Beneficial impact of education on cognition in amyloid-positive individuals with subjective cognitive decline: The SILCODE study

2020 ◽  
Author(s):  
Guanqun Chen ◽  
Chunhua Liu ◽  
Kun Yang ◽  
Jiehui Jiang ◽  
Ying Han

Abstract Background: Previous studies suggest that education is associated with a decreased risk of dementia in individuals with subjective cognitive decline (SCD). However, the influence of education on cognition in amyloid-positive SCD subjects is not clear.Methods: We performed a cross-sectional study that involved 43 amyloid-negative and 29 amyloid-positive SCD subjects from the Sino Longitudinal Study on Cognitive Decline (SILCODE) project. Cognitive assessment included episodic memory, executive function, language, and general cognitive function. Multiple linear regression model was used to assess the association of education on cognitive performance.Results: Multiple linear regression analysis suggested that education has a protective effect on executive function, language for the amyloid-negative SCD group and language, global cognition for the amyloid-positive SCD group.Conclusions: The present study indicated that education has the potential to delay disease progression in amyloid-positive SCD subjects.

2016 ◽  
Vol 2016 ◽  
pp. 1-15 ◽  
Author(s):  
Anna Skoczyńska ◽  
Leszek Gruszczyński ◽  
Anna Wojakowska ◽  
Marek Ścieszka ◽  
Barbara Turczyn ◽  
...  

The aim of the analysis was to retrospectively assess changes in lung function in copper miners depending on the type of workplace. In the groups of 225 operators, 188 welders, and 475 representatives of other jobs, spirometry was performed at the start of employment and subsequently after 10, 20, and 25 years of work. Spirometry Longitudinal Data Analysis software was used to estimate changes in group means for FEV1and FVC. Multiple linear regression analysis was used to assess an association between workplace and lung function. Lung function assessed on the basis of calculation of longitudinal FEV1 (FVC) decline was similar in all studied groups. However, multiple linear regression model used in cross-sectional analysis revealed an association between workplace and lung function. In the group of welders, FEF75 was lower in comparison to operators and other miners as early as after 10 years of work. Simultaneously, in smoking welders, the FEV1/FVC ratio was lower than in nonsmokers (p< 0,05). The interactions between type of workplace and smoking (p< 0,05) in their effect on FVC, FEV1, PEF, and FEF50 were shown. Among underground working copper miners, the group of smoking welders is especially threatened by impairment of lung ventilatory function.


KEUNIS ◽  
2019 ◽  
Vol 7 (2) ◽  
pp. 92
Author(s):  
Anita Kristina ◽  
Prihatiningsih Prihatiningsih ◽  
Ida Savitri Kusmargiani

<em>This research is based on the problems of the company PT Jasa Marga Tbk which has a problem with the performance of the company which is indicated by the DER of companie increased during the period 2009-2018. The purpose of this research is to analyze the influance of direction and significance of Liquidity, Asset Structure, Free Cash Flow and Company Size on Debt Policy (DER) in PT Jasa Marga Tbk for the period 2009-2018. The population and sample in this study were PT Jasa Marga Tbk. The analysis model used in this study is a multiple linear regression model. The results of the multiple linear regression analysis showed that (1) the influance of Liquidity (CR) on Debt Policy (DER) was positive and significant (2) the influance Asset Structure on Debt Policy (DER) was negative and not significant (3) the influance of Free Cash Flow on Debt Policy (DER) is positive and significant (4) the influance of Company Size on Debt Policy (DER) is positive and significant.</em>


2021 ◽  
Vol 16 (2) ◽  
Author(s):  
Rico Januar Sitorus ◽  
Imelda Gernauli Purba ◽  
Merry Natalia ◽  
Kraichat Tantrakarnapa

Smoking leads to disease and disability as well as harm nearly every organ of the body. Furthermore, smoking of tobacco is known to cause pulmonary dysfunction and lead to complications, pain, or even death. This study aims to measure the risk factors for the respiration of carbon monoxide among smokers. A cross-sectional design was implemented by involving 156 smokers in Karyajaya Subdistrict, Palembang City. The dependent variable was carbon monoxide levels (ppm), while the independent variables were smoking frequency, duration, and the last period of smoking. The carbon monoxide levels (ppm) measured with a PiCO + Smokerlyzer® device from Bedfont Scientific Limited were the research tool and the independent variables of the questionnaire. The pearson Correlation and multiple linear regression were used for the analysis. The results of the multiple linear regression analysis revealed that smoking duration assessment is related to carbon monoxide respiration after controlling smoking frequency, the last period of smoking, and the distance of residence to sources of exposure. The smoker's respiration of carbon monoxide level was 72.5% influenced by the duration, frequency, last period of smoking, and distance of residence to sources of exposure. Reducing the frequency of smoking and stopping may prevent and control carbon monoxide respiration.


2021 ◽  
Vol 18 ◽  
Author(s):  
Guanqun Chen ◽  
Li Lin ◽  
Kun Yang ◽  
Ying Han

Background: Education could offer a protective effect on cognition in individuals with Subjective Cognitive Decline (SCD), which is considered to be the early stage of Alzheimer’s Dis- ease (AD). However, the effect of education on cognition in SCD individuals with SCD-plus fea- tures is not clear. Objective: The aim of the study was to explore the effect of education on cognition in SCD individ- uals with SCD-plus features. Methods: A total of 234 individuals with SCD were included from the Sino Longitudinal Study on Cognitive Decline (SILCODE). Cognition was assessed across 4 domains (memory, executive, lan- guage, and general cognitive functions). Multiple linear regression models were constructed to ex- amine the effect of education on cognitive scores in individuals without worry (n=91) and with wor- ry (n=143). Furthermore, we assessed differences in effects between APOE ε4 noncarriers and APOE ε4 carriers in both groups. Results : Multiple linear regression analysis showed a positive effect of education on memory, ex- ecutive, and language cognition in individuals without worry and all cognitive domains in individu- als with worry. Furthermore, we found a positive effect of education on executive cognition in APOE ε4 noncarriers without worry and language and general cognition in APOE ε4 carriers with- out worry. Meanwhile, education had a positive effect on all cognitive domains in APOE ε4 noncar- riers with worry and executive, language, and general cognition in APOE ε4 carriers with worry. Conclusion: This study indicates that education has the potential to delay or reduce cognitive dec- line in SCD individuals with SCD-plus features.


Author(s):  
Masashi Kanai ◽  
Kazuhiro P. Izawa ◽  
Hiroki Kubo ◽  
Masafumi Nozoe ◽  
Kyoshi Mase ◽  
...  

Health-related quality of life (HRQoL) after stroke tends to vary across studies or across stages of stroke. It is useful to use the health utility score to compare HRQoL across studies. Physical activity after stroke also tends to vary similarly. The purpose of the present study was to determine associations between the health utility score and physical activity outcomes in stroke survivors. This cross-sectional study recruited stroke survivors who could ambulate outside, free of assistance. We assessed the health utility score with the EuroQoL 5-Dimension 3-Level questionnaire. The physical activity outcomes were the number of steps taken and duration of moderate-to-vigorous physical activity (MVPA) as measured with an accelerometer. Multiple linear regression analyses were used to determine whether the physical activity outcomes were independently associated with the health utility score. Fifty patients (age: 68.0 years; 40 men, 10 women) were included. Multiple linear regression analysis showed the health utility score to be significantly associated with the number of steps taken (β = 0.304, p = 0.035) but not with MVPA. This is the first study to examine the association between the health utility score and objectively measured physical activity in stroke survivors. Promoting physical activity especially by increasing the number of steps taken might be a priority goal in improving a patient’s health utility score after stroke.


2021 ◽  
Vol 10 (6) ◽  
pp. 1315
Author(s):  
Yoshinori Hayashi ◽  
Hirohide Yokokawa ◽  
Hiroshi Fukuda ◽  
Mizue Saita ◽  
Taiju Miyagami ◽  
...  

Background: Some previous studies have shown reduced levels of plasma B-type natriuretic peptide (BNP) in individuals with obesity. We aimed to estimate the relationship between BNP and abdominal fat distribution, adjusted for confounding factors. Methods: This cross-sectional study included 1806 Japanese individuals (981 men and 825 women) who underwent a medical health check-up. Analyzed data included age, sex, visceral fat area (VFA), and subcutaneous fat area (SFA) as obtained from computed tomography, blood pressure, and blood test results including BNP. Multiple linear regression analysis was used to examine the association between BNP, VFA, and SFA after adjusting for age, sex, comorbidities, and body mass index. Results: In the models analyzed separately for VFA and SFA, BNP correlated independently with VFA in multiple linear regression analysis among all subjects and in both men and women, while SFA correlated inversely with BNP in all subjects and women but not in men. In the model that included both VFA and SFA, BNP correlated independently with VFA, but SFA and BNP were not correlated in any models. Conclusion: Higher VFA showed an independent, significant association with lower BNP. In addition, the inverse correlation with BNP was stronger for VFA than for SFA.


2019 ◽  
Author(s):  
Bramma Kiswanjaya ◽  
Hanna H Bachtiar-Iskandar

Abstract Background The purpose of this study was to investigate the association between the severity of the mandibular inferior cortex (MIC) porosity and the number of remaining teeth in elderly Indonesian people.Materials and methods This cross-sectional study was conducted by measuring secondary data on panoramic digital examinations of patients aged 50 years and older. A total of 428 panoramic radiographs were measured from January 2017 to December 2018. The number of remaining teeth (including the third molars) was evaluated. Mandibular porosity was measured by using panoramic radiographs, according to the MIC classification: normal; mildly to moderately eroded; and severely eroded cortex.Statistical analysis used Data analysis was done using Mann-Whitney nonparametric tests to verify the relationship between the MIC classification and the number of remaining teeth. Multiple linear regression analysis was performed to investigate the relationship between confounding variables.Results A significant correlation was found between MIC classification and the number of remaining teeth on the Mann-Whitney test (P < 0.001). Multiple linear regression analysis showed that MIC classification was significantly associated with the value of the number of remaining teeth after controlling for gender and age (β = -0.37, R2 = 0.22, P < 0.001). Subjects with MIC class 3 were 7.14 times more likely to lose their teeth than subjects with MIC class 1 or class 2.Conclusions Our study demonstrated that there was an association between the severity of mandibular inferior cortex porosity and the number of remaining teeth in elderly Indonesian people.


2015 ◽  
Vol 4 (4) ◽  
pp. 31-53
Author(s):  
Yidnekachew Mare ◽  
Emmanuel Gebreyohannes ◽  
Yohannes Yebabe Tesfay

The purpose of this study was to identify and analyze the factors affecting the perception of Hawassa community towards the tourism industry using Factor Analysis, Multiple linear regression and Multivariate Analysis of Variance (MANOVA). Cross-sectional survey was conducted on a sample of 591 from a target population of 24021 of Hawassa City. The Factor analysis estimation result identified five potential factors that affect the community's perception towards the tourism industry. These potential factors are economic, socio-cultural, environmental, community service and community attitude factors, which explained 77.5 percent of the total variation of the community's perception towards the tourism industry. Multiple linear regression analysis indicated that length of residency, number of tourist contacts, number of recreational activities, job creation and tourism policy participation are found significant in explaining the variation in the underlined perceptions of the community towards tourism. Among the demographic characteristics, sub city, sex, educational level, working profession and monthly income of the respondents are found were statistically significant different for the mean scores of the perceptions towards tourism.


2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Johann Georg Keunecke ◽  
Christine Gall ◽  
Torsten Birkholz ◽  
Andreas Moritz ◽  
Christian Eiche ◽  
...  

Abstract Background Human workload is a key factor for system performance, but data on emergency medical services (EMS) are scarce. We investigated paramedics’ workload and the influencing factors for non-emergency medical transfers. These missions make up a major part of EMS activities in Germany and are growing steadily in number. Methods Paramedics rated missions retrospectively through an online questionnaire. We used the NASA-Task Load Index (TLX) to quantify workload and asked about a variety of medical and procedural aspects for each mission. Teamwork was assessed by the Weller teamwork measurement tool (TMT). With a multiple linear regression model, we identified a set of factors leading to relevant increases or decreases in workload. Results A total of 194 non-emergency missions were analysed. Global workload was rated low (Mean = 27/100). In summary, 42.8% of missions were rated with a TLX under 20/100. TLX subscales revealed low task demands but a very positive self-perception of performance (Mean = 15/100). Teamwork gained high ratings (Mean TMT = 5.8/7), and good teamwork led to decreases in workload. Aggression events originating from patients and bystanders occurred frequently (n = 25, 12.9%) and increased workload significantly. Other factors affecting workload were the patient’s body weight and the transfer of patients with transmittable pathogens. Conclusion The workload during non-emergency medical transfers was low to very low, but performance perception was very positive, and no indicators of task underload were found. We identified several factors that led to workload increases. Future measures should attempt to better train paramedics for aggression incidents, to explore the usefulness of further technical aids in the transfer of obese patients and to reconsider standard operating procedures for missions with transmittable pathogens.


2016 ◽  
Vol 4 (1) ◽  
pp. 58-64
Author(s):  
Rismayanti Rismayanti ◽  
Martha Irene Kartasurya ◽  
Nico L. Kana

Internal marketing and service quality BPJS are things that influence the level of satisfaction of doctors that becomes the deciding factor of doctor performance. The aim of this study is to find the influence of internal marketing and service quality performance of BPJS Kesehatan with doctor performance through doctor satisfaction at RSUD Ulin Banjarmasin. This type of research is analytic with cross sectional design. The research method was developed using a questionnaire based on the literature. The number of respondents who came from the science of internal medicine, pediatric, obstetrical and gynaecology, and surgery and met the inclusion criteria as many as 52 people were surveyed. Data was analyzed using Pearson correlation and multiple linear regression. The results showed correlation between internal marketing to the satisfaction of doctors (r = 0.584, p = 0.000), between service quality BPJS and satisfaction of doctors (r = 0.499, p = 0.001), between the satisfaction of doctors and the performance of doctors (r = 0.583, p = 0.0001). Results of research by multiple linear regression analysis showed that the internal marketing and service quality BPJS have contributed influence on physician satisfaction of 44.6% while 55.4% described other factors. Physician satisfaction have contributed influence on physician performance by 32.7% while 67.3% described other variables outside the model. It was concluded that internal marketing and service quality effect on doctors satisfaction which in turn affect the performance of doctors. Suggested to BPJS Health to improve the financing system INA-CBG’s and disseminate laws and regulations better.


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