Education level and the characteristics cognitive impairment in a Brazilian cohort of multiple sclerosis patients

Abstract Background Approximately half of all patients with multiple sclerosis (MS) experience cognitive impairment, most commonly with regard to new learning and memory. Cognitive dysfunction is a leading cause of disability in MS and it can have profound social and economic consequences for patients and their families. Objective This study was conducted to discover the early cognitive domains affected in multiple sclerosis patients concomitant with the postulated brain atrophy in an Egyptian sample of multiple sclerosis patients. Patients and Methods A cross-sectional observational case-control study conducted on seventy (60) patients who came for follow-up in Ain Shams University hospitals. 40 patients were taken as cases that followed up in MS unit in Ain-Shams university hospitals. 20 participants were taken as controls taken from the general medicine clinics age and sex matched to our patient group. An informed written consent was taken from parents of each person included in the study. Results There was a statistically significant difference between the two groups in brain volumetric changes and in the parameters of cognitive assessment Conclusion Early detection and examination of cognitive functions is important for patient evaluation, follow up and treatment regimen used.

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Effect of Boswellia serrata on cognitive impairment in multiple sclerosis patients

Journal of Herbal Medicine ◽

10.1016/j.hermed.2016.05.003 ◽

2016 ◽

Vol 6 (3) ◽

pp. 119-127 ◽

Cited By ~ 5

Author(s):

Nastaran Majdinasab ◽

Amir Siahpush ◽

Seyedeh Khatoon Mousavinejad ◽

Alireza Malayeri ◽

Seyed Aidin Sajedi ◽

...

Keyword(s):

Multiple Sclerosis ◽

Cognitive Impairment ◽

Boswellia Serrata ◽

Multiple Sclerosis Patients

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Cognitive impairment in newly diagnosed multiple sclerosis patients: A 4-year follow-up study

Journal of the Neurological Sciences ◽

10.1016/j.jns.2005.09.016 ◽

2006 ◽

Vol 245 (1-2) ◽

pp. 77-85 ◽

Cited By ~ 56

Author(s):

Agnete Jønsson ◽

Jente Andresen ◽

Lars Storr ◽

Thomas Tscherning ◽

Per Soelberg Sørensen ◽

...

Keyword(s):

Multiple Sclerosis ◽

Cognitive Impairment ◽

Newly Diagnosed ◽

Follow Up Study ◽

Multiple Sclerosis Patients

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Relation of cognitive impairment and depression to quality of life in multiple sclerosis patients

The Italian Journal of Neurological Sciences ◽

10.1007/bf00539594 ◽

1998 ◽

Vol 19 (S6) ◽

pp. S392-S398 ◽

Cited By ~ 2

Author(s):

A. Solari ◽

A. Ghezzi ◽

L. Mendozzi ◽

G. Filippini ◽

S. Cifani ◽

...

Keyword(s):

Quality Of Life ◽

Multiple Sclerosis ◽

Cognitive Impairment ◽

Multiple Sclerosis Patients

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Clinical features and physical performance in multiple sclerosis patients with and without cognitive impairment: a cross-sectional study

International Journal of Rehabilitation Research ◽

10.1097/mrr.0000000000000428 ◽

2020 ◽

Vol 43 (4) ◽

pp. 316-323

Author(s):

Cagla Ozkul ◽

Arzu Guclu-Gunduz ◽

Kader Eldemir ◽

Yasemin Apaydin ◽

Gokhan Yazici ◽

...

Keyword(s):

Multiple Sclerosis ◽

Cognitive Impairment ◽

Physical Performance ◽

Clinical Features ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

Multiple Sclerosis Patients

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T1 cortical hypointensities and their association with cognitive disability in multiple sclerosis

Multiple Sclerosis Journal ◽

10.1177/1352458510377223 ◽

2010 ◽

Vol 16 (10) ◽

pp. 1203-1212 ◽

Cited By ~ 16

Author(s):

Francesca Bagnato ◽

Zeena Salman ◽

Robert Kane ◽

Sungyoung Auh ◽

Fredric K Cantor ◽

...

Keyword(s):

Multiple Sclerosis ◽

Cognitive Impairment ◽

White Matter ◽

Statistical Significance ◽

Verbal Learning ◽

Lesion Volume ◽

Cognitive Disability ◽

3.0 Tesla ◽

Multiple Sclerosis Patients ◽

The Impact

Background: Neocortical lesions (NLs) largely contribute to the pathology of multiple sclerosis (MS), although their relevance in patients’ disability remains unknown. Objective: To assess the incidence of T1 hypointense NLs by 3.0-Tesla magnetic resonance imaging (MRI) in patients with MS and examine neocortical lesion association with cognitive impairment. Methods: In this case-control study, 21 MS patients and 21 age-, sex- and years of education-matched healthy volunteers underwent: (i) a neuropsychological examination rating cognitive impairment (Minimal Assessment of Cognitive Function in MS); (ii) a 3.0-Tesla MRI inclusive of an isotropic 1.0 mm3 three-dimensional inversion prepared spoiled gradient-recalled-echo (3D-IRSPGR) image and T1- and T2-weighted images. Hypointensities on 3D-IRSPGR lying in the cortex, either entirely or partially were counted and association between NLs and cognitive impairment investigated. Results: A total of 95 NLs were observed in 14 (66.7%) patients. NL+ patients performed poorer (p = 0.020) than NLpatients only on the delayed recall component of the California Verbal Learning Test. This difference lost statistical significance when a correction for white matter lesion volume was employed. Conclusions: Although T 1 hypointense NLs may be present in a relatively high proportion of multiple sclerosis patients, the impact that they have in cognitive impairment is not independent from white matter disease.

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