Update on Iron Chelators in Thalassemia

Hematology ◽  
2010 ◽  
Vol 2010 (1) ◽  
pp. 451-455 ◽  
Author(s):  
Ellis J. Neufeld
Keyword(s):  
United States ◽  
Thalassemia Major ◽  
The United States ◽  
Iron Chelators ◽  
Future Research ◽  
Compassionate Use ◽  
Large Measure ◽  
Specific Patient ◽  
The Past ◽  
The World

Abstract Over the past four decades, there have been dramatic improvements in survival for patients with thalassemia major due in large measure to improved iron chelators. Two chelators are approved for use in the United States and Canada, parenteral deferoxamine and oral deferasirox. Three are available in much of the rest of the world, where oral deferiprone is also approved (in the United States, deferiprone is only available in studies, for emergency use, or on a “compassionate-use” basis). Many trials and worldwide clinical experience demonstrate that each of the three drugs can chelate and remove iron, and thereby prevent or improve transfusional hemosiderosis in thalassemia patients. However, the chelators differ strikingly in side-effect profile, cost, tolerability and ease of adherence, and (to some degree) efficacy for any specific patient. The entire field of chelator clinical trials suffers from the fact that each drug (as monotherapy or in combination) has not been tested directly against all of the other possibilities. Acknowledging the challenges of assessing chelators with diverse properties and imperfect comparative data, the purpose of this review is to summarize the last 4 years of studies that have improved our understanding of the applications and limitations of iron chelators in various settings for thalassemia patients, and to point out areas for much-needed future research.

scholarly journals The great Chinese transformation: cynicism and the future of the world (article two)

2020 ◽  
Vol 2020 (3) ◽  
pp. 5-23
Author(s):  
Grzegorz W. Kolodko ◽  
Keyword(s):  
United States ◽  
Economic Growth ◽  
The United States ◽  
Chinese Economy ◽  
The Past ◽  
Chinese Characteristics ◽  
The World ◽  
The Future ◽  
The Right ◽  
Supranational Level

The huge leap made by the Chinese economy over the past four decades as a result of market reforms and openness to the world is causing fear in some and anxiety in others. Questions arise as to whether China’s economic success is solid and whether economic growth will be followed by political expansion. China makes extensive use of globalization and is therefore interested in continuing it. At the same time, China wants to give it new features and specific Chinese characteristics. This is met with reluctance by the current global hegemon, the United States, all the more so as there are fears that China may promote its original political and economic system, "cynicism", abroad. However, the world is still big enough to accommodate us all. Potentially, not necessarily. For this to happen, we need the right policies, which in the future must also include better coordination at the supranational level.

Analogies at War

2005 ◽  
Vol 74 (3) ◽  
pp. 411-426 ◽  
Author(s):  
T. CHRISTOPHER JESPERSEN
Keyword(s):  
United States ◽  
World War Ii ◽  
American History ◽  
The United States ◽  
World War ◽  
The Past ◽  
Frequent Use ◽  
The World ◽  
Current Events

The frequent use of the Vietnam analogy to describe the situation in Iraq underscores the continuing relevance of Vietnam for American history. At the same time, the Vietnam analogy reinforces the tendency to see current events within the context of the past. Politicians and pundits latch onto analogies as handles for understanding the present, but in so doing, they obscure more complicated situations. The con�ict in Iraq is not Vietnam, Korea, or World War II, but this article considers all three in an effort to see how the past has shaped, and continues to affect, the world the United States now faces.

On the essentials of drought in a changing climate

Science ◽  
2020 ◽  
Vol 368 (6488) ◽  
pp. 256-260 ◽  
Author(s):  
Toby R. Ault
Keyword(s):  
United States ◽  
Greenhouse Gas Emissions ◽  
Greenhouse Gas ◽  
Water Resource ◽  
Historical Context ◽  
The United States ◽  
Early Career ◽  
Future Research ◽  
Resource Managers ◽  
The World

Droughts of the future are likely to be more frequent, severe, and longer lasting than they have been in recent decades, but drought risks will be lower if greenhouse gas emissions are cut aggressively. This review presents a synopsis of the tools required for understanding the statistics, physics, and dynamics of drought and its causes in a historical context. Although these tools have been applied most extensively in the United States, Europe, and the Amazon region, they have not been as widely used in other drought-prone regions throughout the rest of the world, presenting opportunities for future research. Water resource managers, early career scientists, and veteran drought researchers will likely see opportunities to improve our understanding of drought.

scholarly journals Jesus and the World of Grace, 1968–2016: An Idiosyncratic Theological Memoir

Horizons ◽  
2016 ◽  
Vol 43 (2) ◽  
pp. 374-396
Author(s):  
William L. Portier
Keyword(s):  
United States ◽  
The United States ◽  
Catholic Theology ◽  
The Past ◽  
Look Back ◽  
The World

This article1offers an impressionistic look back over the past five decades, from 1968 to 2016, in Catholic theology in the United States. At the heart of this story are Christology, the world of grace, and their relationship. This memoir unfolds in three parts: “Running on Empty, 1968–1980”; “Jesus and the World of Grace, 1980–2016”; “Can Liberal Catholics Come Back?” It identifies the most neuralgic question left to us from this period: How is Christ related to the world of grace?

Running With Your Hair on Fire: Lessons Learned From Transitioning a National University Sales Competition From Face-to-Face to Virtual in 16 Days

2020 ◽  
Vol 42 (3) ◽  
pp. 257-271
Author(s):  
Scott Inks ◽  
Kenyatta Barber ◽  
Terry W. Loe ◽  
Lukas P. Forbes
Keyword(s):  
United States ◽  
The United States ◽  
Educational Environment ◽  
Lessons Learned ◽  
Future Research ◽  
Face To Face ◽  
The Past ◽  
National University ◽  
Virtual Sales

Since their inception, university sales competitions have been key learning and educational components of university sales education. Over the past two decades, the oldest and one of the largest sales competitions in the United States has been held in a face-to-face format. However, due to the educational environment created from the COVID-19 pandemic, this competition was forced to convert to a virtual format over a 16-day period. This research outlines the steps taken to convert this event to virtual format and presents insights for other universities endeavoring to produce virtual sales competition events. Finally, research implications and direction for future research are presented.

Irish nationality and citizenship since 1922

2001 ◽  
Vol 32 (127) ◽  
pp. 377-407 ◽  
Author(s):  
Mary E. Daly
Keyword(s):  
United States ◽  
The United States ◽  
Equal Rights ◽  
Irish Nationalism ◽  
The Past ◽  
The Pacific ◽  
Central Tenet ◽  
The World ◽  
Before And After ◽  
The Republic

In the proclamation that was issued on Easter Monday 1916 the provisional government of the Irish Republic undertook to grant ‘equal rights and opportunities to all its citizens’ and to ‘cherish all the children of the nation equally’. It also emphasised that the Republic was ‘oblivious of the differences carefully fostered by an alien government, which have divided a minority from a majority in the past’ and referred to the support given to the Republic ‘by her exiled children in America’. The belief that the Irish nation included all inhabitants of the island was a central tenet of Irish nationalism both before and after 1922, and the numerous visits that nationalist leaders have paid to the United States from the time of Parnell and Davitt to the present testify to the importance that has been attached to the Irish overseas. In November 1948, while introducing the second reading of the Republic of Ireland Bill, the Taoiseach, John A. Costello, noted that ‘The Irish at home are only one section of a great race which has spread itself throughout the world, particularly in the great countries of North America and the Pacific.’

White Paper: Efficacy of Psychiatric Drugs

2016 ◽  
Vol 18 (1) ◽  
pp. 20-28 ◽  
Author(s):  
Jacqueline A. Sparks
Keyword(s):  
United States ◽  
Emotional Problems ◽  
The United States ◽  
White Paper ◽  
Current Evidence ◽  
Behavioral And Emotional Problems ◽  
The Past ◽  
Psychiatric Drugs ◽  
The World ◽  
Meta Analyses

Psychiatric drugs have been a mainstay of treatment for a range of behavioral and emotional problems over the past 6 decades in the United States and around the world. Although their use has skyrocketed, the problems they purport to alleviate have not diminished but, in fact, have increased (Whitaker, 2010a). This article summarizes current evidence for the efficacy of antidepressants, antipsychotics, and stimulants. Findings from meta-analyses, reviews, and major trials do not support widespread use of these drugs.

Industrialization, Hubs, and Catch-up

2020 ◽  
pp. 145-161
Author(s):  
Deepak Nayyar
Keyword(s):  
United States ◽  
Western Europe ◽  
Industrial Revolution ◽  
The United States ◽  
First Century ◽  
Rapid Decline ◽  
The Past ◽  
Early Twenty ◽  
The World ◽  
Catch Up

This chapter analyses the striking changes in the geographical distribution of manufacturing production amongst countries and across continents since 1750, a period that spans more than two-and-a-half centuries, which could be described as the movement of industrial hubs in the world economy over time. Until around 1820, world manufacturing production was concentrated in China and India. The Industrial Revolution, followed by the advent of colonialism, led to deindustrialization in Asia and, by 1880, Britain became the world industrial hub that extended to northwestern Europe. The United States surpassed Britain in 1900, and was the dominant industrial hub in the world until 2000. During 1950 to 2000, the relative, though not absolute, importance of Western Europe diminished, and Japan emerged as a significant industrial hub, while the other new industrial hub, the USSR and Eastern Europe, was short lived. The early twenty-first century, 2000–2017, witnessed a rapid decline of the United States, Western Europe, and Japan as industrial hubs, to be replaced largely by Asia, particularly China. This process of shifting hubs, associated with industrialization in some countries and deindustrialization in other countries in the past, might be associated with premature deindustrialization in yet other countries in the future.

Egypt will use arms deals to boost regional standing

2019 ◽  
Keyword(s):  
United States ◽  
Armed Forces ◽  
The United States ◽  
Third Place ◽  
Content Type ◽  
The Past ◽  
The World ◽  
Political Leverage

Significance On March 12, Cairo announced a 2-billion-dollar deal to buy advanced fighter jets from Russia. This comes against the background of new data showing that Egypt has climbed to third place in the world in a ranking of arms imports over the past five years. Impacts Diversification of Egypt’s procurement away from the United States will reduce Washington’s political leverage. The Egyptian armed forces’ prestige will be enhanced by the arms build-up. Gulf funders may exert pressure on Egypt to deploy its enhanced military muscle in support of conflicts in which they are engaged.

From Tent Meetings and Store-front Healing Rooms to Walmarts and the Internet: Healing Spaces in the United States, the Americas, and the World, 1906–2006

2006 ◽  
Vol 75 (3) ◽  
pp. 631-647 ◽  
Author(s):  
Candy Gunther Brown
Keyword(s):  
United States ◽  
Medical Science ◽  
Spiritual Healing ◽  
The United States ◽  
Social Boundaries ◽  
Attractive Alternative ◽  
Past Century ◽  
The Past ◽  
Christian Churches ◽  
The World

The centennial of the Azusa Street revivals of 1906 provides us with convenient poles for charting shifts in the landscape of Christian spiritual healing practices during the past century. Alongside unprecedented achievements in medical science, nearly 80 percent of Americans report believing that God supernaturally heals people in answer to prayer. Individuals who need healing, even after trying the best medical cures, readily transgress ecclesiastical, physical, and social boundaries in their quest for health and wholeness. The promise of a tangible experience of divine power, moreover, presents an attractive alternative to seekers disillusioned with what they perceive as the callous materialism of medical science and the religious legalism of traditional Christian churches. This essay calls for new narratives of sacred space that map the ways that pentecostal and charismatic healing practices have proliferated, diversified, and sacralized a growing number and variety of physical, social, and linguistic spaces in the past hundred years. At the turn of the twentieth century, modernist epistemological assumptions that privileged reason over experience encouraged fine intellectual distinctions between the sacred and the secular. In esteeming bodily experience as more trustworthy than disembodied doctrine and in resisting linguistic binaries as culturally constructed, postmodern epistemologies have multiplied the number and range of places available to be endowed with sacred meanings. I argue that boundaries between the sacred and the secular are dissolving at the same time that new boundaries are being established, privileging particular places and defining a new relationship among the United States, the Americas, and the world.

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