Characterization of Pancreas at Diabetic Patients in CT images using Texture Analysis

Author(s):  
Mona E. Elbashier ◽  
Suhaib Alameen ◽  
Caroline Edward Ayad ◽  
Mohamed E. M. Gar-Elnabi

This study concern to characterize the pancreas areato head, body and tail using Gray Level Run Length Matrix (GLRLM) and extract classification features from CT images. The GLRLM techniques included eleven’s features. To find the gray level distribution in CT images it complements the GLRLM features extracted from CT images with runs of gray level in pixels and estimate the size distribution of thesubpatterns. analyzing the image with Interactive Data Language IDL software to measure the grey level distribution of images. The results show that the Gray Level Run Length Matrix and  features give classification accuracy of pancreashead 89.2%, body 93.6 and the tail classification accuracy 93.5%. The overall classification accuracy of pancreas area 92.0%.These relationships are stored in a Texture Dictionary that can be later used to automatically annotate new CT images with the appropriate pancreas area names.

Author(s):  
Amal Alzain ◽  
Suhaib Alameen ◽  
Rani Elmaki ◽  
Mohamed E. M. Gar-Elnabi

This study concern to characterize the brain tissues to ischemic stroke, gray matter, white matter and CSF using texture analysisto extract classification features from CT images. The First Order Statistic techniques included sevenfeatures. To find the gray level variation in CT images it complements the FOS features extracted from CT images withgray level in pixels and estimate the variation of thesubpatterns. analyzing the image with Interactive Data Language IDL software to measure the grey level of images. The results show that the Gray Level variation and   features give classification accuracy of ischemic stroke 97.6%, gray matter95.2%, white matter 97.3% and the CSF classification accuracy 98.0%. The overall classification accuracy of brain tissues 97.0%.These relationships are stored in a Texture Dictionary that can be later used to automatically annotate new CT images with the appropriate brain tissues names.


2014 ◽  
Vol 533 ◽  
pp. 415-420 ◽  
Author(s):  
Wei Fang Liu ◽  
Xu Wang ◽  
Hong Xia

This study investigated three-dimensional (3D) texture as a possible diagnostic marker of Alzheimers disease (AD). Methods: T1-weighted MRI of 18 AD patients, 18 Mild Cognitive Impairment (MCI) patients and 18 normal controls (NC) were selected.3D Texture parameters of the corpus callosum,including contrast, inverse difference moment , entropy, short run emphasis, long run emphasis, grey level nonuniformity, run length nonuniformity and fraction were extracted from the gray level co-occurrence matrix and run length matrix. Finally statistic significance was tested among three groups, and the correlations between parameters and Mini-Mental State Examination (MMSE) scores were calculated. Results: The results showed that the 3D texture features had significant differences (p<0.05) among three groups except grey level nonuniformity and run length nonuniformity that the difference was not significant (p>0.05) between MCI and NC or AD and MCI , and they were correlated with MMSE scores.Conclusions: 3D texture analysis can reflect the pathological changes of corpus callosum in patients with AD and MCI, and it may be helpful to AD early diagnosis.


2016 ◽  
Vol 207 (5) ◽  
pp. W81-W87 ◽  
Author(s):  
Rodrigo Canellas ◽  
Farhad Mehrkhani ◽  
Manuel Patino ◽  
Avinash Kambadakone ◽  
Dushyant Sahani

2012 ◽  
Vol 41 (6) ◽  
pp. 475-480 ◽  
Author(s):  
JV Raja ◽  
M Khan ◽  
VK Ramachandra ◽  
O Al-Kadi

2016 ◽  
Vol 44 (1) ◽  
pp. 151-165 ◽  
Author(s):  
Mathieu Hatt ◽  
Florent Tixier ◽  
Larry Pierce ◽  
Paul E. Kinahan ◽  
Catherine Cheze Le Rest ◽  
...  
Keyword(s):  
The Past ◽  

PLoS ONE ◽  
2020 ◽  
Vol 15 (12) ◽  
pp. e0244965
Author(s):  
Laurentius O. Osapoetra ◽  
William Chan ◽  
William Tran ◽  
Michael C. Kolios ◽  
Gregory J. Czarnota

Purpose Accurate and timely diagnosis of breast carcinoma is very crucial because of its high incidence and high morbidity. Screening can improve overall prognosis by detecting the disease early. Biopsy remains as the gold standard for pathological confirmation of malignancy and tumour grading. The development of diagnostic imaging techniques as an alternative for the rapid and accurate characterization of breast masses is necessitated. Quantitative ultrasound (QUS) spectroscopy is a modality well suited for this purpose. This study was carried out to evaluate different texture analysis methods applied on QUS spectral parametric images for the characterization of breast lesions. Methods Parametric images of mid-band-fit (MBF), spectral-slope (SS), spectral-intercept (SI), average scatterer diameter (ASD), and average acoustic concentration (AAC) were determined using QUS spectroscopy from 193 patients with breast lesions. Texture methods were used to quantify heterogeneities of the parametric images. Three statistical-based approaches for texture analysis that include Gray Level Co-occurrence Matrix (GLCM), Gray Level Run-length Matrix (GRLM), and Gray Level Size Zone Matrix (GLSZM) methods were evaluated. QUS and texture-parameters were determined from both tumour core and a 5-mm tumour margin and were used in comparison to histopathological analysis in order to classify breast lesions as either benign or malignant. We developed a diagnostic model using different classification algorithms including linear discriminant analysis (LDA), k-nearest neighbours (KNN), support vector machine with radial basis function kernel (SVM-RBF), and an artificial neural network (ANN). Model performance was evaluated using leave-one-out cross-validation (LOOCV) and hold-out validation. Results Classifier performances ranged from 73% to 91% in terms of accuracy dependent on tumour margin inclusion and classifier methodology. Utilizing information from tumour core alone, the ANN achieved the best classification performance of 93% sensitivity, 88% specificity, 91% accuracy, 0.95 AUC using QUS parameters and their GLSZM texture features. Conclusions A QUS-based framework and texture analysis methods enabled classification of breast lesions with >90% accuracy. The results suggest that optimizing method for extracting discriminative textural features from QUS spectral parametric images can improve classification performance. Evaluation of the proposed technique on a larger cohort of patients with proper validation technique demonstrated the robustness and generalization of the approach.


2018 ◽  
Vol 8 (9) ◽  
pp. 1835-1843 ◽  
Author(s):  
Jia-Jun Qiu ◽  
Yue Wu ◽  
Bei Hui ◽  
Jia Chen ◽  
Lin Ji ◽  
...  

Purpose: To explore the feasibility of classifying hepatocellular carcinoma (HCC) and hepatic hemangioma (HEM) using texture features of non-enhanced computed tomography (CT) images, especially to investigate the effectiveness of a novel texture analysis method based on the combination of wavelet and co-occurrence matrix. Methods: 269 patients were retrospectively analyzed, including 129 HCCs and 140 HEMs. We cropped tumor regions of interest (ROIs) on non-enhanced CT images, and then used four texture analysis methods to extract quantitative data of the ROIs: gray-level histogram (GLH), gray-level co-occurrence matrix (GLCM), reverse biorthogonal wavelet transform (RBWT), and reverse biorthogonal wavelet co-occurrence matrix (RBCM). The RBCM was a novel method proposed in this study that combined wavelet transform and co-occurrence matrix. It discretized wavelet coefficient matrices based on the statistical characteristics of the training set. Thus, four sets of texture features were obtained. We then conducted classification studies using support vector machine on each set of texture features. 10-fold cross training and testing were used in the classifications, and their results were evaluated and compared. In addition, we tested the significant differences in the texture features of the RBCM method and explored the possible relationships between textures and lesion types. Results: The RBCM method achieved the best classification performance: its average accuracy was 82.14%; its average AUC (area under the receiver operating characteristic curve) was 0.8423. In addition, using the methods of GLH, GLCM, and RBWT, their average accuracies were 75.81%, 78.79%, and 78.8%, respectively. Conclusions: It indicates that the developed texture analysis methods are rewarding for computer-aided diagnosis of HCC and HEM based on non-enhanced CT images. Furthermore, the distinguishing ability of the proposed RBCM method is more pronounced.


2019 ◽  
Author(s):  
Usman Mahmood ◽  
Aditya Apte ◽  
Christopher Kanan ◽  
David D.B. Bates ◽  
Giuseppe Corrias ◽  
...  

ABSTRACTPurposeThis study investigates the robustness of quantitative radiomic features derived from computed tomography (CT) images of a novel patient informed 3-D printed phantom, which captures the morphological heterogeneity of tumors and normal tissue observed on CT scans.MethodsUsing a novel voxel-based multi-material three-dimensional (3D) printer, an anthropomorphic phantom that was modeled after diseased tissue seen on 6 patient CT scans was manufactured. Four patients presented with pancreatic adenocarcinoma tumors (PDAC), 1 with non-small cell lung carcinoma (NSCLC) and 1 with advanced stage hepatic cirrhosis. The 5 tumors were segmented, extracted and then imbedded into CT images of the heterogenous portion of the cirrhotic liver. The composite scan of the implanted tumor within the background cirrhotic liver was then 3D printed. The resultant phantom was scanned sequentially, 30 times with a clinical CT scanner using a reference CT protocol. One hundred and four quantitative radiomic features were then extracted from images of each lesion to determine their repeatability. Repeatability of each radiomic feature was evaluated using the within subject coefficient of variation (wCV, %). A feature with a wCV (%) > 10% was considered as being unrepeatable. A subset of the repeatable features that were also found to be prognostic for lung and pancreatic cancers were then assessed for their percent deviation (pDV, %) from reference values. The reference values were those derived from the repeatability portion of this study. The assessment was conducted by re-scanning the phantom with 11 different clinically relevant sets of scanning parameters. Deviation of radiomic features derived from images of each tumor across all sets of scanning parameters was assessed using the percent deviation relative to the reference values.ResultsTwenty nine of the 104 features presented with wCV (%) > 10%. The lack of repeatability was found to depend on tumor type. The only class of radiomic features with a wCV (%) < 10% were those calculated using the neighboring grey level dependence-based matrices (NGLDM). Notably, skewness, first information correlation, cluster shade, Haralick correlation, autocorrelation, busyness, complexity, high gray level zone emphasis, small area high gray level emphasis, large area low gray level emphasis, large area high gray level emphasis, short run high grey level emphasis, and valley radiomic features had wCV (%) values > 10% for select tumors within the phantom. Two radiomic features prognostic for NSCLC, energy and grey level non-uniformity, had pDV’s (%) that exceeded 30% across all scanning techniques. The pDV (%) for the 4 radiomic features prognostic for PDAC tumors depended on tumor type and selected scanning parameter. Application of the lung kernel caused the largest pDV’s (%). Scans acquired with the reduced tube current of 100 mA and reconstructed with the bone kernel yielded pDV’s (%) within ± 10%.ConclusionWe demonstrated the feasibility with which patient informed 3D printed phantoms can be manufactured directly from lesions seen on CT scans, and demonstrate their potential use for the assessment of robust quantitative radiomic features.


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