A Newly Discovered Manuscript: Second Version of Syarh Rubai of Hamzah Fansuri Written by Syamsuddin Al Sumatrani

2021 ◽  
Vol 27 (1) ◽  
pp. 65-77
Author(s):  
Pramono ◽  
◽  
Sudarmoko ◽  
Keyword(s):  
The Other ◽  
Islamic Studies ◽  
New Information

In the paper we provide a report on the discovery of a manuscript containing Syarh Rubai of Hamzah Fansuri written by his disciple Syamsuddin Al Sumatrani, which was found in the Minangkabau area. The manuscript is a second and largerly independent version in comparison to similar manuscript that has been previously found and edited by Ali Hasjmy in Aceh. We identify differences between both manuscripts such as the presentation structure, introduction, colophon, the number of stanza, the date of writing, and dictions. The manuscripts reflect the polemic on wujudiyah between Hamzah Fansuri and Syamsuddin on one side, and Nuruddin Ar Raniri on the other side. Furthermore, the locations related to the manuscripts, Aceh and Minangkabau, show the spread of wujudiyah in the Malay world that add new information to the discussion on local Islamic studies. We argue that the newly found manuscript shows the spread of wujudiyah from Aceh to Minangkabau and the growing number of its followers in the region.

scholarly journals Contribution of the CK2 Catalytic Isoforms α and α’ to the Glycolytic Phenotype of Tumor Cells

Cells ◽  
2021 ◽  
Vol 10 (1) ◽  
pp. 181
Author(s):  
Francesca Zonta ◽  
Christian Borgo ◽  
Camila Paz Quezada Meza ◽  
Ionica Masgras ◽  
Andrea Rasola ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Protein Kinase ◽  
Cancer Cells ◽  
Tumor Cells ◽  
Therapeutic Strategies ◽  
The Other ◽  
Osteosarcoma Cell ◽  
Monomeric Form ◽  
New Information

CK2 is a Ser/Thr protein kinase overexpressed in many cancers. It is usually present in cells as a tetrameric enzyme, composed of two catalytic (α or α’) and two regulatory (β) subunits, but it is active also in its monomeric form, and the specific role of the different isoforms is largely unknown. CK2 phosphorylates several substrates related to the uncontrolled proliferation, motility, and survival of cancer cells. As a consequence, tumor cells are addicted to CK2, relying on its activity more than healthy cells for their life, and exploiting it for developing multiple oncological hallmarks. However, little is known about CK2 contribution to the metabolic rewiring of cancer cells. With this study we aimed at shedding some light on it, especially focusing on the CK2 role in the glycolytic onco-phenotype. By analyzing neuroblastoma and osteosarcoma cell lines depleted of either one (α) or the other (α’) CK2 catalytic subunit, we also aimed at disclosing possible pro-tumor functions which are specific of a CK2 isoform. Our results suggest that both CK2 α and α’ contribute to cell proliferation, survival and tumorigenicity. The analyzed metabolic features disclosed a role of CK2 in tumor metabolism, and suggest prominent functions for CK2 α isoform. Results were also confirmed by CK2 pharmacological inhibition. Overall, our study provides new information on the mechanism of cancer cells addiction to CK2 and on its isoform-specific functions, with fundamental implications for improving future therapeutic strategies based on CK2 targeting.

Lexical Arguments and Information Types in Malay Oral Narratives

2015 ◽  
Vol 7 (1) ◽  
pp. 80-97
Author(s):  
Siaw-Fong Chung
Keyword(s):  
Information Flow ◽  
The Other ◽  
Discourse Structure ◽  
Oral Narratives ◽  
Clear Cut ◽  
The Core ◽  
New Information ◽  
Intonation Units ◽  
Locative Expressions ◽  
Transitive Verbs

The analysis in this paper was based on five Malay narratives of the “frog story”. In these narratives, the types of lexical arguments and their relations with information flow and topic continuity were analyzed. It was found that most narrators used one lexical argument in telling the frog story (e.g., sarang itu jatuh “the nest fell”). About 60% of the verbs in the narratives contained one lexical argument only. Some transitive verbs that usually require the presence of both lexical arguments were used with one lexical argument only when produced in speech (e.g., dia mencari ø di merata tempat “he searched (for) ø everywhere”). Objects were sometimes omitted, as their meanings could be predicted from previous context. Despite the omission of objects, transitive constructions still prevailed in the stories. The most frequently occurring lexical arguments were objects (O) (37%), followed by intransitive subjects (S) (29%) and transitive subjects (A) (27%). In addition, our results showed that new information in Malay was usually allocated to the core argument of the object and to locative expressions, indicating that most of the new information appeared at the end of a clause. On the other hand, topic continuity was held between the subjects in two continuous intonation units. This clear-cut division of discourse functions in the heads and tails of constructions was consistently found in the five pieces of narration. This observation not only showed how ideas could be continued in Malay oral narratives, but also contributes to the study of discourse structure in Malay.

High-precision abundances of elements in stars with asteroseismic ages

2017 ◽  
Vol 13 (S334) ◽  
pp. 166-169
Author(s):  
P. E. Nissen ◽  
V. Silva Aguirre ◽  
J. Christensen-Dalsgaard ◽  
R. Collet ◽  
F. Grundahl ◽  
...  
Keyword(s):  
High Precision ◽  
Main Sequence ◽  
Potential Problem ◽  
Galactic Evolution ◽  
The Other ◽  
Main Sequence Stars ◽  
Refractory Elements ◽  
Other Hand ◽  
New Information ◽  
Oscillation Frequencies

AbstractHigh-precision abundances of elements have been derived from HARPS-N spectra of F and G main-sequence stars having ages determined from oscillation frequencies delivered by the Kepler mission. The tight relations between abundance ratios of refractory elements, e.g., [Mg/Fe] and [Y/Mg], and stellar age previously found for solar twin stars are confirmed. These relations provide new information on nucleosynthesis and Galactic evolution. Abundance ratios between volatile and refractory elements, e.g., [C/Fe] and [O/Fe], show on the other hand a significant scatter at a given age, which may be related to planet-star interactions. This is a potential problem for chemical tagging studies.

scholarly journals A Systemic Functional Analysis of Theme in Modern Standard Arabic Texts

2021 ◽  
Vol 12 (4) ◽  
pp. 15
Author(s):  
Tareq Alfraidi
Keyword(s):  
Systemic Functional Linguistics ◽  
The Other ◽  
Modern Standard Arabic ◽  
Written Discourse ◽  
Standard Arabic ◽  
Logical Frameworks ◽  
New Information ◽  
The One ◽  
The Empirical Analysis ◽  
Modern Standard

The concept of Theme is regarded as a functional linguistic element that exists in many languages. The main aim of this study is to explore the functions of Theme in Arabic, applying the Systemic Functional Linguistics framework adopted by Downing (1991). Methodologically, several related real examples have been selected from the written discourse of Modern Standard Arabic and then analyzed contextually. The empirical analysis has revealed that (i) Theme can provide different functions, such as Individual, Circumstantial and Subjective and Logical Frameworks for the interpretation of the Rheme, and (ii) Theme can interact dynamically with different grammatical functions (e.g. Subject, Object, etc.) and have different pragmatic functions (e.g. Topic, Given and New information). Therefore, the view that makes a necessary link between Theme on the one hand and Noun Phrase, Topic or Given information on the other hand is proven incorrect and empirically invalid. Similar results have been obtained in the context of English (Downing 1991) but not yet for Arabic? This strengthens not only the universality of the concept of Theme but also its functions.

scholarly journals New or previously unrecorded avian taxa from the Middle Eocene of Messel (Hessen, Germany)

Fossil Record ◽  
2000 ◽  
Vol 3 (1) ◽  
pp. 207-219 ◽  
Author(s):  
G. Mayr
Keyword(s):  
Middle Eocene ◽  
The Other ◽  
New Taxon ◽  
New Information ◽  
Wenn Sich

Three new or from this site previously unrecorded birds are described from the Middle Eocene of Messel (Hessen, Germany). <i>Serudaptus pohli</i> n. gen. n. sp. is a new taxon of the Pseudasturidae and is distinguished from the other species of this family by its short and stout tarsometatarsus and the long and strong claws. An isolated foot of a gruiform bird is assigned to <i>Idiornis</i> cf. <i>itardiensis</i> (Idiornithidae) and would, if this assignment can be confirmed, demonstrate the existence of this species for a period of 23 million years. The proportions of the toes suggest that <i>Idiornis</i> cf. <i>itardiensis</i> was less cursorial than its next recent relatives, the Cariamidae. In addition thereto, an exceptionally well preserved skeleton of a sandcoleid bird (Coliiformes: Sandcoleidae) gives new information on the osteology and feathering of sandcoleid birds. The specimen resembles the genera <i>Eoglaucidium</i> and <i>Anneavis</i> but it has not been possible to assign it to one of these two genera with certainty. <br><br> Drei neue oder von dieser Fundstelle bisher nicht nachgewiesene Vögel werden aus dem Mittel-Eozän von Messel (Hessen, Deutschland) beschrieben. <i>Serudaptus pohli</i> n. gen. n. sp. ist ein neues Taxon der Pseudasturidae und unterscheidet sich von den anderen Arten dieser Familie durch den kurzen und gedrungenen Tarsometatarsus und die langen, kräftigen Krallen. Der isolierte Fuß eines gruiformen Vogels wird <i>Idiornis</i> cf. <i>itardiensis</i> (Idiornithidae) zugeordnet und würde, wenn sich diese Zuordnung bestätigt, die Existenz dieser Art über einen Zeitraum von 23 Millionen Jahren zeigen. Die Zehenproportionen legen nahe, dass <i>Idiornis</i> cf. <i>itardiensis</i> weniger an eine laufende Lebensweise angepasst war als seine nächsten rezenten Verwandten, die Cariamidae. Darüber hinaus zeigt ein außergewöhnlich gut erhaltenes Skelett eines Vertreters der Sandcoleidae bisher unbekannte Einzelheiten der Osteologie und Befiederung dieser Familie. Das Exemplar ähnelt den Gattungen <i>Eoglaucidium</i> und <i>Anneavis</i>, konnte jedoch keiner der beiden Gattungen mit Sicherheit zugeordnet werden. <br><br> doi:<a href="http://dx.doi.org/10.1002/mmng.20000030110" target="_blank">10.1002/mmng.20000030110</a>

Analysis of Torsional Stick-Slip Situations from Recorded Downhole Rotational Speed Measurements

2021 ◽  
pp. 1-15
Author(s):  
Eric Cayeux ◽  
Adrian Ambrus ◽  
Lars Øy ◽  
Arvid Helleland ◽  
Svein Brundtland ◽  
...  
Keyword(s):  
Rotational Speed ◽  
Rotational Velocity ◽  
The Other ◽  
Drilling Process ◽  
Stick Slip ◽  
Torsional Oscillations ◽  
Direct Observations ◽  
New Information ◽  
Weight On Bit ◽  
Downhole Measurements

Summary The use of recorded downhole rotational speed measurements with a bandwidth up to 9 Hz gives new insights into the conditions under which stick-slip torsional oscillations occur. Observations made while drilling two reservoir sections have shown that, out of all the stick-slip situations identified, 72% of them for one well and 64% for the other well occurred in off-bottom conditions. In these off-bottom conditions, stick-slip was systematically observed while starting the topdrive (TD) until a sufficiently high TD rotational velocity was requested. For these two sections, off-bottomstick-slip was either related to using TD speeds below 120 rev/min or to reaming down during reciprocation procedures. In on-bottom conditions, stick-slip events occurred predominantly when the TD speed was less than 120 rev/min (53 and 32% of the on-bottom cases) but also in association with downlinking to the rotary steerable system (RSS) (23 and 46% of the on-bottom cases), and this, even though the TD speed was larger than 120 rev/min. These on-bottomstick-slip situations did not necessarily occur at a very high weight on bit (WOB) because 98% of them for one well and 46% for the other well took place when the WOB was lower than 10 ton. Downhole measurements have shown that when the drillstring is subject to strong stick-slip conditions, the downhole rotational speed changes from stationary to more than 300 rev/min in just a fraction of a second. Direct observations of downhole rotational speed at high frequency help in discovering conditions that were not suspected to lead to large torsional oscillations. This new information can be used to improve drilling operational procedures and models of the drilling process, therefore enabling increased drilling efficiency.

Jewish and Roman Law: A Study in Interaction

2020 ◽  
pp. 379-393
Author(s):  
Haym Soloveitchik
Keyword(s):  
Geographical Distribution ◽  
Twelfth Century ◽  
The Other ◽  
Roman Law ◽  
Jewish Law ◽  
Jewish Literature ◽  
Other Hand ◽  
New Information ◽  
Shed Light

This chapter discusses the laws regulating usury (ribbit). In the course of studying ribbit, more specifically, the problem of personal surety in usury contracts, certain peculiar developments in Provençal halakhic thought came to the author's attention which were not explainable by indigenous forces. The geographical distribution of the discussion seemed oddly disproportionate, the fictions too blatant, the types of problem that were raised seemed inappropriate for the period, and the terminology was occasionally alien. The author was compelled to look outside Jewish law for possible stimuli. Placing the Jewish developments within the context of twelfth-century Provençal law shed light on a number of seemingly inexplicable points. The Jewish literature, on the other hand, provided new information about the Gentile law of the time and yielded fresh corroboration for theories of the penetration of Roman law in Provence. However, at the same time this material seemed to point to an earlier date for certain legal developments than is generally accepted. It is these findings that the author wishes to bring to the attention of the scholars of Provençal law.

Information in the Welfare State: Problems and Approaches

1978 ◽  
Vol 21 (1_suppl) ◽  
pp. 165-180
Author(s):  
Yrjö Littunen
Keyword(s):  
Information Needs ◽  
Western Europe ◽  
Theoretical Orientation ◽  
School Science ◽  
State Regulation ◽  
Welfare States ◽  
The Other ◽  
Science Journalism ◽  
New Information ◽  
Partial Isolation

The most comprehensive approaches toward understanding information in modern ‘welfare states’ have been focussed on outlining state regulation in the monopoly stage of capitalism. This theoretical orientation has instigated a number of studies penetrating into the use of information for the purposes of state control and regulation, e.g. in income policies as well as in legislation. Less developed is the study of the other side of the dialectic: how do counter-processes manifest themselves in the course of increasing bureaucratic-corporativist regulation and control? Evidence on following tendencies in ‘welfare states’ in Western Europe and their accentuation in Scandinavia is discussed. (1) Fragmentation and partial isolation of the traditional information institutions (school, science, journalism) from contemporary information-steering processes, necessitated by increasing flows of raw information in the market of knowledge. (2) Emergence of new information-steering activities, often in organized, institutionalized forms. (3) New information-steering is developed for centralized, state-monopoly regulated information needs and, on the other hand, for democratic information needs: these trends and counter-trends depend not only on power changes in the class struggle but also on changes in the content and experience-coping of information available for the large majorities of the population.

scholarly journals Interplay among IncA and blaKPC-Carrying Plasmids in Citrobacter freundii

2019 ◽  
Vol 63 (5) ◽  
Author(s):  
Ibrahim Bitar ◽  
Mariasofia Caltagirone ◽  
Laura Villa ◽  
Vittoria Mattioni Marchetti ◽  
Elisabetta Nucleo ◽  
...  
Keyword(s):  
The Other ◽  
Conjugative Plasmid ◽  
Citrobacter Freundii ◽  
Content Type ◽  
New Information ◽  
Novel Variant

ABSTRACT We report two KPC-producing Citrobacter freundii isolates from unrelated patients. In one case, blaKPC-2 was harbored on a novel variant of a Tn4401 transposon of an IncN plasmid conjugated together with a coresident IncA plasmid, whereas in the other one, blaKPC-3 was on a Tn4401a transposon located on an IncX3-IncA self-conjugative plasmid fusion. The interplay among plasmids carrying blaKPC and the coresident IncA plasmids offers new information on plasmids coresident within clinically relevant enterobacteria.

scholarly journals Monoclonal Antibodies Reactive with Immunorecessive Epitopes of Glucuronoxylomannan, the Major Capsular Polysaccharide of Cryptococcus neoformans

2003 ◽  
Vol 10 (5) ◽  
pp. 903-909 ◽  
Author(s):  
Suzanne Brandt ◽  
Peter Thorkildson ◽  
Thomas R. Kozel
Keyword(s):  
Monoclonal Antibody ◽  
Immune Response ◽  
Monoclonal Antibodies ◽  
Cryptococcus Neoformans ◽  
Capsular Polysaccharide ◽  
Passive Immunization ◽  
The Other ◽  
Serotype A ◽  
Humoral Immune ◽  
New Information

ABSTRACT Cryptococcus neoformans is surrounded by an antiphagocytic capsule whose primary constituent is glucuronoxylomannan (GXM). An epitope shared by GXM serotypes A, B, C, and D is immunodominant when mice are immunized with serotype A GXM. In contrast, an epitope shared only by serotypes A and D is immunodominant when mice are immunized with serotype D. Hybridomas secreting antibodies reactive with subdominant epitopes were identified through a positive-negative screening procedure in which antibody-secreting colonies were characterized by reactivity with both the immunizing polysaccharide and GXMs from each of the four major serotypes. In this manner, a monoclonal antibody (MAb) that was reactive with an epitope shared only by serotypes A and B was identified and designated F10F5. Such an epitope has not been described previously. Immunization of mice with de-O-acetylated serotype A GXM generated a hybridoma that secreted an antibody, designated F12D2, that was reactive with all four serotypes. Unlike previously described monoclonal and polyclonal panspecific antibodies, the reactivity of MAb F12D2 was not altered by de-O-acetylation of GXM. These results indicate that there are at least two panspecific GXM epitopes; one epitope is dependent on O acetylation for antibody reactivity, and the other is independent of O acetylation. This study identifies strategies for production of MAbs that are reactive with subdominant or cryptic GXM epitopes and provides new information regarding the antigenic makeup and the humoral immune response to GXM, an essential virulence factor that is a target for active and passive immunization.

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