Pengaruh Disiplin, Budaya Organisasi dan Motivasi Kerja terhadap Kinerja Karyawan Perum Bulog Kantor Wilayah Jawa Timur

Quality human resources are a determining factor in improving the performance of a business organization. The performance of a business organization is largely determined by the performance of its employees, and this is the main reason for this research. This study aims to determine the effect of discipline, organizational culture and work motivation on employee performance. This research approach is a descriptive research with a quantitative approach. The data used in this study are primary data obtained directly from respondents through questionnaires in the field and secondary data obtained in finished form, has been collected and processed by other parties. The number of samples taken in this study were 74 respondents. The data analysis technique used in this research is multiple linear regression. The results of the analysis show that the variables of discipline, organizational culture and work motivation have a significant effect on employee performance both simultaneously and partially. The results of this study indicate that the variables of discipline, organizational culture and work motivation are the determining variables in an effort to improve employee performance Keywords : Discipline, Organizational Culture, Work Motivation, Employee Performance.

Comparative advantage of anti-Mullerian hormone over other ovarian reserve metric (basal hormonal test) in prediction of fertility in women with varying menstrual cycle

Objective: Anti-Mullerian hormone has been indicated as a novel biomarker for ovarian reserve assessment. This study aimed to determine the comparative advantage of serum levels of AMH, FSH, LH, E2, and LH/FSH ratio among women with varying menstrual cycles and duration of menstruation. Material and Method: A total of 90 subjects, which consisted of sixty subjects and thirty healthy subjects as control, were recruited. Blood samples were collected on day 3 of the menstrual cycle and evaluated for ovarian markers using the ELISA technique. All data were analyzed using SPSS version 23.0. Results: AMH and LH/FSH levels were lower in women with varying menstrual cycles than in the control group. FSH, LH, and E2 levels were significantly higher in women with varying menstrual cycles and flow duration than in the control group(P<0.05). AMH was negatively correlated with age (r= -0.72), BMI( r= -0.4), FSH(r= - 0.3), LH(r = -0.2) (p<0.05) and E2(r= -0.2, p>0.05). Also age was positively correlated with FSH(r=0.5,p<0.05), E2(r=0.3, p<0.05) and BMI(r=0.4, p<0.05). The level of AMH was not significant with cycle length and days of flow(p>0.05). This implies that AMH can be measured independently of the cycle phase. This show that AMH was lower in women with varying menstrual cycle with an increase in gonadotrophin and E2. The strong negative relationship between age and AMH implies that age is determining factor of ovarian reserve. Conclusion: AMH combined with age and FSH may improve ovarian reserve evaluation, making AMH a better marker

Microbial enhancement of plant nutrient acquisition

Nutrient availability is a determining factor for crop yield and quality. While fertilization is a major approach for improving plant nutrition, its efficacy can be limited and the production and application of fertilizers frequently bring problems to the environment. A large number of soil microbes are capable of enhancing plant nutrient acquisition and thereby offer environmentally benign solutions to meet the requirements of plant nutrition. Herein we provide summations of how beneficial microbes enhance plant acquisition of macronutrients and micronutrients. We also review recent studies on nutrition-dependent plant-microbe interactions, which highlight the plant’s initiative in establishing or deterring the plant-microbe association. By dissecting complex signaling interactions between microbes within the root microbiome, a greater understanding of microbe-enhanced plant nutrition under specific biotic and abiotic stresses will be possible.

Biomarkers Associated with Immune-Related Adverse Events under Checkpoint Inhibitors in Metastatic Melanoma

Immune checkpoint inhibitors (ICI) have revolutionized the therapeutic landscape of metastatic melanoma. However, ICI are often associated with immune-related adverse events (IRAE) such as colitis, hepatitis, pancreatitis, hypophysitis, pneumonitis, thyroiditis, exanthema, nephritis, myositis, encephalitis, or myocarditis. Biomarkers associated with the occurrence of IRAE would be desirable. In the literature, there is only little data available and furthermore mostly speculative, especially in view of genetic alterations. Our major aim was to check for possible associations between NGS-based genetic alterations and IRAE. We therefore analyzed 95 melanoma patients with ICI and evaluated their NGS results. We checked the data in view of potential associations between copy number variations (CNVs), small variations (VARs), human leucocyte antigen (HLA), sex, blood count parameters, pre-existing autoimmune diseases and the occurrence of IRAE. We conducted a literature research on genetic alterations hypothesized to be associated with the occurrence of IRAE. In total, we identified 39 genes that have been discussed as hypothetical biomarkers. We compared the list of these 39 genes with the tumor panel that our patients had received and focused our study on those 16 genes that were also included in the tumor panel used for NGS. Therefore, we focused our analyses on the following genes: AIRE, TERT, SH2B3, LRRK2, IKZF1, SMAD3, JAK2, PRDM1, CTLA4, TSHR, FAN1, SLCO1B1, PDCD1, IL1RN, CD274, UNG. We obtained relevant results: female sex was significantly associated with the development of hepatitis, combined immunotherapy with colitis, increased total and relative monocytes at therapy initiation were significantly associated with the development of pancreatitis, the same, pre-existing autoimmune diseases. Further significant associations were as follows: HLA homozygosity (hepatitis), and VARs on SMAD3 (pancreatitis). Regarding CNVs, significant markers included PRDM1 deletions and IL1RN (IRAE), CD274 duplications and SLCO1B1 (hepatitis), PRDM1 and CD274 (encephalitis), and PRDM1, CD274, TSHR, and FAN1 (myositis). Myositis and encephalitis, both, were associated with alterations of PRDM1 and CD274, which might explain their joined appearance in clinical practice. The association between HLA homozygosity and IRAE was clarified by finding HLA-A homozygosity as determining factor. We identified several genetic alterations hypothesized in the literature to be associated with the development of IRAE and found significant results concerning pre-existing autoimmune diseases and specific blood count parameters. Our findings can help to better understand the development of IRAE in melanoma patients. NGS might be a useful screening tool, however, our findings have yet to be confirmed in larger studies.

Fallacies of Consumerism

The concept of consumerism brings together many of the social transformations that serve as predictors of present and future behaviors and act as vehicles for today's society. Its evolution is diffuse and corresponds to different periods of history that have incorporated the characteristics of desire, superficiality, and exclusivity that drive new needs and potentialities. Its importance underlies the need to analyze 46 theoretical approaches through their categorization in six dimensions and frequency count in Google Scholar. The methodology used a higher-order association, establishing the most significant combinations and weightings. From these results, the concept of consumerism is defined by the economic-social-cultural-ethical categories according to its frequency of use in Google. This shows economic influences as a determining factor, over and above processes that are far from the common good or the general interest.

Workplace ergonomic assessment pada komunitas pekerja internet marketing society

Regular use of computers in the workspace contributes to suffering from many risk factors associated with musculoskeletal disorders (MSDs). Ergonomic principles is a determining factor of comfort and increased worker productivity at work. Ergonomics is also very important for workers who use computers. Working with computers is at high risk of suffering from a variety of complaints, including having the three biggest risk factors: back posture, repetition, and static strength. Preventive measures can minimize the negative impact of the main risks above. The purpose of this study is to assess and measure the ergonomics of the Internet Marketing Society's workplace workers. This service research uses observational methods from survey results with questionnaires distributed via google form. The total sampling is 33 workers from the Internet Marketing Society. The results show that 54.5% of workers do not know about ergonomics, 75.8% of workers do not use wrist and arm support devices. In the complaint problem, most of the workers experienced muscle pain 27.3% and back pain 24.2%, and 24.2% workers experienced shoulder conditions that were not relaxed while working. Based on these results, it is concluded that workers need to implement the principles of K3 and ergonomics in their work while working with computers.

Implications and Asymmetries of the Knowledge Society

The term knowledge society brings together many of the transformations that are taking place in today's society, and its definition serves as an indicator of these changes. The related concentrations or asymmetries that arise from the phenomenon are also the subject of analysis and dispute. Its development and scope have been uneven, constantly incorporating new meanings to the existing terminology, hence the need to analyze 82 concepts of the knowledge society through a frequency count in Google Scholar, with a subsequent categorization saturating in six dimensions, in order to analyze their framing. The methodology used a higher-order association, establishing the most significant combinations and weightings. From these results, the concept of the knowledge society is defined by the dual economic-social category, according to its frequency of use in Google. This shows economic influences as a determining factor in the knowledge society, engendering processes far from the common good or the general interest.

The Influence of Disaster Knowledge and Community Attitudes Towards Preparedness for Landslide Disasters in Cemparam Pakat Jeroh Village Mesidah District Bener Meriah

Background: The high number of natural disasters in the country requires the vigilance and preparedness of all parties. Landslide events still occur in several areas in Indonesia, presumably for all parties to make preparedness and prevention efforts to face the threat of disaster. Objectives: Preparedness is an important factor that is currently the focus of attention, considering that preparedness is a determining factor for disaster risk reduction that can be carried out and pursued from an early age. Methods: This type of research is a quantitative research with a cross sectional approach. The population in this study were 207 respondents, using a random sampling technique using the Slovin formula, a sample of 68 respondents was obtained. Results: The research shows that there is an influence of disaster knowledge, community attitudes and socialization of landslides on preparedness for landslide disasters. Village Studies in Cemparam Pakat Jeroh Village, Mesidah District. Conclusion: the need for the government's role in providing business opportunities for people living in landslide-prone areas so that people can meet the needs of their family's life