scholarly journals Synthesis and characterization of some heterocyclic including oxazoles,Thiazoles, Pyridazines, phthalizines and Pyrazoles with evaluating of biological activity.

2013 ◽  
Vol 10 (3) ◽  
pp. 818-827
Author(s):  
Baghdad Science Journal
Keyword(s):  
Acetic Acid ◽  
Biological Activity ◽  
Nmr Spectroscopy ◽  
1H Nmr ◽  
1H Nmr Spectroscopy ◽  
Acid Hydrazide ◽  
Synthesis And Characterization ◽  
Ft Ir ◽  
New Compounds

A series of new compounds including p-bromo methyl pheno acetate [2]. N-( aminocarbonyl)–p-bromo pheno acetamide [3] , N-( aminothioyl) -p-bromo phenoacetyl amide [4], N-[4-(p-di phenyl)-1,3-oxazol-2-yl]-p-bromopheno acetamide [5],N-[4-p-di phenyl]-1,3-thiazol-2-yl-p-bromo phenoacet amide [6], p-bromopheno acetic acid hydrazide [7] , 1-N-(p-bromo pheno acetyl)-1,2-dihydro-pyridazin-3,6- dione [8], 1-N-(p-bromo pheno acetyl)-1,2-dihydro-phthalazin-3,8- dione[ 9], 1-(p-bromo pheno acetyl)-3-methylpyrazol-5-one [10] and 1-(p-bromo phenol acetyl)- 3,5-dimethyl pyrazole [11] have been synthesized. The prepared compounds were characterized by m.p.,FT-IR and 1H-NMR spectroscopy. Also ,the biological activity was evaluated .

Synthesis and Characterization of Indolylfulgide Photochromic Colorants

2013 ◽  
Vol 821-822 ◽  
pp. 522-526
Author(s):  
Ning Ning Lv ◽  
An Guo Sang ◽  
Yan Zhang
Keyword(s):  
Nmr Spectroscopy ◽  
1H Nmr Spectroscopy ◽  
Room Temperature ◽  
Uv Light ◽  
Synthesis And Characterization ◽  
Indole Derivatives ◽  
Thermal Stabilities ◽  
Nmr Data ◽  
New Compounds

This paper describes the synthesis of two photochromic 2-indolyl-fulgides by stobbe condensation of the corresponding 2-acyl-1,3-dimethyl-indole derivatives with diethyl isopropylidene succinate in the presence of hexamethyldisilazane potassium. The overall yields was up to 41% for 3 steps. Both prepared compounds are sensitive to UV light and change colors upon irradiation. And the two fulgides can be switched back and forth 100 times without obvious degradation. Thermal stabilities of the fulgides in acetonitrile at room temperature for 30 days and at 80 °C for 12 h were measured using UV-vis and 1H NMR spectroscopy. The absorption spectra of both forms did not exhibit any sign of degradation. The NMR data indicated that no new compounds were detected. The utilization of these materials for use in photochromic textiles were discussed.

scholarly journals Synthesis and Characterization of Five, Sevene Heterocyclic Membered Rings

2013 ◽  
Vol 10 (3) ◽  
pp. 803-817
Author(s):  
Baghdad Science Journal
Keyword(s):  
Biological Activity ◽  
Schiff Bases ◽  
13C Nmr ◽  
Starting Material ◽  
Synthesis And Characterization ◽  
Melting Points ◽  
Vis Spectroscopy ◽  
Ft Ir ◽  
New Compounds

New compounds containing heterocyclic units have been synthesized. These compounds include 2-amino 5- phenyl-1,3,4-thiadiazole (1) as starting material to prepare the Schiff bases 2N[3-nitrobenzylidene -2 hydroxy benzylidene and 4-N,N-dimethyl aminobenzylidene] -5-phenyl-1,3,4-thiadiazole (2abc) , 2N[3-nitrophenyl, 2-hydroxyphenyl or 4-N,N-dimethylaminophenyl] 3-]2-amino-5-phenyl-1,3,4-thiadiazole]-2,3-dihydro-[1,3]oxazepine-benzo-4,7-dione] (3abc), 2N[3-nitrophenyl,2-hydroxyphenyl,4-N,N-dimethylaminophenyl]-3-[2-amino-5-phenyl-1,3,4-thiadiazole-2-yl]-2,3-dihydro-[1,3]oxazepine-4,7-dione[(4abc), 2-N-[3-nitrophenyl, 2-hydroxyphenyl or 4-N,N-dimethylaminophenyl]-3-[2-amino-5-phenyl-1,3,4-thiadiazole-2yl]-1,2,3-trihydro-benzo-[1,2-e][1,3] diazepine-4,7-dione (5abc) ,2N[2-(3-nitrophenyl,2-hydroxyphenyl or 4-N,N-dimethylaminophenyl)]-4-oxo-1,3-thiazolidine-3-yl]-2-amino-5-phenyl-1,3,4-thiadiazole (6abc), 2-N-[5-(3-nitrophenyl,2-hydroxyphenyl or 4-N,N-dimethylaminophenyl)-tetrazolo-1-yl]-2-amino-5-phenyl-1,3,4-thiadiazole (7abc) , 2-N-[5-(3-nitrophenyl,2-hydroxyphenyl or 4-N,N-dimethylaminophenyl)-3-[2-amino-5-phenyl-1,3,4-thiadiazole-2-yl]-2,3-dihydro-[1,3]oxazepine-benzo-4,7-dithione (8abc) , 2-N-[5-(3-nitrophenyl,2-hydroxyphenyl or 4-N,N-dimethylaminophenyl)-3-[2-amino-5-phenyl-1,3,4-thiadiazole-2-yl]-2,3-dihydro-[1,3]oxazepine -4,7-dithione -5-ene (9abc) and 2-N-[5-(3-nitrophenyl,2-hydroxyphenyl or 4-N,N-dimethylaminophenyl)-3-[2-amino-5-phenyl-1,3,4-thiadiazole-2-yl] -1,2,3-trihydro-benzo-[1,2-e][1,3] diazepine -4,7-dithione - (10abc) . the structures of these compounds were characterized by FT-IR, 1H,13C-NMR,Uv/vis spectroscopy and the melting points were determined besides the evaluation of its biological activity.

scholarly journals Synthesis and Characterization of Some New Azo Dyes Derivatives Via Chalcone and Study Some of Their Biological Activity

2016 ◽  
Vol 13 (1) ◽  
pp. 122-132
Author(s):  
Baghdad Science Journal
Keyword(s):  
Biological Activity ◽  
Azo Dyes ◽  
Coupling Reaction ◽  
Basic Medium ◽  
Synthesis And Characterization ◽  
Diazonium Salts ◽  
Amino Group ◽  
Ft Ir ◽  
New Compounds

This work includes synthesis of new six membered heterocyclic rings with effective amino group using the reaction of benzylideneacetophenone (chalcone) (1) with thiourea or urea in alcoholic basic medium to form: 1,3-thiazen-2-amine (2), and 1,3-oxazin-2-amine (8) respectively. The diazotization reaction was carried out with sodium nitrite in presence of hydrochloric acid to form diazonium salts which suffered coupling reaction with naphthols and phenols in the presence of sodium hydroxide to form colored azo dyes (4-7, and 10-13). o-methylation reaction of compounds (7) and (10) yielded : 1,3-thiazin -2-yl-diazenyl (14), and 1,3-oxazin-2-yl-diazenyl (15) respectively.The new compounds were characterized using various physical techniques like: UV-Vis., FT-IR, and 1HNMR spectra. Some new compounds were tested against bacteria.

scholarly journals Synthesis and Characterization of 3 - Substituted Coumarin

2016 ◽  
Vol 13 (1) ◽  
pp. 89-96
Author(s):  
Baghdad Science Journal
Keyword(s):  
Acetic Acid ◽  
Schiff Bases ◽  
1H Nmr ◽  
Acetyl Chloride ◽  
Aromatic Aldehydes ◽  
Synthesis And Characterization ◽  
Carbonyl Chloride ◽  
Ft Ir

The reaction of(2-oxo-2H-chromen-3-Carbonyl chloride)(k1) with hydrazine in boiling ethanol gives the hydrazide(K2).When compound (k2) reacts with various aromatic aldehydes ,the corres ponding Schiff bases(k3–k4) achieve new series of thiazotidines (k5–k6) and azetidinones (k7–k8) obtained from the reactions of appropriate Schiff bases with mercapto acetic acid and chloro acetyl chloride respectively. All the compounds are characterized by FT-IR,1H-NMR and GC-Ms.

scholarly journals Synthesis and Characterization of New Compounds Derived from Pyrrolidine-2-One and Evaluation of their Biological Activities

2020 ◽  
Vol 23 (4) ◽  
pp. 5-12
Author(s):  
Nadia A. Betti ◽  
◽  
Redha Ib. Hussain ◽  
Sahar Ab. Kadhem ◽  
Abdul Jabar Kh. Atia ◽  
...  
Keyword(s):  
Biological Activity ◽  
Mass Spectrum ◽  
Biological Activities ◽  
The Other ◽  
Synthesis And Characterization ◽  
E Coli ◽  
Ft Ir ◽  
New Compounds ◽  
Derivatives Of

New derivatives of pyrrolidine-2-one have been prepared by lactamization of -butyrolactone GBL with hydrazine hydrate (NH2NH2(80%)) to afford (1-aminopyrrolidin-2-one) which undergo many reactions to prepare the other derivatives. The prepared derivatives were determined by utilizing their FT-IR,1H-NMR and some by Mass spectrum. These derivatives were evaluated biologically against (Staphylococcus aureusand E. coli).Some of these derivatives exhibited good biological activity against one or both kind of bacteria while some exhibited no biological activity at all.

scholarly journals Synthesis and Characterization of N-(3-(8-Bromoimidazo[1, 2-a] pyridin-2-yl)-4-Fluorophenyl)Benzamide Derivatives

2017 ◽  
Author(s):  
Parameshwar Achugatla ◽  
Majid Ghashang ◽  
S. Guhanathan
Keyword(s):  
1H Nmr ◽  
13C Nmr ◽  
Synthesis And Characterization ◽  
Ms Analysis ◽  
The Family ◽  
Ft Ir ◽  
New Compounds ◽  
Benzamide Derivatives

We report here the synthesis and characterization of new N-(3-(8-bromoimidazo[1, 2-a]pyridin-2-yl)-4-fluorophenyl)benzamide derivatives. This collection was obtained from 3-(8-bromoimidazo [1,2-a]pyridin-2-yl)-4-fluoroaniline(5). The family of new compounds was characterized by 1H-NMR, 13C-NMR, FT-IR and LC-MS analysis.

scholarly journals Synthesis, Characterization of Derivatives Tetrazoles for Trimethoprim Drug

2016 ◽  
Vol 13 (2) ◽  
pp. 266-274
Author(s):  
Baghdad Science Journal
Keyword(s):  
Nmr Spectroscopy ◽  
Physical Properties ◽  
Schiff Bases ◽  
1H Nmr ◽  
13C Nmr ◽  
1H Nmr Spectroscopy ◽  
Second Step ◽  
Direct Reaction ◽  
Ft Ir

The present work involved synthesis of serval new substituted tetrazole via Schiff bases for trimethoprim drug by two steps. The first step involved direct reaction of different ketones and aldehydes with trimethoprim producing the corresponding Schiff bases (1-10), whereas the second step, involved preparation new tetrazoles derivatives (11-20) through reaction of the ready Schiff bases (in the first step) with sodium azidein in dioxin. The prepared compounds were characterized by UV, FT-IR, and some of them by 13C-NMR, 1H-NMR spectroscopy and physical properties.

scholarly journals SYNTHESIS OF NOVEL 4-R-1,2,4-TRIAZOLIN-5-THIONES CONTAINING SPACE-HINDERED FRAGMENT OF PHENOL

2017 ◽  
Vol 60 (3) ◽  
pp. 42
Author(s):  
Vladimir N. Koshelev ◽  
Ludmila V. Ivanova ◽  
Rahman T.Kh. Alasadi ◽  
Olga V. Primerova
Keyword(s):  
Nmr Spectroscopy ◽  
Ir Spectroscopy ◽  
1H Nmr ◽  
1H Nmr Spectroscopy ◽  
Acid Hydrazide ◽  
Aqueous Sodium Hydroxide ◽  
Slight Excess ◽  
Ft Ir ◽  
Radical Processes ◽  
Ft Ir Spectroscopy

Using of additives inhibiting free radical processes is necessary at production of the lubricating oils. In given article such kind target compounds were obtained from the number of new 1-acyl-4-R-thiosemicarbazides which were synthesized on the base of 3- (4-hydroxy-3,5-di-tert-butyl) propanoic acid hydrazide. The starting hydrazide was prepared from commercially available methyl ester (methylox) by refluxing in ethanol with a slight excess of hydrazine hydrate for 8 h. The best yields of the 1-acyl-4-R-isothiocyanates were achieved by refluxing equimolar amounts of isothiocyanates and hydrazide in isopropanol for 4-5 h. Under these conditions the yield was 75-85%. At further cyclization of intermediates obtained at a first step in aqueous sodium hydroxide for 1.5 h the corresponding 3-acyl-4-R-1,2,4-triazolin-5-thiones were obtained with the yield of 70-90%. Also, this method has absolute advantages due to a simple isolation of target compounds. Based on the IR-spectroscopy data in middle region and 1H NMR spectroscopy it was established that the substances obtained in the crystalline state and in DMSO solution exist in a form of thiones. The composition of obtained substances was determined with elemental analysis whereas the structures of the synthesized compounds were confirmed with FT-IR spectroscopy methods, 1H NMR spectroscopy and mass spectrometry.Forcitation:Koshelev V.N., Ivanova L.V., Alasadi R.T.Kh., Primerova O.V. Synthesis of novel 4-R-1,2,4-triazolin-5-thiones containing space-hindered fragment of phenol. Izv. Vyssh. Uchebn. Zaved. Khim. Khim. Tekhnol. 2017. V. 60. N 3. P. 43-47.

Synthesis and characterization of bispyrrolidine derivatives of H2@C60: differentiation of isomers using 1H NMR spectroscopy of endohedral H2

2011 ◽  
Vol 47 (8) ◽  
pp. 2282-2284 ◽  
Author(s):  
Yongjun Li ◽  
Xuegong Lei ◽  
Ronald G. Lawler ◽  
Yasujiro Murata ◽  
Koichi Komatsu ◽  
...  
Keyword(s):  
Nmr Spectroscopy ◽  
1H Nmr ◽  
1H Nmr Spectroscopy ◽  
Synthesis And Characterization ◽  
Derivatives Of
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