Background: Childbirth is one of the essential goals of the family, so that infertility can cause many problems for the family. Therefore, the aims of the current study were the frequency of postpartum depression and evaluate the relationship between postpartum depression, socio-demographic factors, and quality of marital satisfaction in postpartum women with a history of infertility referring to health centers in Hamadan. Methods: This study was a cross-sectional study. The study population consisted of all primiparous women with a history of infertility referring to Hamadan health care centers in 2018, of which 240 randomly selected according to the inclusion criteria for one year. Subjects assessed by demographic and clinical information checklist, Edinburgh Postnatal Depression Scale (EPDS), and marital relationship quality scale (Revised Dyadic Adjustment Scale; RDAS). All statistical calculations performed by busing chi-square with SPSS-17. Results: 152 out of 240 participants (63.3%) had a degree of depression, of which 57 (23.7%) had mild depression, 63 (26.3%) had moderate depression, and 32 (13.3%) had severe depression. According to the result of the study, marital satisfaction in 23.3% (56), 37.1% (89), and 39.6% (95) were excellent, moderate, and low, respectively — the quality of marital relationships associated significantly with and postpartum depression (χ2=19.3, P<0.001). The results of the study showed that there was a significant relationship between age, occupation, educational level, duration of infertility, and depression (P<0.05), but there was no significant relationship between ethnicity, insurance, and depression (P<0.05). Conclusion: Regarding the results obtained in this study and comparison with existing studies, the infertility problem can cause mental and psychological disorders in women. It seems that marital satisfaction and its relationship with different factors and the proper interventions by health care providers are necessary to prevent postpartum depression in these women.