scholarly journals Validating controlled attenuation parameter in the assessment of hepatic steatosis in living liver donors

PLoS ONE ◽  
2021 ◽  
Vol 16 (5) ◽  
pp. e0251487
Author(s):  
Dieter Broering ◽  
Mohamed Shawkat ◽  
Ali Albenmousa ◽  
Faisal Abaalkhail ◽  
Saleh Alabbad ◽  
...  
Keyword(s):  
Liver Biopsy ◽  
Hepatic Steatosis ◽  
Transient Elastography ◽  
Gamma Glutamyl Transferase ◽  
Controlled Attenuation Parameter ◽  
Predictive Values ◽  
Attenuation Parameter ◽  
Glutamyl Transferase ◽  
Living Liver Donors ◽  
Liver Donors

Introduction Hepatic steatosis (HS) negatively impacts transplant outcomes in living liver donors. To date, liver biopsy is preferred for HS evaluation. This study aims to evaluate the measurement of controlled attenuation parameter (CAP) as a diagnostic tool of HS in living liver donors. Methods Candidates recruited to this study, conducted from April 2016 to February 2020, were potential donors who had undergone transient elastography using Fibroscan® and CAP measurements at liver segments VI and VII, followed by liver biopsy. The HS grades from liver biopsy were classified as S0 (<5%), S1 (5–33%), S2 (33–66%), and S3 (>66%). For CAP, they were S0 (≤218dB/m), S1 (218-249dB/m)), S2 (250-305dB/m)), and S3 (>305dB/m)). The CAP measurements were compared with the liver biopsy results. Results Of the 150 potential donors [male, 73.3%; mean age, 30.0±7.0 years; body mass index (BMI), 24.7±3.5kg/m2], 92 (61.3%) had no or mild HS, while 58 (38.7%) and 10% had moderate to severe HS based on CAP and liver biopsy, respectively. Subjects with moderate to severe HS per CAP were mostly males (0.014), and had higher BMI (p = .006), alanine aminotransferase (ALT) (.001), gamma-glutamyl transferase (.026), and high-density lipoprotein (.008). On multivariate analysis, high ALT (OR, 1.051; 95% CI, 1.016–1.087; p = .004) was a predictor of significant HS. The sensitivity, specificity, positive and negative predictive values of CAP to detect significant HS were 93.3%, 67.4, 24.1%, and 98.9%, respectively. Conclusion The high sensitivity and negative predictive values of CAP make it a good screening test to exclude significant HS in potential living liver donors which, in turn, can help avoid unnecessary liver biopsies.

scholarly journals Predicting Hepatic Steatosis in Living Liver Donors Via Controlled Attenuation Parameter

2018 ◽  
Vol 50 (10) ◽  
pp. 3533-3538 ◽  
Author(s):  
Y.H. Yen ◽  
F.Y. Kuo ◽  
C.C. Lin ◽  
C.L. Chen ◽  
K.C. Chang ◽  
...  
Keyword(s):  
Hepatic Steatosis ◽  
Controlled Attenuation Parameter ◽  
Attenuation Parameter ◽  
Living Liver Donors ◽  
Liver Donors

Discordance in steatosis classification between liver biopsy and transient elastography for high controlled attenuation parameter (CAP) values

2018 ◽  
Vol 56 (01) ◽  
pp. 36-42 ◽  
Author(s):  
Johanna Galaski ◽  
Lisa Schulz ◽  
Jenny Krause ◽  
Ansgar Lohse
Keyword(s):  
Liver Biopsy ◽  
Hepatic Steatosis ◽  
Transient Elastography ◽  
Histological Grade ◽  
Histological Evaluation ◽  
Clinical Parameters ◽  
Diagnostic Validity ◽  
Ultrasound Guided ◽  
Controlled Attenuation Parameter ◽  
Attenuation Parameter

Abstract Objective The controlled attenuation parameter (CAP) measured by transient elastography allows for the noninvasive assessment of hepatic steatosis. However, discrepant results between CAP values and histological evaluation have been reported in particular with high CAP values. We therefore investigated the diagnostic validity of high CAP measurements. Methods Forty patients with liver disease and CAP measurements > 300 dB/m that underwent ultrasound-guided or minilaparoscopic liver biopsy were retrospectively enrolled. CAP values were compared with the respective histological and macroscopic evaluation and correlated with clinical parameters. Results CAP values > 300 dB/m had an 87.5 % specificity for detection of hepatic steatosis but failed to discriminate between steatosis grade S1 – S3. Discordant results, defined as a discrepancy of at least 2 steatosis grades between transient elastography and liver biopsy, were observed in 40 % of cases. The interquartile range (IQR) of CAP was confirmed as a predictor of discrepant findings. Macroscopic evaluation as part of minilaparoscopy detected hepatic steatosis in 74 % of patients with histological grade S2 – S3 in contrast to only 10 % classified as histological grade S0 – S1. Conclusion High CAP measurements need to be interpreted with care and with regard to clinical parameters, in particular when high IQR values are registered.

Controlled Attenuation Parameter (CAP): a noninvasive method for the detection of hepatic steatosis based on transient elastography

2012 ◽  
Vol 32 (6) ◽  
pp. 902-910 ◽  
Author(s):  
Robert P. Myers ◽  
Aaron Pollett ◽  
Richard Kirsch ◽  
Gilles Pomier-Layrargues ◽  
Melanie Beaton ◽  
...  
Keyword(s):  
Hepatic Steatosis ◽  
Transient Elastography ◽  
Noninvasive Method ◽  
Controlled Attenuation Parameter ◽  
Attenuation Parameter

Detection of hepatic steatosis using the controlled attenuation parameter: a comparative study with liver biopsy

2014 ◽  
Vol 49 (5) ◽  
pp. 611-616 ◽  
Author(s):  
Yusuf Yilmaz ◽  
Atakan Yesil ◽  
Fatma Gerin ◽  
Rabia Ergelen ◽  
Hakan Akin ◽  
...  
Keyword(s):  
Liver Biopsy ◽  
Comparative Study ◽  
Hepatic Steatosis ◽  
Controlled Attenuation Parameter ◽  
Attenuation Parameter

scholarly journals Vibration-Controlled Transient Elastography and Controlled Attenuation Parameter for the Diagnosis of Liver Steatosis and Fibrosis in Patients with Nonalcoholic Fatty Liver Disease

Diagnostics ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 787
Author(s):  
Sebastian Zenovia ◽  
Carol Stanciu ◽  
Catalin Sfarti ◽  
Ana-Maria Singeap ◽  
Camelia Cojocariu ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Hepatic Steatosis ◽  
Fatty Liver Disease ◽  
Transient Elastography ◽  
Liver Steatosis ◽  
Controlled Attenuation Parameter ◽  
Nonalcoholic Fatty Liver ◽  
Attenuation Parameter

Vibration-Controlled Transient Elastography (VCTE) with Controlled Attenuation Parameter (CAP) is a widely used non-invasive technique for concomitant assessment of liver steatosis and fibrosis in patients with nonalcoholic fatty liver disease (NAFLD). We aimed to evaluate the level both of hepatic steatosis and fibrosis as well as the associated risk factors in patients referred to our unit with clinically suspected NAFLD or diagnosed by abdominal ultrasonography. Two hundred four patients were prospectively included in this study and assessed by VCTE with CAP. The final analysis included 181 patients with reliable liver stiffness measurements (LSMs) (53% female, mean age 57.62 ± 11.8 years and BMI 29.48 ± 4.85 kg/m2). According to the cut-off values for steatosis grading, there were 10 (5.5%) patients without steatosis (S0), 30 (16.6%) with mild (S1), 45 (24.9%) moderate (S2), and 96 (53%) severe (S3) steatosis. Based on LSM, there were 73 (40.3%) patients without fibrosis (F0), 42 (23.2%) with mild (F1), 32 (17.7%) significant (F2), 19 (10.5%) advanced (F3) fibrosis, and 15 (8.3%) with cirrhosis (F4). In addition, we found an association between several metabolic components and hepatic steatosis and fibrosis. Thus, in the multivariate analysis, higher BMI, fasting plasma glucose, triglycerides, low-density lipoprotein cholesterol, and serum uric were associated with increased CAP. Furthermore, higher serum uric acid and alpha-fetoprotein together with lower platelets count and albumin levels were associated with increased LSM. The assessment of steatosis and fibrosis using VCTE and CAP should be performed in all patients with suspected or previously diagnosed NAFLD in units with available facilities.

Sign in / Sign up

Export Citation Format

Share Document