scholarly journals ROLE OF MANIPUR CHAKRA ACTIVATION IN TREATMENT OF DIABETES MELLITUS

2021 ◽  
Vol 5 (01) ◽  
Author(s):  
Dr. yasmeen khan ◽  
VINOD CHOUDHARI
Keyword(s):  
Diabetes Mellitus ◽  
Psychological Health ◽  
Energy Flow ◽  
Spinal Column ◽  
Endocrine System ◽  
The Body ◽  
Unavoidable Stress ◽  
Treatment Of Diabetes ◽  
Flow Through

Chakras are the circular vortex of energy lying across the seven different points on your spinal column. On a physical level, chakras are associated with the major nerve plexuses and endocrine glands in the body. Many asanas have particularly powerful and beneficial effect on one or more of these glands or plexuses. Chakras are not the physical entity and reside in energy body, but help us to understand the body functions and emotions. As they are psychoactive energy centers in human body they are directly related to physiological and psychological health of human being. The unavoidable stress in lifestyle has blocked the entire chakra system and imbalance in the energy flow causes various diseases. We have the great ancient knowledge with us to regulate the energy flow through chakras and get cured from various disorders related to that chakra. Mechanism of yoga effects is the most visible in the systems of chakras and nadis, which specifically and directly correlates with nervous and endocrine system. This study is a small effort to prove the effect and application of Manipur chakra activation in management of life style disorders especially diabetes mellitus.

Ghrelin and Obesity-An Update

2017 ◽  
Vol 9 (1) ◽  
Author(s):  
Gandhi M. ◽  
Swaminathan S.
Keyword(s):  
Diabetes Mellitus ◽  
Cardiac Output ◽  
Energy Balance ◽  
Vascular Resistance ◽  
The Body ◽  
Ghrelin Receptor ◽  
Type2 Diabetes ◽  
Type2 Diabetes Mellitus ◽  
Natural Hormones

Ghrelin as human natural hormones is involved in fundamental regulatory process of eating and energy balance. It is a stomach derived hormone that acts as at the ghrelin receptor in multiple tissues throughout to the body. Its properties includes increasing appetite, decreasing systemic inflammation, decreasing vascular resistance ,increasing cardiac output, increasing glucose and IGF-1 levels, Hence it may play a significant role in Diabetes mellitus. Many studies have linked ghrelin to obesity and this paper is an attempt to bring out recent findings on the role of ghrelin in Diabetes Mellitus, particularly type2 Diabetes mellitus.

Pressure-flow relations in coronary circulation

1990 ◽  
Vol 70 (2) ◽  
pp. 331-390 ◽  
Author(s):  
J. I. Hoffman ◽  
J. A. Spaan
Keyword(s):  
Coronary Vessels ◽  
Good Evidence ◽  
The Body ◽  
Vascular Compression ◽  
Exact Nature ◽  
Coronary Veins ◽  
Collapsible Tubes ◽  
External Pressures ◽  
Flow Through

The blood vessels that run on the surface of the heart and through its muscle are compliant tubes that can be affected by the pressures external to them in at least two ways. If the pressure outside these vessels is higher than the pressure at their downstream ends, the vessels may collapse and become Starling resistors or vascular waterfalls. If this happens, the flow through these vessels depends on their resistance and the pressure drop from their inflow to the pressure around them and is independent of the actual downstream pressure. In the first part of this review, the physics of collapsible tubes is described, and the possible occurrences of vascular waterfalls in the body is evaluated. There is good evidence that waterfall behavior is seen in collateral coronary arteries and in extramural coronary veins, but the evidence that intramural coronary vessels act like vascular waterfalls is inconclusive. There is no doubt that in systole there are high tissue pressures around the intramyocardial vessels, particularly in the subendocardial muscle of the left ventricle. The exact nature and values of the forces that act at the surface of the small intramural vessels, however, are still not known. We are not certain whether radial (compressive) or circumferential and longitudinal (tensile) stresses are the major causes of vascular compression; the role of collagen struts in modifying the reaction of vessel walls to external pressures is unknown but possibly important; direct examination of small subepicardial vessels has failed to show vascular collapse. One of the arguments in favor of intramyocardial vascular waterfalls has been that during a long diastole the flow in the left coronary artery decreases and reaches zero when coronary arterial pressure is still high: it can be as much as 50 mmHg in the autoregulating left coronary arterial bed and approximately 15-20 mmHg even when the vessels have been maximally dilated. These high zero flow pressures, especially during maximal vasodilatation, have been regarded as indicating a high back pressure to flow that is due to waterfall behavior of vessels that are exposed to tissue pressures.(ABSTRACT TRUNCATED AT 400 WORDS)

scholarly journals The Role of Natural Products on Diabetes Mellitus Treatment: A Systematic Review of Randomized Controlled Trials

Pharmaceutics ◽  
2022 ◽  
Vol 14 (1) ◽  
pp. 101
Author(s):  
Lucía Vivó-Barrachina ◽  
María José Rojas-Chacón ◽  
Rocío Navarro-Salazar ◽  
Victoria Belda-Sanchis ◽  
Javier Pérez-Murillo ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Systematic Review ◽  
Natural Products ◽  
Promising Therapeutic Target ◽  
Prevalent Disease ◽  
Bibliographic Search ◽  
Treatment Of Diabetes ◽  
Definition Of ◽  
Diabetes Mellitus Treatment

The present study was carried out to relate the role of natural products in the metabolism of an increasingly prevalent disease, type 2 diabetes mellitus. At present, in addition to the pharmacological resources, an attempt is being made to treat diabetes mellitus with natural products. We carried out a systematic review of studies focusing on the role of natural products on diabetes mellitus treatment. The bibliographic search was done through Medline (Pubmed) and Web of Science. From 193 records, the title and summary of each were examined according to the criteria and whether they met the selection criteria. A total of 15 articles were included; after reviewing the literature, it is apparent that the concept of natural products is ambiguous as no clear boundary has been established between what is natural and what is synthetic, therefore we feel that a more explicit definition of the concept of “natural product” is needed. Gut microbiota is a promising therapeutic target in the treatment of diabetes. Therefore, it would be necessary to work on the relationship between the microbiome and the benefits in the treatment of diabetes mellitus. Treatment based solely on these natural products is not currently recommended as more studies are needed.

scholarly journals EFEKTIVITAS KERASIONALAN PEMBERIAN ANTIDIABETIK PENGOBATAN ORAL PASIEN DIABETES MELLITUS PADA USIA 30-50 TAHUN TIPE 2 DI RAWAT INAP PENYAKIT DALAM RSUD DELI SERDANG LUBUK PAKAM TAHUN 2020

2021 ◽  
Vol 3 (2) ◽  
pp. 74-80
Author(s):  
Loraetta Brety Sebayang ◽  
Romauli Anna Teresia Marbun ◽  
Dewi Kartika
Keyword(s):  
Diabetes Mellitus ◽  
Oral Treatment ◽  
Type Ii Diabetes Mellitus ◽  
The Body ◽  
Quality Assurance Process ◽  
Experimental Type ◽  
Treatment Of Diabetes ◽  
Assurance Process ◽  
The Right

Background: Diabetes Mellitus is a chronic condition, which occurs because the body cannot produce insulin, normally or insulin cannot work effectively. Objective: To determine the effectiveness of the rational administration of antidiabetic, oral treatment of diabetes mellitus patients at the age of 30-50 years type 2 in Deli Serdang Hospital, lubuk pakam in 2020. Method: This study is a non-experimental type of research using descriptive methods. Results: Shows that from 72 samples of Type II Diabetes Mellitus patients at Deli Serdang General Hospital, April-July Period 2020. With the number (52.8%) of male sex patients and the number (47.2%) of type patients  female genitalia and antidiabetic drugs most widely used by patients, in the period of April-July 2020, namely (20.8%) glycionion + metformin and (20.8%) insulin drugs.  the use of DM drugs with the right rational indication (65.3%), Rational with the right medicine (100%), rational with the right dosage (100%), the right rational patient (100%) and the rational way of administration (100:%). Conclusion: Evaluation of drug use is a structured quality assurance process that is carried out continuously to ensure that the drugs used are appropriate, safe, and efficient.

scholarly journals Role of Metallic Nanoparticles in the Treatment of Diabetes Mellitus

2019 ◽  
Vol 09 (02) ◽  
pp. 121-121
Author(s):  
Yogita Kumari ◽  
Gurmandeep Kaur ◽  
Clarisse Ayinkamiye ◽  
Sachin Kumar Singh ◽  
Rajesh Kumar ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Metallic Nanoparticles ◽  
Treatment Of Diabetes

scholarly journals The Role of Soluble L-Selectin with Polymorphism in Iraqi Arabs Patients with Diabetes Mellitus Type 2

2018 ◽  
Vol 9 (01) ◽  
Author(s):  
Asmaa M. Salih Almohaidi ◽  
Kebaa Ahmed Saeed
Keyword(s):  
Diabetes Mellitus ◽  
Serum Level ◽  
Healthy Subjects ◽  
Diabetes Mellitus Type 2 ◽  
The Body ◽  
Diabetes Mellitus Type ◽  
Enzyme Linked Immunosorbent Assay ◽  
Control Group

Diabetes mellitus type 2 [DMT2] is a disturbance of metabolism and complex diseases influenced by environmental, genetic agents, and linked with inflammation, happens when the pancreas either does not use the insulin as it should or the body does not make enough insulin, lead to insulin resistance [IR] alongside with gradual loss of ß-cell secretory ability. The aim of this study was to investigate the role of soluble L-selectin (sL-selectin) in diabetes mellitus type 2 patients in Iraqi Arabs patient. Study includes seventy six Iraqi Arabs patients (male and female) having newly diagnosed type 2 diabetes mellitus (T2DM), with Fifty three Iraqi Arabs healthy subjects matched in age, sex and ethnic group. Patients and healthy subjects were genotyped, by PCR-RFLP analysis, and mesure serum level of L-selectin by enzyme-linked immunosorbent assay (sandwich ELISA) test include 65 patients and 23 controls. The statistical analysis of serum level of sL-selectin in study groups showed that the mean of sL-selectin level high significantly increased in patients group (10.708±1.1007) compared to control group (7.055±0.767) respectively. Thus, our results suggest soluble L-selectin play a role in the development of DMT2 in Iraqi Arabs patients. Present results showed that genotype PS associated with increase the susceptibility of DMT2.

scholarly journals Studying the Prevalence of Mitochondrial tRNAleu Gene Mutation in Iraqi Population

2017 ◽  
Vol 14 (3) ◽  
pp. 1143-1150
Author(s):  
Rasha Sadeq Ameen ◽  
Mohammed Mahdi ◽  
Dhuha Salim Namaa ◽  
Miriam Jasim Shehab ◽  
Suhaeer Hassan ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Family History ◽  
Mitochondrial Gene ◽  
Gene Mutations ◽  
The Body ◽  
National Centre ◽  
Pcr Rflp ◽  
A3243g Mutation ◽  
Treatment Of Diabetes

ABSTRACT: Several studies reported the role of mitochondrial gene mutations in the development of this study conducted to determine the incidence of point mutation A3243G RNALeu (UUR) in diabetes pateints within the Iraqi population and campare it with that reported in other populations. Peripheral blood were collected from 100 patients attended university of Al-Mustansiriyah / national centre for the treatment of diabetes and research. The age, gender, family history, hypertension, retinopathy, nephropathy and smoking in addition to the body mass index, are the information collected from The pateints. The DNA was extracted and by PCR-RFLP method and PCR-sequencing methods, the tRNALeu (UUR) gene screened for A3243G revealed that none of the 100 patients were found to carry the A3243G mutation in the mitochondrial tRNALeu (UUR) gene in the homoplasmic or in the heteroplasmic form. Depending on the obtained results, it can be concluded that the A3243G mutation in mitochondrial tRNALeu (UUR) is not a frequent cause of diabetes in the Iraqi population contrary to other reported populations. And further screening of an enlarged group is necessary to fully determine the prevalence of this mutation in this population.

scholarly journals The Role of Mesenchymal Stromal Cells-Derived Small Extracellular Vesicles in Diabetes and Its Chronic Complications

2021 ◽  
Vol 12 ◽  
Author(s):  
Fu-Xing-Zi Li ◽  
Xiao Lin ◽  
Feng Xu ◽  
Su-Kang Shan ◽  
Bei Guo ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Extracellular Vesicles ◽  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Molecular Mechanisms ◽  
Membrane Vesicles ◽  
Non Coding Rna ◽  
Multiple Differentiation ◽  
Treatment Of Diabetes

Mesenchymal stromal cells (MSCs) are applied in regenerative medicine of several tissues and organs nowadays by virtue of their self-renewal capabilities, multiple differentiation capacity, potent immunomodulatory properties, and their ability to be favourably cultured and manipulated. With the continuous development of “cell-free therapy” research, MSC-derived small extracellular vesicles (MSC-sEVs) have increasingly become a research hotspot in the treatment of various diseases. Small extracellular vesicles (SEVs) are membrane vesicles with diameters of 30 to 150 nm that mediate signal transduction between adjacent or distal cells or organs by delivering non-coding RNA, protein, and DNA. The contents and effects of sEVs vary depending on the properties of the originating cell. In recent years, MSC-sEVs have been found to play an important role in the occurrence and development of diabetes mellitus as a new way of communication between cells. Diabetes mellitus is a common metabolic disease in clinic. Its complications of the heart, brain, kidney, eyes, and peripheral nerves are a serious threat to human health and has been a hot issue for clinicians. MSC-sEVs could be applied to repair or prevent damage from the complications of diabetes mellitus through anti-inflammatory effects, reduction of endoplasmic reticulum-related protein stress, polarization of M2 macrophages, and increasing autophagy. Therefore, we highly recommend that MSC-sEVs-based therapies to treat diabetes mellitus and its chronic complication be further explored. The analysis of the role and molecular mechanisms of MSC-sEVs in diabetes and its related complications will provide new idea and insights for the prevention and treatment of diabetes.

Insights into the Role of DNA Methylation and Protein Misfolding in Diabetes Mellitus

2019 ◽  
Vol 19 (6) ◽  
pp. 744-753 ◽  
Author(s):  
Sara M. Ahmed ◽  
Dina Johar ◽  
Mohamed Medhat Ali ◽  
Nagwa El-Badri
Keyword(s):  
Diabetes Mellitus ◽  
Dna Methylation ◽  
Protein Function ◽  
Protein Misfolding ◽  
Gene Sequence ◽  
Metabolic Memory ◽  
Treatment Of Diabetes

Background: Diabetes mellitus is a metabolic disorder that is characterized by impaired glucose tolerance resulting from defects in insulin secretion, insulin action, or both. Epigenetic modifications, which are defined as inherited changes in gene expression that occur without changes in gene sequence, are involved in the etiology of diabetes. Methods: In this review, we focused on the role of DNA methylation and protein misfolding and their contribution to the development of both type 1 and type 2 diabetes mellitus. Results: Changes in DNA methylation in particular are highly associated with the development of diabetes. Protein function is dependent on their proper folding in the endoplasmic reticulum. Defective protein folding and consequently their functions have also been reported to play a role. Early treatment of diabetes has proven to be of great benefit, as even transient hyperglycemia may lead to pathological effects and complications later on. This has been explained by the theory of the development of a metabolic memory in diabetes. The basis for this metabolic memory was attributed to oxidative stress, chronic inflammation, non-enzymatic glycation of proteins and importantly, epigenetic changes. This highlights the importance of linking new therapeutics targeting epigenetic mechanisms with traditional antidiabetic drugs. Conclusion: Although new data is evolving on the relation between DNA methylation, protein misfolding, and the etiology of diabetes, more studies are required for developing new relevant diagnostics and therapeutics.

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