scholarly journals Multi-Organ Expression Profiling Uncovers a Gene Module in Coronary Artery Disease Involving Transendothelial Migration of Leukocytes and LIM Domain Binding 2: The Stockholm Atherosclerosis Gene Expression (STAGE) Study

PLoS Genetics ◽  
2009 ◽  
Vol 5 (12) ◽  
pp. e1000754 ◽  
Author(s):  
Sara Hägg ◽  
Josefin Skogsberg ◽  
Jesper Lundström ◽  
Peri Noori ◽  
Roland Nilsson ◽  
...  
Keyword(s):  
Gene Expression ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Expression Profiling ◽  
Transendothelial Migration ◽  
Gene Module ◽  
Lim Domain ◽  
Artery Disease

scholarly journals Gene expression profiling in whole blood of patients with coronary artery disease

2010 ◽  
Vol 119 (8) ◽  
pp. 335-343 ◽  
Author(s):  
Chiara Taurino ◽  
William H. Miller ◽  
Martin W. McBride ◽  
John D. McClure ◽  
Raya Khanin ◽  
...  
Keyword(s):  
Gene Expression ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Gene Expression Profiling ◽  
Whole Blood ◽  
Expression Profiling ◽  
Gene Expression Analysis ◽  
Differentially Expressed ◽  
Differentially Expressed Mirnas ◽  
Artery Disease

Owing to the dynamic nature of the transcriptome, gene expression profiling is a promising tool for discovery of disease-related genes and biological pathways. In the present study, we examined gene expression in whole blood of 12 patients with CAD (coronary artery disease) and 12 healthy control subjects. Furthermore, ten patients with CAD underwent whole-blood gene expression analysis before and after the completion of a cardiac rehabilitation programme following surgical coronary revascularization. mRNA and miRNA (microRNA) were isolated for expression profiling. Gene expression analysis identified 365 differentially expressed genes in patients with CAD compared with healthy controls (175 up- and 190 down-regulated in CAD), and 645 in CAD rehabilitation patients (196 up- and 449 down-regulated post-rehabilitation). Biological pathway analysis identified a number of canonical pathways, including oxidative phosphorylation and mitochondrial function, as being significantly and consistently modulated across the groups. Analysis of miRNA expression revealed a number of differentially expressed miRNAs, including hsa-miR-140-3p (control compared with CAD, P=0.017), hsa-miR-182 (control compared with CAD, P=0.093), hsa-miR-92a and hsa-miR-92b (post- compared with pre-exercise, P<0.01). Global analysis of predicted miRNA targets found significantly reduced expression of genes with target regions compared with those without: hsa-miR-140-3p (P=0.002), hsa-miR-182 (P=0.001), hsa-miR-92a and hsa-miR-92b (P=2.2×10−16). In conclusion, using whole blood as a ‘surrogate tissue’ in patients with CAD, we have identified differentially expressed miRNAs, differentially regulated genes and modulated pathways which warrant further investigation in the setting of cardiovascular function. This approach may represent a novel non-invasive strategy to unravel potentially modifiable pathways and possible therapeutic targets in cardiovascular disease.

scholarly journals Gene expression profiling of CD133-positive cells in coronary artery disease

2015 ◽  
Vol 12 (5) ◽  
pp. 7512-7516 ◽  
Author(s):  
JIAYU LI ◽  
CHANGYU ZHOU ◽  
JIARUI LI ◽  
YINGCHUN WAN ◽  
TAO LI ◽  
...  
Keyword(s):  
Gene Expression ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Gene Expression Profiling ◽  
Expression Profiling ◽  
Artery Disease

Gene expression profiling of coronary artery disease and its relation with different severities

2018 ◽  
Vol 97 (4) ◽  
pp. 853-867
Author(s):  
Shiridhar Kashyap ◽  
Sudeep Kumar ◽  
Vikas Agarwal ◽  
Durga P. Misra ◽  
Shubha R. Phadke ◽  
...  
Keyword(s):  
Gene Expression ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Gene Expression Profiling ◽  
Expression Profiling ◽  
Artery Disease

scholarly journals Gene expression profiling for coronary artery disease and its relation with different severity

2017 ◽  
Vol 69 ◽  
pp. S29-S30
Author(s):  
K. Shiridhar ◽  
K. Sudeep ◽  
A. Vikas ◽  
M. Durga ◽  
P. Shubha ◽  
...  
Keyword(s):  
Gene Expression ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Gene Expression Profiling ◽  
Expression Profiling ◽  
Artery Disease
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