N,N-Dimethylformamide (DMF): An Inexpensive and Attractive Reactant

2021 ◽  
Vol 25 ◽  
Author(s):  
Xiao-hua CAI ◽  
Hui GUO
Keyword(s):  
Building Block ◽  
Polar Solvent ◽  
Raw Material ◽  
Synthetic Chemistry ◽  
The Past ◽  
Recent Advances ◽  
Synthetic Reactions ◽  
Simple Atom ◽  
Made In ◽  
Versatile Reagent

: The development of simple, atom-economical, and sustainable methodologies for the construction of various functional molecules from easily available substrates has been of great interest in synthetic chemistry. N,N-dimethylformamide (DMF) is an inexpensive, abundant solvent and industrial raw material. It is considered as an effective polar solvent and a versatile reagent in synthetic transformations. During the past few decades, many significant and attractive achievements have been made in the fields of DMF as a reactant. The mini-review will mainly summarize recent advances in the applicants of DMF as a multipurpose building block in synthetic reactions.

Tertiary Enamides: Versatile and Available Substrates in Synthetic Chemistry

2019 ◽  
Vol 16 (1) ◽  
pp. 70-97 ◽  
Author(s):  
Xiaohua Cai ◽  
Mengzhi Yang ◽  
Hui Guo
Keyword(s):  
Chemical Reaction ◽  
Coupling Reaction ◽  
Building Blocks ◽  
Synthetic Chemistry ◽  
The Past ◽  
Recent Advances ◽  
Complex Building ◽  
Group A ◽  
Unique Stability ◽  
Made In

Background: Enamines and their variant enamides as powerful and versatile synthons have attracted great attention in synthetic chemistry. Enamides display unique stability and reduce enaminic reactivity in view of the electron-withdrawing effect of N-acyl group. A great deal of satisfactory achievements in the synthesis and application of enamides has been made in recent years. Especially, tertiary enamides without N-H bond regarded as low reactivity of compounds in the past can act as excellent nucleophiles to react with electrophiles for the construction of various nitrous molecules. </P><P> Objective: This review focuses on recent advances on tertiary enamides in the synthetic strategies and applications including addition, coupling reaction, functionalization and electro- or photo-chemical reaction. Conclusion: Tertiary enamides as electron-deficient nucleophiles display a satisfactory balance between stability and reactivity to offer multiple opportunities for the construction of various functionalized nitrogencontaining compounds. Further exploration of the reactive mechanisms involved tertiary enamides and the development of novel and efficient transformations to generate ever more complex building blocks starting from tertiary enamides are particularly worth pursuing.

scholarly journals Recent Advances in Palladium-Catalyzed Isocyanide Insertions

Molecules ◽  
2020 ◽  
Vol 25 (21) ◽  
pp. 4906
Author(s):  
Jurriën W. Collet ◽  
Thomas R. Roose ◽  
Bram Weijers ◽  
Bert U. W. Maes ◽  
Eelco Ruijter ◽  
...  
Keyword(s):  
Organic Synthesis ◽  
Building Blocks ◽  
Insertion Reactions ◽  
Chemical Reagents ◽  
The Past ◽  
Recent Advances ◽  
Recent Developments ◽  
Palladium Catalyzed ◽  
Made In ◽  
Rapid Incorporation

Isocyanides have long been known as versatile chemical reagents in organic synthesis. Their ambivalent nature also allows them to function as a CO-substitute in palladium-catalyzed cross couplings. Over the past decades, isocyanides have emerged as practical and versatile C1 building blocks, whose inherent N-substitution allows for the rapid incorporation of nitrogeneous fragments in a wide variety of products. Recent developments in palladium catalyzed isocyanide insertion reactions have significantly expanded the scope and applicability of these imidoylative cross-couplings. This review highlights the advances made in this field over the past eight years.

Recent Advances in Glass Transitions in Polymers

1970 ◽  
Vol 43 (1) ◽  
pp. 156-170 ◽  
Author(s):  
A. Eisenberg ◽  
M. Shen
Keyword(s):  
Glass Transition ◽  
Present Article ◽  
Progress Report ◽  
Previous Article ◽  
Glass Transitions ◽  
The Past ◽  
Recent Advances ◽  
Made In

Abstract Since the publication of our review “Glass Transition in Polymers” in 1966, a number of interesting advances have been made in this field. The present article is intended to be an addendum to this review, reporting the progress that has been made by various workers during the past three years. In addition, a number of topics were not covered in the previous article due to the relatively incomplete understanding at that time. These will now be discussed. This is not because these topics are at present fully understood. Rather, we hope it will serve as a progress report to stimulate further interest in areas where further work is needed. The numbering systems and notations in this paper will follow those in the previous article for the sake of continuity.

scholarly journals Recent advances in the tandem annulation of 1,3-enynes to functionalized pyridine and pyrrole derivatives

2021 ◽  
Vol 17 ◽  
pp. 2462-2476
Author(s):  
Yi Liu ◽  
Puying Luo ◽  
Yang Fu ◽  
Tianxin Hao ◽  
Xuan Liu ◽  
...  
Keyword(s):  
Reaction Mechanisms ◽  
Structural Motifs ◽  
Pyrrole Derivatives ◽  
The Past ◽  
Recent Advances ◽  
Functionalized Pyridine ◽  
Great Progress ◽  
Made In

Great progress has been made in the tandem annulation of enynes in the past few years. This review only presents the corresponding reactions of 1,3-enyne structural motifs to provide the functionalized pyridine and pyrrole derivatives. The functionalization reactions cover iodination, bromination, trifluoromethylation, azidation, carbonylation, arylation, alkylation, selenylation, sulfenylation, amidation, esterification, and hydroxylation. We also briefly introduce the applications of the products and the reaction mechanisms for the synthesis of corresponding N-heterocycles.

scholarly journals Recent advances in the synthesis of α-amino ketones

2021 ◽  
Author(s):  
Lewis A. T. Allen ◽  
Robert-Cristian Raclea ◽  
Philipp Natho ◽  
Philip J. Parsons
Keyword(s):  
Functional Group ◽  
Amino Ketone ◽  
Product Substitution ◽  
The Past ◽  
Recent Advances ◽  
Extended Discussion ◽  
Made In

This review on α-amino ketone synthesis collates and evaluates developments made in this area over the past decade, with an extended discussion on functional group compatibility, resultant product substitution patterns, and medicinal applications.

tert-Butyl Nitrite (TBN) as a Versatile Reagent in Organic Synthesis

Synthesis ◽  
2017 ◽  
Vol 50 (04) ◽  
pp. 711-722 ◽  
Author(s):  
Xiaodong Jia ◽  
Pengfei Li
Keyword(s):  
Molecular Oxygen ◽  
Organic Synthesis ◽  
Radical Reactions ◽  
Organic Transformations ◽  
Metal Free ◽  
Tert Butyl ◽  
The Past ◽  
Recent Advances ◽  
Versatile Reagent

tert-Butyl nitrite (TBN) is an important metal-free reagent that is widely applied in various organic transformations. Besides its traditional applications in nitrosation and diazotization, its ability to activate molecular oxygen to enable the initiation of radical reactions, including nitration, oximation, oxidation, and so on, has attracted extensively attention in the past decade. This review highlights recent advances in this field to promote further exploration of this versatile compound.1 Introduction2 Reactions Involving TBN2.1 Nitrosation2.2 Oximation2.3 Diazotization2.4 Nitration2.5 Oxidation2.6 Other Reactions3 Conclusion and Perspective

Recent advances in the tandem reaction of azides with alkynes or alkynols

2016 ◽  
Vol 14 (48) ◽  
pp. 11317-11331 ◽  
Author(s):  
Xian-Rong Song ◽  
Yi-Feng Qiu ◽  
Xue-Yuan Liu ◽  
Yong-Min Liang
Keyword(s):  
Tandem Reaction ◽  
Synthetic Chemistry ◽  
The Past ◽  
Recent Advances ◽  
Nitrogen Containing Compounds ◽  
Significant Attention

Over the past few decades, the development of versatile methodologies to employ azides as aminating agents for the formation of nitrogen-containing compounds has attracted significant attention in synthetic chemistry.

scholarly journals Recent advances in electrocatalytic chloride oxidation for chlorine gas production

2021 ◽  
Author(s):  
Shen-Long Zhao ◽  
Yihan Wang ◽  
Yangyang Liu ◽  
Dianne Wiley ◽  
Zhiyong Tang
Keyword(s):  
Gas Production ◽  
Raw Material ◽  
Industrial Chemistry ◽  
Brine Solution ◽  
The Past ◽  
Recent Advances ◽  
Chlorine Gas

Chlorine gas is one of the most basic chemicals produced through electrolysis of brine solution which is a key raw material for many areas of industrial chemistry. In the past...

Formic Acid as an Inexpensive and Convenient Reagent

2020 ◽  
Vol 24 ◽  
Author(s):  
Xiao-hua CAI ◽  
Su-qian CAI ◽  
Bing XIE
Keyword(s):  
Formic Acid ◽  
Green Synthesis ◽  
Chemical Industry ◽  
Hydrogen Donor ◽  
Organic Reactions ◽  
The Past ◽  
Recent Advances ◽  
Versatile Reagent

Abstract:: Formic acid (HCOOH) as an inexpensive and versatile reagent has attracted broad attention in the field of green synthesis and chemical industry. Formic acid acts not only as a convenient and less toxic CO surrogate, but also as an excel-lent formylative reagent, C1 source and hydrogen donor in organic reactions. Over the past decades, many exciting contribu-tions have been made which have helped chemists to understand the mechanisms of these reactions. The review will exam-ine recent advances in the utilization of formic acid as economical, practical and multipurpose reactant in synthetic trans-formations.

scholarly journals Recent Advances in Enantioselective Photochemical Reactions of Stabilized Diazo Compounds

Molecules ◽  
2019 ◽  
Vol 24 (17) ◽  
pp. 3191 ◽  
Author(s):  
Ting-Bi Hua ◽  
Qing-Qing Yang ◽  
You-Quan Zou
Keyword(s):  
Photochemical Reactions ◽  
Diazo Compounds ◽  
Reaction Type ◽  
The Past ◽  
Recent Advances ◽  
Wide Range ◽  
Metal Carbenoids ◽  
Metal Catalyzed ◽  
Made In

Diazo compounds have proven to be a useful class of carbenes or metal carbenoids sources under thermal, photochemical, or metal-catalyzed conditions, which can subsequently undergo a wide range of synthetically important transformations. Recently, asymmetric photocatalysis has provoked increasing research interests, and great advances have been made in this discipline towards the synthesis of optically enriched compounds. In this context, the past two decades have been the most productive period in the developments of enantioselective photochemical reactions of diazo compounds due to a better understanding of the reactivities of diazo compounds and the emergence of new catalytic modes, as well as easier access to and treatment of stabilized diazo compounds. This review highlights these impressive achievements according to the reaction type, and the general mechanisms and stereochemical inductions are briefly discussed as well.

Sign in / Sign up

Export Citation Format

Share Document