The Emerging Role of Thiazolidinediones in the Treatment of Diabetes-Mellitus and Related Disorders

1999 ◽  
Vol 21 (1-2) ◽  
pp. 121-136 ◽  
Author(s):  
S. Subramaniam
Keyword(s):  
Diabetes Mellitus ◽  
Treatment Of Diabetes

scholarly journals The Role of Natural Products on Diabetes Mellitus Treatment: A Systematic Review of Randomized Controlled Trials

Pharmaceutics ◽  
2022 ◽  
Vol 14 (1) ◽  
pp. 101
Author(s):  
Lucía Vivó-Barrachina ◽  
María José Rojas-Chacón ◽  
Rocío Navarro-Salazar ◽  
Victoria Belda-Sanchis ◽  
Javier Pérez-Murillo ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Systematic Review ◽  
Natural Products ◽  
Promising Therapeutic Target ◽  
Prevalent Disease ◽  
Bibliographic Search ◽  
Treatment Of Diabetes ◽  
Definition Of ◽  
Diabetes Mellitus Treatment

The present study was carried out to relate the role of natural products in the metabolism of an increasingly prevalent disease, type 2 diabetes mellitus. At present, in addition to the pharmacological resources, an attempt is being made to treat diabetes mellitus with natural products. We carried out a systematic review of studies focusing on the role of natural products on diabetes mellitus treatment. The bibliographic search was done through Medline (Pubmed) and Web of Science. From 193 records, the title and summary of each were examined according to the criteria and whether they met the selection criteria. A total of 15 articles were included; after reviewing the literature, it is apparent that the concept of natural products is ambiguous as no clear boundary has been established between what is natural and what is synthetic, therefore we feel that a more explicit definition of the concept of “natural product” is needed. Gut microbiota is a promising therapeutic target in the treatment of diabetes. Therefore, it would be necessary to work on the relationship between the microbiome and the benefits in the treatment of diabetes mellitus. Treatment based solely on these natural products is not currently recommended as more studies are needed.

scholarly journals Role of Metallic Nanoparticles in the Treatment of Diabetes Mellitus

2019 ◽  
Vol 09 (02) ◽  
pp. 121-121
Author(s):  
Yogita Kumari ◽  
Gurmandeep Kaur ◽  
Clarisse Ayinkamiye ◽  
Sachin Kumar Singh ◽  
Rajesh Kumar ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Metallic Nanoparticles ◽  
Treatment Of Diabetes

scholarly journals The Role of Mesenchymal Stromal Cells-Derived Small Extracellular Vesicles in Diabetes and Its Chronic Complications

2021 ◽  
Vol 12 ◽  
Author(s):  
Fu-Xing-Zi Li ◽  
Xiao Lin ◽  
Feng Xu ◽  
Su-Kang Shan ◽  
Bei Guo ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Extracellular Vesicles ◽  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Molecular Mechanisms ◽  
Membrane Vesicles ◽  
Non Coding Rna ◽  
Multiple Differentiation ◽  
Treatment Of Diabetes

Mesenchymal stromal cells (MSCs) are applied in regenerative medicine of several tissues and organs nowadays by virtue of their self-renewal capabilities, multiple differentiation capacity, potent immunomodulatory properties, and their ability to be favourably cultured and manipulated. With the continuous development of “cell-free therapy” research, MSC-derived small extracellular vesicles (MSC-sEVs) have increasingly become a research hotspot in the treatment of various diseases. Small extracellular vesicles (SEVs) are membrane vesicles with diameters of 30 to 150 nm that mediate signal transduction between adjacent or distal cells or organs by delivering non-coding RNA, protein, and DNA. The contents and effects of sEVs vary depending on the properties of the originating cell. In recent years, MSC-sEVs have been found to play an important role in the occurrence and development of diabetes mellitus as a new way of communication between cells. Diabetes mellitus is a common metabolic disease in clinic. Its complications of the heart, brain, kidney, eyes, and peripheral nerves are a serious threat to human health and has been a hot issue for clinicians. MSC-sEVs could be applied to repair or prevent damage from the complications of diabetes mellitus through anti-inflammatory effects, reduction of endoplasmic reticulum-related protein stress, polarization of M2 macrophages, and increasing autophagy. Therefore, we highly recommend that MSC-sEVs-based therapies to treat diabetes mellitus and its chronic complication be further explored. The analysis of the role and molecular mechanisms of MSC-sEVs in diabetes and its related complications will provide new idea and insights for the prevention and treatment of diabetes.

Insights into the Role of DNA Methylation and Protein Misfolding in Diabetes Mellitus

2019 ◽  
Vol 19 (6) ◽  
pp. 744-753 ◽  
Author(s):  
Sara M. Ahmed ◽  
Dina Johar ◽  
Mohamed Medhat Ali ◽  
Nagwa El-Badri
Keyword(s):  
Diabetes Mellitus ◽  
Dna Methylation ◽  
Protein Function ◽  
Protein Misfolding ◽  
Gene Sequence ◽  
Metabolic Memory ◽  
Treatment Of Diabetes

Background: Diabetes mellitus is a metabolic disorder that is characterized by impaired glucose tolerance resulting from defects in insulin secretion, insulin action, or both. Epigenetic modifications, which are defined as inherited changes in gene expression that occur without changes in gene sequence, are involved in the etiology of diabetes. Methods: In this review, we focused on the role of DNA methylation and protein misfolding and their contribution to the development of both type 1 and type 2 diabetes mellitus. Results: Changes in DNA methylation in particular are highly associated with the development of diabetes. Protein function is dependent on their proper folding in the endoplasmic reticulum. Defective protein folding and consequently their functions have also been reported to play a role. Early treatment of diabetes has proven to be of great benefit, as even transient hyperglycemia may lead to pathological effects and complications later on. This has been explained by the theory of the development of a metabolic memory in diabetes. The basis for this metabolic memory was attributed to oxidative stress, chronic inflammation, non-enzymatic glycation of proteins and importantly, epigenetic changes. This highlights the importance of linking new therapeutics targeting epigenetic mechanisms with traditional antidiabetic drugs. Conclusion: Although new data is evolving on the relation between DNA methylation, protein misfolding, and the etiology of diabetes, more studies are required for developing new relevant diagnostics and therapeutics.

scholarly journals Role of platelet-derived growth factor in type II diabetes mellitus and its complications

2020 ◽  
Vol 17 (4) ◽  
pp. 147916412094211
Author(s):  
Sihong Shen ◽  
Fuyan Wang ◽  
Alejandra Fernandez ◽  
Weining Hu
Keyword(s):  
Diabetes Mellitus ◽  
Growth Factors ◽  
Type Ii Diabetes ◽  
Critical Role ◽  
Type Ii Diabetes Mellitus ◽  
Regulate Cell Growth ◽  
Treatment Of Diabetes ◽  
Diabetes Development

Type 2 diabetes mellitus is a type of metabolic disorder characterized by hyperglycaemia with multiple serious complications, such as diabetic neuropathies, diabetic nephropathy, diabetic retinopathy, and diabetic foot. Platelet-derived growth factors are growth factors that regulate cell growth and division, playing a critical role in diabetes and its harmful complications. This review focused on the cellular mechanism of platelet-derived growth factors and their receptors on diabetes development. Furthermore, we raise some proper therapeutic molecular targets for the treatment of diabetes and its complications.

scholarly journals A REVIEW ON ROLE OF ANTIOXIDANTS IN DIABETES

2018 ◽  
Vol 11 (2) ◽  
pp. 48 ◽  
Author(s):  
Deepa Rajendiran ◽  
Subbulakshmi Packirisamy ◽  
Krishnamoorthy Gunasekaran
Keyword(s):  
Oxidative Stress ◽  
Diabetes Mellitus ◽  
Metabolic Disease ◽  
Medicinal Plants ◽  
Major Part ◽  
Review Article ◽  
Hypoglycemic Activity ◽  
Antioxidants Activity ◽  
Treatment Of Diabetes

 Diabetes mellitus is a chronic metabolic disease. Oxidative stress plays a major part in the pathogenesis of diabetes. Supplementation with antioxidants and the medicinal plants which possess antioxidants activity have been reported their hypoglycemic activity. The antioxidants are used to treat and reduce the complication of diabetes mellitus. The diet supplementations of antioxidants vitamins are beneficial in the treatment of diabetes. This review article was summarizing the role of antioxidants in diabetes mellitus.

scholarly journals ROLE OF MANIPUR CHAKRA ACTIVATION IN TREATMENT OF DIABETES MELLITUS

2021 ◽  
Vol 5 (01) ◽  
Author(s):  
Dr. yasmeen khan ◽  
VINOD CHOUDHARI
Keyword(s):  
Diabetes Mellitus ◽  
Psychological Health ◽  
Energy Flow ◽  
Spinal Column ◽  
Endocrine System ◽  
The Body ◽  
Unavoidable Stress ◽  
Treatment Of Diabetes ◽  
Flow Through

Chakras are the circular vortex of energy lying across the seven different points on your spinal column. On a physical level, chakras are associated with the major nerve plexuses and endocrine glands in the body. Many asanas have particularly powerful and beneficial effect on one or more of these glands or plexuses. Chakras are not the physical entity and reside in energy body, but help us to understand the body functions and emotions. As they are psychoactive energy centers in human body they are directly related to physiological and psychological health of human being. The unavoidable stress in lifestyle has blocked the entire chakra system and imbalance in the energy flow causes various diseases. We have the great ancient knowledge with us to regulate the energy flow through chakras and get cured from various disorders related to that chakra. Mechanism of yoga effects is the most visible in the systems of chakras and nadis, which specifically and directly correlates with nervous and endocrine system. This study is a small effort to prove the effect and application of Manipur chakra activation in management of life style disorders especially diabetes mellitus.

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