scholarly journals Cytokeratin overexpression in Submandibular Salivary Glands of Rats Treated with Botulinum Toxin and Epidermal Growth Factor

2021 ◽  
pp. 3491-3496
Author(s):  
Mohamed Shamel ◽  
Keyword(s):  
Botulinum Toxin ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Salivary Glands ◽  
Submandibular Salivary Glands ◽  
Epidermal Growth

scholarly journals Epidermal Growth Factor Secreted from Submandibular Salivary Glands Interferes with the Lipolytic Effect of Adrenaline in Mice*

Endocrinology ◽  
2000 ◽  
Vol 141 (3) ◽  
pp. 876-882 ◽  
Author(s):  
Francesc Tebar ◽  
Montserrat Grau ◽  
Maria-Pau Mena ◽  
Anna Arnau ◽  
Maria Soley ◽  
...  
Keyword(s):  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Salivary Glands ◽  
Lipolytic Effect ◽  
Submandibular Salivary Glands ◽  
Epidermal Growth

Effect of sialoadenectomy on ethanol-induced gastric mucosal damage in the rat: role of neutrophils

1990 ◽  
Vol 68 (2) ◽  
pp. 207-210 ◽  
Author(s):  
B. L. Tepperman ◽  
B. D. Soper
Keyword(s):  
Growth Factor ◽  
Gastric Mucosa ◽  
Epidermal Growth Factor ◽  
Salivary Glands ◽  
Mucosal Damage ◽  
Gastric Mucosal Damage ◽  
Mucosal Inflammation ◽  
Prostaglandin E ◽  
Epidermal Growth ◽  
Extent Of Damage

We have observed that removal of the salivary glands is associated with an increase in the susceptibility to gastric mucosal damage in the rat. In the present study, we have examined the effect of sialoadenectomy on ethanol-induced mucosal hemorrhagic damage and myeloperoxidase (MPO) activity. Hemorrhagic damage and MPO activity in response to intragastric 50% w/v ethanol were greater in sialoadenectomized rats when compared with sham-operated animals. Pretreatment with 16,16-dimethylprostaglandin E2 (0.3 μg/kg s.c.) reduced damage and MPO activity in both sialoadenectomized and sham control rats receiving 50% ethanol. The reduction in these parameters was greater in control than in sialoadenectomized rats. Pretreatment with epidermal growth factor (5 μg/kg s.c.) significantly reduced MPO activity but did not significantly affect the extent of damage. These data suggest that sialoadenectomy is associated with an increase in mucosal inflammation in animals given ethanol. However, in some situations tissue inflammation (as indicated by MPO activity) was reduced, while the proportion of gastric mucosa exhibiting hemorrhagic damage was not changed.Key words: salivary glands, gastric mucosa, neutrophils, prostaglandin E2, epidermal growth factor.

The effect of sialoadenectomy on gastric mucosal integrity in the rat: roles of epidermal growth factor and prostaglandin E2

1989 ◽  
Vol 67 (12) ◽  
pp. 1512-1519 ◽  
Author(s):  
B. L. Tepperman ◽  
J. A. Kiernan ◽  
B. D. Soper
Keyword(s):  
Growth Factor ◽  
Gastric Mucosa ◽  
Epidermal Growth Factor ◽  
Salivary Glands ◽  
Ethanol Administration ◽  
Prostaglandin E ◽  
Functional Link ◽  
Mucosal Integrity ◽  
Epidermal Growth ◽  
And Control

Removal of the salivary glands (SALX) in rats has been shown to increase the susceptibility of gastric mucosa to ulcerogens. In the present study, we have investigated the role of specific salivary glands in this response. In addition, we have examined whether a functional link exists between the salivary glands, epidermal growth factor (EGF), and prostaglandin E2 (PGE2) by determining whether SALX decreases the responsiveness of the mucosa to the protective actions of either of both of these agents. Removal of the parotid salivary glands did not significantly increase ulceration in response to intragastric administration of 100% w/v ethanol. Animals were examined 60 min after ethanol administration. Removal of the submandibular–sublingual gland complexes was associated with a significant increase in the area of mucosal damage and a decrease in gastric pit depth in ethanol-treated animals when compared with sham-operated control rats. Furthermore, in both SALX and control animals, exogenous PGE2 and EGF resulted in a dose-dependent reduction in both groups of animals, although the protective effects of PGE2 and EGF were attenuated in SALX rats. PGE2 and EGF administered in combination resulted in the same degree of protection in both SALX and control rats. Sialoadenectomy resulted in a reduction in mucosal PGE2 synthesis. EGF administration did not consistently increase mucosal PGE2 synthesis. Conversely, sialoadenectomy did not reduce mucosal levels of EGF nor did exogenous PGE2 consistently increase salivary or mucosal content of EGF. If animals were examined 5 min after ethanol instillation, there were no differences in the degree of damage between SALX and control animals whether determined by measuring surface areas of lesions or changes in histology. These data suggest that SALX is associated with a reduction in the responsiveness of rat gastric mucosa to PGE2 and EGF. The data is not totally consistent with reductions in endogenous levels or synthesis of these agents.Key words: salivary glands, mucosal integrity, EGF immunoassay, PGE2 synthesis.

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