Grenzenlose Verantwortung

2010 ◽  
Vol 2010 (1) ◽  
pp. 5-22
Author(s):  
Ralf Becker
Keyword(s):  
Personal Freedom ◽  
The Relationship ◽  
The Brain

The article examines the relationship between freedom, guilt and responsibility in Dostojewski’s and Sartre’s works. Both attribute a great measure of personal freedom to man. Therefore, they do not tolerate excuses. Whoever is free, carries responsibility and gets caught up in guilt. Dostojewski’s focus is mainly on guilt, Sartre’s is on responsibility. They share the conviction that we can delegate responsibility for our actions or our way of living neither to a whole, of which we are a part, like society (the ,milieu'), nor to a part, for which we are the whole, like the ,brain' or the ,genes'. In that sense, Dostojewski’s and Sartre’s attempts at an ethic of responsibility also offer convincing arguments against determinism.

EXPERIMENTAL ASSESSMENT OF THE NANOPARTICLES TOXICITY OF NICKEL OXIDE IN TWO SIZES IN THE SUBCHRONIC EXPERIMENT

2018 ◽  
pp. 30-35
Author(s):  
M.P. Sutunkova ◽  
B.A. Katsnelson ◽  
L.I. Privalova ◽  
S.N. Solovjeva ◽  
V.B. Gurvich ◽  
...  
Keyword(s):  
Nickel Oxide ◽  
Nervous Activity ◽  
Equal Mass ◽  
The Body ◽  
Subchronic Toxicity ◽  
Physiological Mechanisms ◽  
Nickel Oxide Nanoparticles ◽  
The Relationship ◽  
The Brain ◽  
Nanoparticles Toxicity

We conducted a comparative assessment of the nickel oxide nanoparticles toxicity (NiO) of two sizes (11 and 25 nm) according to a number of indicators of the body state after repeated intraperitoneal injections of these particles suspensions. At equal mass doses, NiO nanoparticles have been found to cause various manifestations of systemic subchronic toxicity with a particularly pronounced effect on liver, kidney function, the body’s antioxidant system, lipid metabolism, white and red blood, redox metabolism, spleen damage, and some disorders of nervous activity allegedly related to the possibility of nickel penetration into the brain from the blood. The relationship between the diameter and toxicity of particles is ambiguous, which may be due to differences in toxicokinetics, which is controlled by both physiological mechanisms and direct penetration of nanoparticles through biological barriers and, finally, unequal solubility.

Polymeric Nanoparticles for Brain Drug Delivery - A Review

2020 ◽  
Vol 21 (9) ◽  
pp. 649-660
Author(s):  
Subashini Raman ◽  
Syed Mahmood ◽  
Ayah R. Hilles ◽  
Md Noushad Javed ◽  
Motia Azmana ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Surface Modification ◽  
Polymeric Nanoparticles ◽  
Drug Loading ◽  
Preparation Methods ◽  
Brain Drug Delivery ◽  
Polymeric Nanoparticle ◽  
Relationship Of ◽  
The Relationship ◽  
The Brain

Background: Blood-brain barrier (BBB) plays a most hindering role in drug delivery to the brain. Recent research comes out with the nanoparticles approach, is continuously working towards improving the delivery to the brain. Currently, polymeric nanoparticle is extensively involved in many therapies for spatial and temporal targeted areas delivery. Methods: We did a non-systematic review, and the literature was searched in Google, Science Direct and PubMed. An overview is provided for the formulation of polymeric nanoparticles using different methods, effect of surface modification on the nanoparticle properties with types of polymeric nanoparticles and preparation methods. An account of different nanomedicine employed with therapeutic agent to cross the BBB alone with biodistribution of the drugs. Results: We found that various types of polymeric nanoparticle systems are available and they prosper in delivering the therapeutic amount of the drug to the targeted area. The effect of physicochemical properties on nanoformulation includes change in their size, shape, elasticity, surface charge and hydrophobicity. Surface modification of polymers or nanocarriers is also vital in the formulation of nanoparticles to enhance targeting efficiency to the brain. Conclusion: More standardized methods for the preparation of nanoparticles and to assess the relationship of surface modification on drug delivery. While the preparation and its output like drug loading, particle size, and charge, permeation is always conflicted, so it requires more attention for the acceptance of nanoparticles for brain delivery.

scholarly journals The relationship of morphometric changes of the brain with IL-6 levels, systemic inflammation and immune disturbances in the patients with schizophrenia

2021 ◽  
Vol 190 ◽  
pp. 553-559
Author(s):  
Irina K. Malashenkova ◽  
Vadim L. Ushakov ◽  
Sergey A. Krynskiy ◽  
Daniil P. Ogurtsov ◽  
Nikita A. Khailov ◽  
...  
Keyword(s):  
Systemic Inflammation ◽  
Relationship Of ◽  
The Relationship ◽  
The Brain

scholarly journals Relationship between fractional anisotropy and neuropsychological evaluation in sports-related concussion

Neurology ◽  
2018 ◽  
Vol 91 (23 Supplement 1) ◽  
pp. S17.1-S17
Author(s):  
Haruo Nakayama ◽  
Yu Hiramoto ◽  
Yuriko Numata ◽  
Satoshi Fujita ◽  
Nozomi Hirai ◽  
...  
Keyword(s):  
Processing Speed ◽  
Corticospinal Tract ◽  
Diffusion Tensor ◽  
Neuropsychological Testing ◽  
Diffusion Tensor Mri ◽  
Neuropsychological Evaluation ◽  
Neuropsychological Function ◽  
Significant Fluctuation ◽  
The Relationship ◽  
The Brain

ObjectiveTo evaluate the relationship between functional anisotropy (FA) and neuropsychological evaluation in concussion.MethodsDiffusion tensor MRI included FA of the Brain and neuropsychological evaluation were conducted on 10 patients with concussion who were diagnosed from April 2017 to March 2018. FA was extracted from 2 regions of interest in Corpus callosum (CC) and corticospinal tract (CT). Detailed neuropsychological testing with an emphasis on Working memory (WM) and Processing speed (PS) was also conducted. The FA value in that 2 regions were compared between the 2 groups of 5 patients (group F) who failed either in WM or PS and 5 cases (group NF) who did not admit it.ResultsMean FA values in CC and CT in the Group F were 0.70 and 0.52. Mean FA values in CC and CT in the Group NF were 0.48 and 0.55.ConclusionsOur result suggests that the FA value of CC did not explain the significant fluctuation of the neuropsychological function. However, FA value in CT were shown to explain the fluctuation of WM and PS.

scholarly journals Extending the extended consciousness debate: perception, imagination, and the common kind assumption

2021 ◽  
Author(s):  
James Deery
Keyword(s):  
Perceptual Experience ◽  
Phenomenal Consciousness ◽  
Psychological Theory ◽  
Predictive Processing ◽  
Mental Event ◽  
The World ◽  
Predictive Approach ◽  
The Common ◽  
The Relationship ◽  
The Brain

AbstractFor some, the states and processes involved in the realisation of phenomenal consciousness are not confined to within the organismic boundaries of the experiencing subject. Instead, the sub-personal basis of perceptual experience can, and does, extend beyond the brain and body to implicate environmental elements through one’s interaction with the world. These claims are met by proponents of predictive processing, who propose that perception and imagination should be understood as a product of the same internal mechanisms. On this view, as visually imagining is not considered to be world-involving, it is assumed that world-involvement must not be essential for perception, and thus internalism about the sub-personal basis is true. However, the argument for internalism from the unity of perception and imagination relies for its strength on a questionable conception of the relationship between the two experiential states. I argue that proponents of the predictive approach are guilty of harbouring an implicit commitment to the common kind assumption which does not follow trivially from their framework. That is, the assumption that perception and imagination are of the same fundamental kind of mental event. I will argue that there are plausible alternative ways of conceiving of this relationship without drawing internalist metaphysical conclusions from their psychological theory. Thus, the internalist owes the debate clarification of this relationship and further argumentation to secure their position.

Sleep Phenomena from the Perspectives of Islam and Science

2014 ◽  
Vol 67 (1) ◽  
Author(s):  
Farahwahida Mohd Yusof ◽  
Siti Norlina Muhamad ◽  
Arieff Salleh Rosman ◽  
Sarimah Noor Ahmad ◽  
Nor Farhah Razak ◽  
...  
Keyword(s):  
20Th Century ◽  
Advanced Technology ◽  
Complex Phenomena ◽  
Scientific Facts ◽  
The Relationship ◽  
The Brain ◽  
Taking Care

This article discusses the phenomenon of sleep, with emphasized to its importance, sleeping times, sleeping positions and even the etiquette of sleeping, from the views of Islam and Science. The Quran and Science are inseparable and the relationship between the two is highly balanced. Scientists have said that the phenomena of sleep is a miracle that deserves to be analysed and studied in depth, as it is a complex phenomena. Glory and Praise to be Allah Almighty has decreed in the Quran of the importance of sleep in the day and night, and that sleep is one of the signs of Allah’s Almighty power and is a miracle to be studied by each individual. Islam places great importance on taking care of one’s body and sleep is one need that has to be fulfilled. Scientists have stressed that sleep is needed to rest the brain, improve memory, and increase one’s energy. This shows that Islam places great importance on having productivity and alertness in each individual’s deed. Many scientific facts that had been clearly stated in a fundamental manner in the Quran could only be analysed with the advanced technology of the 20th century. These facts were not known when they were first revealed and are proof that the Quran is the book of Allah Almighty. The view of Islam on the sleep phenomenon is in line with and is according to the findings of contemporary scien

Dream Bizarreness as the Cognitive Correlate of Altered Neuronal Behavior in REM Sleep

1989 ◽  
Vol 1 (3) ◽  
pp. 201-222 ◽  
Author(s):  
Adam N. Mamelak ◽  
J. Allan Hobson
Keyword(s):  
Neural Networks ◽  
Cerebral Cortex ◽  
Rem Sleep ◽  
Neuronal Dynamics ◽  
Neurophysiological Model ◽  
The Relationship ◽  
Cognitive Feature ◽  
The Brain ◽  
Cognitive Correlate ◽  
Raphe Neurons

Bizarreness is a cognitive feature common to REM sleep dreams, which can be easily measured. Because bizarreness is highly specific to dreaming, we propose that it is most likely brought about by changes in neuronal activity that are specific to REM sleep. At the level of the dream plot, bizarreness can be defined as either discontinuity or incongruity. In addition, the dreamer's thoughts about the plot may be logically deficient. We propose that dream bizarreness is the cognitive concomitant of two kinds of changes in neuronal dynamics during REM sleep. One is the disinhibition of forebrain networks caused by the withdrawal of the modulatory influences of norepinephrine (NE) and serotonin (5HT) in REM sleep, secondary to cessation of firing of locus coeruleus and dorsal raphe neurons. This aminergic demodulation can be mathematically modeled as a shift toward increased error at the outputs from neural networks, and these errors might be represented cognitively as incongruities and/or discontinuities. We also consider the possibility that discontinuities are the cognitive concomitant of sudden bifurcations or “jumps” in the responses of forebrain neuronal networks. These bifurcations are caused by phasic discharge of pontogeniculooccipital (PGO) neurons during REM sleep, providing a source of cholinergic modulation to the forebrain which could evoke unpredictable network responses. When phasic PGO activity stops, the resultant activity in the brain may be wholly unrelated to patterns of activity dominant before such phasic stimulation began. Mathematically such sudden shifts from one pattern of activity to a second, unrelated one is called a bifurcation. We propose that the neuronal bifurcations brought about by PGO activity might be represented cognitively as bizarre discontinuities of dream plot. We regard these proposals as preliminary attempts to model the relationship between dream cognition and REM sleep neurophysiology. This neurophysiological model of dream bizarreness may also prove useful in understanding the contributions of REM sleep to the developmental and experiential plasticity of the cerebral cortex.

Neurodevelopment in the first three years: implications for child development, professional practice and policy

2014 ◽  
Vol 9 (2) ◽  
pp. 154-164 ◽  
Author(s):  
Danya Glaser
Keyword(s):  
Brain Development ◽  
Brain Activity ◽  
Brain Maturation ◽  
Policy And Practice ◽  
Content Type ◽  
Key Issues ◽  
And Function ◽  
The Relationship ◽  
The Brain ◽  
Brain Connections

Purpose – The purpose of this paper is to outline brain structure and development, the relationship between environment and brain development and implications for practice. Design/methodology/approach – The paper is based on a selected review of the literature and clinical experience. Findings – While genetics determine the sequence of brain maturation, the nature of brain development and functioning is determined by the young child's caregiving environment, to which the developing brain constantly adapts. The absence of input during sensitive periods may lead to later reduced functioning. There is an undoubted immediate equivalence between every mind function – emotion, cognition, behaviour and brain activity, although the precise location of this in the brain is only very partially determinable, since brain connections and function are extremely complex. Originality/value – This paper provides an overview of key issues in neurodevelopment relating to the development of young children, and implications for policy and practice.

A discussion of apraxia, aphasia, and gestural language

1984 ◽  
Vol 246 (6) ◽  
pp. R884-R887
Author(s):  
N. Helm-Estabrooks
Keyword(s):  
Sign Language ◽  
Cerebral Hemisphere ◽  
Communication Disorder ◽  
Left Cerebral Hemisphere ◽  
Language Behavior ◽  
Normal Language ◽  
Symbolic Gestures ◽  
The Many ◽  
The Relationship ◽  
The Brain

It is understood that damage to the left cerebral hemisphere in adulthood may result in syndromes of language disturbances called the aphasias. The study of these syndromes sheds light on normal language processes, the relationship between language behavior and the brain, and how best to treat aphasic individuals. Aphasia, for some, is a central communication disorder affecting all symbolic behavior in all modalities (i.e., speech, writing, and gesture). Difficulty producing symbolic gestures on command is called apraxia. Others view aphasia as a manifestation of a motor-sequencing disorder affecting all gestural systems including those required for speech movements. These divergent theories of the underlying nature of aphasia can be tested through examination of deaf individuals who use sign language before onset of aphasia. Poizner et al. [Am. J. Physiol. 246 (Regulatory Integrative Comp. Physiol. 15): R868-R883, 1984] studied three such patients with different aphasia syndromes: one patient had a nonsymbolic, motor-sequencing disorder; one had a gestural apraxia; and one had neither. These findings force the conclusion that neither the symbolic nor motor-sequencing theory of aphasia can account for the many varieties of that disorder.

Mortal Body, Immortal Mind

2012 ◽  
Vol 17 (1) ◽  
pp. 5-26
Author(s):  
Hans Goller
Keyword(s):  
Brain Activity ◽  
The Body ◽  
Activity Data ◽  
Brain Functions ◽  
Body Experiences ◽  
Research Findings ◽  
The Relationship ◽  
Near Death Experiences ◽  
The Brain ◽  
Alternative Theories

Neuroscientists keep telling us that the brain produces consciousness and consciousness does not survive brain death because it ceases when brain activity ceases. Research findings on near-death-experiences during cardiac arrest contradict this widely held conviction. They raise perplexing questions with regard to our current understanding of the relationship between consciousness and brain functions. Reports on veridical perceptions during out-of-body experiences suggest that consciousness may be experienced independently of a functioning brain and that self-consciousness may continue even after the termination of brain activity. Data on studies of near-death-experiences could be an incentive to develop alternative theories of the body-mind relation as seen in contemporary neuroscience.

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