scholarly journals The demographic data and the high frequency of chromosome/chromatid breaks as biomarkers for genome integrity have a role in predicting the susceptibility to have Down syndrome in a cohort of Egyptian young-aged mothers

2019 ◽  
Vol 20 (1) ◽  
Author(s):  
Lama M. El-Attar ◽  
Noha M. Issa ◽  
Hanan Salah Eldin Mahrous
Keyword(s):  
Socioeconomic Status ◽  
Down Syndrome ◽  
Low Socioeconomic Status ◽  
Rural Areas ◽  
Demographic Data ◽  
Chromosome 21 ◽  
Genome Integrity ◽  
Young Mothers ◽  
Low Socioeconomic ◽  
History Of

Abstract Background Down syndrome (DS) is a common numerical chromosome disorder that has its burden on both family and community. The well-known risk factor for chromosome 21 nondisjunction is advanced maternal age which failed to explain the occurrence of Down syndrome born to mothers less than 35 years. This study aimed to assess the effect of demographic data (consanguinity, residency area, and socioeconomic state) and chromosome/chromatid breaks as biomarkers for genome integrity on the susceptibility of young mothers to have a child with Down syndrome. Results Fifty mothers with a history of at least one DS pregnancy before the age of 35 were compared to 50 control mothers. There was a significant increase in DS births in consanguineous parents (46%) compared to 20% in non-consanguineous ones (OR = 3.40; 95% CI = 1.4–8.20, P = 0.006). Young mothers with DS children were more likely to be from rural areas (60%) than urban areas (40%) (OR = 2.66; 95%, CI = 1.18–5.98, P = 0.017) and of a low socioeconomic status (62%) rather than a high socioeconomic status (38%) (OR = 3.80; 95%, CI = 1.65–8.74, P = 0.001). Chromosome/chromatid breaks were detected in 76% of DS young mothers and 32% of control mothers (P < 0.001). There was an odds ratio of chromatid breaks of 8.50 (3.411–21.17) and chromosome breaks of 3.93 (1.40–11.05) with significant difference between the studied groups (P < 0.001 and P = 0.009 respectively). Conclusion In addition to advanced maternal age, consanguinity, residency in rural areas, and low socioeconomic status could be considered as possible risk factors for Down syndrome. The high frequency of chromosome/chromatid breaks in young mothers with a previous history of DS children highlights the impact of genome integrity on the tendency to chromosome 21 nondisjunction. These findings are valuable in predicting having a Down syndrome baby and providing proper genetic counseling for high-risk families.

Demographic Profile Associated With Malnutrition

2021 ◽  
Vol 3 (2) ◽  
Author(s):  
Adnan Khalil ◽  
Shahid Bashir ◽  
Morad Yaser Al Mostafa
Keyword(s):  
Socioeconomic Status ◽  
Low Socioeconomic Status ◽  
Health Problem ◽  
Rural Areas ◽  
Sampling Technique ◽  
Questionnaire Data ◽  
Low Socioeconomic ◽  
Demographic Profile ◽  
Malnourished Children ◽  
One Year

Worldwide, malnutrition is the severe most health problem leading to the highest rate of disease andmortality among children less than 5 years of age. Objective: To find out the association betweenmalnutrition and demographic profile. Methods: 350 malnourished children were chosen by nonprobabilityconvenient sampling technique from Sir Ganga Ram Hospital, Lahore. Children wereassessed through pre-tested questionnaire. Data were analyzed by SPSS version 21.0. Results: 45%malnourished children were 1-3 years of age, majority of the children were females (52%), 89% childrenwere from rural areas, 82.6% children were from low socioeconomic status, 54.6% mothers wereuneducated, 50% malnourished children were not having their own house, 115 malnourished childrenwere having 3 or more siblings and 89 mothers were having less than one year of pregnancy gap.Conclusions: Low socioeconomic status, illiteracy of mothers, rural area, gap between pregnancy andfemale gender has been found to be linked with malnutrition in children below 5 years of age.

Nutritional anaemia in children in post supplementation era: A cross sectional study

2021 ◽  
Vol 12 (6) ◽  
pp. 44-49
Author(s):  
Rajesh Kumar ◽  
Manoj Kumar Singh ◽  
Vineet Kumar Singh ◽  
Pankaj Kumar ◽  
Sheo Pratap Singh ◽  
...  
Keyword(s):  
Socioeconomic Status ◽  
Low Socioeconomic Status ◽  
Rural Areas ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Low Socioeconomic ◽  
Female Children ◽  
B12 Deficiency ◽  
Folate And Vitamin B12

Background: Nutritional anemia is still the primary cause of anemia despite of various nutritional programmes in developing countries. Aims and Objective: The present study was planned to asses Iron, Folate, and Vitamin B12 deficiency anaemia in developing countries. Materials and Methods: This cross-sectional study was conducted at a tertiary care centre in Agra in collaboration with Institute of Genomics and Integrative Biology, New Delhi. Admitted children of age 6 months to 14 years having signs and symptoms of anaemia were included in the study. Sample size calculated was 157. All the cases were subjected to CBC, GBP, serum iron, ferritin, folate and vitamin B12 level estimation. Results: Out of 672 children, 157 children with clinical feature of anaemia were enrolled in the study. Among these 157 children, 52.87% were male. Percent proportion of anaemia was highest among toddlers (27.39%) and lowest in adolescent (10.83%). The maximum cases were of urban area (65.6%) and middle socioeconomic status (47.13%). Most of the children were undernourished/underweight (60.4%). Mean iron level was significantly low in female children, children of rural areas, low socioeconomic status and malnutrition/underweight. Mixed iron, folate and B12 deficiency was found in 48.41%, 30.57% and 22.93% cases respectively. In 24.20% cases no deficiencies were found and were classified as anaemia due to some unspecified causes. Conclusion: Nutritional deficiency anaemia is contributing to a large proportion of anaemic patients. More intensified programmes are needed especially for female children, children of rural areas, low socioeconomic status and malnutrition/underweight.

Demographic and Clinical Characteristics Associated With Adherence to Guideline-Based Polysomnography in Children With Down Syndrome

2020 ◽  
pp. 019459982095483
Author(s):  
Philip D. Knollman ◽  
Christine H. Heubi ◽  
Susan Wiley ◽  
David F. Smith ◽  
Sally R. Shott ◽  
...  
Keyword(s):  
Socioeconomic Status ◽  
Down Syndrome ◽  
Clinical Characteristics ◽  
Medical Center ◽  
Demographic Data ◽  
Children With Down Syndrome ◽  
Medical Need ◽  
Obstructive Sleep ◽  
Significant Difference ◽  
History Of

Objectives To compare the demographic and clinical characteristics of children with Down syndrome who did and did not receive polysomnography to evaluate for obstructive sleep apnea after publication of the American Academy of Pediatrics’ guidelines recommending universal screening by age 4 years. Study Design Retrospective cohort study. Setting Single tertiary pediatric hospital. Methods Review was conducted of children with Down syndrome born between 2007 and 2012. Children who obtained polysomnography were compared with children who did not, regarding demographic data, socioeconomic status, and comorbidities. Results We included 460 children with Down syndrome; 273 (59.3%) received at least 1 polysomnogram, with a median age of 3.6 years (range, 0.1-8.9 years). There was no difference in the distribution of sex, insurance status, or socioeconomic status between children who received polysomnography and those who did not. There was a significant difference in race distribution ( P = .0004) and distance from home to the medical center ( P < .0001) between groups. Among multiple medical comorbidities, only children with a history of hypothyroidism ( P = .003) or pulmonary aspiration ( P = .01) were significantly more likely to have obtained polysomnography. Conclusions Overall, 60% of children with Down syndrome obtained a polysomnogram. There was no difference between groups by payer status or socioeconomic status. A significant difference in race distribution was noted. Proximity to the medical center and increased medical need appear to be associated with increased likelihood of obtaining a polysomnogram. This study illustrates the need for improvement initiatives to increase the proportion of patients receiving guideline-based screening.

scholarly journals Influence of Residence Area and Basic Livelihood Conditions on the Prevalence and Diagnosis Experience of Osteoporosis in Postmenopausal Women Aged over 50 Years: Evaluation Using Korea National Health and Nutrition Examination Survey Data

2021 ◽  
Vol 18 (18) ◽  
pp. 9478
Author(s):  
Suk-Woong Kang ◽  
Ji-Hee Yang ◽  
Won-Chul Shin ◽  
Yoon-Ji Kim ◽  
Min-Hyeok Choi
Keyword(s):  
Socioeconomic Status ◽  
Postmenopausal Women ◽  
Low Socioeconomic Status ◽  
Rural Areas ◽  
Odds Ratio ◽  
Nutrition Examination Survey ◽  
Low Socioeconomic ◽  
Health And Nutrition ◽  
Diagnosis Rate ◽  
Osteoporosis Prevalence

Patients with osteoporosis are asymptomatic and are at risk for fractures. Therefore, early detection and interventions are important. We found that a population with a low socioeconomic status living in rural areas was reported to have a high osteoporosis prevalence but a relatively low diagnosis rate. Research on the disparity of osteoporosis prevalence and treatment from the socioeconomic perspective was conducted. This study aimed to investigate the influence of residence area and basic livelihood conditions on osteoporosis prevalence and diagnosis in postmenopausal women aged over 50 years. The cross-sectional data of 1477 postmenopausal women aged over 50 years obtained from the Korea National Health and Nutrition Examination Survey V-2 were analyzed. Univariate analyses were performed to calculate the prevalence and diagnosis rate according to risk factor categories. A multivariate logistic regression analysis was performed to identify the influence of residence area and basic livelihood conditions after controlling for other factors. The osteoporosis prevalence in basic livelihood beneficiaries (53.7%) and rural area residents (41.9%) was higher than that in non-beneficiaries (33.1%) and urban area residents (31.8%). There was no significant difference in the diagnosis rates in relation to the basic livelihood conditions or residence areas. The adjusted odds ratio for the prevalence among the beneficiaries living in rural areas was 2.08 (95% confidence interval: 1.06–4.10). However, the odds ratio for diagnosis was not significantly different. Earlier screening examination policies for osteoporosis in postmenopausal women with a low socioeconomic status living in rural areas are needed.

scholarly journals Food Insecurity and Preeclampsia: A Case-Control Study

2021 ◽  
Author(s):  
Junaid Bigdeli ◽  
Golnaz Ranjbar ◽  
Lida Jarahi ◽  
Nayereh Khadem Ghaebi ◽  
Davood Soleimani ◽  
...  
Keyword(s):  
Socioeconomic Status ◽  
Food Insecurity ◽  
Low Socioeconomic Status ◽  
Case Control Study ◽  
Case Control ◽  
Low Socioeconomic ◽  
History Of ◽  
Safe Food ◽  
Control Study ◽  
Risk Of Preeclampsia

Background: Household food insecurity is defined as the limited or uncertain access to adequate and safe food or limited ability to obtain food in a socially acceptable manner. Preeclampsia is a severe case of high-risk pregnancy, which endangers the health of women across the world, especially in developing countries. The current study aimed to use the nutritional deficiencies theory in pathogenesis of preeclampsia and determine the correlation between food insecurity and preeclampsia. Methods: This case-control study was conducted on 100 women with preeclampsia and 200 normal pregnant women with the gestational age of 20 weeks. Participants were selected via purposive sampling according to the eligibility criteria. Data were collected using the USDA questionnaire for food insecurity, socioeconomic data, and demographic data through interviews. Results: The findings indicated that the frequency of food insecurity was significantly higher in the preeclampsia women than the healthy women (71% vs. 21%; P < 0.001). Logistic regression indicated that the risk of preeclampsia was six times higher among pregnant women in the unsafe food status group than those in safe food status group [odds = 6.4; 95%CI: 3.3-12.4; P < 0.001]. Among the studied variables, socioeconomic status, history of stillbirth, history of preterm delivery, and ethnicity were significantly associated with preeclampsia during pregnancy (P < 0.05). In addition, women with low socioeconomic status were twice at the higher risk of preeclampsia compared to those with favorable socioeconomic status [odds = 2.7; 95%CI: 1.1-6.2; P = 0.01]. Conclusion: The current study indicated that the prevalence of food insecurity was high in Iranian women with preeclampsia, especially those with a history of preterm labor, history of stillbirth, low socioeconomic status, or non-Persian.

scholarly journals Clinical Pattern of Liver Abscess among the Patients Admitted in Rajshahi Medical College Hospital

2015 ◽  
Vol 26 (2) ◽  
pp. 55-60
Author(s):  
Chanchal Kumar Ghosh ◽  
Fakhrul Alam ◽  
M Mahmuduzzaman ◽  
AKM Shamsul Kabir ◽  
M Saif Uddoula ◽  
...  
Keyword(s):  
Socioeconomic Status ◽  
Liver Abscess ◽  
Low Socioeconomic Status ◽  
Middle Aged ◽  
College Hospital ◽  
Low Socioeconomic ◽  
Clinical Pattern ◽  
Palm Wine ◽  
Medical College ◽  
History Of

Introduction: Liver abscess is an important clinical problem in tropical regions of the world. Current assessment of liver abscesses should allow for better understanding of the aetiopathogenesis of the disease. This study was conducted to find the clinical pattern and aetiopathogenesis of liver abscess in patients admitted in Rajshahi Medical College Hospital.Methodology: The present cross-sectional study was carried out in the Department of Medicine, Rajshahi Medical College Hospital (RMCH) on consecutive 34 patients of liver abscess admitted between the period of July 2002 and June 2003. Detailed history and clinical examination were performed in all patients. All routine investigations were done. Liver abscess was confirmed by ultrasonography (USG). Aspiration of liver abscess was done under sonographic guidance in the Nuclear Medicine Department of RMCH to diagnose the cause of liver abscess. Aspirated materials were sent for microscopical examination and culture and sensitivity in the Department of Microbiology of the same Institute.Result: The findings showed that early middle-aged population were usually affected by liver abscess followed by middle aged (mean age around 40 years). The patients were predominantly male with males being 16 times more likely to suffer from the disease than the females. Most of the patients belong to low socioeconomic status (82.4%). All patients had fever and malaise. Other common manifestations were loss of appetite, lump in the abdomen, intercostal tenderness, nausea/ vomiting, loss of weight. Less common presentations were diarrhoea (29.4%), jaundice (23.5%), cough (11.8%), chest pain (11.8%) and breathlessness (2.9%). Liver span of the patients measured by ultra-sonogram showed hepatomegaly in all cases. All patients with pyogenic liver abscess and 75% of the patients with amoebic abscess had the history of prolonged intake of fermented palm juice (palm wine). Microscopic examination of the pus/aspirate drawn from the liver revealed trophozoite in 7(20.6%) cases. However, on culture of the specimen, 12(35.3%) were culture positive and 22(64.7%) were culture negative.Conclusion: Middle-aged male with low socioeconomic status with the history of prolonged palm wine intake are the most common characteristic of patients with liver abscess. Multi-center study with large sample size is recommended to verify the findings of the present study.Bangladesh J Medicine Jul 2015; 26 (2) : 55-60

The “Homogamy” of Road Rage Revisited

2008 ◽  
Vol 23 (6) ◽  
pp. 758-772 ◽  
Author(s):  
Lynne D. Roberts ◽  
David W. Indermaur
Keyword(s):  
Socioeconomic Status ◽  
Violent Crime ◽  
Low Socioeconomic Status ◽  
Demographic Characteristics ◽  
Aggressive Driving ◽  
Road Rage ◽  
Low Socioeconomic ◽  
Young Males ◽  
Driving Behaviors ◽  
History Of

The principle of homogamy, the tendency for victims and offenders to share behavioral and demographic characteristics, has been applied to various forms of violent crime. This article explores how this principle relates to types of “road rage” using a survey of 1,208 Australian drivers. Two-thirds of drivers who perpetrated violent forms of road rage also reported being victims of the same crime, providing support for the homogamy thesis. Perpetrators were predominantly young males with low socioeconomic status who lacked the ability to control their temper. Perpetrator-victims were more likely than other victims to have a history of driving violations and higher levels of general aggression and report more frequent aggressive driving behaviors. The implications for theories of violence are discussed.

scholarly journals DEMOGRAPHICS AND MAJOR INDICATIONS FOR THE WARFARIN USE, THE COMPLIANCE RATE AND THE FACTORS CONTRIBUTING IN NON-ADHERENCE AMONG PATIENTS PRESENTING TO A TERTIARY CARDIAC CENTER OF PAKISTAN

2021 ◽  
Vol 70 (Suppl-4) ◽  
pp. S887-91
Author(s):  
Muhammad Talha Bin Nazir ◽  
Muhammad Mujtaba Ali Siddiqui ◽  
Hamid Sharif Khan ◽  
Mohsin Saif ◽  
Shabana Kousar ◽  
...  
Keyword(s):  
Socioeconomic Status ◽  
Valve Replacement ◽  
Low Socioeconomic Status ◽  
Rural Areas ◽  
Warfarin Therapy ◽  
Compliance Rate ◽  
Cross Sectional ◽  
Low Socioeconomic ◽  
The Impact ◽  
Cardiac Center

Objective: To assess the impact of a dedicated hospital based warfarin clinic assessing patients’ knowledge and improving the drug compliance in a tertiary cardiac center of Pakistan. Study Design: Descriptive cross sectional study. Place and Duration of Study: Rawalpindi Institute of Cardiology from Jan 2019 to Jul 2019. Methodology: Patients presenting in the anticoagulation clinic using warfarin for different cardiovascular indications from Jan to Jul 2019 were included in the study. Patients were assessed for their underlying cardiovascular condition, their international normalized ratio levels checked using a standard technique. The patients’ knowledge about the drug and the degree of compliance was judged by eight-item Morisky Medication Adherence Scale (MMAS-8). The patients were thoroughly counseled and reassessed six months later assessing the improvement in compliance with the warfarin therapy. Results: Total number of 401 patients using warfarin for different cardiovascular diseases were studied. The mean age was 43.3 ± 13.3 years with 218 (54.5%) patients being male. Most of the patient 300 (75%) belonged to the low socio-economic group with average monthly income of <PKR 10,000/$65. In addition, 61.4% of the patients belonged to the rural set up. Mechanical valve replacement made the bulk of the indication for warfarin therapy with 44.7% of patients with mechanical mitral valve, 14% with mechanical double valve and 13% with mechanical aortic valve replacement. 13.7% of the patients on warfarin therapy had atrial fibrillation while 6.9% either had venous thromboembolism and pulmonary embolism. The compliance was good in 76.1% on baseline visit which increased to 86.7% on the first visit at six-month interval. Residence in rural areas and low socioeconomic status were the two factors contributing to poorer compliance which improved on the first visit. Conclusion: Low socioeconomic status and residents of rural areas were resulting in comparatively poorer compliance with warfarin therapy which improved by educating such patients in specific warfarin clinic.

scholarly journals A study on clinicopathological evaluation of rhinosporidiosis

2017 ◽  
Vol 5 (10) ◽  
pp. 4519
Author(s):  
Prangya Panda ◽  
Bijaya Kumar Sadangi ◽  
Dhaneswari Jena ◽  
Sarita Panda
Keyword(s):  
Socioeconomic Status ◽  
Low Socioeconomic Status ◽  
Pond Water ◽  
Lacrimal Sac ◽  
Low Socioeconomic ◽  
Medical College ◽  
Palpebral Conjunctiva ◽  
History Of ◽  
The Common ◽  
Almost All

Background: Rhinosporidiosis is a chronic granulomatous disease. Aim of the study was to do a clinicopathological evaluation of the cases of rhinosporidiosis. Study design was longitudinal.Methods: The study was undertaken in MKCG medical college. 151 cases of rhinosporidiosis were taken. Pedunculated or sessile, fleshy, polypoidal, reddish looking mass with spores on the surface were clinically diagnosed as rhinosporidiosis. Age, sex distribution, site of presentation and socioeconomic status was studied. The swellings of lacrimal sac were doughy in consistency. The conjunctival mass was excised and thermocautery applied. For the cases of lacrimal sac dacryocystectomy was done.Results: The cases were more common in male children of low socioeconomic status. Palpebral conjunctiva is the common site of involvement. History of pond bath was present in almost all the cases. History of bleeding from nose and eye was present in many cases.Conclusions: Rhinosporidiosis is a common condition of our locality. Treatment is simple by excising the growth and cauterising the site. Taking bath in pond water is supposed to be the cause of the disease. The disease can be prevented by avoiding pond bath.

scholarly journals Determinants of Preterm Labour in a Rural Medical College Hospital in Western Maharashtra

2013 ◽  
Vol 8 (1) ◽  
pp. 31-33 ◽  
Author(s):  
Sunil Avachat Shubhada ◽  
SV Kambale ◽  
BD Phalke
Keyword(s):  
Socioeconomic Status ◽  
Rural Area ◽  
Teaching Hospital ◽  
Low Socioeconomic Status ◽  
Preterm Labour ◽  
Previous History ◽  
College Hospital ◽  
Low Socioeconomic ◽  
Medical College ◽  
History Of

Aims: This study was done to estimate the incidence of preterm labour and to study the causes of preterm labour in a teaching hospital. Methods: A cross sectional study was conducted in a medical college hospital in rural area among all patients who delivered during study period. Data was collected by interview technique and analyzed by appropriate statistical methods. Results: Total 2105 deliveries occurred during study period and the incidence of preterm delivery in the study was 15%. Incidence of preterm labour was comparatively more among multigravida (49.5%). Out of 315 preterm labour cases, 234 (74.25%) were from low socioeconomic status. Forty-one percent preterm labors were idiopathic, 17% cases had maternal- fetal complications and 15% cases had recurrent urinary tract infections. Significant association was observed between previous history of preterm labour and current preterm labour after applying Z test. Conclusions: Incidence of preterm labour was 15% among the hospital deliveries in a teaching hospital in rural area. Preterm labour was more common among women of low socioeconomic status, among multigravida and among women having previous history of preterm labour. Nepal Journal of Obstetrics and Gynaecology / Vol 8 / No. 1 / Issue 15 / Jan- June, 2013 / 31-33 DOI: http://dx.doi.org/10.3126/njog.v8i1.8858

Sign in / Sign up

Export Citation Format

Share Document