scholarly journals Umbilical cord levels of sclerostin, placental weight, and birth weight are predictors of total bone mineral content in neonates

2013 ◽  
Vol 168 (3) ◽  
pp. 371-378 ◽  
Author(s):  
Kristin Godang ◽  
Kathrine Frey Frøslie ◽  
Tore Henriksen ◽  
Gunhild A Isaksen ◽  
Nanna Voldner ◽  
...  
Keyword(s):  
Birth Weight ◽  
Bone Mineral Content ◽  
Umbilical Cord ◽  
Bone Mineral ◽  
Mineral Content ◽  
Skeletal Development ◽  
Fibroblast Growth Factor 23 ◽  
Wnt Signaling Pathway ◽  
Placental Weight ◽  
Main Role

ContextDuring pregnancy, changes occur in the maternal calcium homeostasis to fulfill fetal demand. We hypothesized that the fibroblast growth factor 23 (FGF23) system and Wnt signaling pathway are important for normal skeletal development in the offspring.AimsCirculating α-klotho, FGF23, sclerostin, and 25-hydroxyvitamin D (25(OH)D) at the fetal and maternal sides of the placenta were measured to investigate associations with newborn bone mass independent of maternal BMI, calcium and phosphate levels, placental weight, and birth weight.MethodsIn a prospective cohort of healthy pregnant women, the total body bone mineral content (BMC) in 202 newborns was measured by dual-energy X-ray absorptiometry. Maternal circulating levels of the biomarkers were measured at gestational weeks 30–32 and in umbilical cord plasma (UCP) at birth.ResultsMean α-klotho and sclerostin concentrations in the UCP were significantly higher than maternal levels (3004 vs 1077 pg/ml;P<0.001 and 629 vs 346 pg/ml;P<0.001 respectively), and mean 25(OH)D was lower (31 vs 45 nmol/l;P<0.001). The UCP and maternal FGF23 levels were similar. No significant effects of maternal biomarkers on BMC were found in regression analyses. Among UCP biomarkers, only UCP sclerostin was significantly associated with BMC in univariate analyses, and the effect remained significant after adjustment for birth weight and other confounders.ConclusionsWe found that UCP sclerostin levels, birth weight, and placental weight were significant predictors of neonatal BMC but found no evidence for a main role of maternal levels of α-klotho, FGF23, sclerostin, or 25(OH)D nor of UCP levels of α-klotho, FGF23, or 25(OH)D.

scholarly journals Diabetes during Pregnancy Does Not Alter Whole Body Bone Mineral Content in Infants

1997 ◽  
Vol 82 (12) ◽  
pp. 3993-3997 ◽  
Author(s):  
Alexandre Lapillonne ◽  
Sophie Guerin ◽  
Pierre Braillon ◽  
Olivier Claris ◽  
Pierre D. Delmas ◽  
...  
Keyword(s):  
Birth Weight ◽  
Bone Mineral Content ◽  
Bone Mineral ◽  
Fat Mass ◽  
Gestational Age ◽  
Mineral Content ◽  
Whole Body ◽  
X Ray ◽  
Diabetic Mothers ◽  
Body Bone

A previous study using single photon absorptiometry has reported low bone mineral density of the radius in infants of diabetic mothers. The aim of this study was to assess by dual x-ray absorptiometry the whole body bone mineral content (WbBMC) and the body composition of 40 infants of diabetic mothers at birth (mean gestational age ± sd, 37.5 ± 1.3 weeks; mean birth weight ± sd, 3815 ± 641 g). WbBMC was not correlated with gestational age, but was well correlated with birth weight (r = 0.73; P = 0.0001) and also with fat mass (r = 0.87; P = 0.0001) and lean mass (r = 0.42; P = 0.008). The z-scores ± sd adjusted for weight for WbBMC and fat mass were significantly increased (1.3 ± 0.9 and 2.6 ± 1.3, respectively (P &lt; 0.0001), but were not significantly influenced either by in utero growth or by the type of the diabetes mellitus of the mother. Bone mineralization and fat mass studied by whole body dual x-ray absorptiometry are increased at birth in these infants compared with reference curves.

scholarly journals Maternal and Neonatal Factors Affecting Bone Mineral Content of Indonesian Term Newborns

2021 ◽  
Vol 9 ◽  
Author(s):  
Tunjung Wibowo ◽  
Neti Nurani ◽  
Janatin Hastuti ◽  
Alifah Anggraini ◽  
Rina Susilowati ◽  
...  
Keyword(s):  
Birth Weight ◽  
Bone Mineral Content ◽  
Bone Mineral ◽  
Gestational Age ◽  
Mineral Content ◽  
Bone Mineralization ◽  
Adult Life ◽  
Developed Countries ◽  
Whole Body ◽  
Term Newborns

Background: Interactions between the genome and intrauterine environment can affect bone mineralization in newborns and even in adult life. Several studies show that intrauterine fetal bone mineralization or early postnatal bone condition influences the risk of osteoporosis in later life.Objectives: To determine whole body bone mineral content (WB BMC) and factors that influence neonatal WB BMC in Indonesian term newborns.Subjects/Methods: A cross-sectional study was conducted in Dr. Sardjito General Hospital, Yogyakarta, Indonesia. A total of 45 term, appropriate for gestational age (AGA) newborns were included in this study. BMC was assessed by dual-energy x-ray absorptiometry (DXA) in the first week of life. Weight (g), length (cm) and head circumference (cm) were measured at birth. Data on maternal characteristics were obtained from the maternal health records or reported by the mothers.Results: WB BMC measured in the present study (mean ± SD: 33.2 ± 9.3 g) was lower than WB BMC of similar populations in developed countries. Multiple linear regression showed that birth weight, birth length, and gestational age had a positive association with WB BMC (p = 0.048, 0.017, and &lt;0.001, respectively), while maternal cigarette exposure had a negative association with WB BMC (p = 0.012). Male infants had significantly higher of WB BMC than female (p = 0.025). These determinants contribute to 55% variability of WB BMC.Conclusions: WB BMC in Indonesian term newborns is lower than populations in developed countries. Birth weight, length, gestational age, sex, and maternal cigarette exposure during pregnancy are significantly associated with WB BMC observed in Indonesian newborns.

scholarly journals Bone Mineral Content at Birth Is Determined Both by Birth Weight and Fetal Growth Pattern

2008 ◽  
Vol 64 (1) ◽  
pp. 86-90 ◽  
Author(s):  
Jacques Beltrand ◽  
Marianne Alison ◽  
Ramona Nicolescu ◽  
Rasa Verkauskiene ◽  
Samia Deghmoun ◽  
...  
Keyword(s):  
Birth Weight ◽  
Bone Mineral Content ◽  
Bone Mineral ◽  
Fetal Growth ◽  
Growth Pattern ◽  
Mineral Content

Is there an impact of birth weight and early life nutrition on bone mineral content in preterm born infants and children?

1993 ◽  
Vol 82 (9) ◽  
pp. 711-713 ◽  
Author(s):  
Alessandro Rubinacci ◽  
Paolo Sirtori ◽  
Guido Moro ◽  
Laura Galli ◽  
Iolanda Minoli ◽  
...  
Keyword(s):  
Birth Weight ◽  
Bone Mineral Content ◽  
Bone Mineral ◽  
Early Life ◽  
Mineral Content ◽  
Infants And Children ◽  
Preterm Born

Mineral balance and whole body bone mineral content in very low-birth-weight infants

1994 ◽  
Vol 83 (s405) ◽  
pp. 117-122 ◽  
Author(s):  
AA Lapillonne ◽  
FH Glorieux ◽  
BL Salle ◽  
PM Braillon ◽  
M Chambon ◽  
...  
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Bone Mineral Content ◽  
Bone Mineral ◽  
Mineral Content ◽  
Very Low Birth Weight ◽  
Whole Body ◽  
Low Birth Weight Infants ◽  
Mineral Balance ◽  
Body Bone

scholarly journals Enhanced lumbar spine bone mineral content in piglets fed arachidonic acid and docosahexaenoic acid is modulated by severity of growth restriction

2009 ◽  
Vol 102 (8) ◽  
pp. 1117-1120 ◽  
Author(s):  
June Kohut ◽  
Bruce Watkins ◽  
Hope Weiler
Keyword(s):  
Arachidonic Acid ◽  
Fatty Acid ◽  
Birth Weight ◽  
Lumbar Spine ◽  
Bone Resorption ◽  
Low Birth Weight ◽  
Bone Mass ◽  
Bone Mineral Content ◽  
Bone Mineral ◽  
Mineral Content

The infant born small size for gestational age (SGA) has low bone mass. Since dietary arachidonic acid (AA) and DHA enhance bone mass in normal-birth-weight piglets the objective of the present study was to test for such benefits in the SGA piglet. In the present 15 d study, two levels of dietary AA and DHA (6:1 ratio of AA:DHA diets, 0·6:0·1 or 1·2:0·2 g/100 g dietary fat) v. a control diet were tested for effects on growth, fatty acid status, whole-body and regional bone mineral content (BMC) and metabolism in SGA piglets categorised as either very low birth weight (VLBW; ≤ 1·0 kg; n 12) or low birth weight (LBW; 1·1 to 1·2 kg; n 18). Differences in outcomes for each body weight category were detected using ANOVA with post hoc Bonferroni tests. Growth was not influenced by diet, yet the LBW piglets fed 0·6:0·1 AA and DHA as g/100 g fat had elevated BMC in the spine, whereas the VLBW piglets had higher BMC of the spine if fed the higher intake of AA and DHA. In both weight categories, the higher intake of AA and DHA lowered bone resorption relative to controls, whereas bone formation was unchanged. Tissue fatty acid concentrations reflected dietary AA and DHA, especially trabecular bone of VLBW piglets. Whether the enhanced lumbar spine BMC is due to enhanced Ca absorption and thus suppression of bone resorption remains to be established.

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