scholarly journals Association Between Mast Cells and Collagen Maturation in Chronic Periodontitis in Humans

2018 ◽  
Vol 66 (6) ◽  
pp. 467-475 ◽  
Author(s):  
Lívia S.F. e Ribeiro ◽  
Jean N. dos Santos ◽  
Clarissa A.G. Rocha ◽  
Patricia R. Cury
Keyword(s):  
Mast Cells ◽  
Connective Tissue ◽  
Chronic Periodontitis ◽  
Periodontal Diseases ◽  
Positive Association ◽  
Collagen Fibers ◽  
Gingival Tissue ◽  
Chi Square ◽  
Probing Depth ◽  
The Relationship

Mast cells (MCs) can influence the maturation of collagen fibers. This study evaluated the relationship between the distribution and degranulation of MCs and collagen maturation in human gingival tissue in chronic periodontitis. A total of 16 specimens of patients clinically diagnosed as periodontitis and 18 controls clinically diagnosed as healthy or gingivitis were included. Immunohistochemistry and Picrosirius staining were performed to identify MCs and assess collagen fibers, respectively. Chi-square, t test, and Pearson’s correlation test ( p<0.05) were used. In control specimens, there was a positive association between MCs in the connective tissue and the presence of immature collagen ( p=0.001); in periodontitis samples, this association was not confirmed ( p≥0.12). There was no significant relationship between periodontal diagnosis and collagen maturation or MC degranulation ( p≥0.35). MC density was significantly higher ( p=0.04) in periodontitis tissue (339.01 ± 188.94 MCs/mm2) than in control tissue (211.14 ± 131.13 MCs/mm2) in the area of connective tissue containing inflammatory infiltrate. There was a correlation between the number of MCs and probing depth ( r = 0.34, p=0.04). MCs are involved in the pathogenesis of periodontal diseases and might be associated with collagen maturation in periodontal tissue during the early stages of periodontal disease pathogenesis.

scholarly journals HUBUNGAN UMUR KEHAMILAN DENGAN STATUS KESEHATAN GINGIVA PADA IBU HAMIL DI WILAYAH KERJA PUSKESMAS ANDALAS KECAMATAN PADANG TIMUR

2015 ◽  
Vol 3 (1) ◽  
pp. 43-49
Author(s):  
Kinanti Fauzin ◽  
Hafni Bachtiar ◽  
Susi Susi
Keyword(s):  
Public Health ◽  
Pregnant Women ◽  
Gestational Age ◽  
Soft Tissues ◽  
Gingival Tissue ◽  
Physiological Changes ◽  
Gingival Index ◽  
Chi Square ◽  
Cross Sectional ◽  
The Relationship

Gingivitis is an inflammation of the soft tissues inoral cavity that invade the free gingival. There are two kinds of etiologies that can cause gingivitis, they are plaque and non-plaque. Pregnant women will have some maternal physiological changes during pregnancy, one of them is the increasing of estrogen and progesterone. It will cause the gingival tissue to react to irritant such as plaque excessively. The aim of this study was to determine the relationship between gestational age and gingival index in pregnant women. This analytic correlation research used cross sectional approach. The gestational age were observed from Mom’s and Kid’s Health Book. The Gingival Index was observed by using Loe and Silness index to each pregnant woman’s oral cavity. Data was analysed by using Chi –square. The study took place in Andalas Public Health Center, from 16th  February 2-15 until 26th  February 2015. Most of the pregnant women had mild gingivitis, no pregnant women were found with healthy gingiva or severe gingivitis. The result showed that there was no significantly relationship between gestational age and gingival index in pregnant women (p>0,005).

Is There a Relationship Between Obesity and Periodontal Diseases?

2018 ◽  
Vol 69 (10) ◽  
pp. 2652-2654
Author(s):  
Alina Ormenisan ◽  
Alexandra Balmos ◽  
Mihai Vlad Golu ◽  
Despina Bereczki Temistocle ◽  
Alina Baldean ◽  
...  
Keyword(s):  
Risk Factor ◽  
Chronic Periodontitis ◽  
Periodontal Diseases ◽  
Economic Status ◽  
Smoking Habit ◽  
Aggressive Periodontitis ◽  
Cross Sectional Study ◽  
Cerebrovascular Diseases ◽  
Cross Sectional ◽  
Probing Depth

Obesity, a common metabolic disorder, is a condition for the development of chronic diseases, such as hypertension, diabetes mellitus, cardiovascular and cerebrovascular diseases. The present study evaluates the prevalence of periodontal diseases in Romania and their association with obesity, as a risk factor. This cross-sectional study included 170 subjects aged between 18-65, with healthy periodontal status, gingivitis, aggressive periodontitis and chronic periodontitis. All subjects completed the questionnaire with independent variables: age, education, socio-economic status, oral hygiene habits, smoking habit, the presence of any systemic diseases. Periodontal examination included: plaque index, gingival index, probing depth, clinical attachment level. Body mass index (BMI) and waist circumference (WC) were measured. Statistically significant correlations were found between periodontal diseases and BMI and WC: according to BMI 30.5% were obese, and 42.5% had high WC. 51.9% of obese participants had chronic periodontitis. Gingivitis and initial periodontitis do not influence BMI and WC, only the chronic periodontitis remained significantly associated with obesity. Our study suggests that there is an association between chronic periodontitis and BMI- defined obesity or WC, but further prospective studies should be carried on to establish the extent of it. The prevention and management of obesity may represent an approach to control periodontal health. Our study evaluates the prevalence of periodontal diseases in Romania and their association with obesity, as a risk factor.

scholarly journals RADIOGRAPHIC AND IMMUNO HISTOCHEMICAL DIAGNOSTIC STUDY OF STRONTIUM RANELATE AND METAL-SUBSTITUTED HYDROXYAPATITE BONE GRAFT MATERIALS IN DIABETES MELLITUS WITH CHRONIC PERIODONTITIS

2020 ◽  
Vol 8 (11) ◽  
pp. 473-483
Author(s):  
Khashaba Oh ◽  
◽  
Alasfar Aa ◽  
Elgendy Ea ◽  
El-Nagdy Sy ◽  
...  
Keyword(s):  
Strontium Ranelate ◽  
Chronic Periodontitis ◽  
Alveolar Bone ◽  
Periodontal Diseases ◽  
Diabetic Rats ◽  
Treatment Modalities ◽  
Gingival Tissue ◽  
Diagnostic Study ◽  
Tissue Samples ◽  
Periapical Radiography

Objective: The aim of the present study is to assess the radiographic and immunohistochemical effect of strontium ranelate (SR) and metal substituted hydroxyapatite (MSHA) on the treatment of chronic periodontitis among diabetic rats Materials and Methods: The study involved ten adult male and female rice rats (1-month-old) weighting (250- 300g). After a 24-hour fast, a single intraperitoneal dose of freshly prepared alloxan was injected to induce diabetes. A month after the injection of alloxan, the rats were randomly assigned to one of the two treatment modalities: SR with gengigel or MSHA with gengigel. Digital periapical radiography was taken at baseline, a month after the injection of alloxan to see resorbed alveolar bone and after 3months post-operative surgery for radiographic assessment. The diabetic rats were sacrificed using an overdose of anesthesia, and gingival tissue samples were collected. The specimens were processed for hematoxylin and eosin (H & E) staining and immune stain for expression of matrix metalloproteinases 2 (MMP-2). Results: Digital periapical radiography showed an increase of nearly 0.37 mm in the height of the alveolar bone in the side of the SR group while the other side in the MSHA group increased by nearly 0.12 mm. A statistically significant reduction in the expression of MMP2 in the SR group as compared to the MSHA group was found upon comparing the immunohistochemical results of the 2 groups. Conclusion: Radiographic and immunohistochemical results showed that SR was a promising material in the treatment of periodontal diseases.

scholarly journals Mast cell degranulation in periodontal disease from HIV-infected individuals

2019 ◽  
Vol 18 ◽  
pp. e191445
Author(s):  
Giovanna Ribeiro Souto ◽  
Alessandro Oliveira de Jesus ◽  
Takeshi Kato Segundo ◽  
Paôlla Freitas Perdigão ◽  
Fernando de Oliveira Costa ◽  
...  
Keyword(s):  
Mast Cell ◽  
Antiretroviral Therapy ◽  
Mast Cells ◽  
Chronic Periodontitis ◽  
Highly Active Antiretroviral Therapy ◽  
Inflammatory Infiltrate ◽  
Mast Cell Degranulation ◽  
Gingival Tissue ◽  
Highly Active ◽  
Mast Cell Density

Aim: The objective was to compare the density and degranulation of mast cells on specimens obtained from individuals diagnosed with gingivitis or chronic periodontitis who were either non-HIV-infected or HIV-infected patients treated with highly active antiretroviral therapy (HAART). Methods: Gingival samples were taken from 16 non-HIV-infected individuals and 17 HIV-infected individuals diagnosed with gingivitis and chronic periodontitis. The samples were processed and stained with 0.3 percent o-toluidine blue. Densities (cells/mm²) and percentages of intact and degranulated mast cells were obtained. Results: No statistically significant differences were observed in the mast cell density and the percentage of degranulated mast cells between non-HIV-infected and HIV-infected individuals diagnosed with gingivitis and chronic periodontitis. Mononuclear inflammatory infiltrate was weakly correlated with the percentage of mast cells degranulated for both groups. Conclusions: There are no differences of the density and degranulation of mast cells in gingival tissue between non-HIV-infected and HIV-infected patients undergoing HAART, both groups with diagnosis of gingivitis or chronic periodontitis. This may be a result of the recovery of the immunologic system by HAART treatment.

scholarly journals Association of Service Quality with Customer Satisfaction

2020 ◽  
Vol 2 (2) ◽  
pp. 48-68
Author(s):  
Syed Huzaifa Ahmed
Keyword(s):  
Customer Satisfaction ◽  
Service Quality ◽  
Positive Association ◽  
Influential Factors ◽  
Chi Square ◽  
Mba Program ◽  
Qualitative Variables ◽  
Chi Square Test ◽  
The University ◽  
The Relationship

The purpose of this explanatory research is to investigate the relationship of service quality with customer satisfaction. To examine the relationship, the study was conducted on students of the executive MBA program at a business school in Karachi, Pakistan. The research technique adopted for this study was probabilistic in nature. Both variables under consideration are observed through multiple dimensions. A chi-square test was performed to test the relationship between the qualitative variables. Findings indicate that service quality and all its dimensions have a significant and positive association with customer satisfaction at the university level. The education sector is a significant industry in Pakistan’s economy and has seen unparalleled growth and progression over the last decade. Therefore, this study has been explicitly conducted to look into the service quality phenomenon and seek credible scientific justification in this regard by studying service quality as one of the main influential factors towards customer satisfaction.

scholarly journals Evaluation of the Relationship between Drink Intake and Periodontitis Using KoGES Data

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Seok Jin Hong ◽  
Bin Kwon ◽  
Byoung Eun Yang ◽  
Hyo Geun Choi ◽  
Soo Hwan Byun
Keyword(s):  
Green Tea ◽  
Periodontal Diseases ◽  
Soft Drink ◽  
Epidemiological Data ◽  
Chi Square ◽  
Nutritional Factors ◽  
Chi Square Test ◽  
Adjusted Model ◽  
The Relationship

It was hypothesized that periodontal diseases could be influenced by nutrition and food types. However, the role of nutritional factors in the risk of periodontal disease has not been clearly elucidated. This study was aimed at investigating the relationship between coffee, green tea, or soft drink intake and periodontitis. This prospective cohort study used epidemiological data from 2004 to 2016 from the Korean Genome and Epidemiology Study. Among 173,209 participants, 9,933 with periodontitis and 124,922 controls were selected. The frequency histories of coffee/green tea/soft drink intake among the participants were analyzed, and intake was categorized as no drink, mild drink (one time a month through six times a week), and heavy drink (one or more times a day). Variable factors were adjusted using logistic regression analysis (adjusted model). The chi-square test and independent t -test were used for statistical analysis. Adjusted odds ratio (aOR) for coffee or green tea intake and periodontitis were not statistically significant. The aOR was 1.16 (95% confidence interval   CI = 1.11 –1.21, P < 0.001 ) for mild soft drink intake and 1.02 ( 95 % CI = 0.96 –1.09, P = 0.518 ) for heavy soft drink intake. Subgroup analysis showed that mild soft drink intake was significant across all groups ( P < 0.05 ), whereas coffee and green tea intakes were not significant in any subgroup. Overall, the study elucidated an association between mild soft drink intake and periodontitis.

scholarly journals Mast Cells in Human Periodontal Disease

2004 ◽  
Vol 83 (5) ◽  
pp. 384-387 ◽  
Author(s):  
E. Gemmell ◽  
C.L. Carter ◽  
G.J. Seymour
Keyword(s):  
Mast Cell ◽  
Mast Cells ◽  
Periodontal Disease ◽  
Chronic Periodontitis ◽  
Clinical Status ◽  
T Cell Subsets ◽  
Th2 Cells ◽  
Th2 Response ◽  
Cell Numbers ◽  
The Relationship

Recently, mast cells have been shown to produce cytokines which can direct the development of T-cell subsets. The aim of the present study was to determine the relationship between mast cells and the Th1/Th2 response in human periodontal disease. Tryptase+ mast cell numbers were decreased in chronic periodontitis tissues compared with healthy/gingivitis lesions. Lower numbers of c-kit+ cells, which remained constant regardless of clinical status, indicate that there may be no increased migration of mast cells into periodontal disease lesions. While there were no differences in IgG2+ or IgG4+ cell numbers in healthy/gingivitis samples, there was an increase in IgG4+ cells compared with IgG2+ cells in periodontitis lesions, numbers increasing with disease severity. This suggests a predominance of Th2 cells in periodontitis, although mast cells may not be the source of Th2-inducing cytokines.

Periodontal diseases in children

2018 ◽  
Author(s):  
P.A. Heasman ◽  
P.J. Waterhouse
Keyword(s):  
Connective Tissue ◽  
Chronic Periodontitis ◽  
Soft Tissues ◽  
Periodontal Diseases ◽  
Primary Dentition ◽  
Permanent Teeth ◽  
Drug Induced ◽  
Hygiene Practices ◽  
Gingival Diseases ◽  
Herpetic Gingivostomatitis

Periodontal diseases comprise a group of infections that affect the supporting structures of the teeth: marginal and attached gingiva, periodontal ligament, cementum, and alveolar bone. Acute gingival diseases—primarily herpetic gingivostomatitis and necrotizing gingivitis—are ulcerative conditions that result from specific viral and bacterial infection. Chronic gingivitis, however, is a non-specific inflammatory lesion of the marginal gingiva which reflects the bacterial challenge to the host when dental plaque accumulates in the gingival crevice. The development of chronic gingivitis is enhanced when routine oral hygiene practices are impaired. Chronic gingivitis is reversible if effective plaque control measures are introduced. If left untreated, the condition invariably converts to chronic periodontitis, which is characterized by resorption of the supporting connective tissue attachment and apical migration of the junctional epithelia. Slowly progressing, chronic periodontitis affects most of the adult population to a greater or lesser extent, although the early stages of the disease are detected in adolescents. Children are also susceptible to aggressive periodontal diseases that involve the primary and permanent dentitions, and present in localized or generalized forms. These conditions, which are distinct clinical entities affecting otherwise healthy children, must be differentiated from the extensive periodontal destruction that is associated with certain systemic diseases, degenerative disorders, and congenital syndromes. Periodontal tissues are also susceptible to changes that are not, primarily, of an infectious nature. Factitious stomatitis is characterized by self-inflicted trauma to oral soft tissues and the gingiva are invariably involved. Drug-induced gingival enlargement is becoming increasingly prevalent with the widespread use of organ transplant procedures and long-term immunosuppressant therapy. Localized enlargement may occur as a gingival complication of orthodontic treatment. A classification of periodontal diseases in children is given in Table 12.1. Marginal gingival tissues around the primary dentition are more highly vascular and contain fewer connective tissue fibres than tissues around the permanent teeth. The epithelia are thinner with a lesser degree of keratinization, giving an appearance of increased redness that may be interpreted as mild inflammation. Furthermore, the localized hyperaemia that accompanies eruption of the primary dentition can persist, leading to swollen and rounded interproximal papillae and a depth of gingival sulcus exceeding 3mm.

scholarly journals Expression Profile of IL-35 mRNA in Gingiva of Chronic Periodontitis and Aggressive Periodontitis Patients: A Semiquantitative RT-PCR Study

2013 ◽  
Vol 35 ◽  
pp. 819-823 ◽  
Author(s):  
Nagaraj B. Kalburgi ◽  
Akshay Muley ◽  
B. M. Shivaprasad ◽  
Arati C. Koregol
Keyword(s):  
Mrna Expression ◽  
Chronic Periodontitis ◽  
T Regulatory Cells ◽  
Periodontal Diseases ◽  
Aggressive Periodontitis ◽  
Gingival Tissue ◽  
Regulatory Cells ◽  
Rt Pcr ◽  
Tissue Samples ◽  
Polymerase Chain

Background. Proinflammatory and anti-inflammatory cytokines play a key role in the pathogenesis of periodontal diseases. Secretion of bioactive IL-35 has been described by T regulatory cells () and is required for their maximal suppressive activity. are involved in the modulation of local immune response in chronic periodontitis patients.Objective. Hence, the present study was aimed to investigate the expression of IL-35 mRNA in chronic periodontitis and aggressive periodontitis patients.Materials and Methods. The present study was carried out in 60 subjects, which included 20 chronic periodontitis patients, 20 aggressive periodontitis patients, and 20 periodontally healthy controls. IL-35 mRNA expression in gingival tissue samples of all subjects was semiquantitatively analyzed using Reverse Transcriptase Polymerase Chain Reaction (RT-PCR).Results. The present study demonstrated the expression of IL-35 mRNA in gingival tissues of all the three groups. IL-35 mRNA expression was highest in chronic periodontitis subjects () as compared to the aggressive periodontitis group () and least seen in healthy patients ().Conclusion. The increased expression of IL-35 in chronic and aggressive periodontitis suggests its possible role in pathogenesis of periodontitis. Future studies done on large samples with intervention will strengthen our result.

scholarly journals “Low Testosterone Levels in Body Fluids Are Associated With Chronic Periodontitis”

2016 ◽  
Vol 11 (2) ◽  
pp. 443-453 ◽  
Author(s):  
Sergio Varela Kellesarian ◽  
Hans Malmstrom ◽  
Tariq Abduljabbar ◽  
Fahim Vohra ◽  
Tammy Varela Kellesarian ◽  
...  
Keyword(s):  
Systematic Review ◽  
Chronic Periodontitis ◽  
Periodontal Diseases ◽  
Positive Association ◽  
Body Fluids ◽  
Salivary Testosterone ◽  
Testosterone Levels ◽  
Significant Difference ◽  
Low Testosterone ◽  
Present Systematic Review

There is a debate over the association between low testosterone levels in body fluids and the occurrence of chronic periodontitis (CP). The aim of the present systematic review was to assess whether low testosterone levels in body fluids reflect CP. In order to identify studies relevant to the focus question: “Is there a relationship between low testosterone levels in body fluids and CP?” an electronic search without time or language restrictions was conducted up to June 2016 in indexed databases using different keywords: periodontitis, chronic periodontitis, periodontal diseases, testosterone, and gonadal steroid hormones. A total of eight studies were included in the present systematic review. The number of study participants ranged from 24 to 1,838 male individuals with ages ranging from 15 to 95 years. Seven studies measured testosterone levels in serum, two studies in saliva, and one study in gingiva. Four studies reported a negative association between serum testosterone levels and CP. Two studies reported a positive association between decreased testosterone levels in serum and CP. Increased levels of salivary testosterone among patients with CP were reported in one study; whereas one study reported no significant difference in the concentration of salivary testosterone between patients with and without CP. One study identified significant increase in the metabolism of testosterone in the gingiva of patients with CP. Within the limits of the evidence available, the relationship between low testosterone levels and CP remains debatable and further longitudinal studies and control trials are needed.

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