scholarly journals Prevalence of Vitamin D Deficiency and Its Associated Risk Factors Among Rural Population of the Northern Part of the Persian Gulf

2020 ◽  
Author(s):  
Maryam Marzban ◽  
Mohammadreza Kalantarhormozi ◽  
Mehdi Mahmudpour ◽  
Afshin Ostovar ◽  
Saeed Keshmiri ◽  
...  
Keyword(s):  
Risk Factors ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Rural Areas ◽  
Persian Gulf ◽  
Rural Population ◽  
Vitamin D Levels ◽  
Significant Difference ◽  
The Persian Gulf ◽  
Associated Risk Factors

Abstract Background: Accumulating evidence indicates that vitamin D deficiency has been increased globally since the last two decades. However, the majority of these studies concerned on cities and there is scant information regarding the prevalence of vitamin D in rural areas. The main aim of this study was to investigate the prevalence of vitamin D deficiency and its associated risk factors among rural population in Bushehr province which has the longest border with the Persian Gulf.Methods: The rural inhabitants with ≥25 years old from three mountainous, plain, and seashore areas of Bushehr province were selected through a stratified multi-cluster random sampling method. After obtaining the participants’ demographic and anthropometric data and their past medical history, serum 25- hydroxy vitamin D was measured using ELISA.Results: A total of 1806 (means±SD, 46.30± 14.22 years old) rural subjects (34.84% males and 64.88%) participated in this study. The prevalence of vitamin D deficiency, insufficiency and sufficiency were 27.87%, 50.39% and 21.74%, respectively. The deficiency of vitamin D in women was higher than men (OR=1.27, 95% CI: 1.05 to 1.54, P=0.040). There was a positive significant correlation between age and serum vitamin D levels. Men with vitamin D deficiency had higher BMI (P=0.008); this association was not observed among women (P=0.74). There was no significant difference between the food items consumption frequencies, and vitamin D status (P>0.05). The mountainous, and plain areas had the highest and lowest vitamin D levels, respectively.Conclusion: Although, Bushehr province is located in a sunny part of Iran, the prevalence of vitamin D deficiency was high among its rural population. The shift of their life styles patterns and rapid industrialization in these rural areas may be responsible. Therefore, the enrichment of dietary sources with vitamin D and the use of vitamin D supplements are recommended to tackle the high prevalence of vitamin D deficiency in the rural population of the northern part of the Persian Gulf.

scholarly journals Prevalence of vitamin D deficiency and its associated risk factors among rural population of the northern part of the Persian Gulf

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Maryam Marzban ◽  
Mohammadreza Kalantarhormozi ◽  
Mehdi Mahmudpour ◽  
Afshin Ostovar ◽  
Saeed Keshmiri ◽  
...  
Keyword(s):  
Risk Factors ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Rural Areas ◽  
Persian Gulf ◽  
Rural Population ◽  
Vitamin D Levels ◽  
Significant Difference ◽  
The Persian Gulf ◽  
Associated Risk Factors

Abstract Background Accumulating evidence indicates that vitamin D deficiency has been increased globally over the last two decades. However, the majority of these studies are concerned with cities and there is scant information regarding the prevalence of vitamin D in rural areas. The main aim of this study was to investigate the prevalence of vitamin D deficiency and its associated risk factors among the rural population in Bushehr province which shares the longest border with the Persian Gulf. Methods The rural inhabitants of more than 25 years old from three mountainous, plain, and seashore areas of Bushehr province were selected through a stratified multi-cluster random sampling method. After obtaining the participants’ demographic and anthropometric data and their past medical history, serum 25-hydroxyvitamin D [25(OH)D] was measured using ELISA. Results A total of 1806 (means ±SD, 46± 14years old) rural subjects (35 % males and 65 % females) participated in this study. The prevalence of vitamin D deficiency, insufficiency, and sufficiency were 28 %, 50 %, and 22 %, respectively. The deficiency of vitamin D in women was higher than in men (OR=1.27, 95 % CI: 1.05 to 1.54, P=0.04). There was a positive significant correlation between age and serum vitamin D levels. Men with vitamin D deficiency had higher BMI (P=0.008); this association was not observed among women (P=0.7). There was no significant difference between the food item’s consumption frequencies, and vitamin D status (P>0.05). The mountainous, and plain areas had the highest and lowest vitamin D levels, respectively. Conclusions Although, Bushehr province is located in a sunny part of Iran, the prevalence of vitamin D deficiency was high among its rural population. The shift of their lifestyle patterns and rapid industrialization in these rural areas may be responsible. Therefore, the enrichment of dietary sources with vitamin D and the use of vitamin D supplements are recommended to tackle the high prevalence of vitamin D deficiency in the rural population of the northern part of the Persian Gulf.

scholarly journals PREVALENCE OF VITAMIN D DEFICIENCY IN PEOPLE OVER 50 YEARS OLD RESIDING IN REPUBLIC OF BASHKORTOSTAN IN PERIODS OF LOW INSOLATION

2012 ◽  
Vol 15 (3) ◽  
pp. 7-9 ◽  
Author(s):  
R Z Nurlygayanov ◽  
E R Syrtlanova
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Rural Areas ◽  
Sun Exposure ◽  
Severe Vitamin ◽  
Republic Of Bashkortostan ◽  
Vitamin D Levels ◽  
Significant Difference ◽  
The Republic ◽  
The City

Objectives. To study the vitamin D levels in the period of minimal sun exposure in individuals older than 50 years residing in the Republic of Bashkortostan. Materials and methods. In the period of low insolation (March) in 188 people (68 men and 120 women) aged over 50 years (mean age 66,1 ± 0,75 years) residing in the city (Ufa) and rural areas of the Republic of Bashkortostan we investigated the levels of 25 (OH) D and parathyroid hormone (PTH) by the indirect ELISA. Level of 25 (OH) D 25-50 nmol/l were considered as mild vitamin D deficiency; 12,5-25 nmol/l-as moderate deficiency, and levels below 12.5 nmol/l - as a severe vitamin D deficiency. Results. The average level of 25 (OH) D was 33,55 ± 1,28 nmol/l; in urban area 43,48 ± 1,59 nmol/l; in rural area 21,25 ± 1,06 nmol/l; 36,29±2,43 nmol/l in men; 32,28± 1,47 nmol/l in women. The levels of vitamin D in the urban population were twice as high as in rural areas. A statistically significant difference by gender in terms of the levels of vitamin D was not found. We saw normal levels of vitamin D only in 18 % of subjects (in the city- 30 %, in the rural areas - 2 %), 43 % of people had a mild vitamin D deficiency (in the city - 59 %, in rural areas - 24 %), 33 % - a moderate deficiency of vitamin D (in the city -11 %, in the rural areas - 60 %), and 6 % of the patients had a severe vitamin D deficiency (in the city - 0 %, in rural areas -14 %). Moderate to severe vitamin D deficiency in rural areas was significantly more prevalent (74 %) than in urban (11 %). Gender was not found to be a risk factor for the development of vitamin D deficit in people over 50 years. There was a negative correlation between vitamin D levels and patient age (r=-0,356, p <0,001) and between levels of vitamin D andPTH (r =-0,313, p <0.001).

scholarly journals P652 Underweight patients with Crohn’s disease and without vitamin D supplementation are at high risk of vitamin D deficiency

2020 ◽  
Vol 14 (Supplement_1) ◽  
pp. S536-S537
Author(s):  
D Vranesic Bender ◽  
V Domislović ◽  
M Brinar ◽  
D Ljubas Kelečić ◽  
I Karas ◽  
...  
Keyword(s):  
Vitamin D ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Vitamin D Deficiency ◽  
Vitamin D Supplementation ◽  
Lower Range ◽  
Total Study Population ◽  
Vitamin D Levels ◽  
Significant Difference ◽  
Underweight Patients

Abstract Background Vitamin D deficiency is frequently present in inflammatory bowel disease (IBD) with a higher incidence in Crohn’s disease (CD) than in ulcerative colitis (UC). Given the involvement of the alimentary tract, many factors can contribute to vitamin D deficiency. The aim of the study was to investigate the association of vitamin D deficiency according to body mass index (BMI) in adult patients with IBD. Methods A cross-sectional study was conducted on a cohort of 152 IBD patients, 68.1% (n = 104) CD and 31.9% (n = 48) UC. The mean age of the total study population was 37.3±11.8 years and 57.3% (n = 87) were male. All patients were adult, Caucasian and without vitamin D supplementation. Patients were recruited during one year period. Results Out of all IBD patients, 60.5% (n = 92) had vitamin D deficiency, 32.2%, (n = 49) insufficiency and 7.2% (n = 11) sufficiency. According to BMI categories there were 12.5% (n = 19) obese patients, 27.6% (n = 42) overweight, 51.3% (n = 78) with normal body weight, and 8.6% (n = 13) underweight. There was a significant difference in vitamin D levels according to different BMI categories in terms of underweight patients having the lowest vitamin D levels; underweight 29.84±11.94 mmol/l, normal 46 ± 20.7 mmol/l, overweight 48±20.1 mmol/l, obese 51±15.3 mmol/l. In addition, there was a significant correlation of vitamin D levels and BMI values (Rho = 0.212, 95% CI 0.069–0.345, p = 0.004), which was more clearly observed in the lower range of BMI values (Figure 1). Male underweight patients had lower levels of vitamin D compared with female patients (26.6 ± 9 vs. 34.7 ± 5.6, p &lt; 0.05). Both patients with CD and UC had significant positive correlation of vitamin D levels and BMI values (UC Rho=0.40, 95% CI 0.16–0.59, p = 0.001, UC Rho = 0.27, 95% CI 0.01–0.05, p = 0.044). However, when comparing vitamin D levels according to phenotype, a significant difference in vitamin D levels was observed in underweight CD (28.4 ± 11.1) comparing to underweight UC patients (40.6 ± 10.6), p &lt; 0.05. In logistic regression analysis, CD phenotype was risk factor for vitamin D deficiency (OR 2.18 95% CI 1.01–4.72, β = 1.22, p = 0.04). Conclusion Our results on untreated IBD patients show a high proportion of vitamin D deficiency both in CD and UC, and significant correlation of vitamin D levels and BMI values, especially in the lower range of BMI values. Moreover, underweight CD patients have lower vitamin D levels comparing to UC. This suggests the need for regular vitamin D monitoring and supplementation especially in IBD patients at risk.

scholarly journals Vitamin D Deficiency and Associated Risk Factors in Women from Riyadh, Saudi Arabia

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Nora A. AlFaris ◽  
Nora M. AlKehayez ◽  
Fatema I. AlMushawah ◽  
AbdulRhman N. AlNaeem ◽  
Nadia D. AlAmri ◽  
...  
Keyword(s):  
Risk Factors ◽  
Vitamin D ◽  
Saudi Arabia ◽  
Vitamin D Deficiency ◽  
Public Awareness ◽  
Public Health Problem ◽  
Hypovitaminosis D ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Associated Risk Factors

AbstractVitamin D deficiency is an epidemic public health problem worldwide. It is common in the Middle East and is more severe in women. This cross-sectional study was conducted to assess vitamin D deficiency and associated risk factors in women living in Riyadh, Saudi Arabia. Serum 25-hydroxyvitamin D (25(OH)D) was measured in 166 women aged 30–65 years. Socio-demographic, lifestyle and health status characteristics, as well as intake of selected dietary supplements, were collected. Weight and height were measured. Vitamin D deficiency (25(OH)D < 20 ng/mL) was reported in 60.2% of participants. Mean of serum 25(OH)D was 20.7 ng/mL. Older age and taking the supplements of vitamin D, multi-vitamins or calcium were identified as factors that associated with a lower risk of hypovitaminosis D. A national strategy is needed to control a hypovitaminosis D crisis in Saudi Arabia. This could be accomplished by raising public awareness regarding vitamin D, regulating and enhancing vitamin D fortification and supplementation and screening vitamin D status among women at high risk.

scholarly journals Vitamin D Deficiency and Outcomes after Ankle Fusion

2020 ◽  
Vol 5 (4) ◽  
pp. 2473011420S0007
Author(s):  
Deepak Ramanathan ◽  
Mark J. Berkowitz ◽  
Alan Davis ◽  
Stephen J. Pinney ◽  
Sara Lyn Miniaci-Coxhead
Keyword(s):  
Risk Factors ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Reoperation Rate ◽  
Hardware Removal ◽  
Ankle Fusion ◽  
Vitamin D Levels ◽  
Normal Vitamin ◽  
Local Risk ◽  
The Impact

Category: Ankle Arthritis; Ankle; Basic Sciences/Biologics; Hindfoot Introduction/Purpose: Ankle fusions are associated with a complication profile including nonunion with associated poor functional outcomes, chronic pain, and need for reoperation. Local risk factors (bone and soft-tissue loss, infection, ankle and hindfoot deformity, and neuropathy) and systemic risk factors (advanced age, smoking, alcohol abuse, worker’s compensation, noncompliance, obesity, and systemic comorbidities such as diabetes and immunodeficiency) have been shown to be associated with the development of a nonunion following fusion procedures. Vitamin D has an important role in bone healing, and vitamin D deficiency has been proposed as a potential risk factor for the development of non-unions. The purpose of this study is to assess the impact of low vitamin D levels on reoperation rates and the development of nonunions following ankle fusion surgery. Methods: A retrospective chart review of all ankle fusions performed at a major health system from January 2010 to July 2019 was performed. In total, 240 ankle fusions were performed by seven surgeons. All patients who underwent primary fusion procedures were eligible for inclusion in this study. Exclusion criteria included: age less than 18 years; revision surgery; ankle fusion with the use of bulk allograft; ankle fusion performed as part of an oncologic reconstruction; and an absence of recorded vitamin D levels with 12 months of surgery. In total, 47 patients met inclusion criteria and formed the study group. In this group, 29/47 (61.7%) were female and 18/47 (38.3%) were male. Average age was 57.0 +- 12.3 years (range: 18.6 to 75.7). Patients were grouped according to their vitamin D levels as being deficient (<31 ng/ml) or normal (31-80 ng/ml). Results: Prevalence of vitamin D deficiency was 36.2% (17/47) at average of 35.7 ng/ml. In vitamin D deficient subgroup (n=17), average vitamin D level was 16.9 ng/ml. In normal vitamin D subgroup (n=30), average vitamin D was 46.4 ng/ml. Overall, reoperation rate was 21.3% (10/47). Reoperation rate was 35.3% (6/17) in vitamin D deficiency subgroup compared with 13.3% (4/30) reoperation rate in normal vitamin D subgroup (p<0.05). In vitamin D deficient subgroup, 5 procedures for nonunion included: dynamization (n=1), revision fusion (n=1), staged revision (n=2) and amputation (n=1) due to infected nonunion. There was also a symptomatic hardware removal. In normal vitamin D subgroup, reoperation indications included: malunion (n=1), elective dynamization before weightbearing (n=1), and symptomatic hardware removal (n=2). Normal vitamin D subgroup had zero nonunions. Conclusion: In patients undergoing ankle fusion, vitamin D deficiency (< 31 ng/ml) was associated with a reoperation rate over double that of patients with normal vitamin D levels. In the vitamin D deficient subgroup, nearly all reoperations were for nonunion as compared to zero nonunion incidence in those with normal vitamin D levels. These results suggest routine preoperative screening of vitamin D level is indicated as a key component of ankle fusion care. Vitamin D supplementation during the perioperative period may be indicated in regions with low sunlight to improve fusion rates and lower the risk of reoperation.

Baseline Characteristics Associated with Vitamin D Deficiency in Sickle Cell Disease and the Effect of Vitamin D Replacement

Blood ◽  
2011 ◽  
Vol 118 (21) ◽  
pp. 2139-2139
Author(s):  
Soyoung Park ◽  
Rebecca Kruse-Jarres ◽  
Davis Ogitani
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Sickle Cell ◽  
Total Bilirubin ◽  
Reticulocyte Count ◽  
Outdoor Activity ◽  
Vitamin D Levels ◽  
Significant Difference ◽  
Pain Frequency ◽  
Lower Vitamin

Abstract Abstract 2139 Background: African Americans have lower vitamin D levels than the general population, which is thought to be due to decreased utilization of ultraviolet rays to convert vitamin D into an active form. Sickle cell patients have even lower vitamin D levels than African American controls. Preliminary studies at Tulane University correlated low vitamin D levels with markers of hemolysis (decreased hemoglobin (Hgb), increased reticulocyte count and lactate dehydrogenase (LDH)). Our main question was whether vitamin D deficiency in sickle cell patients is due to lack of outdoor activity or diet, or increased vitamin D metabolism during bone marrow turnover secondary to hemolysis. Design and Methods: 80 adult sickle cell patients received pain, dietary, and outdoor activity level surveys. Vitamin D 25-hydroxy (25(OH)D), hemolytic lab markers (Hgb, Hct, LDH, total bilirubin, and reticulocyte count) were obtained. Results: Baseline Assessment: Vitamin D levels were available on 70 patients: 24.3% were normal or mildly deficient (≥20 ng/mL), 30% moderately deficient (10-<20 ng/mL), and 45.7% severely deficient (<10 ng/mL). We could not verify a correlation between LDH and 25(OH)D levels, but there was a trend towards increased total bilirubin in patients severely deficient in vitamin D (p = 0.06). Severely anemic patients (Hgb 5-<7 gm/dL) had significantly lower average 25(OH)D levels (p = 0.02). When comparing patients with moderately and severely deficient 25(OH)D levels to patients with no or mild deficiency, there was a significantly increased use of healthcare facilities (see Table 1). Though there was no significant difference in intake of fish, cheese, or eggs, there was a significant decrease in milk intake (see Table 1). There was no significant difference in days spent in bed or time spent outdoors (see Table 1). Subjectively, patients did not report increased frequency of mild to moderate pain, vasocclusive crises, or use of pain medications in the moderately and severely vitamin D deficient groups but they did report higher rates of hospitalization due to sickle cell crises (p = 0.03, 0.005 respectively). Effects of Vitamin D replacement: 56 patients took vitamin D replacement. After replacement, there was no difference in frequency of pain and pain medicine use, or days in the hospital and ER. However, pain levels appeared to be less intense (see Table 2). There was a trend towards fewer days spent in the hospital and ER (p = 0.089) in the 6 months following vitamin D replacement and there were significantly fewer Sickle Cell Day Hospital visits (p = 0.037). Conclusions: Though we could not correlate vitamin D deficiency with LDH as a marker of hemolysis, lower Hgb levels seemed to be predictive of more severe vitamin D deficiency. Patients with more severe vitamin D deficiency did not report to have increased pain frequency or pain medication use, but had more ER visits and hospitalizations. When vitamin D was replaced, it did not decrease pain frequency, but it did decrease severity. We conclude that vitamin D replacement could lessen pain in sickle cell patients and thus utilization. Disclosures: Kruse-Jarres: Bayer: Consultancy; Grifols: Consultancy; Talecris: Consultancy; Inspiration: Consultancy; NovoNordisk: Consultancy; Baxter: Consultancy.

scholarly journals Vitamin D Status and Its Associated Risk Factors among Adults in the Southwest Region of Cameroon

2018 ◽  
Vol 2018 ◽  
pp. 1-9 ◽  
Author(s):  
Delphine A. Tangoh ◽  
Tobias O. Apinjoh ◽  
Yasir Mahmood ◽  
Robert V. Nyingchu ◽  
Beatrice A. Tangunyi ◽  
...  
Keyword(s):  
Risk Factors ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Hypovitaminosis D ◽  
Vitamin D Status ◽  
West Region ◽  
South West ◽  
Study Population ◽  
Associated Risk Factors ◽  
South West Region

Background. Vitamin D has been shown to exert its actions on the musculoskeletal, gastrointestinal, prostate, renal, endocrine, immune, and cardiovascular systems. Current reported data of hypovitaminosis D reveals a global pandemic, with an estimated one billion people worldwide presenting with hypovitaminosis D. Objective. This study aimed at investigating the vitamin D status and its associated risk factors in Cameroonians from the South West Region. Method. The study was a community- and hospital-based prospective longitudinal study. It was carried out during the dry and rainy seasons between the months of July and December 2015 in the South West Region of Cameroon involving 372 participants aged 35 years and above. After obtaining informed consent, a structured questionnaire was used to capture demographic data and risk factors of vitamin D deficiency. Blood samples were collected from the volunteer participants in the peak months of the rainy season and dry season, and the serum used to analyse for vitamin D by ELISA and calcium by spectrophotometry. 25(OH)D levels ≥75 nmol/L (≥30 ng/mL) were considered sufficient while levels <75 nmol/L were considered as hypovitaminosis D (insufficiency/deficiency). Results. Hypovitaminosis D (deficiency/insufficiency) was prevalent in 25.8% (96) of the study population, with only 3.2% (12) deficiency and 22.6% (84) insufficiency. There was a significant inverse relationship r=−0.119,p=0.02 between age and 25(OH)D levels; however, this relationship was not significant when controlled for gender, number of hours spent outdoors, and percentage of body covered. Gender, ethnic origin, percentage of body covered, time spent outdoors, and season did not influence serum vitamin D levels. Conclusion. Results of this study suggest that the prevalence of hypovitaminosis D is relatively low in this study population and only age is a risk factor of vitamin D deficiency.

scholarly journals The Prevalence of Hypovitaminosis D and Its Associated Risk Factors Among Women of Reproductive Age in Saudi Arabia: A Systematic Review and Meta-Analysis

2018 ◽  
Vol 11 ◽  
pp. 1179562X1876788 ◽  
Author(s):  
Riyadh A Alzaheb
Keyword(s):  
Risk Factors ◽  
Vitamin D ◽  
Saudi Arabia ◽  
Vitamin D Deficiency ◽  
Meta Analysis ◽  
Hypovitaminosis D ◽  
Reproductive Age ◽  
Vitamin D Status ◽  
Women Of Reproductive Age ◽  
Associated Risk Factors

Vitamin D deficiency is currently a worldwide epidemic. Middle Eastern countries, including Saudi Arabia, have high vitamin D deficiency prevalence, most prominently among women, despite their plentiful year-round sunshine. Previous research investigating vitamin D status among Saudi women of reproductive age (15-49 years) is scarce, and no study has used a nationally representative sample, so this review quantified overall hypovitaminosis D prevalence among women in Saudi Arabia and explored the associated risk factors. The Web of Science, Scopus, and Medline databases were searched for prior studies in Saudi Arabia exploring vitamin D status among women of reproductive age, published between January 1, 2000 and May 25, 2017. Data were extracted from the identified studies, and a random effects model meta-analysis established the overall hypovitaminosis D prevalence. The initial search yielded 223 possibly relevant articles; 13 were confirmed as eligible, with samples totaling 2877 women aged between 15 and 49 years. Meta-analysis revealed a mean serum 25-hydroxyvitamin D, 25(OH)D, level of 13.1 ng/mL (95% confidence interval [CI]: 11.6-14.6) and an overall prevalence of hypovitaminosis D, defined as 25(OH)D < 30 ng/mL, of 77.4% (95% CI: 63.2-87.3), mostly due to insufficient sunlight exposure and low dietary vitamin D intake. There is therefore a need for a national strategy to raise vitamin D levels among women in Saudi Arabia by advising them on natural vitamin D sources, and recommending the timing and duration of sun exposure, while also defining a national approach to vitamin D fortification and supplementation.

scholarly journals Vitamin D status in adults and children in Transcarpathia, Ukrainein 2019

2020 ◽  
Author(s):  
Khrystyna Shchubelka
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Adult Population ◽  
Winter Season ◽  
Epidemiological Data ◽  
Adult Women ◽  
Vitamin D Levels ◽  
Significant Difference ◽  
Adults And Children ◽  
The Mean

Abstract Background: Vitamin D deficiency is a global health problem, it is assessed by measuring serum 25-hydroxivitamin D (25(OH) D), nevertheless epidemiological data for many countries remains underreported.Objectives:To study the prevalence of vitamin D deficiency throughout the calendar year in a large cohort recruited ina multiethnic Transcarpathian region of Ukraine.Methods: In this retrospective study 25(OH)D serum concentration was measured during all 12 months of the year 2019 by electrochemoluminescent assay on the automatic analyzer Cobas e411 in 1,823 subjects, including both children and adults (1551 females (85.03%) and 273 males (14.97%)). ResultsThe mean 25(OH) D concentration in adults demonstrates significantly lower levels compared to children (22.67±8.63 ng/ml vs. 26.00±10.72 ng/ml respectively, p<0.001). Adult women expressed significantly lower mean annual serum 25 (OH) D concentrations in comparison to men (22.29±8.46 ng/ml vs. 25.75±9.38 ng/ml respectively, p< 0.001). In contrast, children did not show a significant difference between sexes (girls 24.98±10.38 ng/ml vs. boys 27.01±11.01 ng/ml, p=0.2003). In the winter months, 25(OH)D levels fell below 20 ng/ml in 51,74 % of adult population of Thranscarpathia, and in 12.91%, - below 12 ng/ml.ConclusionsThe results of this study contradict the previously reported evaluations of the vitamin D levels in Ukraine which were assessed by measuring serum 25(OH) D. Specifically, only approximately half of the studied population is vitamin D deficient during winter season. This study features the most representative sample size in Ukraine to date.

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