scholarly journals Elevated Serum Levels of Resistin, Leptin, and Adiponectin are Associated with C-reactive Protein and also Other Clinical Conditions in Rheumatoid Arthritis

2011 ◽  
Vol 50 (4) ◽  
pp. 269-275 ◽  
Author(s):  
Takumi Yoshino ◽  
Natsuko Kusunoki ◽  
Nahoko Tanaka ◽  
Kaichi Kaneko ◽  
Yoshie Kusunoki ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Elevated Serum ◽  
Serum Levels ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Clinical Conditions

scholarly journals Expression of ICAM1 and VCAM1 Serum Levels in Rheumatoid Arthritis Clinical Activity. Association with Genetic Polymorphisms

2009 ◽  
Vol 26 (3) ◽  
pp. 119-126 ◽  
Author(s):  
Rosa Elena Navarro-Hernández ◽  
Edith Oregon-Romero ◽  
Mónica Vázquez-Del Mercado ◽  
Héctor Rangel-Villalobos ◽  
Claudia Azucena Palafox-Sánchez ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Clinical Status ◽  
Serum Levels ◽  
Clinical Activity ◽  
C Reactive Protein ◽  
Soluble Adhesion Molecules ◽  
Reactive Protein ◽  
Erythrocyte Sedimentation ◽  
Pcr Rflp ◽  
Elisa Technique

To investigate the association of sICAM-1 and sVCAM-1 with ICAM1 721G>A and VCAM1 1238G>C polymorphisms and rheumatoid arthritis (RA) clinical activity, sixty RA patients and 60 healthy non-related subjects (HS) matched for age and sex were recruited. Soluble adhesion molecules were determined by ELISA technique. Rheumatoid factor (RF), C reactive protein (CRP) and the erythrocyte sedimentation rate (ESR) were measured by routine methods. Disability and clinical activity was measured with Spanish-HAQ-DI and DAS28 scores, respectively. The ICAM1 and VCAM1 polymorphism were identified using the PCR-RFLP procedure. Inter-group comparison showed increased levels of sICAM-1 and sVCAM-1 in RA patients (284 and 481 ng/mL) versus HS (132 and 280 ng/mL); in the RA group, significant correlations between sVCAM-1 and RF (r= 0.402), ESR (r= 0.426), Spanish-HAQ-DI (r= 0.276), and DAS28 (r= 0.342) were found, whereas sICAM-1 only correlated with RF (r= 0.445). In RA patients, a significant association with the 721A allele of ICAM1 polymorphism (p= 0.04), was found. In addition, the allele impact (G/A+A/A) of this polymorphism was confirmed, (p= 0.038, OR = 2.3, C.I. 1.1–5.0). sVCAM-1 and sICAM-1 serum levels reflected the clinical status in RA, independently of the ICAM1 and VCAM1 polymorphism. However, the ICAM1 721A allele could be a genetic marker to RA susceptibility.

Biomarkers of Bone Metabolism in Ankylosing Spondylitis in Relation to Osteoproliferation and Osteoporosis

2014 ◽  
Vol 41 (7) ◽  
pp. 1349-1356 ◽  
Author(s):  
Eva Klingberg ◽  
Merja Nurkkala ◽  
Hans Carlsten ◽  
Helena Forsblad-d’Elia
Keyword(s):  
Ankylosing Spondylitis ◽  
Disease Activity ◽  
Bone Metabolism ◽  
Activity Index ◽  
Elevated Serum ◽  
Serum Levels ◽  
Spinal Mobility ◽  
C Reactive Protein ◽  
Mineral Density ◽  
Reactive Protein

Objective.To identify biomarkers for bone metabolism in patients with ankylosing spondylitis (AS) and to determine the relationship between these biomarkers and disease activity, back mobility, osteoproliferation, and bone mineral density (BMD).Methods.Serum levels of Wingless protein (Wnt-3a), Dickkopf-1 (DKK-1), sclerostin, soluble receptor activator of nuclear factor-κB ligand (sRANKL), and osteoprotegerin were assessed using ELISA. Ankylosing Spondylitis Disease Activity Score-C reactive protein, Bath Ankylosing Spondylitis Disease Activity Index, Bath Ankylosing Spondylitis patient global score, and C-reactive protein (CRP) were used as disease activity measures, and Bath Ankylosing Spondylitis Metrology Index (BASMI) as a measure of spinal mobility. Lateral spine radiographs were scored for chronic AS-related changes (mSASSS). BMD was measured with dual-energy x-ray absorptiometry.Results.Two hundred four patients with AS (NY criteria; 57% men), with a mean age of 50 ± 13 years and disease duration 15 ± 11 years, and 80 age and sex-matched controls were included. The patients with AS had significantly higher serum levels of Wnt-3a (p < 0.001) and lower levels of sclerostin (p = 0.014) and sRANKL (p = 0.047) compared with the controls. High CRP was associated with low sclerostin (rS = −0.21, p = 0.003) and DKK-1 (rS = −0.14, p = 0.045). In multiple linear regression analyses, increasing BASMI and mSASSS were independently associated with older age, male sex, high CRP, and elevated serum levels of Wnt-3a. In addition, mSASSS remained associated with a high number of smoking pack-years after adjusting for age. Low BMD of femoral neck was associated with high mSASSS after adjusting for age.Conclusion.Serum levels of Wnt-3a are elevated in AS and associated with increased BASMI and mSASSS, independent of age, indicating that Wnt-3a could be a biomarker for the osteoproliferative process.

scholarly journals Prognostic and Predictive Value of Serum C-Reactive Protein Levels in Patients with Metastatic Or Locally Recurrent Gastric Cancer

2016 ◽  
Vol 31 (3) ◽  
pp. 294-299 ◽  
Author(s):  
Zhigang Chen ◽  
Yongchen Sun ◽  
Ji Wang ◽  
Xudong Shen ◽  
Lei Chen ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Overall Survival ◽  
Malignant Tumors ◽  
Elevated Serum ◽  
Roc Curves ◽  
Serum Levels ◽  
C Reactive Protein ◽  
Term Survival ◽  
Reactive Protein ◽  
Serum Crp

Background and Aims Increasing evidence suggests that elevated serum levels of C-reactive protein (CRP) are associated with poor survival in many malignant tumors. However, the prognostic value of CRP in advanced gastric cancer (AGC) remains uncertain. This study was undertaken to evaluate the significance of serum CRP as a biomarker of long-term survival in patients with AGC. Methods The serum CRP levels of AGC patients were analyzed for clinicopathological significance. Data were collected retrospectively for 244 patients treated between October 1, 2006 and September 30, 2013. The prognostic effect of serum CRP levels was evaluated. Results The baseline CRP level before chemotherapy was significantly associated with overall survival. The median survival was 351 days for patients with CRP ≥10 mg/L and 370 days for patients with CRP c10 mg/L (p = 0.033). Cox analysis revealed CRP to be an independent prognostic factor for overall survival. In the 93 patients whose baseline CRP was ≥10 mg/L, a cutoff point of 22% for the CRP declining rate provided optimum sensitivity and specificity for 1-year survival based on ROC curves. A CRP declining rate >22% was found to predict longer overall survival (410 days versus 299 days; p = 0.001). Conclusions Elevated serum CRP baseline levels before chemotherapy were associated with reduced overall survival in patients with AGC. The CRP declining rate was also associated with overall survival. The CRP baseline concentration before chemotherapy and CRP declining rate after chemotherapy may be used as novel, widely available and real-time independent prognostic and predictive markers of AGC.

Periodontitis is associated with elevated serum levels of cardiac biomarkers—Soluble ST2 and C‐reactive protein

2019 ◽  
Vol 46 (8) ◽  
pp. 809-818 ◽  
Author(s):  
Kitti Torrungruang ◽  
Dissayawadee Katudat ◽  
Rangsini Mahanonda ◽  
Piyamitr Sritara ◽  
Artit Udomsak
Keyword(s):  
Elevated Serum ◽  
Serum Levels ◽  
Cardiac Biomarkers ◽  
C Reactive Protein ◽  
Soluble St2 ◽  
Reactive Protein

Elevated serum levels of C-reactive protein are associated with more severe psychopathology in a subgroup of patients with schizophrenia

2007 ◽  
Vol 149 (1-3) ◽  
pp. 267-271 ◽  
Author(s):  
Xiaoduo Fan ◽  
Cynthia Pristach ◽  
Emily Y. Liu ◽  
Oliver Freudenreich ◽  
David C. Henderson ◽  
...  
Keyword(s):  
Elevated Serum ◽  
Serum Levels ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Severe Psychopathology

scholarly journals Does Chronic Low-grade Systemic Inflammation Change Tumor Markers Levels in Patients on Hemodialysis?

Folia Medica ◽  
2020 ◽  
Vol 62 (4) ◽  
pp. 838-842
Author(s):  
Gilmar Pereira Silva ◽  
Vítor Pereira Xavier Grangeiro ◽  
Carmelita Félix Dantas de Oliveira
Keyword(s):  
Tumor Markers ◽  
Systemic Inflammation ◽  
Elevated Serum ◽  
Serum Levels ◽  
Hemodialysis Patients ◽  
Low Grade ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Significant Difference ◽  
The University

Introduction: End-stage renal disease (ESRD) patients are known to have a high risk of developing cancer-related inflammation. Elevated serum levels of tumor markers in ESRD/hemodialysis patients makes analysis and interpretation difficult.&nbsp; Aim: To verify the possible relationship between chronic low-grade systemic inflammation serum levels determined by C-reactive protein (CRP) and the tumor biomarkers in patients on hemodialysis.&nbsp; Materials and methods: A prospective study of prevalence was conducted in the Hemodialysis Sector of the University Hospital of the University of Bras&iacute;lia between July 2016 and December 2016 in men aged 18 to 60 years without clinically detectable cancer. We assessed inflammation by serum high-sensitivity CRP test (hs-CRP) and serum tumor in the case groups and controls. The hemodialysis group was split into two subgroups: group 1: patients with inflammation (CRP > 5 mg/L, n=27), and group 2: patients without inflam-mation (CRP &le;5 mg/L, n=33). Results: There was no significant difference in age mean levels between case groups and controls (44.00&plusmn;08.00 vs. 41.00&plusmn;07.00, p=0.08). There was no difference or correlation (p>0.05) between tumor markers levels and patients with and without inflammation.&nbsp; Conclusions: The results of this study suggest that chronic low-grade systemic inflammation defined by C-reactive protein serum levels does not promote elevated serum PSA levels in chronic hemodialysis patients.

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