The Biophysical Modeling of the Hemodynamic in the Human Organism

2020 ◽  
Vol 7 (11) ◽  
pp. 494-502
Author(s):  
Janos Vincze ◽  
Gabriella Vincze-Tiszay ◽  
Julianna Szakacs
Keyword(s):  
Blood Flow ◽  
Vascular System ◽  
Experimental Testing ◽  
Real Life ◽  
Pathological Process ◽  
Human Organism ◽  
Main Function ◽  
Biophysical Modeling ◽  
Circulatory Apparatus ◽  
Cardio Vascular

The circulatory apparatus has as a main function the constant maintaining of the internal environment in all the regions of the organism. The blood is a liquid tissue, being formed of a fundamental substance – plasma and blood cells. Heart is the central organ of the cardiovascular apparatus. The heart muscles have numerous biophysical properties. The cardiac muscle is never tired unless it suffered a pathological process. During the diastole, blood is aspired in the heart and during the systole it is pushed in the big and small circulation. The blood amount pushed from the heart in the vascular system in a certain time represents the blood flow. The biophysical methods are next: we administer a certain substance amount, then its passing speed will depend on its concentration; to apply the calorimetric principles for the measurement of the gastric blood flow; the diagnostic of a chronic peripheral arteriopathy we use the calorimetric method is based on measuring the heat being introduced in a certain amount of water which has known temperature; one of the most often used methods for the evaluation of the use of radioisotopes in the cardio-vascular system is the compartment method. Any attempt to apply biophysics to the life systems involves three stages. First we observe the phenomena and formulate a biophysical description in the form of equations; after to solve the equations. Finally we return to the real life system and interpret this solution in terms of reality, this interpretation may requiew experimental testing.

Some Biophysical Modeling of the Human Circulation Apparatus

2020 ◽  
Vol 3 (8) ◽  
Author(s):  
Janos Vincze ◽  
Gabriella Vincze- Tiszay
Keyword(s):  
Circulatory System ◽  
Work Capacity ◽  
Human Organism ◽  
Biophysical Modeling ◽  
System Disease ◽  
Control Functions ◽  
Global Trend ◽  
Circulatory Apparatus ◽  
Peripheral Arterial ◽  
Contraction And Relaxation

Statistics from Hungary over the last seven years clearly show that diseases of the circulatory device lead the statistics on the causes of death. The Hungarian trend is the same as the global trend, with circulatory system disease being the most common cause of death in every country. The modeling of the blood volume, if we administer a certain substance amount, then its passing speed will depend on its concentration, hence the volume at which it spreads in the deposit. Consider the contraction and relaxation of the atrium/ventricle of the human heart; use the function of the rhythmic change for this. We apply the calorimetric principles for the measurement of the gastric blood flow. In the physio­pathology research of the circulation in arteriopathic people, when there are necessary arguments refering to the efficiency of new medicines or for the purpose of reestablishing the work capacity, the clinic diagnostic must be completed with laboratory samples: regional debt, peripheral arterial resistance, circulation time. Its measuring can be made with a normal double walls calorimeter and we measure the water temperature variations. Knowing the values of the previous formulas and the mass of blood circulated in that segment, we find out the segment’s flow. The human organism is a system because it is made up of a finite number of interacting p1, p2,… pn elements, characterized by the quantitative degree of q1, q2,… qn. The circulatory apparatus is a subsystem of the human body. In our opinion, the circulatory device should have a control associated with its own structure, which is likely to consist of neurons with hyperordonated spatial structure, called the “hypothetical secondary brain”, which performs certain control functions. This “hypothetical secondary brain” of the circulatory apparatus, in humans, functions continuously throughout their life.

Changes of State of Cardio-Vascular System in People with Different Levels of Meteosensitivity

2017 ◽  
Vol 2 (2) ◽  
pp. 66-70
Author(s):  
N. A. Vaschuk ◽  
◽  
M. U. Prudenko ◽  
N. S. Hloba ◽  
A. A. Kurbel
Keyword(s):  
Vascular System ◽  
Cardio Vascular ◽  
Different Levels ◽  
Changes Of State

Microfluidics of blood in blood vessels stenosis

2016 ◽  
Vol 11 (2) ◽  
pp. 210-217 ◽  
Author(s):  
A.T. Akhmetov ◽  
A.A. Valiev ◽  
A.A. Rakhimov ◽  
S.P. Sametov ◽  
R.R. Habibullina
Keyword(s):  
Blood Flow ◽  
Blood Vessels ◽  
Hydraulic Resistance ◽  
Microfluidic Device ◽  
Human Body ◽  
Vascular System ◽  
Hydrodynamic Conditions ◽  
Microstructure Change ◽  
Healthy Part

It is mentioned in the paper that hydrodynamic conditions of a flow in blood vessels with the stenosis are abnormal in relation to the total hemodynamic conditions of blood flow in a vascular system of a human body. A microfluidic device developed with a stepped narrowing for studying of the blood flow at abnormal conditions allowed to reveal blood structure in microchannels simulating the stenosis. Microstructure change is observed during the flow of both native and diluted blood through the narrowing. The study of hemorheological properties allowed us to determine an increasing contribution of the hydraulic resistance of the healthy part of the vessel during the stenosis formation.

A model of a human heart via graph nano topological spaces

2019 ◽  
Vol 12 (01) ◽  
pp. 1950006 ◽  
Author(s):  
Ashraf S. Nawar ◽  
Abd El Fattah A. El Atik
Keyword(s):  
Blood Flow ◽  
Blood Circulation ◽  
Human Heart ◽  
Flow System ◽  
Real Life ◽  
Topological Spaces ◽  
Neighborhood System

In this paper, new forms of nano topological spaces through a neighborhood system of vertices for a digraph will be presented and studied. We apply the connection between digraph theory and nano topological spaces in the human heart as an example in real life. We have a blood flow system in the human heart with respect to oxygenated and deoxygenated blood circulation. Our study will be definitely helpful to develop a tool in solving the blood flow system in the human heart. Finally, we have succeeded in improving Proposition 1.6 in [7] and Proposition 4.4.1 in [11].

Retinal and choroidal blood flow variations after an endurance exercise: A real-life pilot study at the Paris Marathon

2021 ◽  
Author(s):  
Martine Mauget-Faÿsse ◽  
Nicolas Arej ◽  
Morgane Paternoster ◽  
Kevin Zuber ◽  
Sabine Derrien ◽  
...  
Keyword(s):  
Blood Flow ◽  
Pilot Study ◽  
Endurance Exercise ◽  
Real Life ◽  
Choroidal Blood Flow

Growth regulation of the vascular system: evidence for a metabolic hypothesis

1990 ◽  
Vol 259 (3) ◽  
pp. R393-R404 ◽  
Author(s):  
T. H. Adair ◽  
W. J. Gay ◽  
J. P. Montani
Keyword(s):  
Blood Flow ◽  
Blood Vessels ◽  
Growth Regulation ◽  
Vascular System ◽  
Major Influence ◽  
Control Element ◽  
Hypoxic Conditions ◽  
Control Growth ◽  
Vessel Growth ◽  
Tissue Cells

Prolonged imbalances between the perfusion capabilities of the blood vessels and the metabolic requirements of the tissue cells often lead to modification of the vasculature to satisfy the tissue needs. This homeostatic response appears to be bidirectional, since the vascularity of a tissue can increase or decrease in parallel with primary changes in metabolic rate. The factors that mediate the responses are not well understood, but oxygen has been implicated as a major control element, since vessel growth increases during hypoxic conditions and decreases during hyperoxic conditions. The following feedback control hypothesis may apply to many different physiological situations. Decreased oxygenation causes the tissues to become hypoxic, and this initiates a variety of signals that lead to the growth of blood vessels. The increase in vascularity promotes oxygen delivery to the tissue cells by decreasing diffusion distances, increasing capillary surface area, and increasing the maximum rate of blood flow. When the tissues receive adequate amounts of oxygen even during periods of peak activity, the intermediate effectors return to normal levels, and this negative signal, in turn, stops the further development of the vasculature. Although the effector mechanisms of the hypoxic stimulus are still being investigated, adenosine, which is produced in hypoxic tissues, appears to mediate hypoxia-induced increases in vascularity in some instances. Roles for fibroblast growth factor as well as mechanical factors associated with vasodilation and increased blood flow are postulated. Although blood vessel growth is a multifactorial process, a major influence in its regulation appears to be metabolic need. If this view is correct, it may be found that many of the quantitatively significant factors that control growth in a given vasculature are themselves modulated or controlled by metabolic signals reflecting the nutritional status of the tissues which that vasculature supplies.

Sign in / Sign up

Export Citation Format

Share Document