7B43 Evaluation of morphological changes and anisotropic load-supporting function in osteoporotic trabecular bone by bone remodeling simulation

2012 ◽  
Vol 2012.24 (0) ◽  
pp. _7B43-1_-_7B43-2_
Author(s):  
Daisuke TAWARA ◽  
Ken NAGURA ◽  
Takeshi HORIKAWA ◽  
Taiji ADACHI
Keyword(s):  
Trabecular Bone ◽  
Bone Remodeling ◽  
Morphological Changes ◽  
Supporting Function ◽  
Bone Remodeling Simulation

Nanostructured bone-like scaffolds for restoration of trabecular bone remodeling capability

2011 ◽  
Vol 59 (1) ◽  
pp. 57-61
Author(s):  
M. Nowak ◽  
I. Firkowska ◽  
M. Giersig
Keyword(s):  
Trabecular Bone ◽  
Bone Remodeling ◽  
Material Properties ◽  
Theoretical Study ◽  
Simulation Method ◽  
Tissue Growth ◽  
Artificial Tissue ◽  
Bone Remodeling Simulation ◽  
Natural Tissue ◽  
Trabecular Bone Remodeling

Nanostructured bone-like scaffolds for restoration of trabecular bone remodeling capabilityThis paper presents the theoretical study about carbon nanotube substrates for tissue engineering and its applications. Because the replacement of bone tissue with artificial tissue can violate the remodeling process completely, the artificial material should not only consist of the same material properties, but also exhibit other characteristics which are equally important and need to be taken into consideration. These are above all the mechanosensation. Besides replacing natural tissue, the nanostructured scaffolds presented in the paper can help the tissue growth by stimulating this process. The developed trabecular bone remodeling simulation method responsible for the nanostructured scaffold behavior is implemented here. Thus, the nanostructured bone-like scaffolds reflect the remodeling capability of the biological system, not only due to their application as replacement of natural tissue, but also due to their effects in the field of mechanosensation.

The Effect of Number of Cycles on Microdamage Accumulation in Bovine Trabecular Bone

2001 ◽  
Author(s):  
Tara L. Arthur Moore ◽  
Lorna J. Gibson
Keyword(s):  
Trabecular Bone ◽  
Bone Remodeling ◽  
Low Cycle Fatigue ◽  
Cycle Fatigue ◽  
Repetitive Motion ◽  
Microdamage Accumulation ◽  
Lower Load ◽  
Small Cracks ◽  
Number Of Cycles ◽  
Fatigue Microdamage

Abstract Microdamage, in the form of small cracks, exists in healthy bone. Microdamage can be created by an overload or by repetitive motion (fatigue) during daily activities. Usually, microdamage is repaired during bone remodeling and a steady state is maintained. However, in cases of excessive microdamage creation or slowed bone remodeling, microdamage can coalesce to create a fracture. Our previous work [1,2] has investigated microdamage accumulation with increasing strain in bovine trabecular bone loaded in monotonic compression and compressive fatigue. Specimens fatigued at relatively high load levels fail after a few loading cycles, while specimens fatigued at lower load levels may undergo thousands of cycles before failure. During high cycle fatigue, microdamage may accumulate by the growth of pre-existing microcracks, as well as by the crack initiation seen in low cycle fatigue.

Bone Biology

2017 ◽  
Author(s):  
Elizabeth Weiss
Keyword(s):  
Trabecular Bone ◽  
Bone Remodeling ◽  
Calcium Homeostasis ◽  
Bone Biology ◽  
Diarthrodial Joint ◽  
Bone Damage ◽  
Bone Changes ◽  
Cartilage Cells ◽  
Wolff’S Law ◽  
Haversian System

This chapter introduces readers to the basics of understanding bone’s functions, which include calcium homeostasis and enabling movement, bone’s components, such as the collagen, and bone’s organization, such as the Haversian system found in cortical bone. The focus of this chapter is on explaining concepts of bone remodeling, which is thought to prevent fractures and other bone damage, and repair, which can take place at macro-levels and micro-levels. Wolff’s Law of bone remodeling, which was initially focused on trabecular bone changes, is discussed in terms of bone’s response to forces that result in strains and stresses. Finally, diarthrodial joint remodeling and repair are discussed; cartilage cells were once thought to be static, yet now they are known to also respond to stresses.

scholarly journals Effects of Interferon-Gamma on Bone Remodeling during Experimental Tooth Movement

2007 ◽  
Vol 77 (1) ◽  
pp. 135-141 ◽  
Author(s):  
Sila Mermut ◽  
Ali Osman Bengi ◽  
Erol Akin ◽  
Mehmet Kürkçü ◽  
Şeniz Karaçay
Keyword(s):  
Trabecular Bone ◽  
Bone Remodeling ◽  
Interferon Gamma ◽  
Tooth Movement ◽  
Orthodontic Tooth Movement ◽  
Bone Area ◽  
Sprague Dawley ◽  
Sprague Dawley Rats ◽  
Ifn Γ ◽  
Different Doses

Abstract Objective: To determine the effects of interferon-gamma (IFN-γ) on bone remodeling during orthodontic tooth movement. Materials and Methods: Thirty adult male Sprague Dawley rats were randomly categorized into five groups. IFN-γ was administered in three different doses (0.01, 0.02, and 0.05 μg/20 μL) and the remaining two groups served as control. Mandibular first molars were moved mesially by means of Ni-Ti closed coil springs in all groups. The results were evaluated histomorphometrically, and parameters of trabecular bone volume (BV/TV), trabecular bone number (Tr.N), and trabecular separation (Tr.Sep) were observed at the interradicular bone area of the mandibular first molars. Results: Increases in BV/TV and Tr.N and decreases in Tr.Sep revealed the antiosteoclastic activity of IFN-γ. Conclusion: IFN-γ administration may be useful clinically for anchorage control.

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