Interaaaes Sinnrgicas E Transbordamento Do Efeito Multiplicador De Produuuo Das Grandes Regiies Do Brasil (Synergistic Interactions and Overflow of the Multiplier Effect of the Production from Large Regions of Brazil)

2006 ◽  
Author(s):  
Umberto Antonio Sesso Filho ◽  
Antonio Carlos Moretto ◽  
Rossana Lott Rodrigues ◽  
Joaquim Guilhoto
Keyword(s):  
Synergistic Interactions ◽  
Multiplier Effect

On the Concept of the Foreign Exchange Multiplier

1975 ◽  
Vol 14 (2) ◽  
pp. 233-237
Author(s):  
J. Diamond
Keyword(s):  
Foreign Exchange ◽  
Realistic Model ◽  
Domestic Production ◽  
Supply Elasticity ◽  
Aggregate Supply ◽  
Multiplier Effect ◽  
Special Case

Although in recent years there has been increasing recognition of the import¬ance of intermediary imports, the conventional Keynesian treatment of aggregate " supply has-generally been adopted. By assuming supply elasticity and conditions of over-production, such imports are treated as a leakage and-therefore deflationary. This paper investigates another special case which may be a more realistic model for many industrialising economies like Pakistan. Namely, J,y assuming supply bottlenecks and the technical dependence of domestic production on imported inputs, an increase in imports may be inflationary and have an import or foreign exchange multiplier effect.

Problems and prospects of innovative development of enterprises of agroindustrial business

2018 ◽  
pp. 13-16
Author(s):  
O. N. Kolomyts
Keyword(s):  
Agricultural Sector ◽  
Maximum Effect ◽  
Innovative Development ◽  
Innovation Development ◽  
Agricultural Enterprises ◽  
Barriers To Innovation ◽  
Multiplier Effect

The article deals with the main barriers to innovation development directly or indirectly affecting the activities of agricultural enterprises. The directions of development of innovations in the enterprises of the agricultural sector are proposed, which will lead to the maximum effect in terms of the multiplier effect on the economy as a whole.

A Program for Analyzing Synergistic Interactions from Dose-Effect Data

Analgesia ◽  
1998 ◽  
Vol 3 (5) ◽  
pp. 297-305 ◽  
Author(s):  
Jeffrey D. McCary ◽  
Ronald J. Tallarida
Keyword(s):  
Dose Effect ◽  
Effect Data ◽  
Synergistic Interactions

Exhibition and Trade Fair Activity and Economic Crises: response measures and factors for recovery

Communicology ◽  
2020 ◽  
Vol 8 (2) ◽  
pp. 80-89
Author(s):  
A.A. Nazarov
Keyword(s):  
Trade Fair ◽  
Government Support ◽  
Economic Sectors ◽  
Current Crisis ◽  
Governmental Organizations ◽  
Non Governmental Organizations ◽  
Multiplier Effect ◽  
Response Measures ◽  
The Impact ◽  
Exhibition Industry

The paper represents the analysis of the impact on the exhibition and trade fair activity of the Russian Federation during crisis situations caused by external factors. The author examined the major anticrisis measures, industry statistics and the main trends in the postcrisis phase. The fundamental role of the exhibition industry as a tool is caused by stimulation of economic sectors recovery from the crisis due to the multiplier effect. The particular relevance of the article is justified by a comprehensive study of the state of the industry during the current crisis caused by the COVID-19 pandemic. The author provides an overview of main government support measures for the industry and explains factors that have reduced some of these measures. Also, the author examined in detail activities of non-governmental organizations and associations of the exhibition industry in lobbying for the provision of state support and educational and legal assistance to Russian exhibition companies. Thus, the importance of coordinating activities of all participants in the exhibition industry and, in particular, further consolidation of interaction at the level of industry associations, becomes apparent. Besides, the author suggests a number of measures, such as highlighting exhibitions, trade fairs and congresses from the list of mass events following the example of Germany, introducing insurability for exhibition organizers in case of postponement or cancellation of events due to emergency circumstances, standardizing public health and hygiene rules. Their practical application should mitigate the way out of the current situation.

Anticancer Hybrid Combinations: Mechanisms of Action, Implications and Future Perspectives

2019 ◽  
Vol 24 (36) ◽  
pp. 4312-4333 ◽  
Author(s):  
Eva M. Domínguez-Martín ◽  
Ana M. Díaz-Lanza ◽  
Célia M. C. Faustino
Keyword(s):  
Paradigm Shift ◽  
Molecular Level ◽  
Chemotherapeutic Agent ◽  
Synergistic Effects ◽  
Extensive Literature ◽  
Synergistic Interactions ◽  
Extensive Literature Search ◽  
Preclinical And Clinical Studies ◽  
Phytochemical Components ◽  
Combination Regimens

The exponential growth of cancer cases worldwide together with recent advances concerning the pathophysiological mechanisms of the disease at the molecular level led to a paradigm shift in chemotherapy, from monotherapy to targeted drug combination regimens. However, adverse effects and the emergence of multidrug resistance (MDR) limit the effectiveness of these therapies. In this context, hybrid combinations mixing anticancer drugs and bioactive phytochemical components from medicinal plants, or even plant extracts, that can act synergistically on multiple targets and signaling pathways represent a promising approach with the potential to expand the current therapeutic arsenal. This review aims to provide a synopsis on anticancer hybrid combinations based on their multi-target mechanisms and synergistic effects from an extensive literature search focusing mainly on publications from the last ten years. In most of these combinations, the phytochemical component was shown to enhance the anticancer activity of the chemotherapeutic agent and to sensitize chemoresistant tumors in several types of cancer. Hybrid combinations, due to synergistic interactions, are also associated with less severe adverse events since lower doses can be used to achieve the same therapeutic effect. Further preclinical and clinical studies are needed, as well as the development of an adequate regulatory framework, before hybrid combination therapy can be translated into clinical practice.

Periodontal Pathogens and Neuropsychiatric Health

2020 ◽  
Vol 20 (15) ◽  
pp. 1353-1397 ◽  
Author(s):  
Abhishek Wadhawan ◽  
Mark A. Reynolds ◽  
Hina Makkar ◽  
Alison J. Scott ◽  
Eileen Potocki ◽  
...  
Keyword(s):  
Molecular Mechanisms ◽  
Metabolic Diseases ◽  
Low Grade ◽  
Periodontal Pathogens ◽  
Synergistic Interactions ◽  
Brain Vasculature ◽  
Micro Rnas ◽  
Clinical Conditions ◽  
Low Grade Inflammation ◽  
Neuropsychiatric Illness

Increasing evidence incriminates low-grade inflammation in cardiovascular, metabolic diseases, and neuropsychiatric clinical conditions, all important causes of morbidity and mortality. One of the upstream and modifiable precipitants and perpetrators of inflammation is chronic periodontitis, a polymicrobial infection with Porphyromonas gingivalis (P. gingivalis) playing a central role in the disease pathogenesis. We review the association between P. gingivalis and cardiovascular, metabolic, and neuropsychiatric illness, and the molecular mechanisms potentially implicated in immune upregulation as well as downregulation induced by the pathogen. In addition to inflammation, translocation of the pathogens to the coronary and peripheral arteries, including brain vasculature, and gut and liver vasculature has important pathophysiological consequences. Distant effects via translocation rely on virulence factors of P. gingivalis such as gingipains, on its synergistic interactions with other pathogens, and on its capability to manipulate the immune system via several mechanisms, including its capacity to induce production of immune-downregulating micro-RNAs. Possible targets for intervention and drug development to manage distal consequences of infection with P. gingivalis are also reviewed.

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