scholarly journals Impact of Global Mean Normalization on Regional Glucose Metabolism in the Human Brain

2018 ◽  
Vol 2018 ◽  
pp. 1-16 ◽  
Author(s):  
Kristian N. Mortensen ◽  
Albert Gjedde ◽  
Garth J. Thompson ◽  
Peter Herman ◽  
Maxime J. Parent ◽  
...  
Keyword(s):  
Glucose Metabolism ◽  
Human Brain ◽  
Disease Biomarkers ◽  
Eyes Closed ◽  
Positron Emission ◽  
Congenitally Blind ◽  
Eyes Open ◽  
Health And Disease ◽  
The Impact ◽  
Global Mean

Because the human brain consumes a disproportionate fraction of the resting body’s energy, positron emission tomography (PET) measurements of absolute glucose metabolism (CMRglc) can serve as disease biomarkers. Global mean normalization (GMN) of PET data reveals disease-based differences from healthy individuals as fractional changes across regions relative to a global mean. To assess the impact of GMN applied to metabolic data, we compared CMRglc with and without GMN in healthy awake volunteers with eyes closed (i.e., control) against specific physiological/clinical states, including healthy/awake with eyes open, healthy/awake but congenitally blind, healthy/sedated with anesthetics, and patients with disorders of consciousness. Without GMN, global CMRglc alterations compared to control were detected in all conditions except in congenitally blind where regional CMRglc variations were detected in the visual cortex. However, GMN introduced regional and bidirectional CMRglc changes at smaller fractions of the quantitative delocalized changes. While global information was lost with GMN, the quantitative approach (i.e., a validated method for quantitative baseline metabolic activity without GMN) not only preserved global CMRglc alterations induced by opening eyes, sedation, and varying consciousness but also detected regional CMRglc variations in the congenitally blind. These results caution the use of GMN upon PET-measured CMRglc data in health and disease.

scholarly journals The effect of congenital blindness on resting-state functional connectivity revisited

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Maria J. S. Guerreiro ◽  
Madita Linke ◽  
Sunitha Lingareddy ◽  
Ramesh Kekunnaya ◽  
Brigitte Röder
Keyword(s):  
Functional Connectivity ◽  
Resting State ◽  
Visual Experience ◽  
Brain Regions ◽  
State Condition ◽  
Resting State Functional Connectivity ◽  
Congenital Blindness ◽  
Eyes Closed ◽  
Congenitally Blind ◽  
Eyes Open

AbstractLower resting-state functional connectivity (RSFC) between ‘visual’ and non-‘visual’ neural circuits has been reported as a hallmark of congenital blindness. In sighted individuals, RSFC between visual and non-visual brain regions has been shown to increase during rest with eyes closed relative to rest with eyes open. To determine the role of visual experience on the modulation of RSFC by resting state condition—as well as to evaluate the effect of resting state condition on group differences in RSFC—, we compared RSFC between visual and somatosensory/auditory regions in congenitally blind individuals (n = 9) and sighted participants (n = 9) during eyes open and eyes closed conditions. In the sighted group, we replicated the increase of RSFC between visual and non-visual areas during rest with eyes closed relative to rest with eyes open. This was not the case in the congenitally blind group, resulting in a lower RSFC between ‘visual’ and non-‘visual’ circuits relative to sighted controls only in the eyes closed condition. These results indicate that visual experience is necessary for the modulation of RSFC by resting state condition and highlight the importance of considering whether sighted controls should be tested with eyes open or closed in studies of functional brain reorganization as a consequence of blindness.

scholarly journals The Ability of Gymnastics Motoric Perceptual Based on Local Culture for Early Childhood in Aceh Province

2020 ◽  
Vol 3 (2) ◽  
pp. 749-762
Author(s):  
Muhammad Riski Kurniawan ◽  
Syamsulrizal Syamsulrizal ◽  
Razali Razali ◽  
Israwati Israwati
Keyword(s):  
Early Childhood ◽  
The Body ◽  
Local Culture ◽  
Homogeneity Test ◽  
Tennis Ball ◽  
Eyes Closed ◽  
Aceh Province ◽  
Eyes Open ◽  
Perceptual Ability ◽  
The Impact

Local culture-based gymnastics is a combination of Seudati dance with Saman dances movements as well as cheerful healthy exercises that are already in kindergarten. The purpose of this study was to determine the impact of the implementation of local culture-based exercise on the motorized perceptual ability of early childhood in Banda Aceh Kindergarten. This study uses a quantitative approach to the type of experimental research. Population and a sample of 30 students were selected by purposive sampling. Data collection techniques of motoric perceptual ability using tests: (1) Standing on the beam while touching the limbs as instructed by the teacher with eyes open, (2 ) Standing on the beam while touching the body as instructed by the teacher with eyes closed, (3) Jumping and landing in a line with two feet pressed together as instructed by the teacher with eyes open, (4) Jumping and landing in a line with two feet pressed together as instructed by the teacher with eyes closed , (5) Walking in balance, (6) Throwing a tennis ball into a basket with a distance of 2 meters. Before the data is analyzed, the research data is tested for the analysis requirements, namely the normality and homogeneity test. Then the data is analyzed using the t-test. Based on the results of data analysis obtained t count (18.455)> t table (2.045), thus it can be concluded that there is a significant influence between local culture-based exercise on the motoric perceptual ability of early childhood in Aceh kindergarten.      

scholarly journals The Impact of Obesity on Tumor Glucose Uptake in Breast and Lung Cancer

2020 ◽  
Vol 4 (2) ◽  
Author(s):  
Brooks P Leitner ◽  
Rachel J Perry
Keyword(s):  
Lung Cancer ◽  
Glucose Metabolism ◽  
Glucose Uptake ◽  
Protective Effects ◽  
Clinical Prognosis ◽  
Computed Tomography Images ◽  
Positron Emission ◽  
Altered Glucose ◽  
Poor Outcomes ◽  
The Impact

Abstract Obesity confers an increased incidence and poorer clinical prognosis in more than 10 cancer types. Paradoxically, obesity may provide protection from poor outcomes in lung cancer. Mechanisms for the obesity-cancer links are not fully elucidated, with altered glucose metabolism being a promising candidate. Using 18F-fluorodeoxyglucose positron-emission-tomography/computed tomography images from The Cancer Imaging Archive, we explored the relationship between body mass index (BMI) and glucose metabolism in several cancers. In 188 patients (BMI mean [SD] = 27.7 [5.1], range = 17.4–49.3 kg/m2), higher BMI was associated with greater tumor glucose uptake in breast cancer (r = 0.36; P = .02) and with lower tumor glucose uptake in non-small cell lung cancer (r = -0.26; P = .048) using two-sided Pearson correlations. No relationship was observed in soft tissue sarcoma or squamous cell carcinoma. Harnessing the National Cancer Institute’s open-access database, we demonstrate altered tumor glucose metabolism as a potential mechanism for the detrimental and protective effects of obesity on breast and lung cancer, respectively.

scholarly journals Frequency-Dependent Modulation of Regional Synchrony in the Human Brain by Eyes Open and Eyes Closed Resting-States

PLoS ONE ◽  
2015 ◽  
Vol 10 (11) ◽  
pp. e0141507 ◽  
Author(s):  
Xiaopeng Song ◽  
Shuqin Zhou ◽  
Yi Zhang ◽  
Yijun Liu ◽  
Huaiqiu Zhu ◽  
...  
Keyword(s):  
Human Brain ◽  
Frequency Dependent ◽  
Eyes Closed ◽  
Eyes Open ◽  
Regional Synchrony

scholarly journals The impact of modern jazz dance on the electrical brain activity

2018 ◽  
Author(s):  
Johanna Wind ◽  
Wolfgang Schöllhorn
Keyword(s):  
Brain Activity ◽  
Brain Activation ◽  
Brain Areas ◽  
Eyes Closed ◽  
Gamma Frequency ◽  
Electrical Brain Activity ◽  
Modern Jazz ◽  
Before And After ◽  
Eyes Open ◽  
The Impact

AbstractDance as one of the earliest cultural assets of mankind is practised in different cultures, mostly for wellbeing or for treating psycho-physiological disorders like Parkinson, depression, autism. However, the underlying neurophysiological mechanisms are still unclear and only few studies address the effects of particular dance styles. For a first impression, we were interested in the effects of modern jazz dance (MJD) on the brain activation that would contribute to the understanding of these mechanisms. 11 female subjects rehearsed a MJD choreography for three weeks (1h per week) and passed electroencephalographic (EEG) measurements in a crossover-design thereafter. The objectives were to establish the differences between dancing physically and participating just mentally with or without music. Therefore, each subject realized the four following test conditions: dancing physically to and without music, dancing mentally to and without music. Each of the conditions were performed for 15 minutes. Before and after each condition, the EEG activities were recorded under resting conditions (2 min. eyes-open, 2 min. eyes-closed) followed by a subsequent wash-out phase of 10 minutes.The results of the study revealed no time effects for the mental dancing conditions, either to or without music. An increased electrical brain activation was followed by the physical dancing conditions with and without music for the theta, alpha-1, alpha-2, beta and gamma frequency band across the entire scalp. Especially the higher frequencies (alpha-2, beta, gamma) showed increased brain activation across all brain areas. Higher brain activities for the physical dancing conditions were identified in comparison to the mental dancing condition. No statistically significant differences could be found as to dancing to or without music. Our findings demonstrate evidence for the immediate influence of modern jazz dance and its sweeping effects on all brain areas for all measured frequency bands, when dancing physically. In comparison, dancing just mentally does not result in similar effects.

scholarly journals Impact of Single Bout of Physical Exercise on Adolescents’ Strength and Balance Abilities

2018 ◽  
Vol 1 (96) ◽  
Author(s):  
Lina Kreivėnaitė ◽  
Vytautas Streckis ◽  
Sandra Raizgytė ◽  
Asta Lileikienė
Keyword(s):  
Physical Exercise ◽  
High Intensity ◽  
Postural Sway ◽  
High Intensity Exercise ◽  
Body Balance ◽  
Low Intensity ◽  
Eyes Closed ◽  
Single Bout ◽  
Eyes Open ◽  
The Impact

Background. There is evidence of physical exercise effect on the adolescents’ balance and strength; however it is not known how aforementioned variables respond to physical exercise with different loads and intensities. Therefore, the aim of the study was to assess the impact of single bout of physical exercise of different intensity on adolescents’ body balance and muscular strength.Methods. Thirty healthy, physically active 11–13-year-old adolescents were randomly allocated to one of the two groups. Both groups performed single bout of physical exercise of high- or low-intensity climbing up and down-stairs. Postural sway and maximum voluntary contractions (MVC) were assessed before and after physical exercise. Results. No statistically significant impact of low or high intensity exercise was found at adolescents’ MVC. High intensity exercise influenced bigger postural sway with eyes closed compared to eyes open ( p < .05). After high-intensity exercise there was a significantly greater postural sway with eyes closed than with eyes open (p < .05). Conclusions. High and low intensity physical exercise had no impact on the adolescents’ maximum voluntary contraction, whereas high intensity exercise deteriorated body balance with eyes closed.Keywords:  adolescence, physical exercise, MVC, balance

Decreased Alpha Reactivity from Eyes-Closed to Eyes-Open in Non-Demented Older Adults with Alzheimer’s Disease: A Combined EEG and [18F]florbetaben PET Study

2020 ◽  
Vol 77 (4) ◽  
pp. 1681-1692
Author(s):  
Soohyun Chae ◽  
Jinsick Park ◽  
Min Soo Byun ◽  
Dahyun Yi ◽  
Jun Ho Lee ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Early Stage ◽  
Memory Function ◽  
Amyloid Β ◽  
Clinical Predictors ◽  
Eyes Closed ◽  
Positron Emission ◽  
Eyes Open ◽  
Early Biomarker

Background: The degree of alpha attenuation from eyes-closed (EC) to eyes-open (EO) has been suggested as a neural marker of cognitive health, and its disruption has been reported in patients with clinically defined Alzheimer’s disease (AD) dementia. Objective: We tested if EC-to-EO alpha reactivity was related to cerebral amyloid-β (Aβ) deposition during the early stage of AD. Methods: Non-demented participants aged ≥55 years who visited the memory clinic between March 2018 and June 2019 (N = 143; 67.8% female; mean age±standard deviation, 74.0±7.6 years) were included in the analyses. Based on the [18F]florbetaben positron emission tomography assessment, the participants were divided into Aβ+ (N = 70) and Aβ- (N = 73) groups. EEG was recorded during the 7 min EC condition followed by a 3 min EO phase, and a Fourier transform spectral analysis was performed. Results: A significant three-way interaction was detected among Aβ positivity, eye condition, and the laterality factor on alpha-band power after adjusting for age, sex, educational years, global cognition, depression, medication use, and white matter hyperintensities on magnetic resonance imaging (F = 5.987, p = 0.016); EC-to-EO alpha reactivity in the left hemisphere was significantly reduced in Aβ+ subjects without dementia compared with the others (F = 3.984, p = 0.048). Conclusion: Among mild cognitive impairment subjects, alpha reactivity additively contributed to predict cerebral Aβ positivity beyond the clinical predictors, including vascular risks, impaired memory function, and apolipoprotein E ɛ4. These findings support that EC-to-EO alpha reactivity acts as an early biomarker of cerebral Aβ deposition and is a useful measurement for screening early-stage AD.

PET - diagnostics of cognitive impairment in patients with parkinson’s disease

2016 ◽  
Vol 7 (2) ◽  
pp. 63-68 ◽  
Author(s):  
Sergey A Lytaev ◽  
Daniil S Susin
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cognitive Impairment ◽  
Glucose Metabolism ◽  
Human Brain ◽  
Control Group ◽  
Frontal Dysfunction ◽  
Brief Assessment ◽  
Positron Emission ◽  
Relationship Of

Traditionally, Parkinson’s disease is associated with a deficit of dopaminergic system, manifested in the extrapyramidal motor disorders. In addition, the disease is characterized by a wide variety of not movement disorders. For example, the spectrum of autonomic, mental, cognitive and sensory symptoms is presented. Cognitive impairment, including mild cognitive impairment and dementia in Parkinson’s disease are among the most common disorders are not motor. The purpose of this study was aimed to investigate the relationship of early cognitive impairment and rate of glucose metabolism in different parts of the brain in patients with Parkinson’s disease. Positron emission tomography (PET) with fluorodeoxyglucose synthesis in patients suffering from Parkinson’s disease was performed. Study group consisted of patients (31 persons, age 41-77 years). Patients have passed inpatient and/or outpatient treatment at the clinic of the Institute of Human Brain of the Russian Academy of Sciences. The control group (15 persons) consisted of patients of similar age group without cognitive impairment. To estimate the rate of glucose metabolism was used an original technique of the Institute of Human Brain. Immediately prior to the intravenous administration of radiopharmaceutical [18F]-deoxyglucose was synthesized. Psychological testing consisted of a clinical interview, observation, survey, test, as described in a brief assessment of mental status (MMSE) and the battery frontal dysfunction (BFD). The study found that when the initial cognitive impairment observed pattern of changes in the rate of metabolism of glucose, characteristic of patients with severe cognitive impairment in Parkinson’s disease. This fact leads to the assumption of a high validity of the test battery frontal dysfunction for early diagnosis of cognitive impairment in Parkinson’s disease.

scholarly journals The competition with a concurrent cognitive task affects posturographic measures in patients with Parkinson disease

2015 ◽  
Vol 73 (11) ◽  
pp. 906-912 ◽  
Author(s):  
Alessandra Ferreira Barbosa ◽  
Carolina de Oliveira Souza ◽  
Janini Chen ◽  
Débora Valente Francato ◽  
Fátima Aparecida Caromano ◽  
...  
Keyword(s):  
Parkinson Disease ◽  
Dual Task ◽  
Cognitive Task ◽  
Berg Balance Scale ◽  
Functional Balance ◽  
Eyes Closed ◽  
Static Posturography ◽  
Eyes Open ◽  
The Impact ◽  
General Balance

ABSTRACTObjectives To estimate the impact of a sensory-motor- cognitive task on postural balance, in Parkinson disease patients (Hoehn and Yahr 2-3) and to investigate possible relationships between posturography and functional balance clinical scales.Method Parkinson disease patients (n = 40) and healthy controls (n = 27) were evaluated with fluency tests, Berg Balance scale, Mini Best test and static posturography on the conditions eyes open, eyes closed and dual-task (simultaneous balance and fluency tasks).Results Posturographic data showed that Parkinson disease patients performed worse than controls in all evaluations. In general, balance on dual-task was significantly poorer than balance with eyes closed. Posturographic data were weakly correlated to clinical balance scales.Conclusion In clinical practice, Parkinson disease patients are commonly assessed with eyes closed, to sensitize balance. Our study showed that adding a cognitive task is even more effective. Static posturographic data should be carefully overgeneralized to infer functional balance impairments.

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