Quantitive Changes In Cellularity Of The Red Bone Marrow In Rats After Irradiation And Xenogenic Cerebrospinal Fluid Correction

2014 ◽  
Vol 13 (3) ◽  
pp. 26-29
Author(s):  
A. I. Absettarova
Keyword(s):  
Bone Marrow ◽  
Cerebrospinal Fluid ◽  
Red Bone Marrow

Dosimetry with 188Re-labelled monoclonal anti-CD66 antibodies

2006 ◽  
Vol 45 (03) ◽  
pp. 134-138 ◽  
Author(s):  
T. Kull ◽  
N. M. Blumstein ◽  
D. Bunjes ◽  
B. Neumaier ◽  
A. K. Buck ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Bone Marrow ◽  
Gamma Camera ◽  
Absorbed Dose ◽  
Correlation Coefficients ◽  
Residence Times ◽  
Reliable Prediction ◽  
Red Bone Marrow ◽  
Antibody Preparation ◽  
Simplified Method

SummaryAim: For the therapeutic application of radiopharmaceuticals the activity is determined on an individual basis. Here we investigated the accuracy for a simplified assessment of the residence times for a 188Re-labelled anti-CD66 monoclonal antibody. Patients, methods: For 49 patients with high risk leukaemia (24 men, 25 women, age: 44 ± 12 years) the residence times were determined for the injected 188Re-labelled anti-CD66 antibodies (1.3 ± 0.4 GBq, 5–7 GBq/mg protein, >95% 188Re bound to the antibody) based on 5 measurements (1.5, 3, 20, 26, and 44 h p.i.) using planar conjugate view gamma camera images (complete method). In a simplified method the residence times were calculated based on a single measurement 3 h p.i. Results: The residence times for kidneys, liver, red bone marrow, spleen and remainder of body for the complete method were 0.4 ± 0.2 h, 1.9 ± 0.8 h, 7.8 ± 2.1 h, 0.6 ± 0.3 h and 8.6 ± 2.1 h, respectively. For all organs a linear correlation exists between the residence times of the complete method and the simplified method with the slopes (correlation coefficients R > 0.89) of 0.89, 0.99, 1.23, 1.13 and 1.09 for kidneys, liver, red bone marrow, spleen and remainder of body, respectively. Conclusion: The proposed approach allows reliable prediction of biokinetics of 188Re-labelled anti-CD66 monoclonal antibody biodistribution with a single study. Efficient pretherapeutic estimation of organ absorbed dose may be possible, provided that a more stable anti-CD66 antibody preparation is available.

scholarly journals The ICRP recommended methods of red bone marrow dosimetry

2021 ◽  
pp. 106611
Author(s):  
Maria Zankl ◽  
Jonathan Eakins ◽  
José-María Gómez Ros ◽  
Christelle Huet
Keyword(s):  
Bone Marrow ◽  
Red Bone Marrow

IMMUNE SYSTEM OF POIKILOTHERMIC AQUATIC ORGANISMS

2021 ◽  
pp. 71-91
Author(s):  
G.I. PRONINA ◽  
◽  
A.A. IVANOV ◽  
A.G. MANNAPOV ◽  
O.V. SANAYA
Keyword(s):  
Bone Marrow ◽  
Immune System ◽  
Lymphoid Tissue ◽  
Cellular Response ◽  
Aquatic Organisms ◽  
Immune Defense ◽  
Cationic Protein ◽  
Complement Components ◽  
Red Bone Marrow

The paper shows features of the immune system of poikilothermic aquatic organisms of different taxonomic groups: crustaceans, fish, and amphibians. Defense mechanisms of crustaceans are presented by largely innate non-specific factors: external covers (including the exoskeleton), mucus, physical and chemical barriers lysozyme in the hemolymph, propanolamine system, and phagocytosis. The authors identified 4 types of cells (hemocytes) found in the circulating fluid of crayfish, depending on the morphological and functional properties: agranulocytes, progranulin,granulocytes, and transparent cells. Each type performs different functions in the process of immune defense. In fish, there is no red bone marrow and lymph nodes, the main organs of hematopoiesis include thymus, spleen, liver, lymphoid tissue of the brain and the trunk of the kidneys,accumulation of lymphoid tissue of the cranial box, intestine, and pericardium. Humoral components of the immune response of fish are represented by immunoglobulins, system complement components, lysozyme, C-reactive protein, interferon, lysine, hemolysin, hemagglutinin. Only IgM-like antibodies represent immunoglobulins in fish. The central organ of the amphibian immune system is the red bone marrow, but its role in the immune defense of amphibians has not been sufficiently studied. Peripheral organs of the immune system include kidneys, thymus, spleen, lymphomyeloid organs. Depending on the characteristics of the immune system of poikilothermic hydrobionts of different types, the authors offer methods for assessing their humoralimmunity (by determining phenoloxidase) and cellular response (by phagocytosis). Cellular immunity, and phagocytic activity, in particular, can be evaluated using cytochemical methods taking into account oxygenindependent factors – the content of enzymatic lysosomal cationic protein in phagocytes – and oxygendependent ones – NBT-test with nitrosonium tetrazolium that records cytotoxic oxygen radicals generated during the respiratory explosion of cell stimulation in vitro.

Radiologic case study. Diffuse red bone marrow hyperplasia of the spine, pelvis and femurs

Orthopedics ◽  
1999 ◽  
Vol 22 (8) ◽  
pp. 780-780
Author(s):  
James F Glockner ◽  
Murali Sundaram
Keyword(s):  
Bone Marrow ◽  
Red Bone Marrow

Long-term culture and differentiation of porcine red bone marrow hematopoietic cells co-cultured with immortalized mesenchymal cells

2017 ◽  
Vol 191 ◽  
pp. 44-50
Author(s):  
Abubakar Garba ◽  
Delphine D. Acar ◽  
Inge D.M. Roukaerts ◽  
Lowiese M.B. Desmarets ◽  
Bert Devriendt ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Hematopoietic Cells ◽  
Mesenchymal Cells ◽  
Red Bone Marrow ◽  
Long Term Culture

Influence of red bone marrow allotransplantation on neuron-specific (NSE) and histamine-containing lymph node cells

2021 ◽  
pp. 246-249
Author(s):  
V. O. Romanov ◽  
◽  
L. A. Lyubovtseva ◽  
O. V. Vorob'eva ◽  
L. P. Romanova ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Lymph Node ◽  
Red Bone Marrow ◽  
Lymph Node Cells
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