Role of Some Neosynthesized Styryl Heterocycles in Ochratoxin A Control in Aspergillus carbonarius

2016 ◽  
Vol 20 (19) ◽  
pp. 2029-2035 ◽  
Author(s):  
Roberto Antonioletti ◽  
Angela Viglianti ◽  
Stefano Cristofoli ◽  
Alessandra Ricelli
Keyword(s):  
Ochratoxin A ◽  
Aspergillus Carbonarius

scholarly journals Role of Some Food-Grade Synthesized Flavonoids on the Control of Ochratoxin A in Aspergillus carbonarius

Molecules ◽  
2019 ◽  
Vol 24 (14) ◽  
pp. 2553 ◽  
Author(s):  
Alessandra Ricelli ◽  
Martina De Angelis ◽  
Ludovica Primitivo ◽  
Giuliana Righi ◽  
Carla Sappino ◽  
...  
Keyword(s):  
Ochratoxin A ◽  
Methoxy Group ◽  
Aspergillus Carbonarius ◽  
Control Effect ◽  
Food Grade ◽  
Inhibiting Effect ◽  
Mediterranean Countries ◽  
Methoxy Flavone ◽  
Determining Factor

Ochratoxin A (OTA) is a mycotoxin with a serious impact on human health. In Mediterranean countries, the black Aspergilli group, in particular Aspergillus carbonarius, causes the highest OTA contamination. Here we describe the synthesis of three polyphenolic flavonoids: 5-hydroxy-6,7-dimethoxy-flavone (MOS), 5,6-dihydroxy-7-methoxy-flavone (NEG), and 5,6 dihydroxy-flavone (DHF), as well as their effect on the prevention of OTA biosynthesis and lipoxygenase (LOX) activity in A. carbonarius cultured in a conducive liquid medium. The best control effect on OTA biosynthesis was achieved using NEG and DHF. In fungal cultures treated with these compounds at 5, 25, and 50 μg/mL, OTA biosynthesis significantly decreased throughout the 8-day experiment. NEG and DHF appear to have an inhibiting effect also on the activity of LOX, whereas MOS, which did not significantly inhibit OTA production, had no effect on LOX activity. The presence of free hydroxyls in catecholic position in the molecule appears to be a determining factor for significantly inhibiting OTA biosynthesis. However, the presence of a methoxy group in C-7 in NEG could slightly lower the molecule’s reactivity increasing OTA inhibition by this molecule at 5 μg/mL. Polyphenolic flavonoids present in edible plants may be easily synthesized and used to control OTA biosynthesis.

Kinetics of Ochratoxin A Production and Accumulation by Aspergillus carbonarius on Synthetic Grape Medium at Different Temperature Levels

2006 ◽  
Vol 71 (6) ◽  
pp. M196-M200 ◽  
Author(s):  
S. Marín ◽  
N. Bellí ◽  
S. Lasram ◽  
S. Chebil ◽  
A.J. Ramos ◽  
...  
Keyword(s):  
Ochratoxin A ◽  
Aspergillus Carbonarius ◽  
Temperature Levels ◽  
Kinetics Of

Study of the effect of water activity and temperature on ochratoxin A production by Aspergillus carbonarius

2006 ◽  
Vol 23 (7) ◽  
pp. 634-640 ◽  
Author(s):  
A. Esteban ◽  
M.L. Abarca ◽  
M.R. Bragulat ◽  
F.J. Cabañes
Keyword(s):  
Ochratoxin A ◽  
Water Activity ◽  
Aspergillus Carbonarius ◽  
Effect Of Water

Effect of Aspergillus carbonarius amounts on winemaking and ochratoxin A contamination

Food Control ◽  
2014 ◽  
Vol 40 ◽  
pp. 85-92 ◽  
Author(s):  
Chunmei Jiang ◽  
Junling Shi ◽  
Yongle Cheng ◽  
Yanlin Liu
Keyword(s):  
Ochratoxin A ◽  
Aspergillus Carbonarius

Identification and characterization of the polyketide synthase involved in ochratoxin A biosynthesis in Aspergillus carbonarius

2014 ◽  
Vol 179 ◽  
pp. 10-17 ◽  
Author(s):  
Antonia Gallo ◽  
Benjamin P. Knox ◽  
Kenneth S. Bruno ◽  
Michele Solfrizzo ◽  
Scott E. Baker ◽  
...  
Keyword(s):  
Ochratoxin A ◽  
Polyketide Synthase ◽  
Aspergillus Carbonarius ◽  
Identification And Characterization

Three Stilbenes Make Difference to the Antifungal Effects on Ochratoxin A and its Precursor Production of Aspergillus Carbonarius

2021 ◽  
Author(s):  
XInyu Cai ◽  
Jianrui Qi ◽  
Zhe Xu ◽  
Lingxuan Huang ◽  
Yihan Li ◽  
...  
Keyword(s):  
Ochratoxin A ◽  
Aspergillus Carbonarius ◽  
Antifungal Effects

Ameliorative role of dietary activated carbon against ochratoxin-A induced oxidative damage, suppressed performance and toxicological effects

Toxin Reviews ◽  
2020 ◽  
pp. 1-11
Author(s):  
Sheraz Ahmed Bhatti ◽  
Muhammad Zargham Khan ◽  
Muhammad Kashif Saleemi ◽  
Zahoor Ul Hassan ◽  
Ahrar Khan
Keyword(s):  
Activated Carbon ◽  
Oxidative Damage ◽  
Ochratoxin A ◽  
Toxicological Effects
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