THE ROLE OF ESTRADIOL IN THE SUSTENTATION OF FETOPLACENTAL SYSTEM

2016 ◽  
Vol 1 (61) ◽  
pp. 75-79
Author(s):  
Андриевская ◽  
Irina Andrievskaya ◽  
Луценко ◽  
Mikhail Lutsenko ◽  
Довжикова ◽  
...  
Keyword(s):  
The State ◽  
Cmv Infection ◽  
Histochemical Reaction ◽  
Third Trimester ◽  
Paraffin Sections ◽  
Igg Antibody ◽  
The Third ◽  
Exchange Processes ◽  
Hormonal Dysfunction

The aim of the study is to define the role of abnormalities in the formation of estriol hormones in the development of hormonal dysfunction of fetoplacental system. There were examined 39 placentas from women with exacerbation of chronic cytomegalovirus infection at the third trimester of pregnancy and IgG antibody titer 1:1600 and 30 placentas from women with latent CMV infection and titer 1:400. The activity of androstenedione dehydrogenase was found out with histochemical method on cryostat sections of freshly frozen tissues of placentas by Lloyd’s method. The assessment of intensiveness of histochemical reaction was done with cytophotometric method by Scion program. Estradiol in homogenate of placenta was measured with immune-enzyme method. The quantity of nuclei of placenta syncytiotrophoblast in the state of apoptosis was done with cytophotometric method on paraffin sections stained by ISEL method. By the results of the study the exacerbation of CMV infection at the third trimester of pregnancy leads to the decrease of intensiveness of histochemical reaction in placentas to androstenedione dehydrogenase till 32.1±2.88 pixel/mcm2 (at the latent course it is 54.2±4.31 pixel/mcm2, р<0.001), and in homogenate of placenta to the decrease of estradiol till 18443.2±117.53 pmole/l (at the latent course of the disease it is 28977.7±158.13 pmole/l, p<0.001), on paraffin sections in syncytiotrophoblast by the increase of nuclei number in the state of apoptosis till 5.0±0.03% (at latent course of the disease it is 1.2±0.001%, р<0.001) and vacuole formation, which leads to destructive damages of syncytiotrophoblast cytoplasm. The obtained results prove that the exacerbation of CMV infection at the third trimester of pregnancy causes the decrease of estriol hormones formation, which is accompanied by the damage of morphostructure and exchange processes in cell elements of placenta.

Deoxyribonuclease activity negative correlates with extracellular DNA in uncomplicated singleton pregnancies in the third trimester

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Barbora Vlková ◽  
Ľubica Janovičová ◽  
Petra Pšenková ◽  
Lívia Melníková ◽  
Barbora Balažovjechová ◽  
...  
Keyword(s):  
Pregnancy Complications ◽  
Extracellular Dna ◽  
Dnase Activity ◽  
Diffusion Method ◽  
Third Trimester ◽  
The Third ◽  
Healthy Women ◽  
Mitochondrial Origin ◽  
Singleton Pregnancies

Abstract Objectives It is not clear, which factors affect extracellular DNA (ecDNA) concentrations in healthy women with singleton uncomplicated pregnancies, although deoxyribonucleases (DNases) are hypothesized to be responsible for the cleavage of plasma ecDNA. The aim of this study was to analyze potential determinants of total ecDNA including plasma DNase activity. Methods Plasma samples were collected from 48 healthy women with singleton uncomplicated pregnancies in the third trimester (gestation week 37). DNA was isolated and quantified using fluorometry and real time PCR. DNase activity was assessed using the single radial enzyme-diffusion method. Results Neither ecDNA, nor DNase activity were affected by maternal age or BMI. DNase activity negatively correlated with total plasma ecDNA (r=−0.40, p=0.007). Similar associations were found for ecDNA of nuclear and mitochondrial origin, but not with fetal DNA quantified using Y-targeted PCR in male fetus-bearing pregnancies. Conclusions The role of plasma ecDNA of fetal and maternal origin is studied in the pathogenesis of pregnancy-complications. The results indicate that plasma DNase activity could negatively regulate ecDNA concentrations and should, thus, be analyzed in preeclampsia, preterm birth and other ecDNA-related pregnancy complications.

Minding the State — or a State of Mind?

1990 ◽  
Vol 23 (1) ◽  
pp. 25-55 ◽  
Author(s):  
BERT A. ROCKMAN
Keyword(s):  
Political Theory ◽  
The State ◽  
The Public ◽  
The Third ◽  
State Of Mind ◽  
Unique Definition ◽  
Public Cultures ◽  
State Organization ◽  
Decisional Authority

In political theory the state has been enjoying a conceptual rebirth even while some of its activities have been receding. The state, however, remains conceptually ambiguous and is thus molded into many different conceptual forms. Three of those forms are discussed in this article: the decision-making state, the production state, and the intermediary state. The first relates to the organization and architecture of decisional authority; the second to the public and distributive goods supplied by the state; and the third to the interconnections between state organization and the organizations of civil society. Although the state lacks unique definition as a concept, its value lies in bringing together the most important macro-level connections of the polity, the society, and the economy that cannot otherwise be adequately analyzed in isolation from one another. In particular, the state provides a focus for the study of statecraft within a given constellation of institutional and interest formations and public cultures. And yet statecraft itself cannot be detached from an analytic focus on the role of incentives, which must be effectively manipulated in order to preserve the fundamental functions of the state.

scholarly journals Immunology and Genetic of Preeclampsia

2006 ◽  
Vol 13 (2-4) ◽  
pp. 197-201 ◽  
Author(s):  
Norma C. Serrano
Keyword(s):  
Developing Countries ◽  
Growth Factors ◽  
Fetal Death ◽  
Preventive Strategies ◽  
Angiogenic Growth Factors ◽  
Third Trimester ◽  
Maternal Circulation ◽  
Familial Predisposition ◽  
The Third

Preeclampsia is a disease characterized by hypertension and proteinuria in the third trimester of pregnancy. Preeclampsia is a major cause of maternal mortality, and fetal death, especially in developing countries, but its aetiology remains unclear. Key findings support a causal role of superficial placentation driven by immune mal maladaptation, which then lead to reduced concentrations of angiogenic growth factors and to an increase in placental debris in the maternal circulation resulting in a maternal inflammatory response. Epidemiological research has consistently demonstrated a substantial familial predisposition to preeclampsia. Unfortunately, the conquest of the genes explaining such a individual susceptibility has been proved to be a hard task. However, genetics will also inform us about causality of environmental factors, and then serve as a tool to prioritize therapeutic targets for preventive strategies.

scholarly journals PERBANDINGAN PENGARUH SUKU BUNGA DAN INFLASI TERHADAP KREDIT DAN PEMBIAYAAN (Studi Kasus pada Bank Umum Konvensional dan Bank Umum Syariah periode 2011-2015)

IQTISHODUNA ◽  
2017 ◽  
Vol 12 (2) ◽  
pp. 91-97
Author(s):  
Hasannudin Nursalim Putra ◽  
Irnin Miladyan Aryq ◽  
Lilik Jazilatul Mufidah
Keyword(s):  
Interest Rate ◽  
Interest Rates ◽  
Path Analysis ◽  
The State ◽  
Financial Policy ◽  
The Third ◽  
The Interest Rate ◽  
Policy Interest

Inflationary pressures that often time there was a can shake economy the state, to face inflationarypressures one of the efforts of the country to control the inflation is by issuing policy interest rate by theIndonesia bank as central financial policy monetary and fiscal. The banks have the role of to control the rateinflation. The interest rate that set by the bank will affect the level distribution credit of bank conventional andfinancing of sharia bank. For that researchers want to see the influence of direct and indirect interest rates tocredit and financingand inflation as variable intervening. The kind of research is quantitative with the sampleof six general Sharia Bank and the generalconventional bank in Indonesia period 2011 until 2015 taken withpurposive sampling. Themethod is path analysis. Based onsignificant test, the first significant test has resultthat interest rates significant of inflation. Thesecond significant testhas results that the interest rate notsignificant on the distribution credit and financing. The third significant test has result that inflation is notsignificant to distribution credit and financing. So this is can concluded that inflation will not be variableintervening for the distribution credit and financing.

Civil Society and Philanthropy in Africa: Parallels, Paradoxes and Promise

2021 ◽  
pp. 089976402110574
Author(s):  
Ebenezer Obadare ◽  
Kelly Krawczyk
Keyword(s):  
Civil Society ◽  
Third Sector ◽  
The State ◽  
The Third ◽  
The Third Sector ◽  
The Relationship

Civil society and philanthropy in Africa are regularly theorized in formal terms and oft perceived as inherently democratizing forces. Yet, existing evidence exposes the limitations of these assumptions. This article provides an introduction to the symposium issue on civil society and philanthropy in Africa. The objective of the introduction, and the articles contained in the symposium, is to examine important questions related to civil society and philanthropy on the continent: What is the complex history and role of civil society and philanthropy in Africa? How have donor dependence and professionalization affected the effectiveness of the third sector? What are the contours of the relationship between the state and civil society? We ask these crucial questions in an attempt to provide a more nuanced and contextualized understanding of civil society and philanthropy on the continent.

Ontogeny of Serum Complement Proteins

PEDIATRICS ◽  
1979 ◽  
Vol 64 (5) ◽  
pp. 775-780
Author(s):  
Harvey R. Colten ◽  
Gabriel Goldberger
Keyword(s):  
First Trimester ◽  
In Utero ◽  
Serum Complement ◽  
Third Trimester ◽  
Complement Proteins ◽  
The Third ◽  
Apparent Change ◽  
Fetal Serum

The capacity for complement biosynthesis appears early in gestation. In most species, functional complement and properdin systems are intact by the end of the first trimester. An increase in fetal serum complement concentration (several components) occurs early in the third trimester reaching 30 to 50% of adult levels. The mechanisms for initiation of fetal biosynthesis of complement and the apparent change in rate of synthesis are knknown. The role of complement, if any, in utero is also not known. These will most certainly be subjectics of further investigations.

The Role of Private Property in the Nazi Economy: The Case of Industry

2006 ◽  
Vol 66 (2) ◽  
pp. 390-416 ◽  
Author(s):  
CHRISTOPH BUCHHEIM ◽  
JONAS SCHERNER
Keyword(s):  
Private Property ◽  
Third Reich ◽  
The State ◽  
Freedom Of Contract ◽  
The Third ◽  
The Third Reich

Private property in the industry of the Third Reich is often considered a mere nominal provision without much substance. However, that is not correct, because firms, despite the rationing and licensing activities of the state, still had ample scope to devise their own production and investment profiles. Even regarding war-related projects, freedom of contract was generally respected; instead of using power, the state offered firms a number of contract options to choose from. There were several motives behind this attitude of the regime, among them the conviction that private property provided important incentives for increasing efficiency.

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