Vagal Nerve Stimulation to Probe Inflammation and Brain in Post-traumatic Stress

2019 ◽  
Author(s):  
Keyword(s):  
Nerve Stimulation ◽  
Traumatic Stress ◽  
Vagal Nerve ◽  
Vagal Nerve Stimulation ◽  
Post Traumatic Stress ◽  
Post Traumatic

scholarly journals Automatic Detection of Target Engagement in Transcutaneous Cervical Vagal Nerve Stimulation for Traumatic Stress Triggers

2020 ◽  
Author(s):  
Nil Z. Gurel ◽  
Matthew T. Wittbrodt ◽  
Hewon Jung ◽  
Stacy L. Ladd ◽  
Amit J. Shah ◽  
...  
Keyword(s):  
Nerve Stimulation ◽  
Traumatic Stress ◽  
Human Subjects ◽  
Therapy Response ◽  
Vagal Nerve ◽  
Vagal Nerve Stimulation ◽  
Sufficient Information ◽  
Target Engagement ◽  
Surgical Implants ◽  
At Home

AbstractTranscutaneous cervical vagal nerve stimulation (tcVNS) devices are attractive alternatives to surgical implants, and can be applied for a number of conditions in ambulatory settings, including stress-related neuropsychiatric disorders. Transferring tcVNS technologies to at-home settings brings challenges associated with the assessment of therapy response. The ability to accurately detect whether tcVNS has been effectively delivered in a remote setting such as the home has never been investigated. We designed and conducted a study in which 12 human subjects received active tcVNS and 14 received sham stimulation in tandem with traumatic stress, and measured continuous cardiopulmonary signals including the electrocardiogram (ECG), photoplethysmogram (PPG), seismocardiogram (SCG), and respiratory effort (RSP). We extracted physiological parameters related to autonomic nervous system activity, and created a feature set from these parameters to: 1) detect active (vs. sham) tcVNS stimulation presence with machine learning methods, and 2) determine which sensing modalities and features provide the most salient markers of tcVNS-based changes in physiological signals. Heart rate (ECG), vasomotor activity (PPG), and pulse arrival time (ECG+PPG) provided sufficient information to determine target engagement (compared to sham) in addition to other combinations of sensors. resulting in 96% accuracy, precision, and recall with a receiver operator characteristics area of 0.96. Two commonly utilized sensing modalities (ECG and PPG) that are suitable for home use can provide useful information on therapy response for tcVNS. The methods presented herein could be deployed in wearable devices to quantify adherence for at-home use of tcVNS technologies.

scholarly journals Trigeminal Nerve Stimulation (TNS) for Post-traumatic Stress Disorder: A Case Study

2015 ◽  
Vol 8 (3) ◽  
pp. 676-678 ◽  
Author(s):  
Alisson Paulino Trevizol ◽  
Pedro Shiozawa ◽  
Isa Albuquerque Sato ◽  
Mailu Enokibara da Silva ◽  
Elie Leal de Barros Calfat ◽  
...  
Keyword(s):  
Trigeminal Nerve ◽  
Nerve Stimulation ◽  
Post Traumatic Stress Disorder ◽  
Traumatic Stress ◽  
Stress Disorder ◽  
Post Traumatic Stress ◽  
Trigeminal Nerve Stimulation ◽  
Post Traumatic

scholarly journals Non-Invasive Cervical Vagal Nerve Stimulation Alters Brain Activity During Traumatic Stress in Individuals with Posttraumatic Stress Disorder

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Matthew T. Wittbrodt ◽  
Nil Z. Gurel ◽  
Jonathon A. Nye ◽  
Md Mobashir H. Shandhi ◽  
Asim H. Gazi ◽  
...  
Keyword(s):  
Posttraumatic Stress Disorder ◽  
Posttraumatic Stress ◽  
Nerve Stimulation ◽  
Traumatic Stress ◽  
Stress Disorder ◽  
Brain Activity ◽  
Vagal Nerve ◽  
Vagal Nerve Stimulation ◽  
Non Invasive
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