scholarly journals Synthesis, Characterization and Antimicrobial Activity of some New Oxadiazole Derivatives in DMSO and DMF

2015 ◽  
Vol 56 ◽  
pp. 104-112
Author(s):  
Shipra Baluja ◽  
Sumitra Chanda ◽  
Paras Ramavat
Keyword(s):  
Antimicrobial Activity ◽  
Mass Spectroscopy ◽  
Gram Negative Bacteria ◽  
Gram Positive ◽  
Gram Negative ◽  
Fungal Strains ◽  
Gram Positive Bacteria ◽  
H Nmr ◽  
Oxadiazole Derivatives

A series of oxadiazole derivatives were synthesized and were characterized by IR, 1H NMR and mass spectroscopy. All these synthesized compounds were tested for in vitro antimicrobial against four Gram positive bacteria, four Gram negative bacteria and four fungal strains in DMSO and DMF.

scholarly journals Synthesis and Evaluation of Some Coumarin Based Schiff's Bases as Potential Antimicrobial Agents'

2012 ◽  
Vol 9 (4) ◽  
pp. 2079-2088 ◽  
Author(s):  
Vishakha Bansode ◽  
Meenakshi N. Deodhar
Keyword(s):  
Antimicrobial Activity ◽  
Antimicrobial Agents ◽  
Gram Negative Bacteria ◽  
Gram Positive ◽  
Gram Negative ◽  
Gram Positive Bacteria ◽  
H Nmr ◽  
Nmr Data ◽  
Bacteria And Fungi

A series of the title compounds 3-(4-(4, 5-dihydro-5-(substituted phenyl)-1H-3-pyrazolyl) phenylimino) methyl)-4-chloro-2H-chromen-2-one 5(a-g) have been synthesized. These compounds were characterized on the basis of their spectral (IR,1H NMR) data and evaluated for antimicrobial activityin vitroagainst gram positive bacteria, gram negative bacteria and fungi. The compound (5b) was found to be the most active with MIC of 20 µg/ml against all the tested organisms.

scholarly journals Synthesis and Pharmacological Evaluation of Some New 2-Phenyl benzimidazoles Derivatives and their Schiff's Bases

2009 ◽  
Vol 6 (s1) ◽  
pp. S342-S346 ◽  
Author(s):  
Y. S. Chhonker ◽  
B. Veenu ◽  
S. R. Hasim ◽  
Niranjan Kaushik ◽  
Devendra Kumar ◽  
...  
Keyword(s):  
Antimicrobial Activities ◽  
Benzimidazole Derivatives ◽  
Spectroscopic Techniques ◽  
Gram Negative Bacteria ◽  
Gram Positive ◽  
Gram Negative ◽  
Gram Positive Bacteria ◽  
H Nmr ◽  
Ir Spectroscopic

Some new 2- phenyl benzimidazole derivatives were synthesised by cyclocondensation with appropriate reagents. The compounds synthesised were identified by1H NMR, FAB Mass and FT-IR spectroscopic techniques. All compounds studied in this work were screened for theirin vitroantimicrobial activities against the standard strains:Staphylococcus aureusATCC - 25923, ATCC - 441 andBacillus subtilisATCC- 6633 as gram positive,Escherichia coliATCC - 11775 andPseudomonas aeruginosaATCC 10145 as gram negative bacteria. Some of the compounds inhibited the growth of gram-positive bacteria (B. subtilisandS. aureus) at MIC values between 25 and 200 mg/mL. Some of the compounds exhibit antimicrobial activity against gram negative bacteria (E. coliandP. Aeruginosa) MIC values between 25 and 200 mg/mL.

scholarly journals Chemical Composition and in vitro Antimicrobial Activity of the Essential Oil of the Flowers of Tridax procumbens

2012 ◽  
Vol 7 (7) ◽  
pp. 1934578X1200700 ◽  
Author(s):  
Rajesh K. Joshi ◽  
Vijaylaxmi Badakar
Keyword(s):  
Gas Chromatography ◽  
Antimicrobial Activity ◽  
Essential Oil ◽  
Gram Negative Bacteria ◽  
Gram Positive ◽  
Gram Negative ◽  
Gram Positive Bacteria ◽  
Flame Ionization ◽  
Tridax Procumbens

The essential oil of the flowers of Tridax procumbens L. was obtained by hydro-distillation and analyzed by gas chromatography equipped with a flame ionization detector (GC-FID) and gas chromatography coupled with mass spectrometry (GC/MS). Twenty-six compounds were identified, which comprised 90.6% of the total constituents. The most abundant compound was ( Z)-falcarinol (25.9%), followed by α-selinene (15.3%), limonene (8.3%) and zerumbone (4.3%). Antimicrobial activity was tested against six Gram-positive and eight Gram-negative bacteria, and three fungi. The oil was active against the tested Gram-positive bacteria at a concentration range of 0.14 ± 0.03 - 0.57±0.05 mg/mL, while 0.67 ± 0.12 - 4.58 ± 0.41 mg/mL was effective against the studied Gram-negative bacteria. Remarkable antifungal activity was found against the tested fungi at a concentration range of 0.06 ± 0.008 - 0.10 ± 0.01 mg/mL.

scholarly journals Synthesis and Preliminary Biological Activity Evaluation of New N- Substituted Phthalimide Derivatives

2020 ◽  
Vol 29 (1) ◽  
pp. 247-252
Author(s):  
Halah A. Sahib ◽  
Mohammed H. Mohammed
Keyword(s):  
Antimicrobial Activity ◽  
Methyl Ester ◽  
Gram Negative Bacteria ◽  
Gram Positive ◽  
Gram Negative ◽  
Gram Positive Bacteria ◽  
Ft Ir ◽  
Bacteria And Fungi ◽  
Phenylalanine Methyl Ester

A A new series of bases of Schiff (H2-H4) derived from phthalic anhydrideweresynthesized. These Schiff bases were prepared by the reaction of different amines (tyrosine methyl ester, phenylalanine methyl ester, and isoniazid) with the phthalimide derived aldehyde with the aid of glacial acetic acid or triethylamine ascatalysts. All the synthesized compounds were characterized by (FT-IR and 1HNMR) analyses and were in vitro evaluated for their antimicrobial activity against six various kinds of microorganisms. All the synthesized compounds had been screened for their antimicrobial activity against two Gram-positive bacteria “Staph. Aureus, and Bacillus subtilis”, two Gram-negative bacteria “Escherichia coli, and Klebsiella pneumoniae”, and two fungi species “Candida tropicalis and Candida albicans” using concentrations of 62.5, 125 and 250 µg\mLof derivative in dimethyl sulfoxide(DMSO). All the synthesized compounds showed no activity at all against Gram-positive bacteria, for Gram-negative bacteria and fungi they showed moderate or no activity except compound H1revealedhigh antifungal activityagainstCandida tropicalisat concentrations 125 and 250 µg\ mL. Keywords: Schiff base, phthalic anhydride, antimicrobial.  

scholarly journals Synthesis and Evaluation of Some Coumarin Containing Potential Antimicrobial Agents

2012 ◽  
Vol 9 (4) ◽  
pp. 2493-2500
Author(s):  
Sayali D. Kudale ◽  
Meenakshi N. Deodhar
Keyword(s):  
Antimicrobial Activity ◽  
Antimicrobial Agents ◽  
Gram Negative Bacteria ◽  
Schiff’S Bases ◽  
Gram Positive ◽  
Gram Negative ◽  
H Nmr ◽  
Nmr Data ◽  
Bacteria And Fungi

A series of the Schiff’s bases incorporating coumarin and chalcone moeities, 3-(4-(4-(substituted phenyl)prop-1-ene-3-one) phenylimino) methyl)-4-chloro-2h-chromen-2-one 4(a-g) were synthesized as potential antimicrobial agents. These compounds were characterized on the basis of their spectral (IR,1H NMR) data and evaluated for antimicrobial activity in vitro against gram positive and gram negative bacteria and fungi. Compound 4b was found to be most active with an MIC of 20 µg/mL against all the tested organisms.

scholarly journals Synthesis and Antimicrobial Screening of some New Pyrimido[1,2-a]Benzimidazole Derivatives

2014 ◽  
Vol 25 ◽  
pp. 56-60 ◽  
Author(s):  
Nirav M. Shah ◽  
Hitendra S. Joshi
Keyword(s):  
Antimicrobial Activity ◽  
Mass Spectroscopy ◽  
Benzimidazole Derivatives ◽  
Gram Negative Bacteria ◽  
Good Activity ◽  
Gram Positive ◽  
Gram Negative ◽  
Antimicrobial Screening ◽  
H Nmr ◽  
Reflux Temperature

Some new pyrimido[1,2-a]benzimidazole derivatives were synthesized by reacting 2-amino benzimidazole and chalcones in n-butanol at reflux temperature. In our present study we have used various heterocyclic chalcones derived from furfural and substituted acetophenones. All synthesized compounds were characterized by IR, 1H NMR and Mass spectroscopy. All synthesized compounds were screened for their antimicrobial activity against gram positive and gram negative bacteria which showed moderate to good activity.

scholarly journals Design, Synthesis and Evaluation of Schiff’s Bases of 4-Chloro-3-coumarin aldehyde as Antimicrobial Agents

2009 ◽  
Vol 6 (3) ◽  
pp. 759-762 ◽  
Author(s):  
Shriram Bairagi ◽  
Ashok Bhosale ◽  
Meenakshi N. Deodhar
Keyword(s):  
Antimicrobial Activity ◽  
Antimicrobial Agents ◽  
Gram Negative Bacteria ◽  
Gram Positive ◽  
Design Synthesis ◽  
Gram Negative ◽  
H Nmr ◽  
Nmr Data ◽  
Bacteria And Fungi

4-Chloro-2-oxo-2H-chromene-3-carbaldehyde(2)was reacted with different anilines in rectified spirit as solvent to yield a series of the title compoundsi.e. 4-chloro-3-((substituted-phenylimino) methyl)-2H-chromen-2-one(3a-i). These compounds were charaterised on the basis of their spectral (IR,1H NMR) data and evaluated for antimicrobial activityin vitroagainst gram positive and gram negative bacteria and fungi. Compound3Cwas found to be most active with an MIC of 15 μg /mL against all the tested organisms.

scholarly journals Enaminone-Derived Pyrazoles with Antimicrobial Activity

2019 ◽  
Vol 2019 ◽  
pp. 1-10
Author(s):  
Mashooq Ahmad Bhat ◽  
Mohamed A. Al-Omar ◽  
Ahmed M. Naglah ◽  
Abdul Arif Khan
Keyword(s):  
Antimicrobial Activity ◽  
Gram Negative Bacteria ◽  
Significant Activity ◽  
Disc Diffusion ◽  
Initial Screening ◽  
Gram Positive ◽  
Gram Negative ◽  
Disc Diffusion Assay ◽  
Gram Positive Bacteria ◽  
Diffusion Assay

A series of pyrazoles derived from the substituted enaminones were synthesized and were evaluated for antimicrobial activity. All the compounds were characterized by the spectral data and elemental analysis. The synthesized compounds were initially screened for their antimicrobial activity against ATCC 6538, NCTC 10400, NCTC 10418, and ATCC 27853. During initial screening, compounds (P1, P6, and P11) presented significant antimicrobial activity through disc diffusion assay. These compounds were further evaluated for antimicrobial activity at different time points against Gram-positive and Gram-negative bacteria and presented significant activity for 6 hours. The activity was found to be greater against Gram-positive bacteria. In contrast at 24 hours, the activity was found only against Gram-positive bacteria except compound (P11), showing activity against both types of bacteria. Compound (P11) was found to have highest activity against both Gram-positive and Gram-negative bacteria.

scholarly journals In Vitro and In Vivo Antibacterial Activities of DW-224a, a New Fluoronaphthyridone

2006 ◽  
Vol 50 (6) ◽  
pp. 2261-2264 ◽  
Author(s):  
Hee-Soo Park ◽  
Hyun-Joo Kim ◽  
Min-Jung Seol ◽  
Dong-Rack Choi ◽  
Eung-Chil Choi ◽  
...  
Keyword(s):  
Antibacterial Activities ◽  
The Other ◽  
Vitro Activity ◽  
Gram Negative Bacteria ◽  
In Vitro Activity ◽  
Gram Positive ◽  
Gram Negative ◽  
Gram Positive Bacteria

ABSTRACT DW-224a showed the most potent in vitro activity among the quinolone compounds tested against clinical isolates of gram-positive bacteria. Against gram-negative bacteria, DW-224a was slightly less active than the other fluoroquinolones. The in vivo activities of DW-224a against gram-positive bacteria were more potent than those of other quinolones.

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