Abstract P037: Interleukin-10 is a dominant and reversible mechanism of immune evasion in human colorectal cancer liver metastasis

2022 ◽  
Author(s):  
Teresa S. Kim ◽  
Kevin Sullivan ◽  
Xiuyun Jiang ◽  
Cynthia Hsu ◽  
Kevin Labadie ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Liver Metastasis ◽  
Immune Evasion ◽  
Interleukin 10 ◽  
Human Colorectal Cancer ◽  
Colorectal Cancer Liver Metastasis

scholarly journals Cancer metastasis linked to macrophage size, shape, and metabolism

2020 ◽  
Vol 217 (11) ◽  
Author(s):  
Peter J. Murray
Keyword(s):  
Colorectal Cancer ◽  
Lipid Metabolism ◽  
Liver Metastasis ◽  
Clinical Application ◽  
Cancer Metastasis ◽  
Human Colorectal Cancer ◽  
Colorectal Cancer Liver Metastasis ◽  
Foamy Macrophages

Using macrophage morphology in human colorectal cancer liver metastasis, Donadon et al. in this issue of JEM (https://doi.org/10.1084/jem.20191847) provide a window into lipid metabolism and foamy macrophages, which accrue in numerous pathological states and here are shown to have clinical application.

scholarly journals Therapeutic efficacy of tumor-targetingSalmonella typhimuriumA1-R on human colorectal cancer liver metastasis in orthotopic nude-mouse models

Oncotarget ◽  
2015 ◽  
Vol 6 (31) ◽  
pp. 31368-31377 ◽  
Author(s):  
Takashi Murakami ◽  
Yukihiko Hiroshima ◽  
Ming Zhao ◽  
Yong Zhang ◽  
Takashi Chishima ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Liver Metastasis ◽  
Mouse Models ◽  
Nude Mouse ◽  
Therapeutic Efficacy ◽  
Human Colorectal Cancer ◽  
Colorectal Cancer Liver Metastasis

Immune evasion mechanisms in colorectal cancer liver metastasis patients vaccinated with TroVax (MVA-5T4)

2009 ◽  
Vol 58 (10) ◽  
pp. 1657-1667 ◽  
Author(s):  
Eyad Elkord ◽  
Adam Dangoor ◽  
Deborah J. Burt ◽  
Thomas D. Southgate ◽  
Sai Daayana ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Liver Metastasis ◽  
Immune Evasion ◽  
Colorectal Cancer Liver Metastasis

scholarly journals LncRNA MIR17HG promotes colorectal cancer liver metastasis by mediating a glycolysis-associated positive feedback circuit

Oncogene ◽  
2021 ◽  
Author(s):  
Senlin Zhao ◽  
Bingjie Guan ◽  
Yushuai Mi ◽  
Debing Shi ◽  
Ping Wei ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Liver Metastasis ◽  
Positive Feedback ◽  
Feedback Loop ◽  
Metastatic Tumor ◽  
Feedback Circuit ◽  
Colorectal Cancer Liver Metastasis ◽  
Positive Feedback Circuit

AbstractGlycolysis plays a crucial role in reprogramming the metastatic tumor microenvironment. A series of lncRNAs have been identified to function as oncogenic molecules by regulating glycolysis. However, the roles of glycolysis-related lncRNAs in regulating colorectal cancer liver metastasis (CRLM) remain poorly understood. In the present study, the expression of the glycolysis-related lncRNA MIR17HG gradually increased from adjacent normal to CRC to the paired liver metastatic tissues, and high MIR17HG expression predicted poor survival, especially in patients with liver metastasis. Functionally, MIR17HG promoted glycolysis in CRC cells and enhanced their invasion and liver metastasis in vitro and in vivo. Mechanistically, MIR17HG functioned as a ceRNA to regulate HK1 expression by sponging miR-138-5p, resulting in glycolysis in CRC cells and leading to their invasion and liver metastasis. More interestingly, lactate accumulated via glycolysis activated the p38/Elk-1 signaling pathway to promote the transcriptional expression of MIR17HG in CRC cells, forming a positive feedback loop, which eventually resulted in persistent glycolysis and the invasion and liver metastasis of CRC cells. In conclusion, the present study indicates that the lactate-responsive lncRNA MIR17HG, acting as a ceRNA, promotes CRLM through a glycolysis-mediated positive feedback circuit and might be a novel biomarker and therapeutic target for CRLM.

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