scholarly journals Involvement of Carrier-Mediated Transport at the Blood–Cerebrospinal Fluid Barrier in Spermine Clearance from Rat Brain

2017 ◽  
Vol 40 (9) ◽  
pp. 1599-1603 ◽  
Author(s):  
Shin-ichi Akanuma ◽  
Hirokazu Shimada ◽  
Yoshiyuki Kubo ◽  
Ken-ichi Hosoya
Keyword(s):  
Cerebrospinal Fluid ◽  
Rat Brain ◽  
Carrier Mediated Transport

scholarly journals Biological effect on blood cerebrospinal fluid barrier due to radio frequency electromagnetic fields exposure of the rat brain in vivo

2007 ◽  
Vol 27 (4) ◽  
pp. 489-492 ◽  
Author(s):  
A. Ushiyama ◽  
H. Masuda ◽  
S. Hirota ◽  
K. Wake ◽  
H. Kawai ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Radio Frequency ◽  
Rat Brain ◽  
Electromagnetic Fields ◽  
Biological Effect

Kineties of ciprofloxacin in rat brain and cerebrospinal fluid after coadministration with fenbufen

1990 ◽  
Vol 183 (6) ◽  
pp. 2294
Author(s):  
K. Naora ◽  
Y. Katagiri ◽  
N. Ichikawa ◽  
M. Hayashibara ◽  
K. Iwamoto
Keyword(s):  
Cerebrospinal Fluid ◽  
Rat Brain

The involvement of the blood–brain and the blood–cerebrospinal fluid barriers in the distribution of leptin into and out of the rat brain

Neuroscience ◽  
2004 ◽  
Vol 123 (2) ◽  
pp. 527-536 ◽  
Author(s):  
D Kurrimbux ◽  
Z Gaffen ◽  
C.L Farrell ◽  
D Martin ◽  
S.A Thomas
Keyword(s):  
Cerebrospinal Fluid ◽  
Rat Brain ◽  
Blood Brain

scholarly journals Paravascular channels, cisterns, and the subarachnoid space in the rat brain: A single compartment with preferential pathways

2016 ◽  
Vol 37 (4) ◽  
pp. 1374-1385 ◽  
Author(s):  
Beatrice Bedussi ◽  
Nicole N van der Wel ◽  
Judith de Vos ◽  
Henk van Veen ◽  
Maria Siebes ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Cerebrospinal Fluid ◽  
Rat Brain ◽  
Subarachnoid Space ◽  
Light And Electron Microscopy ◽  
Confocal Imaging ◽  
Brain Vasculature ◽  
Fluid Compartment ◽  
Male Wistar Rats ◽  
Preferential Pathways

Recent evidence suggests an extensive exchange of fluid and solutes between the subarachnoid space and the brain interstitium, involving preferential pathways along blood vessels. We studied the anatomical relations between brain vasculature, cerebrospinal fluid compartments, and paravascular spaces in male Wistar rats. A fluorescent tracer was infused into the cisterna magna, without affecting intracranial pressure. Tracer distribution was analyzed using a 3D imaging cryomicrotome, confocal microscopy, and correlative light and electron microscopy. We found a strong 3D colocalization of tracer with major arteries and veins in the subarachnoid space and large cisterns, attributed to relatively large subarachnoid space volumes around the vessels. Confocal imaging confirmed this colocalization and also revealed novel cisternal connections between the subarachnoid space and ventricles. Unlike the vessels in the subarachnoid space, penetrating arteries but not veins were surrounded by tracer. Correlative light and electron microscopy images indicated that this paravascular space was located outside of the endothelial layer in capillaries and just outside of the smooth muscle cells in arteries. In conclusion, the cerebrospinal fluid compartment, consisting of the subarachnoid space, cisterns, ventricles, and para-arteriolar spaces, forms a continuous and extensive network that surrounds and penetrates the rat brain, in which mixing may facilitate exchange between interstitial fluid and cerebrospinal fluid.

The Distribution of Ammonia between Extracellular and Intracellular Compartments of the Rat Brain

1975 ◽  
Vol 48 (1) ◽  
pp. 33-37 ◽  
Author(s):  
B. Hindfelt
Keyword(s):  
Cerebrospinal Fluid ◽  
Rat Brain ◽  
Concentration Gradient ◽  
Ionic Diffusion ◽  
Anaesthetized Rats ◽  
Intracellular Compartments ◽  
Ph Dependent ◽  
Arterial Plasma ◽  
Cellular Compartments ◽  
The Brain

1. The distribution of ammonia between extra- and intra-cellular compartments of the brain was evaluated in anaesthetized rats exposed to sustained hyperammonaemia and superimposed acute hypo- or hyper-capnia. 2. It is concluded that the concentration gradient for ammonia between arterial plasma and cerebrospinal fluid (CSF) cannot be explained by pH-dependent non-ionic diffusion of ammonia. A continuous uptake by the brain tissue of ammonia from the CSF is postulated and possible mechanisms are discussed.

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