Abstract 1443: CHKing melanoma: CHK1 inhibitor +low dose hydroxyurea triggers immunogenic cell death and immunostimulatory cytokine expression to drive an anti-tumor immune response

2021 ◽  
Author(s):  
Brian G. Gabrielli ◽  
Martina Proctor ◽  
Jazmina Gonzalez Cruz ◽  
Bijun Zeng ◽  
Riccardo Dolcetti ◽  
...  
Keyword(s):  
Immune Response ◽  
Cell Death ◽  
Low Dose ◽  
Cytokine Expression ◽  
Immunogenic Cell Death ◽  
Chk1 Inhibitor

scholarly journals Consensus guidelines for the definition, detection and interpretation of immunogenic cell death

2020 ◽  
Vol 8 (1) ◽  
pp. e000337 ◽  
Author(s):  
Lorenzo Galluzzi ◽  
Ilio Vitale ◽  
Sarah Warren ◽  
Sandy Adjemian ◽  
Patrizia Agostinis ◽  
...  
Keyword(s):  
Immune Response ◽  
Cell Death ◽  
Adaptive Immune Response ◽  
Operational Definition ◽  
Immunogenic Cell Death ◽  
Adaptive Immune ◽  
Regulated Cell Death ◽  
Definition Of

Cells succumbing to stress via regulated cell death (RCD) can initiate an adaptive immune response associated with immunological memory, provided they display sufficient antigenicity and adjuvanticity. Moreover, multiple intracellular and microenvironmental features determine the propensity of RCD to drive adaptive immunity. Here, we provide an updated operational definition of immunogenic cell death (ICD), discuss the key factors that dictate the ability of dying cells to drive an adaptive immune response, summarize experimental assays that are currently available for the assessment of ICD in vitro and in vivo, and formulate guidelines for their interpretation.

scholarly journals Platinum Derivatives Effects on Anticancer Immune Response

Biomolecules ◽  
2019 ◽  
Vol 10 (1) ◽  
pp. 13 ◽  
Author(s):  
Cédric Rébé ◽  
Lucie Demontoux ◽  
Thomas Pilot ◽  
François Ghiringhelli
Keyword(s):  
Immune Response ◽  
Cell Death ◽  
Immune Cells ◽  
Chemotherapeutic Agents ◽  
Immune Checkpoints ◽  
Immunogenic Cell Death ◽  
Host Immune System ◽  
Cytotoxic Effects ◽  
Cancer Types ◽  
Platinum Derivative

Along with surgery and radiotherapy, chemotherapeutic agents belong to the therapeutic arsenal in cancer treatment. In addition to their direct cytotoxic effects, these agents also impact the host immune system, which might enhance or counteract their antitumor activity. The platinum derivative compounds family, mainly composed of carboplatin, cisplatin and oxaliplatin, belongs to the chemotherapeutical arsenal used in numerous cancer types. Here, we will focus on the effects of these molecules on antitumor immune response. These compounds can induce or not immunogenic cell death (ICD), and some strategies have been found to induce or further enhance it. They also regulate immune cells’ fate. Platinum derivatives can lead to their activation. Additionally, they can also dampen immune cells by selective killing or inhibiting their activity, particularly by modulating immune checkpoints’ expression.

scholarly journals Natural Compounds of Marine Origin as Inducers of Immunogenic Cell Death (ICD): Potential Role for Cancer Interception and Therapy

Cells ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 231
Author(s):  
Clementina Sansone ◽  
Antonino Bruno ◽  
Concetta Piscitelli ◽  
Denisa Baci ◽  
Angelo Fontana ◽  
...  
Keyword(s):  
Immune Response ◽  
Cell Death ◽  
Immune System ◽  
Immune Cell ◽  
Cytotoxic T Cells ◽  
Immunogenic Cell Death ◽  
Type I ◽  
Bioactive Natural Products ◽  
Signalling Molecules ◽  
Major Factors

Regulated cell death (RCD) has always been considered a tolerogenic event. Immunogenic cell death (ICD) occurs as a consequence of tumour cell death accompanied by the release of damage-associated molecular patterns (DAMPs), triggering an immune response. ICD plays a major role in stimulating the function of the immune system in cancer during chemotherapy and radiotherapy. ICD can therefore represent one of the routes to boost anticancer immune responses. According to the recommendations of the Nomenclature Committee on Cell Death (2018), apoptosis (type I cell death) and necrosis (type II cell death) represent are not the only types of RCD, which also includes necroptosis, pyroptosis, ferroptosis and others. Specific downstream signalling molecules and death-inducing stimuli can regulate distinct forms of ICD, which develop and promote the immune cell response. Dying cells deliver different potential immunogenic signals, such as DAMPs, which are able to stimulate the immune system. The acute exposure of DAMPs can prime antitumour immunity by inducing activation of antigen-presenting cells (APC), such as dendritic cells (DC), leading to the downstream response by cytotoxic T cells and natural killer cells (NK). As ICD represents an important target to direct and develop new pharmacological interventions, the identification of bioactive natural products, which are endowed with low side effects, higher tolerability and preferentially inducing immunogenic programmed cell death, represents a priority in biomedical research. The ability of ICD to drive the immune response depends on two major factors, neither of which is intrinsic to cell death: ‘Antigenicity and adjuvanticity’. Indeed, the use of natural ICD-triggering molecules, alone or in combination with different (immuno)therapies, can result in higher efficacy and tolerability. Here, we focused on natural (marine) compounds, particularly on marine microalgae derived molecules such as exopolysaccharides, sulphated polysaccharides, glycopeptides, glycolipids, phospholipids, that are endowed with ICD-inducing properties and sulfavants. Here, we discuss novel and repurposed small-molecule ICD triggers, as well as their ability to target important molecular pathways including the IL-6, TNF-α and interferons (IFNs), leading to immune stimulation, which could be used alone or in combinatorial immunotherapeutic strategies in cancer prevention and therapies.

Rediscovery of Nanoparticle-based Therapeutics: Boosting Immunogenic Cell Death for Potential Application in Cancer Immunotherapy

2021 ◽  
Author(s):  
Suah Yang ◽  
In-Cheol Sun ◽  
Hee Sook Hwang ◽  
Man Kyu Shim ◽  
Hong Yeol Yoon ◽  
...  
Keyword(s):  
Immune Response ◽  
Cell Death ◽  
Cancer Immunotherapy ◽  
Potential Application ◽  
Adaptive Immune Response ◽  
Immunogenic Cell Death ◽  
Living Body ◽  
Adaptive Immune ◽  
Physical Stimuli ◽  
Molecular Patterns

Immunogenic cell death (ICD) occurred by chemical and physical stimuli has shown the potential to activate an adaptive immune response in the immune-competent living body through releasing danger-associated molecular patterns...

Abstract 627: Immunogenic cell death as novel immune response mechanism to EGFR-targeted therapy in CRC

2014 ◽  
Author(s):  
Giuseppe Penna ◽  
Chiara Pozzi ◽  
Elena Magni ◽  
Giuseppe Curigliano ◽  
Maria Giulia Zampino ◽  
...  
Keyword(s):  
Immune Response ◽  
Cell Death ◽  
Targeted Therapy ◽  
Immunogenic Cell Death ◽  
Response Mechanism

scholarly journals Colon cancer cell treatment with rose bengal generates a protective immune response via immunogenic cell death

2017 ◽  
Vol 8 (2) ◽  
pp. e2584-e2584 ◽  
Author(s):  
Jianzhong Qin ◽  
Nicholas Kunda ◽  
Guilin Qiao ◽  
Jed F Calata ◽  
Krunal Pardiwala ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Immune Response ◽  
Cell Death ◽  
Cancer Cell ◽  
Rose Bengal ◽  
Colon Cancer Cell ◽  
Protective Immune Response ◽  
Immunogenic Cell Death
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