The Resistance Training with Blood Flow Reduction and Vascular Endothelial Function in Healthy Old Volunteers

2011 ◽  
Vol 43 (Suppl 1) ◽  
pp. 936
Author(s):  
Ryosuke Shimizu ◽  
Kazuki Hotta ◽  
Naoko Aiba ◽  
Daisuke Kamekawa ◽  
Ayako Akiyama ◽  
...  
Keyword(s):  
Blood Flow ◽  
Resistance Training ◽  
Endothelial Function ◽  
Vascular Endothelial ◽  
Vascular Endothelial Function ◽  
Flow Reduction ◽  
Blood Flow Reduction

scholarly journals Folic acid supplementation improves vascular endothelial function, yet not skin blood flow during exercise in the heat, in patients with heart failure

2018 ◽  
Vol 315 (4) ◽  
pp. R810-R819 ◽  
Author(s):  
Bryce N. Balmain ◽  
Ollie Jay ◽  
Norman R. Morris ◽  
Glenn M. Stewart ◽  
Kenji Shiino ◽  
...  
Keyword(s):  
Heart Failure ◽  
Blood Flow ◽  
Folic Acid ◽  
Endothelial Function ◽  
Skin Blood Flow ◽  
Heat Production ◽  
Folic Acid Supplementation ◽  
Vascular Endothelial ◽  
Vascular Endothelial Function ◽  
Metabolic Heat

Heart failure (HF) patients are susceptible to heat strain during exercise, secondary to blunted skin blood flow (SkBF) responses, which may be explained by impaired nitric oxide (NO)-dependent vasodilation. Folic acid improves vascular endothelial function and SkBF through NO-dependent mechanisms in healthy older individuals and patients with cardiovascular disease. We examined the effect of folic acid supplementation (5 mg/day for 6 wk) on vascular function [brachial artery flow-mediated dilation (FMD)] and SkBF responses [cutaneous vascular conductance (CVC)] during 60 min of exercise at a fixed metabolic heat production (300 ẆHprod) in a 30°C environment in 10 patients with HF (New York Heart Association Class I–II) and 10 healthy controls (CON). Serum folic acid concentration increased in HF [preintervention (pre): 1.4 ± 0.2; postintervention (post): 8.9 ± 6.7 ng/ml, P = 0.01] and CON (pre: 1.3 ± 0.6; post: 5.2 ± 4.9 ng/ml, P = 0.03). FMD improved by 2.1 ± 1.3% in HF ( P < 0.01), but no change was observed in CON postintervention ( P = 0.20). During exercise, the external workload performed on the cycle ergometer to attain the fixed level of heat production for exercise was similar between groups (HF: 60 ± 13; CON: 65 ± 20 external workload, P = 0.52). Increases in CVC during exercise were similar in HF (pre: 0.89 ± 0.43; post: 0.83 ± 0.45 au/mmHg, P = 0.80) and CON (pre: 2.01 ± 0.79; post: 2.03 ± 0.72 au/mmHg, P = 0.73), although the values were consistently lower in HF for both pre- and postintervention measurement intervals ( P < 0.05). These findings demonstrate that folic acid improves vascular endothelial function in patients with HF but does not enhance SkBF during exercise at a fixed metabolic heat production in a warm environment.

scholarly journals Eight weeks of resistance training with blood flow restriction improve cardiac function and vascular endothelial function in healthy young Asian males

2020 ◽  
Author(s):  
Yan Zhao ◽  
Aicui Lin ◽  
Long Jiao
Keyword(s):  
Coronary Artery Disease ◽  
Resistance Training ◽  
Endothelial Function ◽  
Cardiac Function ◽  
Vascular Endothelial ◽  
Vascular Endothelial Function ◽  
Flow Restriction ◽  
Low Intensity ◽  
Before And After ◽  
Artery Disease

Abstract Background Resistance training with blood flow restriction (BFR) is a physiological ischaemic training method. Before it is applied to patients with coronary artery disease, it must be proven safe and effective. Methods Twenty-four healthy adult males were randomly assigned to three groups: the resistance training (RT) group, low-pressure BFR and resistance training (LP-RT) group and high-pressure BFR and resistance training (HP-RT) group. The training protocol was 20 times/min/set, with a 2-min break, five sets/day and 5 d/week for 8 weeks. Cardiac function, haemodynamics and vascular endothelial function were evaluated before and after the first training and the last training. Results There were no significant differences among groups before and after training. After 8 weeks of training, the resting heart rate (p&lt;0.05) of the three groups significantly decreased (p&lt;0.05). The rate–pressure product in the LP-RT group significantly decreased (p&lt;0.05) compared with before training. Just after the last training, heart rate (p&lt;0.05) and cardiac output (p&lt;0.05) in the LP-RT and HP-RT groups significantly decreased compared with those just after the first training. At the end of the experiment, vascular endothelial growth factor (VEGF; p&lt;0.01), soluble VEGF receptor (VEGFR) (p&lt;0.05) and interleukin-6 (p&lt;0.01) significantly increased, except for soluble VEGFR in the RT group. Conclusions Low-intensity resistance training with BFR moderately alters cardiac function. The expression levels of proteins related to vascular endothelial function have significantly changed. Both findings suggest that low-intensity resistance training with BFR may be safely and effectively applied to patients with coronary artery disease.

scholarly journals Habitual exercise and arterial aging

2008 ◽  
Vol 105 (4) ◽  
pp. 1323-1332 ◽  
Author(s):  
Douglas R. Seals ◽  
Christopher A. DeSouza ◽  
Anthony J. Donato ◽  
Hirofumi Tanaka
Keyword(s):  
Blood Flow ◽  
Endothelial Function ◽  
Aerobic Exercise ◽  
Moderate Intensity ◽  
Vascular Endothelial ◽  
Vascular Endothelial Function ◽  
Arterial Aging ◽  
Habitual Exercise ◽  
Artery Stiffness ◽  
Elastic Artery

Aging affects the function and structure of arteries and increases the risk of cardiovascular diseases (CVD). In healthy sedentary adults, aging is associated with increased stiffness (reduced compliance) of large elastic arteries; impaired vascular endothelial function, including reductions in endothelium-dependent dilation (EDD), release of tissue-type plasminogen activator (fibrinolytic capacity) and endothelial progenitor cell number and function; increased intima-media wall thickness (IMT); and peripheral vasoconstriction (decreased basal leg blood flow). Habitual physical activity/increased aerobic exercise capacity is associated with reduced risk of CVD. Compared with their sedentary peers, adults who regularly perform aerobic exercise demonstrate smaller or no age-associated increases in large elastic artery stiffness, reductions in vascular endothelial function, and increases in femoral artery IMT. A short-term, moderate-intensity aerobic exercise intervention (brisk daily walking for 12 wk) improves carotid artery compliance and can restore vascular endothelial function in previously sedentary middle-aged and older adults. Reduced oxidative stress may be an important mechanism contributing to these effects. Habitual resistance exercise increases (high-intensity) or does not affect (moderate-intensity) large elastic artery stiffness, and prevents/restores the age-associated reduction in basal leg blood flow independent of changes in leg fat-free mass. Habitual exercise favorably modulates several expressions of arterial aging, thus preserving vascular function and possibly reducing the risk of CVD.

scholarly journals A 50 Hz magnetic field affects hemodynamics, ECG and vascular endothelial function in healthy adults: A pilot randomized controlled trial

PLoS ONE ◽  
2021 ◽  
Vol 16 (8) ◽  
pp. e0255242
Author(s):  
Hideyuki Okano ◽  
Akikatsu Fujimura ◽  
Tsukasa Kondo ◽  
Ilkka Laakso ◽  
Hiromi Ishiwatari ◽  
...  
Keyword(s):  
Blood Flow ◽  
Endothelial Function ◽  
Controlled Trial ◽  
Oxygenation Index ◽  
Arterial Blood Flow ◽  
Vascular Endothelial ◽  
Vascular Endothelial Function ◽  
Upper Arm ◽  
Arterial Blood ◽  
Sham Exposure

Application of exposure to 50/60 Hz magnetic fields (MFs) has been conducted in the treatment of muscle pain and fatigue mainly in Japan. However, whether MFs could increase blood flow leading to muscle fatigue recovery has not been sufficiently tested. We investigated the acute effects of a 50 Hz sinusoidal MF at Bmax 180 mT on hemodynamics, electrocardiogram, and vascular endothelial function in healthy young men. Three types of regional exposures to a 50 Hz MF, i.e., forearm, upper arm, or neck exposure to MF were performed. Participants who received three types of real MF exposures had significantly increased ulnar arterial blood flow velocity compared to the sham exposures. Furthermore, after muscle loading exercise, MF exposure recovered hemoglobin oxygenation index values faster and higher than sham exposure from the loading condition. Moreover, participants who received real MF exposure in the neck region had significantly increased parasympathetic high-frequency activity relative to the sham exposure. The MF exposure in the upper arm region significantly increased the brachial artery flow-mediated dilation compared to the sham exposure. Computer simulations of induced in situ electric fields indicated that the order-of-magnitude estimates of the peak values were 100–500 mV/m, depending on the exposure conditions. This study provides the first evidence that a 50 Hz MF can activate parasympathetic activity and thereby lead to increase vasodilation and blood flow via a nitric oxide-dependent mechanism. Trial registration: UMIN Clinical Trial Registry (CTR) UMIN000038834. The authors confirm that all ongoing and related trials for this drug/intervention are registered.

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