals The Role of the TGF-β Coreceptor Endoglin in Cancer

2010 ◽  
Vol 10 ◽  
pp. 2367-2384 ◽  
Author(s):  
Eduardo Pérez-Gómez ◽  
Gaelle del Castillo ◽  
Juan Francisco Santibáñez ◽  
Jose Miguel Lêpez-Novoa ◽  
Carmelo Bernabéu ◽  
...  
Keyword(s):  
Transforming Growth Factor Beta ◽  
Transforming Growth Factor ◽  
Tumor Development ◽  
Experimental Models ◽  
Type I ◽  
Type Ii ◽  
Invasion And Metastasis ◽  
Promising Target ◽  
Growth Factor Beta

Endoglin (CD105) is an auxiliary membrane receptor of transforming growth factor beta (TGF-β) that interacts with type I and type II TGF-β receptors and modulates TGF-β signaling. Endoglin is overexpressed in the tumor-associated vascular endothelium, where it modulates angiogenesis. This feature makes endoglin a promising target for antiangiogenic cancer therapy. In addition, recent studies on human and experimental models of carcinogenesis point to an important tumor cell–autonomous role of endoglin by regulating proliferation, migration, invasion, and metastasis. These studies suggest that endoglin behaves as a suppressor of malignancy in experimental and human epithelial carcinogenesis, although it can also promote metastasis in other types of cancer. In this review, we evaluate the implication of endoglin in tumor development underlying studies developed in our laboratories in recent years.

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